GB1455728A - 5-6-benzene ring substituted benzimidazole-2-carbamate deriva tives having anthelmintic activity - Google Patents

5-6-benzene ring substituted benzimidazole-2-carbamate deriva tives having anthelmintic activity

Info

Publication number
GB1455728A
GB1455728A GB5792573A GB5792573A GB1455728A GB 1455728 A GB1455728 A GB 1455728A GB 5792573 A GB5792573 A GB 5792573A GB 5792573 A GB5792573 A GB 5792573A GB 1455728 A GB1455728 A GB 1455728A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
carbamate
benzene ring
ring substituted
substituted benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5792573A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26981949&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1455728(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of GB1455728A publication Critical patent/GB1455728A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/38—Isothioureas containing any of the groups, X being a hetero atom, Y being any atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB5792573A 1972-12-29 1973-12-13 5-6-benzene ring substituted benzimidazole-2-carbamate deriva tives having anthelmintic activity Expired GB1455728A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31929972A 1972-12-29 1972-12-29
US417963A US3929821A (en) 1972-12-29 1973-11-21 5 (6)-Benzene ring substituted benzimidazole-2-carbamate derivatives

Publications (1)

Publication Number Publication Date
GB1455728A true GB1455728A (en) 1976-11-17

Family

ID=26981949

Family Applications (2)

Application Number Title Priority Date Filing Date
GB5792573A Expired GB1455728A (en) 1972-12-29 1973-12-13 5-6-benzene ring substituted benzimidazole-2-carbamate deriva tives having anthelmintic activity
GB3023476A Expired GB1456497A (en) 1972-12-29 1973-12-13 5-6-benzene ring substituted benzimidazole-2-carbamate derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB3023476A Expired GB1456497A (en) 1972-12-29 1973-12-13 5-6-benzene ring substituted benzimidazole-2-carbamate derivatives

Country Status (25)

Country Link
US (1) US3929821A (enrdf_load_stackoverflow)
JP (1) JPS5939428B2 (enrdf_load_stackoverflow)
AR (2) AR216037A1 (enrdf_load_stackoverflow)
AT (1) AT332883B (enrdf_load_stackoverflow)
BR (1) BR7310296D0 (enrdf_load_stackoverflow)
CH (2) CH613955A5 (enrdf_load_stackoverflow)
CS (1) CS187390B2 (enrdf_load_stackoverflow)
DE (3) DE2363351C2 (enrdf_load_stackoverflow)
DK (1) DK137329B (enrdf_load_stackoverflow)
ES (2) ES421927A1 (enrdf_load_stackoverflow)
FR (1) FR2212150B1 (enrdf_load_stackoverflow)
GB (2) GB1455728A (enrdf_load_stackoverflow)
HK (1) HK8280A (enrdf_load_stackoverflow)
HU (1) HU169272B (enrdf_load_stackoverflow)
IE (1) IE40046B1 (enrdf_load_stackoverflow)
IL (1) IL43860A (enrdf_load_stackoverflow)
IN (1) IN138644B (enrdf_load_stackoverflow)
IT (1) IT1046097B (enrdf_load_stackoverflow)
MY (1) MY8000273A (enrdf_load_stackoverflow)
NL (1) NL169738C (enrdf_load_stackoverflow)
PL (1) PL95987B1 (enrdf_load_stackoverflow)
RO (1) RO67150A (enrdf_load_stackoverflow)
SE (1) SE414402B (enrdf_load_stackoverflow)
SU (1) SU727143A3 (enrdf_load_stackoverflow)
YU (2) YU36706B (enrdf_load_stackoverflow)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2843008A1 (de) * 1977-10-06 1979-04-19 Montedison Spa 5(6)-eckige klammer auf (cyclopropylethyl)-sulphinyl eckige klammer zu -benzimidazol-2-methylcarbamat, ein verfahren zu seiner herstellung, sowie pharmazeutische zusammensetzung
US4299837A (en) 1979-12-05 1981-11-10 Montedison S.P.A. Anthelmintic benzimidazole-carbamates

