GB0316294D0 - Conjugated biological molecules and their preparation - Google Patents
Conjugated biological molecules and their preparationInfo
- Publication number
- GB0316294D0 GB0316294D0 GBGB0316294.8A GB0316294A GB0316294D0 GB 0316294 D0 GB0316294 D0 GB 0316294D0 GB 0316294 A GB0316294 A GB 0316294A GB 0316294 D0 GB0316294 D0 GB 0316294D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- general formula
- protein
- compound
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229920001223 polyethylene glycol Polymers 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004185 ester group Chemical group 0.000 abstract 2
- 125000000468 ketone group Chemical group 0.000 abstract 2
- -1 poly(ethylene glycol) Polymers 0.000 abstract 2
- 125000001174 sulfone group Chemical group 0.000 abstract 2
- 229930194542 Keto Natural products 0.000 abstract 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 239000012431 aqueous reaction media Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F10/00—Homopolymers and copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyrrole Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (29)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0316294.8A GB0316294D0 (en) | 2003-07-11 | 2003-07-11 | Conjugated biological molecules and their preparation |
| ES09167191.7T ES2632515T3 (es) | 2003-07-11 | 2004-07-12 | Moléculas biológicas conjugadas y su preparación |
| PL04743335T PL1648518T3 (pl) | 2003-07-11 | 2004-07-12 | Skoniugowane cząsteczki biologiczne i ich wytwarzanie |
| AU2004257448A AU2004257448B2 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| AT04743335T ATE440620T1 (de) | 2003-07-11 | 2004-07-12 | Konjugierte biologische moleküle und ihre herstellung |
| EP10175140.2A EP2253330B1 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| KR1020067000278A KR101152500B1 (ko) | 2003-07-11 | 2004-07-12 | 접합된 생물학적 분자 및 그의 제조방법 |
| DK04743335T DK1648518T3 (da) | 2003-07-11 | 2004-07-12 | Konjugerede biologiske molekyler og deres fremstilling |
| DK09167191.7T DK2133099T3 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| ES10175143.6T ES2542531T3 (es) | 2003-07-11 | 2004-07-12 | Procedimiento de preparación de moléculas biológicas conjugadas |
| US10/564,340 US7595292B2 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| CN2010101399434A CN101792525B (zh) | 2003-07-11 | 2004-07-12 | 偶联生物分子及其制备 |
| JP2006518372A JP4958549B2 (ja) | 2003-07-11 | 2004-07-12 | 複合生物学的分子及びそれらの調製 |
| ES10175140.2T ES2549427T3 (es) | 2003-07-11 | 2004-07-12 | Moléculas biológicas conjugadas y su preparación |
| DE602004022824T DE602004022824D1 (de) | 2003-07-11 | 2004-07-12 | Konjugierte biologische moleküle und ihre herstellung |
| EP20100175143 EP2277550B1 (en) | 2003-07-11 | 2004-07-12 | Process for the preparation of conjugated biological molecules. |
| DK10175143.6T DK2277550T3 (en) | 2003-07-11 | 2004-07-12 | A process for the preparation of conjugated biological molecules |
| EP09167191.7A EP2133099B1 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| PL10175140T PL2253330T3 (pl) | 2003-07-11 | 2004-07-12 | Skoniugowane cząsteczki biologiczne i ich otrzymywanie |
| ES04743335T ES2331004T3 (es) | 2003-07-11 | 2004-07-12 | Moleculas biologicas conjugadas y su preparacion. |
| CN2004800198144A CN1822860B (zh) | 2003-07-11 | 2004-07-12 | 偶联生物分子及其制备 |
| EP04743335A EP1648518B1 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| DK10175140.2T DK2253330T3 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| PCT/GB2004/002994 WO2005007197A2 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| US12/458,931 US7939630B2 (en) | 2003-07-11 | 2009-07-28 | Conjugated biological molecules and their preparation |
