GB1385086A - Insulin product - Google Patents

Info

Publication number

GB1385086A

GB1385086A GB1974172A GB1974172A GB1385086A GB 1385086 A GB1385086 A GB 1385086A GB 1974172 A GB1974172 A GB 1974172A GB 1974172 A GB1974172 A GB 1974172A GB 1385086 A GB1385086 A GB 1385086A

Authority

GB

United Kingdom

Prior art keywords

insulin

alkali metal

protamine

salt

aqueous medium

Prior art date

1971-04-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

• Espacenet
• Global Dossier
• Discuss

• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 17
• 102000004877 Insulin Human genes 0.000 title abstract 8
• 108090001061 Insulin Proteins 0.000 title abstract 8
• 229940125396 insulin Drugs 0.000 title abstract 8
• 229940048914 protamine Drugs 0.000 abstract 4
• 102000007327 Protamines Human genes 0.000 abstract 3
• 108010007568 Protamines Proteins 0.000 abstract 3
• 229910052783 alkali metal Inorganic materials 0.000 abstract 3
• 239000012736 aqueous medium Substances 0.000 abstract 3
• 150000001340 alkali metals Chemical class 0.000 abstract 2
• 150000003863 ammonium salts Chemical class 0.000 abstract 2
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
• WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
• 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
• 229910001413 alkali metal ion Inorganic materials 0.000 abstract 1
• -1 alkali metal salt Chemical class 0.000 abstract 1
• 229910052792 caesium Inorganic materials 0.000 abstract 1
• TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 abstract 1
• 238000002425 crystallisation Methods 0.000 abstract 1
• 230000008025 crystallization Effects 0.000 abstract 1
• 230000000694 effects Effects 0.000 abstract 1
• 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
• 239000000644 isotonic solution Substances 0.000 abstract 1
• 229910052744 lithium Inorganic materials 0.000 abstract 1
• 229910052700 potassium Inorganic materials 0.000 abstract 1
• 239000011591 potassium Substances 0.000 abstract 1
• 230000002035 prolonged effect Effects 0.000 abstract 1
• 150000003839 salts Chemical class 0.000 abstract 1
• 229910052708 sodium Inorganic materials 0.000 abstract 1
• 239000011734 sodium Substances 0.000 abstract 1
• 239000000725 suspension Substances 0.000 abstract 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1