CA1016537A - Alpha-aminoacyl-3-halo cephalosporins - Google Patents

Alpha-aminoacyl-3-halo cephalosporins

Info

Publication number
CA1016537A
CA1016537A CA193,236A CA193236A CA1016537A CA 1016537 A CA1016537 A CA 1016537A CA 193236 A CA193236 A CA 193236A CA 1016537 A CA1016537 A CA 1016537A
Authority
CA
Canada
Prior art keywords
aminoacyl
alpha
cephalosporins
halo
halo cephalosporins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA193,236A
Inventor
Robert R. Chauvette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US33538173A priority Critical
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of CA1016537A publication Critical patent/CA1016537A/en
Application status is Expired legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02Preparation
    • C07D501/04Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of products other than chlorine, adipic acid, caprolactam, or chlorodifluoromethane, e.g. bulk or fine chemicals or pharmaceuticals
    • Y02P20/55Synthetic design, e.g. reducing the use of auxiliary or protecting groups
CA193,236A 1973-02-23 1974-02-22 Alpha-aminoacyl-3-halo cephalosporins Expired CA1016537A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US33538173A true 1973-02-23 1973-02-23

Publications (1)

Publication Number Publication Date
CA1016537A true CA1016537A (en) 1977-08-30

Family

ID=23311540

Family Applications (1)

Application Number Title Priority Date Filing Date
CA193,236A Expired CA1016537A (en) 1973-02-23 1974-02-22 Alpha-aminoacyl-3-halo cephalosporins

Country Status (37)

Country Link
JP (4) JPS6139313B2 (en)
AR (1) AR199510A1 (en)
AT (1) AT333953B (en)
BE (1) BE811495A (en)
BR (1) BR7401384D0 (en)
CA (1) CA1016537A (en)
CH (1) CH593988A5 (en)
CS (1) CS187409B2 (en)
CY (1) CY1043A (en)
DD (1) DD110278A5 (en)
DE (1) DE2408698C2 (en)
DK (1) DK153157C (en)
EG (1) EG11104A (en)
ES (1) ES423531A1 (en)
FI (1) FI63035C (en)
FR (1) FR2218877B1 (en)
GB (1) GB1461323A (en)
GT (1) GT197432133A (en)
HK (1) HK20080A (en)
HU (1) HU166849B (en)
IE (1) IE39046B1 (en)
IL (1) IL44262A (en)
IN (1) IN139620B (en)
KE (1) KE3027A (en)
MW (1) MW674A1 (en)
MY (1) MY8100024A (en)
NL (1) NL179057C (en)
NO (2) NO148375C (en)
OA (1) OA4809A (en)
PH (1) PH9616A (en)
PL (1) PL88702B1 (en)
RO (1) RO64663A (en)
SE (1) SE411212B (en)
SU (1) SU676166A3 (en)
YU (1) YU36970B (en)
ZA (1) ZA7401191B (en)
ZM (1) ZM3574A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342197B (en) * 1975-02-20 1978-03-28 Ciba Geigy Ag cephem-3 new process for the production of
CH619233A5 (en) * 1975-07-31 1980-09-15 Ciba Geigy Ag
CH622802A5 (en) * 1975-08-20 1981-04-30 Ciba Geigy Ag
IE45158B1 (en) * 1976-08-16 1982-06-30 Lilly Co Eli 3-chloro-cephem synthesis
DE3508258A1 (en) * 1985-03-08 1986-09-18 Bayer Ag Ss-lactam antibiotics, process for manufacture and their use as pharmaceuticals and
DE3509618A1 (en) 1985-03-16 1986-09-18 Bayer Ag Ss-lactam antibiotics, process for manufacture and their use as medicines
JPS6436445U (en) * 1987-08-28 1989-03-06
DE3803169A1 (en) 1988-02-03 1989-08-17 Bayer Ag Ss-lactam antibiotics, process for their production and their use as pharmaceuticals and
ES2010075A6 (en) * 1989-01-10 1989-10-16 Antibioticos Sa A process for the preparation of compounds of 3-chloro-cephem.
JP2539459Y2 (en) * 1991-12-18 1997-06-25 三重ホーロー株式会社 Prefabricated garbage incinerator
IT1255458B (en) * 1992-05-11 1995-11-02 Col Marco Da Process for the preparation of beta-lactam halogenated
ES2079327B1 (en) 1994-12-13 1996-08-01 Lilly Sa Pharmaceutical formulations of cefaclor.
CN101805357B (en) * 2010-04-28 2012-01-11 陶灵刚 Cefaclor compound and novel preparation method thereof
CN103588790A (en) * 2013-11-29 2014-02-19 中国科学院长春应用化学研究所 Preparation method of 7-amino-3-chloro-3-cephem-4-carboxylic acid-p-nitrobenzyl ester
CN106632400A (en) * 2016-12-16 2017-05-10 石家庄柏奇化工有限公司 Method for preparing 7-ACCA by removing 4-nitrobenzyl through catalytic hydrogenation of Pd-C