| AU2010257308A AU2010257308B2 (en) | 2003-07-11 | 2010-12-20 | Conjugated biological molecules and their preparation |
| US13/077,980 US8816051B2 (en) | 2003-07-11 | 2011-03-31 | Conjugated biological molecules and their preparation |
| JP2011170597A JP5349552B2 (ja) | 2003-07-11 | 2011-08-04 | 複合生物学的分子及びそれらの調製 |
| US14/444,859 US9439974B2 (en) | 2003-07-11 | 2014-07-28 | Conjugated biological molecules and their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0316294.8A GB0316294D0 (en) | 2003-07-11 | 2003-07-11 | Conjugated biological molecules and their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB0316294D0 true GB0316294D0 (en) | 2003-08-13 |
Family
ID=27742023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB0316294.8A Ceased GB0316294D0 (en) | 2003-07-11 | 2003-07-11 | Conjugated biological molecules and their preparation |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US7595292B2 (enExample) |
| EP (4) | EP2133099B1 (enExample) |
| JP (2) | JP4958549B2 (enExample) |
| KR (1) | KR101152500B1 (enExample) |
| CN (2) | CN1822860B (enExample) |
| AT (1) | ATE440620T1 (enExample) |
| AU (2) | AU2004257448B2 (enExample) |
| DE (1) | DE602004022824D1 (enExample) |
| DK (4) | DK1648518T3 (enExample) |
| ES (4) | ES2549427T3 (enExample) |
| GB (1) | GB0316294D0 (enExample) |
| PL (2) | PL2253330T3 (enExample) |
| WO (1) | WO2005007197A2 (enExample) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5207590B2 (ja) | 2002-12-26 | 2013-06-12 | マウンテン ビュー ファーマシューティカルズ,インコーポレイテッド | 増強された生物学的能力を有するインターフェロン−βのポリマー結合体 |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| US7046714B2 (en) * | 2003-09-10 | 2006-05-16 | Intel Corporation | Method and apparatus for Raman ring resonator based laser/wavelength converter |
| ES2533695T3 (es) * | 2004-03-02 | 2015-04-14 | Seattle Genetics, Inc. | Anticuerpos cargados parcialmente y métodos para su conjugación |
| KR20080068004A (ko) * | 2005-08-15 | 2008-07-22 | 아라나 테라퓨틱스 리미티드 | 뉴 월드 영장류 구조형성영역을 가진 조작 항체 |
| BRPI0707425A2 (pt) * | 2006-02-01 | 2011-05-03 | Arana Therapeutics Ltd | construção de anticorpo de domìnio, molécula isolada de ácido nucleico, composição farmacêutica, e, métodos para detectar tnf-alfa humano em uma amostra, e para tratar um distúrbio |
| US20080139790A1 (en) * | 2006-12-08 | 2008-06-12 | Jennings Philip A | Chimeric antibodies |
| WO2008098930A1 (en) * | 2007-02-14 | 2008-08-21 | Biocompatibes Uk Limited | Derivatisation of biological molecules |
| GB0708376D0 (en) | 2007-05-01 | 2007-06-06 | Alligator Bioscience Ab | Novel polypeptides and uses thereof |
| US8658148B2 (en) | 2007-06-22 | 2014-02-25 | Genzyme Corporation | Chemically modified dendrimers |
| TWI360535B (en) * | 2007-08-30 | 2012-03-21 | Univ Nat Sun Yat Sen | Sulfur-containing compound, method of preparation |
| JP5933923B2 (ja) * | 2007-10-09 | 2016-06-22 | ポリテリクス リミテッド | 新規な複合タンパク質及びペプチド |
| ES2466340T3 (es) * | 2008-04-24 | 2014-06-10 | Cantab Biopharmaceuticals Patents Limited | Conjugados de Factor IX con semividas extendidas |
| RU2016108598A (ru) | 2008-06-30 | 2018-11-23 | ИЭсБиЭйТЕК, ЭН АЛЬКОН БАЙОМЕДИКАЛ РИСЕРЧ ЮНИТ ЭлЭлСи | Функционализированные полипептиды |
| MX2011000009A (es) | 2008-07-10 | 2011-08-15 | Esbatech Alcon Biomed Res Unit | Metodos y composiciones para la administracion mejorada de macromoleculas. |
| KR101763559B1 (ko) | 2008-07-21 | 2017-08-14 | 폴리테릭스 리미티드 | 생물학적 분자의 컨쥬게이팅을 위한 신규한 시약 및 방법 |
