FR2949061B1 - Microgranules flottants - Google Patents

Microgranules flottants

Info

Publication number
FR2949061B1
FR2949061B1 FR0955641A FR0955641A FR2949061B1 FR 2949061 B1 FR2949061 B1 FR 2949061B1 FR 0955641 A FR0955641 A FR 0955641A FR 0955641 A FR0955641 A FR 0955641A FR 2949061 B1 FR2949061 B1 FR 2949061B1
Authority
FR
France
Prior art keywords
microgranules
floating
floating microgranules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0955641A
Other languages
English (en)
French (fr)
Other versions
FR2949061A1 (fr
Inventor
Christophe Lebon
Pascal Suplie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debregeas Et Associes Pharma SAS
Original Assignee
Debregeas Et Associes Pharma SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0955641A priority Critical patent/FR2949061B1/fr
Application filed by Debregeas Et Associes Pharma SAS filed Critical Debregeas Et Associes Pharma SAS
Priority to JP2012524262A priority patent/JP6068142B2/ja
Priority to BR112012003289-5A priority patent/BR112012003289B1/pt
Priority to PE2012000216A priority patent/PE20120805A1/es
Priority to HUE10761038A priority patent/HUE030027T2/en
Priority to PT107610388T priority patent/PT2464333T/pt
Priority to HRP20161149TT priority patent/HRP20161149T1/hr
Priority to DK10761038.8T priority patent/DK2464333T3/en
Priority to US13/390,217 priority patent/US8916202B2/en
Priority to ES10761038.8T priority patent/ES2588430T3/es
Priority to SI201031271A priority patent/SI2464333T1/sl
Priority to EA201200269A priority patent/EA023532B1/ru
Priority to SM201600347T priority patent/SMT201600347B/it
Priority to IN1864DEN2012 priority patent/IN2012DN01864A/en
Priority to SG2012009965A priority patent/SG180305A1/en
Priority to LTEP10761038.8T priority patent/LT2464333T/lt
Priority to CN201080044056.7A priority patent/CN102548541B/zh
Priority to PCT/FR2010/051691 priority patent/WO2011018582A2/fr
Priority to EP10761038.8A priority patent/EP2464333B1/fr
Priority to TW099126758A priority patent/TWI478731B/zh
Priority to NZ598468A priority patent/NZ598468A/en
Priority to HK12113624.3A priority patent/HK1172824B/xx
Priority to KR1020127006333A priority patent/KR20120050477A/ko
Priority to AU2010283608A priority patent/AU2010283608B9/en
Priority to KR1020177030037A priority patent/KR20170119743A/ko
Priority to MX2012001878A priority patent/MX2012001878A/es
Priority to CA2771053A priority patent/CA2771053C/fr
Priority to PL10761038.8T priority patent/PL2464333T3/pl
Priority to ARP100102964A priority patent/AR077864A1/es
Priority to UAA201202667A priority patent/UA107361C2/ru
Publication of FR2949061A1 publication Critical patent/FR2949061A1/fr
Priority to CL2012000376A priority patent/CL2012000376A1/es
Priority to MA34624A priority patent/MA33523B1/fr
Priority to TNP2012000068A priority patent/TN2012000068A1/fr
Priority to IL218072A priority patent/IL218072A/en
Priority to ZA2012/01711A priority patent/ZA201201711B/en
Application granted granted Critical
Publication of FR2949061B1 publication Critical patent/FR2949061B1/fr
Priority to CY20161100954T priority patent/CY1118119T1/el
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacture Of Metal Powder And Suspensions Thereof (AREA)
  • Glanulating (AREA)
FR0955641A 2009-08-12 2009-08-12 Microgranules flottants Expired - Fee Related FR2949061B1 (fr)

Priority Applications (36)