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002640A (en) * 1972-12-29 1977-01-11 Syntex (U.S.A.) Inc. 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
US4258198A (en) * 1973-05-29 1981-03-24 Smithkline Corporation 5-Cycloalkyl thio- and oxy-2-carbalkoxyaminobenzimidazoles
DE2441201C2 (de) * 1974-08-28 1986-08-07 Hoechst Ag, 6230 Frankfurt Anthelminthisch wirksame 2-Carbalkoxyamino-5(6)-phenyl-sulfonyloxy-benzimidazole und Verfahren zu ihrer Herstellung
DE2441202C2 (de) * 1974-08-28 1986-05-28 Hoechst Ag, 6230 Frankfurt 2-Carbalkoxyamino-benzimidazolyl-5(6)-sulfonsäure-phenylester, Verfahren zu ihrer Herstellung und diese enthaltende anthelmintische Mittel
US4086235A (en) * 1976-04-12 1978-04-25 Syntex (U.S.A.) Inc. 5 (6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
USRE30990E (en) * 1976-07-16 1982-07-06 E. R. Squibb & Sons, Inc. Benzimidazole derivatives, compositions thereof and method of use as anthelmintics
US4046908A (en) * 1976-07-16 1977-09-06 E. R. Squibb & Sons, Inc. Benzimidazole derivatives, compositions thereof and method of use as anthelmintics
US4166858A (en) * 1976-08-13 1979-09-04 Burroughs Wellcome Co. Method and composition for treating fluke infections
FR2361109A1 (fr) * 1976-08-13 1978-03-10 Wellcome Found Medicaments anthelminthiques
FR2362116A1 (fr) * 1976-08-20 1978-03-17 Oreal Metaphenylenediamines et compositions tinctoriales les contenant
US4093732A (en) * 1977-02-17 1978-06-06 E. R. Squibb & Sons, Inc. Sulfoxide derivatives of benzimidazoles
IT1076022B (it) * 1977-04-20 1985-04-22 Montedison Spa Benzimidazolcarbammati antielmintici
US4152522A (en) * 1978-01-03 1979-05-01 Ethyl Corporation Process for the preparation of 2-benzimidazole carbamates
US4136174A (en) * 1978-01-18 1979-01-23 E. R. Squibb & Sons, Inc. Benzimidazolecarbamates and method
US4156006A (en) * 1978-01-09 1979-05-22 E. R. Squibb & Sons, Inc. Vinyl sulfide derivatives of benzimidazoles
JPS54104837A (en) * 1978-02-03 1979-08-17 Nippon Denso Co Ltd Controller of copying machines
US4145431A (en) * 1978-02-16 1979-03-20 E. R. Squibb & Sons, Inc. Method of treating helminthiasis by parenteral administration of sulfide- and sulfoxide-derivatives of benzimidazoles
US4154846A (en) * 1978-06-16 1979-05-15 E. R. Squibb & Sons, Inc. Substituted thio-, sulfinyl-, and sulfonyl-alkyl benzimidazole carbamates
US4174400A (en) * 1978-09-13 1979-11-13 Merck & Co., Inc. Anthelmintic benzimidazoles
DE2845537A1 (de) * 1978-10-19 1980-04-30 Bayer Ag Benzimidazolylcarbamidsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
IT1100788B (it) * 1978-12-06 1985-09-28 Montedison Spa Benzimidazol-carbammati
SE445641B (sv) * 1978-12-06 1986-07-07 Montedison Spa Bensimidazolkarbamat och forfarande for framstellning derav
US4198422A (en) * 1979-05-17 1980-04-15 E. R. Squibb & Sons, Inc. Substituted 2,3-naphthimidazole carbamates and method
EP0028455A1 (en) * 1979-10-12 1981-05-13 Imperial Chemical Industries Plc 5-Phenylselenobenzimidazole derivatives, their preparation and anthelmintic or fasciolicidal compositions containing them
US4599428A (en) * 1979-10-19 1986-07-08 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt Process for the preparation of 5(6)-thio substituted benzimidazoles
HU182763B (hu) * 1979-10-19 1984-03-28 Chinoin Gyogyszer Es Vegyeszet Eljárás 5(6)-alkiltio-benzimidazolil-alkil-karbamátok előállítására
IL61232A (en) * 1979-10-19 1985-09-29 Chinoin Gyogyszer Es Vegyeszet Process for the preparation of 2-amino(or alkoxycarbonylamino)-5(6)-thiocyanato(or thiol)benzimidazole derivatives
DE3719783A1 (de) * 1987-06-13 1988-12-22 Hoechst Ag Verfahren zur herstellung von 5-phenylsulfinyl-1h-2-(methoxycarbonylamino)- benzimidazol
GB9205368D0 (en) * 1992-03-12 1992-04-22 Pfizer Ltd Benzimidozole anthelmintic agents
US6593466B1 (en) 1999-07-07 2003-07-15 Isis Pharmaceuticals, Inc. Guanidinium functionalized nucleotides and precursors thereof
CA2616512A1 (en) * 2005-07-28 2007-02-08 Intervet International B.V. Novel benzimidazole (thio) carbamates with antiparasitic activity and the synthesis thereof
US20130197527A1 (en) * 2006-06-12 2013-08-01 Smith & Nephew, Inc. Systems, methods and devices for tibial resection
AR061351A1 (es) 2006-06-14 2008-08-20 Intervet Int Bv Composicion de carbamato de bencimidazol
CN102241635A (zh) * 2011-04-28 2011-11-16 江苏宝众宝达药业有限公司 一种苯并咪唑类驱虫药苯硫咪唑的制备方法
CN102863392A (zh) * 2012-10-18 2013-01-09 江苏宝众宝达药业有限公司 一种奥芬达唑生产过程中大幅减少溶剂使用量的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2933502A (en) * 1958-02-12 1960-04-19 Du Pont Benzimidazolone derivatives
US2933504A (en) * 1959-08-10 1960-04-19 Du Pont Derivatives of polyalkoxycarbonyl imine
US3010968A (en) 1959-11-25 1961-11-28 Du Pont Process for manufacture of certain alkyl esters of benzimidazole carbamic acids
BE666795A (enrdf_load_stackoverflow) * 1964-08-04 1966-01-13
US3506767A (en) * 1965-08-06 1970-04-14 Geigy Chem Corp Benzimidazole compositions and methods of use
US3401171A (en) * 1966-03-11 1968-09-10 Smithkline Corp 2-amidobenzimidazoles
CH456236A (de) * 1966-05-06 1968-07-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasermaterialien vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3480642A (en) * 1967-03-22 1969-11-25 Smithkline Corp Process for producing 2-carbalkoxyaminobenzimidazoles
CH490010A (de) * 1967-10-26 1970-05-15 Ciba Geigy Schädlingsbekämpfungsmittel
US3562290A (en) * 1967-11-07 1971-02-09 Du Pont Process for making 2-benzimidazolecarbamic acid alkyl esters
FR2059938A1 (en) * 1969-03-14 1971-06-11 Aries Robert 1-haloalk(en)yl sulphenyl-2-aryloxycarbon-yl -
US3657267A (en) * 1969-06-20 1972-04-18 Janssen Pharmaceutica Nv Benzimidazole carbamates
US3714180A (en) * 1970-08-12 1973-01-30 Squibb & Sons Inc Sulfonyl benzimidazoles
US3694455A (en) * 1970-11-19 1972-09-26 Smith Kline French Lab Acyloxyalkyl amidobenzimidazoles
US3720686A (en) * 1971-04-01 1973-03-13 Squibb & Sons Inc Mercaptobenzimidazole derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2843008A1 (de) * 1977-10-06 1979-04-19 Montedison Spa 5(6)-eckige klammer auf (cyclopropylethyl)-sulphinyl eckige klammer zu -benzimidazol-2-methylcarbamat, ein verfahren zu seiner herstellung, sowie pharmazeutische zusammensetzung
US4299837A (en) 1979-12-05 1981-11-10 Montedison S.P.A. Anthelmintic benzimidazole-carbamates