| GB0817978D0 (en) * | 2008-10-01 | 2008-11-05 | Imp Innovations Ltd | Peptides |
| EA201170647A1 (ru) * | 2008-11-04 | 2011-12-30 | Янссен Фармацевтика Нв | Пептиды-агонисты crhr2 и их использование |
| GB0912485D0 (en) * | 2009-07-17 | 2009-08-26 | Polytherics Ltd | Improved conjugation method |
| GB0922354D0 (en) | 2009-12-21 | 2010-02-03 | Polytherics Ltd | Novel polymer conjugates |
| WO2010100430A1 (en) | 2009-03-04 | 2010-09-10 | Polytherics Limited | Conjugated proteins and peptides |
| US10370245B2 (en) | 2009-06-22 | 2019-08-06 | Sanford-Burnham Medical Research Institute | Methods and compositions using peptides and proteins with C-terminal elements |
| GB0916576D0 (en) | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| GB0916578D0 (en) | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| FI124016B (fi) * | 2009-10-26 | 2014-01-31 | Vapo Oy | Menetelmä biomassakuivattimessa käytetyn kuivatusilman lämmittämiseksi välipiirinesteen avulla sekä vesi-glykoliseoksen tai sitä vastaavan jäätymättömän välipiirinesteen käyttö biomassakuivattimessa käytetyn kuivatusilman lämmittämiseksi |
| WO2011057027A2 (en) | 2009-11-04 | 2011-05-12 | Janssen Pharmaceutica Nv | Method for treating heart failure with stresscopin-like peptides |
| GB201007357D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| WO2012118778A1 (en) | 2011-02-28 | 2012-09-07 | Sanford-Burnham Medical Research Institute | Truncated car peptides and methods and compositions using truncated car peptides |
| GB2490655A (en) | 2011-04-28 | 2012-11-14 | Univ Aston | Modulators of tissue transglutaminase |
| CA2837588A1 (en) | 2011-05-31 | 2012-12-06 | Airware, Inc. | Re-calibration of ab ndir gas sensors |
| US10179801B2 (en) | 2011-08-26 | 2019-01-15 | Sanford-Burnham Medical Research Institute | Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides |
| US20150086524A1 (en) | 2012-04-16 | 2015-03-26 | Cantab Biopharmaceuticals Patents Limited | Optimised subcutaneous therapeutic agents |
| WO2013177481A1 (en) | 2012-05-25 | 2013-11-28 | Immunogen, Inc. | Benzodiazepines and conjugates thereof |
| GB201210770D0 (en) | 2012-06-18 | 2012-08-01 | Polytherics Ltd | Novel conjugation reagents |
| US9650331B2 (en) | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
| EP2861261A2 (en) * | 2012-06-19 | 2015-04-22 | Polytherics Limited | Process for preparation of antibody conjugates and antibody conjugates |
| IN2015DN02349A (enExample) | 2012-10-24 | 2015-08-28 | Polytherics Ltd | |
| NO2789793T3 (enExample) | 2012-10-24 | 2018-01-27 | ||
| CN104853781B (zh) | 2012-11-30 | 2017-10-24 | 诺华股份有限公司 | 从含二硫化物的蛋白质制备缀合物的方法 |
| CA2892863C (en) | 2012-12-10 | 2022-03-15 | Mersana Therapeutics, Inc. | Polymeric scaffold based on phf for targeted drug delivery |
| US10226535B2 (en) | 2012-12-10 | 2019-03-12 | Mersana Therapeutics, Inc. | Auristatin compounds and conjugates thereof |
| EP2931316B1 (en) | 2012-12-12 | 2019-02-20 | Mersana Therapeutics, Inc. | Hydroxyl-polymer-drug-protein conjugates |
| EP2968593B1 (en) | 2013-03-15 | 2024-11-20 | Regeneron Pharmaceuticals, Inc. | Biologically active molecules, conjugates thereof, and therapeutic uses |
| GB201308738D0 (en) * | 2013-05-15 | 2013-06-26 | Polytherics Ltd | Novel polymer conjugates |
| MX373528B (es) | 2013-08-26 | 2020-04-21 | Regeneron Pharma | Composiciones farmacéuticas que contienen diasterómeros macrólidos, métodos para su síntesis y usos terapéuticos. |
| KR20160055253A (ko) | 2013-09-12 | 2016-05-17 | 할로자임, 아이엔씨 | 변형된 항-상피세포 성장인자 수용체 항체 및 이의 사용 방법 |