Application Number Priority Date Filing Date Title
FR0955641A FR2949061B1 (fr) 2009-08-12 2009-08-12 Microgranules flottants
TW099126758A TWI478731B (zh) 2009-08-12 2010-08-11 浮動性微細顆粒
PE2012000216A PE20120805A1 (es) 2009-08-12 2010-08-11 Microgranulos flotantes
HUE10761038A HUE030027T2 (en) 2009-08-12 2010-08-11 Floating microgranules
PT107610388T PT2464333T (pt) 2009-08-12 2010-08-11 Microgrânulos flutuantes
HRP20161149TT HRP20161149T1 (hr) 2009-08-12 2010-08-11 Plutajuće mikrogranule
DK10761038.8T DK2464333T3 (en) 2009-08-12 2010-08-11 Liquid microgranules
US13/390,217 US8916202B2 (en) 2009-08-12 2010-08-11 Floating microgranules
ES10761038.8T ES2588430T3 (es) 2009-08-12 2010-08-11 Microgránulos flotantes
SI201031271A SI2464333T1 (sl) 2009-08-12 2010-08-11 Plavajoče mikrogranule
EA201200269A EA023532B1 (ru) 2009-08-12 2010-08-11 Флотирующие микрогранулы
SM201600347T SMT201600347B (it) 2009-08-12 2010-08-11 Microgranuli flottanti
IN1864DEN2012 IN2012DN01864A (enExample) 2009-08-12 2010-08-11
SG2012009965A SG180305A1 (en) 2009-08-12 2010-08-11 Floating microgranules
BR112012003289-5A BR112012003289B1 (pt) 2009-08-12 2010-08-11 Granulado do tipo nucleo-casca
CN201080044056.7A CN102548541B (zh) 2009-08-12 2010-08-11 漂浮微颗粒剂
PCT/FR2010/051691 WO2011018582A2 (fr) 2009-08-12 2010-08-11 Microgranulés flottants
EP10761038.8A EP2464333B1 (fr) 2009-08-12 2010-08-11 Microgranulés flottants
JP2012524262A JP6068142B2 (ja) 2009-08-12 2010-08-11 浮遊微粒剤
LTEP10761038.8T LT2464333T (lt) 2009-08-12 2010-08-11 Plūduriuojančios mikrogranulės
CA2771053A CA2771053C (fr) 2009-08-12 2010-08-11 Microgranules flottants
KR1020127006333A KR20120050477A (ko) 2009-08-12 2010-08-11 유동성 마이크로과립체
AU2010283608A AU2010283608B9 (en) 2009-08-12 2010-08-11 Floating microgranules
KR1020177030037A KR20170119743A (ko) 2009-08-12 2010-08-11 유동성 마이크로과립체
MX2012001878A MX2012001878A (es) 2009-08-12 2010-08-11 Microgranulos flotantes.
HK12113624.3A HK1172824B (en) 2009-08-12 2010-08-11 Floating microgranules
PL10761038.8T PL2464333T3 (pl) 2009-08-12 2010-08-11 Mikrogranulaty flotacyjne
NZ598468A NZ598468A (en) 2009-08-12 2010-08-11 Floating microgranules
ARP100102964A AR077864A1 (es) 2009-08-12 2010-08-12 Microgranulos flotantes
UAA201202667A UA107361C2 (en) 2009-08-12 2010-11-08 Floating microgranules
CL2012000376A CL2012000376A1 (es) 2009-08-12 2012-02-13 Granulado flotante que comprende un nucleo solido soporte de principio activo y un agente alcalino suceptible de generar un desprendimiento gaseoso y no comprende un acido susceptible de generar un desprendimiento gaseoso, ya que se genera gas en contacto con el acido del fluido gastrico; procedimiento para prepararlo.
MA34624A MA33523B1 (fr) 2009-08-12 2012-02-13 Microgranulés flottants
TNP2012000068A TN2012000068A1 (fr) 2009-08-12 2012-02-13 Microgranules flottants
IL218072A IL218072A (en) 2009-08-12 2012-02-13 Floating microgranules
ZA2012/01711A ZA201201711B (en) 2009-08-12 2012-03-08 Floating microgranules
CY20161100954T CY1118119T1 (el) 2009-08-12 2016-09-26 Επιπλεοντα μικροκοκκια