Also Published As

Publication number Publication date
BR7310296D0 (pt) 1974-09-24
SU727143A3 (ru) 1980-04-05
AR221816A1 (es) 1981-03-31
CS187390B2 (en) 1979-01-31
CH608006A5 (enrdf_load_stackoverflow) 1978-12-15
DK137329B (da) 1978-02-20
DE2363351A1 (de) 1974-07-11
RO67150A (ro) 1980-12-30
IE40046B1 (en) 1979-02-28
IL43860A0 (en) 1974-03-14
DE2366069A1 (de) 1977-11-10
HU169272B (enrdf_load_stackoverflow) 1976-10-28
FR2212150B1 (enrdf_load_stackoverflow) 1977-01-28
ES421927A1 (es) 1977-01-01
DK137329C (enrdf_load_stackoverflow) 1978-07-24
YU40868B (en) 1986-06-30
IL43860A (en) 1977-05-31
IE40046L (en) 1974-06-29
YU36706B (en) 1984-08-31
CH613955A5 (enrdf_load_stackoverflow) 1979-10-31
IN138644B (enrdf_load_stackoverflow) 1976-03-06
IT1046097B (it) 1980-06-30
JPS505518A (enrdf_load_stackoverflow) 1975-01-21
ES445257A1 (es) 1977-10-01
AU6367473A (en) 1975-06-19
DE2366070C2 (enrdf_load_stackoverflow) 1987-06-11
US3929821A (en) 1975-12-30
ATA1075173A (de) 1976-02-15
AT332883B (de) 1976-10-25
HK8280A (en) 1980-03-14
NL169738B (nl) 1982-03-16
JPS5939428B2 (ja) 1984-09-22
GB1456497A (en) 1976-11-24
MY8000273A (en) 1980-12-31
AR216037A1 (es) 1979-11-30
DE2363351C2 (de) 1987-03-12
PL95987B1 (pl) 1977-11-30
YU64180A (en) 1983-04-30
FR2212150A1 (enrdf_load_stackoverflow) 1974-07-26
DE2366069C2 (enrdf_load_stackoverflow) 1987-06-11
NL7317797A (enrdf_load_stackoverflow) 1974-07-02
SE414402B (sv) 1980-07-28
YU337173A (en) 1981-11-13
NL169738C (nl) 1982-08-16

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
CTFF Supplementary protection certificate filed

Free format text: SPC/GB93/105, 930628

CTFG Supplementary protection certificate granted

Free format text: SPC/GB93/105, 931126, EXPIRES:19981212

PE20 Patent expired after termination of 20 years

Effective date: 19931212

CTFE Supplementary protection certificate entered into force

Free format text: SPC/GB93/105, 931213, EXPIRES:19981212

CTFG Supplementary protection certificate granted

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CTFG Supplementary protection certificate granted

Free format text: SPC/GB93/105, 931126 ERRATUM IN OJ(P)5465 PAGE 5739, EXPIRES:YYYYMMDD

SPCE Supplementary protection certificate expired

Free format text: SPC/GB93/105, 981212

SPCE Supplementary protection certificate expired

Free format text: SPC/GB93/105, 981212