| BR112015032713B1 (pt) | 2013-09-17 | 2023-03-21 | Obi Pharma, Inc | Composto, composição farmacêutica, uso de uma quantidade terapeuticamente efetiva da composição farmacêutica, e uso do composto |
| BR112016007736B1 (pt) | 2013-10-11 | 2022-09-27 | Mersana Therapeutics, Inc | Armação polimérica, e, composição farmacêutica |
| IL245009B (en) | 2013-10-11 | 2022-08-01 | Asana Biosciences Llc | Protein-polymer-drug conjugates |
| EA201691075A1 (ru) * | 2013-11-26 | 2016-09-30 | Новартис Аг | Способы оксимной конъюгации с кетон-модифицированными полипептидами |
| GB201403875D0 (en) | 2014-03-05 | 2014-04-16 | Cantargia Ab | Novel antibodies and uses thereof |
| EP3145552B1 (en) | 2014-05-23 | 2020-03-04 | Novartis AG | Methods for making conjugates from disulfide-containing proteins |
| HK1231367A1 (zh) | 2014-06-02 | 2017-12-22 | Regeneron Pharmaceuticals, Inc. | 抗体药物偶联物、试剂和制备方法及其治疗用途 |
| GB201413913D0 (en) | 2014-08-06 | 2014-09-17 | Cantargia Ab | Novel antibodies and uses thereof |
| ES2885854T3 (es) | 2014-10-14 | 2021-12-15 | Polytherics Ltd | Proceso para la conjugación de un péptido o proteína con un reactivo que comprende un grupo saliente que incluye una porción de PEG |
| CA2975810C (en) * | 2015-02-05 | 2025-05-13 | Ablynx Nv | NANOBODY DIMERS LINKED VIA C-TERMINAL ENGINEERED CYSTEINS |
| SG11201707148PA (en) | 2015-03-27 | 2017-10-30 | Regeneron Pharma | Maytansinoid derivatives, conjugates thereof, and methods of use |
| US10098960B2 (en) | 2015-04-03 | 2018-10-16 | Ucl Business Plc | Polymer conjugate |
| US10509035B2 (en) | 2015-08-07 | 2019-12-17 | Gamamabs Pharma Sa | Antibodies, antibody drug conjugates and methods of use |
| JP2018532990A (ja) | 2015-09-04 | 2018-11-08 | オービーアイ ファーマ,インコーポレイテッド | グリカンアレイおよび使用の方法 |
| US10975161B2 (en) | 2016-01-12 | 2021-04-13 | Crescendo Biologics Limited | Molecules that bind prostate specific membrane antigen (PSMA) |
| GB201601136D0 (en) | 2016-01-21 | 2016-03-09 | Mörgelin Matthias And Abdillahi Suado M | Novel polypeptides and medical uses thereof |
| CN108779127B (zh) | 2016-01-25 | 2022-07-05 | 里珍纳龙药品有限公司 | 美登素类化合物衍生物、其偶联物和使用方法 |
| WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| KR20180121786A (ko) | 2016-03-29 | 2018-11-08 | 오비아이 파머 인코퍼레이티드 | 항체, 제약 조성물 및 방법 |
| WO2017178828A1 (en) | 2016-04-14 | 2017-10-19 | Polytherics Limited | Conjugates and conjugating reagents comprising a linker that includes at least two (-ch2-ch2-0-) units in a ring |
| KR20250048399A (ko) | 2016-04-22 | 2025-04-08 | 오비아이 파머 인코퍼레이티드 | 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에 의한 암 면역요법 |
| GB201608936D0 (en) | 2016-05-20 | 2016-07-06 | Polytherics Ltd | Novel conjugates and novel conjugating reagents |
| ES2965349T3 (es) | 2016-06-06 | 2024-04-12 | Abzena Uk Ltd | Anticuerpos, usos de los mismos y conjugados de los mismos |
| US11642400B2 (en) | 2016-07-27 | 2023-05-09 | Obi Pharma, Inc. | Immunogenic/therapeutic glycan compositions and uses thereof |
| JP7121724B2 (ja) | 2016-07-29 | 2022-08-18 | オービーアイ ファーマ,インコーポレイテッド | ヒト抗体、医薬組成物及び方法 |
| GB201614162D0 (en) | 2016-08-18 | 2016-10-05 | Polytherics Ltd | Antibodies, uses thereof and conjugates thereof |
| GB201615725D0 (en) | 2016-09-15 | 2016-11-02 | Polytherics Ltd | Novel cytotoxic agents and conjugates thereof |
| CA3044274A1 (en) | 2016-11-21 | 2018-05-24 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| US10772971B2 (en) | 2017-06-22 | 2020-09-15 | Mersana Therpeutics, Inc. | Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates |
| GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