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0955641A FR2949061B1 (fr) 2009-08-12 2009-08-12 Microgranules flottants

Publications (2)

Publication Number Publication Date
FR2949061A1 FR2949061A1 (fr) 2011-02-18
FR2949061B1 true FR2949061B1 (fr) 2013-04-19

Family

ID=42115979

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0955641A Expired - Fee Related FR2949061B1 (fr) 2009-08-12 2009-08-12 Microgranules flottants

Country Status (34)

Country Link
US (1) US8916202B2 (enExample)
EP (1) EP2464333B1 (enExample)
JP (1) JP6068142B2 (enExample)
KR (2) KR20120050477A (enExample)
CN (1) CN102548541B (enExample)
AR (1) AR077864A1 (enExample)
AU (1) AU2010283608B9 (enExample)
BR (1) BR112012003289B1 (enExample)
CA (1) CA2771053C (enExample)
CL (1) CL2012000376A1 (enExample)
CY (1) CY1118119T1 (enExample)
DK (1) DK2464333T3 (enExample)
EA (1) EA023532B1 (enExample)
ES (1) ES2588430T3 (enExample)
FR (1) FR2949061B1 (enExample)
HR (1) HRP20161149T1 (enExample)
HU (1) HUE030027T2 (enExample)
IL (1) IL218072A (enExample)
IN (1) IN2012DN01864A (enExample)
LT (1) LT2464333T (enExample)
MA (1) MA33523B1 (enExample)
MX (1) MX2012001878A (enExample)
NZ (1) NZ598468A (enExample)
PE (1) PE20120805A1 (enExample)
PL (1) PL2464333T3 (enExample)
PT (1) PT2464333T (enExample)
SG (1) SG180305A1 (enExample)
SI (1) SI2464333T1 (enExample)
SM (1) SMT201600347B (enExample)
TN (1) TN2012000068A1 (enExample)
TW (1) TWI478731B (enExample)
UA (1) UA107361C2 (enExample)
WO (1) WO2011018582A2 (enExample)
ZA (1) ZA201201711B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
CA2687979C (en) 2007-05-25 2017-07-04 Tolmar Therapeutics, Inc. Sustained delivery formulations of risperidone compounds
FR2938431B1 (fr) 2008-11-14 2013-12-20 Debregeas Et Associes Pharma Nouvelle composition a base d'acide gamma-hydroxybutyrique
FR2949062B1 (fr) 2009-08-12 2011-09-02 Debregeas Et Associes Pharma Nouvelles formulations pharmaceutiques contre le mesusage des medicaments
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2481017B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
US9321956B2 (en) 2012-11-28 2016-04-26 Halliburton Energy Services, Inc. Methods for hindering the settling of particulates in a subterranean formation
WO2015102629A1 (en) 2014-01-02 2015-07-09 Halliburton Energy Services, Inc. Generating and maintaining conductivity of microfractures in tight formations by generating gas and heat
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
CA2989297A1 (en) 2015-07-24 2017-02-02 Halliburton Energy Services, Inc. Microbubbles for heat and/or gas generation in subterranean formations
CA2986545C (en) 2015-07-24 2019-09-03 Halliburton Energy Services, Inc. Microbubbles for treatment chemical delivery in subterranean formations
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12186296B1 (en) 2016-07-22 2025-01-07 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
IL275312B2 (en) 2017-12-18 2024-09-01 Tris Pharma Inc Ghb pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
JP2021506984A (ja) * 2017-12-18 2021-02-22 トリス・フアルマ・インコーポレーテツド トリガーパルス薬物放出を有する胃内滞留型ｒａｆｔ形成システムを含む放出調節薬物粉末組成物
US11337920B2 (en) 2017-12-18 2022-05-24 Tris Pharma, Inc. Pharmaceutical composition comprising GHB gastro-retentive raft forming systems having trigger pulse drug release