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds
DE2265798C2 (en) * 1971-06-24 1985-09-26 Fujisawa Pharmaceutical Co., Ltd., Osaka, Jp
AR206201A1 (en) * 1972-06-29 1976-07-07 Ciba Geigy Ag Procedure for obtaining acid compounds 7beta-amino-3-cephem-3-01-4-carboxilico0-substituted

Also Published As

Publication number Publication date
CY1043A (en) 1980-08-01
HK20080A (en) 1980-04-25
IL44262D0 (en) 1974-05-16
NO148377C (en) 1983-09-28
IN139620B (en) 1976-07-10
ES423531A1 (en) 1976-05-16
FI63035B (en) 1982-12-31
JPS56138192A (en) 1981-10-28
FR2218877B1 (en) 1977-03-11
SE411212B (en) 1979-12-10
DK153157C (en) 1988-10-31
NO148375C (en) 1983-09-28
NL179057C (en) 1986-07-01
FR2218877A1 (en) 1974-09-20
OA4809A (en) 1980-08-31
MW674A1 (en) 1975-04-09
SU676166A3 (en) 1979-07-25
BE811495A (en) 1974-08-22
DE2408698A1 (en) 1974-09-05
JPS6139313B2 (en) 1986-09-03
YU36970B (en) 1984-08-31
NO792681L (en) 1974-08-26
FI63035C (en) 1983-04-11
HU166849B (en) 1975-06-28
JPS56138191A (en) 1981-10-28
IL44262A (en) 1977-08-31
AR199510A1 (en) 1974-09-09
YU39974A (en) 1982-06-18
DE2408698C2 (en) 1983-11-10
IE39046B1 (en) 1978-07-19
AT333953B (en) 1976-12-27
NO148377B (en) 1983-06-20
MY8100024A (en) 1981-12-31
PL88702B1 (en) 1976-09-30
RO64663A (en) 1979-02-15
CS187409B2 (en) 1979-01-31
BE811495A1 (en)
KE3027A (en) 1980-03-14
JPS49110689A (en) 1974-10-22
NL179057B (en) 1986-02-03
ZA7401191B (en) 1975-10-29
JPS56138190A (en) 1981-10-28
NO148375B (en) 1983-06-20
IE39046L (en) 1974-08-23
ZM3574A1 (en) 1975-11-21
PH9616A (en) 1976-01-20
CA1016537A1 (en)
NL7402489A (en) 1974-08-27
JPS6140237B2 (en) 1986-09-08
ATA142574A (en) 1976-04-15
GT197432133A (en) 1975-08-16
GB1461323A (en) 1977-01-13
JPS6140235B2 (en) 1986-09-08
EG11104A (en) 1976-12-31
DK153157B (en) 1988-06-20
BR7401384D0 (en) 1974-11-05
DD110278A5 (en) 1974-12-12
CH593988A5 (en) 1977-12-30
AU6591674A (en) 1975-08-28
JPS6140236B2 (en) 1986-09-08

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