| US11203645B2 (en) | 2018-06-27 | 2021-12-21 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| GB201909298D0 (en) | 2019-06-28 | 2019-08-14 | Colzyx Ab | Novel compositions and uses thereof |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| GB202016456D0 (en) | 2020-10-16 | 2020-12-02 | Colzyx Ab | Novel bioactive peptide combinations and uses thereof |
| CN119836305A (zh) | 2022-07-15 | 2025-04-15 | 费恩治疗有限公司 | 抗体-药物缀合物 |
| CN115304524A (zh) * | 2022-07-21 | 2022-11-08 | 湖南大学 | 一种β-酰基烯丙基甲基砜类化合物及其高效合成方法 |
| TW202421207A (zh) | 2022-09-30 | 2024-06-01 | 大陸商上海迪諾醫藥科技有限公司 | 苯并氮雜卓衍生物、含其的偶聯物及其應用 |
| AU2023393382A1 (en) | 2022-12-14 | 2025-06-19 | Pheon Therapeutics Ltd | Cytotoxic compounds |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US680343A (en) * | 1899-04-15 | 1901-08-13 | Johan Peter Moeller | Glove. |
| US3828412A (en) * | 1971-03-19 | 1974-08-13 | Dunham Bush Inc | Method of forming high integrity epoxy joint between aluminum tubes |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| EP0298101A1 (en) | 1987-01-15 | 1989-01-11 | Celltech Limited | Thiol-reactive cross-linking reagents |
| US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| ES2247656T3 (es) | 1989-04-19 | 2006-03-01 | Enzon, Inc. | Un proceso para formar un polipeptido modificado que comprende un polipeptido y un oxido de polialquileno. |
| US6552170B1 (en) * | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| JP3693671B2 (ja) | 1991-03-15 | 2005-09-07 | アムゲン インコーポレーテッド | ポリペプチドのpeg化 |
| WO1994004193A1 (en) | 1992-08-21 | 1994-03-03 | Enzon, Inc. | Novel attachment of polyalkylene oxides to bio-effecting substances |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5786387A (en) * | 1994-03-23 | 1998-07-28 | Meiji Seika Kabushiki Kaisha | Lipid double-chain derivative containing polyoxyethylene |
| US5877224A (en) | 1995-07-28 | 1999-03-02 | Rutgers, The State University Of New Jersey | Polymeric drug formulations |
| GB9713979D0 (en) | 1997-07-03 | 1997-09-10 | Univ Nottingham | Method for attaching peg to macromolecules |
| JP4078032B2 (ja) * | 1998-03-12 | 2008-04-23 | ネクター セラピューティックス エイエル,コーポレイション | 近位の反応性基を持つポリ(エチレングリコール)誘導体 |
| US6153655A (en) | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| SI1421956T1 (sl) * | 1998-04-28 | 2007-10-31 | Serono Lab | Postopek za stopenjsko vezavo polietilenglikola (peg) na polipeptid |
| AU4934299A (en) * | 1999-07-15 | 2001-02-05 | Kuhnil Pharm. Co., Ltd. | Novel water soluble-cyclosporine conjugated compounds |
| WO2001017515A1 (en) | 1999-09-03 | 2001-03-15 | School Of Pharmacy, University Of London | Degradable polymers |
| US6828412B1 (en) | 1999-09-03 | 2004-12-07 | School Of Pharmacy, University Of London | Degradable polymers |
| US6803438B1 (en) | 1999-09-08 | 2004-10-12 | Polytherics Limited | Uniform molecular weight polymers |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| GB0400264D0 (en) | 2004-01-07 | 2004-02-11 | Polytherics Ltd | Complexes |
| WO2008098930A1 (en) | 2007-02-14 | 2008-08-21 | Biocompatibes Uk Limited | Derivatisation of biological molecules |
| JP5933923B2 (ja) | 2007-10-09 | 2016-06-22 | ポリテリクス リミテッド | 新規な複合タンパク質及びペプチド |
| KR101763559B1 (ko) | 2008-07-21 | 2017-08-14 | 폴리테릭스 리미티드 | 생물학적 분자의 컨쥬게이팅을 위한 신규한 시약 및 방법 |
| WO2010100430A1 (en) | 2009-03-04 | 2010-09-10 | Polytherics Limited | Conjugated proteins and peptides |
| GB0912485D0 (en) | 2009-07-17 | 2009-08-26 | Polytherics Ltd | Improved conjugation method |
| US9650331B2 (en) | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
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