AU2020231916B2 (en) 2019-03-01 2025-08-28 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
NL2024652B1 (en) * 2020-01-10 2021-09-07 Stabican B V Process for preparing cannabinoid-containing particles
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5276418A (en) * 1975-12-19 1977-06-27 Microbial Chem Res Found Method of preparing foamable micro-capsule preparations
US4101650A (en) * 1977-04-06 1978-07-18 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Pepstatin floating minicapsules
US4424235A (en) 1981-09-14 1984-01-03 Hoffmann-La Roche Inc. Hydrodynamically balanced controlled release compositions containing L-dopa and a decarboxylase inhibitor
JPS62195323A (ja) * 1986-02-24 1987-08-28 Eisai Co Ltd 胃内滞留型粒子
IT1217783B (it) 1988-06-03 1990-03-30 Farmaceutico Ct S R L Lab Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative
IT1248588B (it) 1991-06-28 1995-01-19 Gaetano Crepaldi Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari.
IT1266565B1 (it) 1993-07-22 1997-01-09 Ct Lab Farm Srl Composizioni farmaceutiche a rilascio controllato a base di uno o piu' sali farmaceuticamente accettabili dell'acido gamma-idrossi-butirrico.
US5824339A (en) 1995-09-08 1998-10-20 Takeda Chemical Industries, Ltd Effervescent composition and its production
US6214386B1 (en) * 1995-11-22 2001-04-10 Recordati, S.A. Prompt-release oral pharmaceutical compositions for extemporaneous suspensions
US5846971A (en) 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
DE19630035A1 (de) 1996-07-25 1998-01-29 Asta Medica Ag Tramadol Multiple Unit Formulierungen
US6649186B1 (en) 1996-09-20 2003-11-18 Ethypharm Effervescent granules and methods for their preparation
FR2762213B1 (fr) * 1997-04-18 1999-05-14 Synthelabo Composition pharmaceutique a retention gastrique
SE9702533D0 (sv) * 1997-07-01 1997-07-01 Astra Ab New oral formulation
JP3447042B2 (ja) 1997-07-23 2003-09-16 フロイント産業株式会社 単一物質球形粒の製造方法
US20050244497A1 (en) * 1997-11-05 2005-11-03 Wockhardt Limited Delayed delivery system for acid-sensitive drugs
US6350470B1 (en) * 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
FR2784583B1 (fr) * 1998-10-16 2002-01-25 Synthelabo Composition pharmaceutique a residence gastrique et a liberation controlee
JP4374441B2 (ja) 1998-12-23 2009-12-02 ジェイピーアイ コマーシャル，リミティド ライアビリティ カンパニー 睡眠発作治療のための、ガンマ−ヒドロキシ酪酸塩の微生物的に安全で安定な液剤
FR2797185B1 (fr) 1999-08-06 2001-10-26 Galenix Dev Composition pharmaceutique flottante comprenant une phase active et une phase non active
FR2823668B1 (fr) 2001-04-20 2004-02-27 Ethypharm Lab Prod Ethiques Comprimes effervescents orodispersibles
US7141250B2 (en) 2001-08-06 2006-11-28 Euro-Celtique S.A. Pharmaceutical formulation containing bittering agent
KR20040060917A (ko) 2001-08-06 2004-07-06 유로-셀티크 소시에떼 아노뉨 오피오이드 남용을 방지하기 위한 조성물 및 방법
US20030059397A1 (en) 2001-09-17 2003-03-27 Lyn Hughes Dosage forms
FR2829932B1 (fr) 2001-09-21 2006-11-24 Ellipse Pharmaceuticals Procede de fabrication d'un produit pharmaceutique administrable par voie orale avec des agents detrompeurs et produit obtenu
CA2409552A1 (en) * 2001-10-25 2003-04-25 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
CN1688292A (zh) 2002-09-04 2005-10-26 兰贝克赛实验室有限公司 掩味剂型及其制造方法
EP2422773A3 (en) 2002-09-20 2012-04-18 Alpharma, Inc. Sequestering subunit and related compositions and methods
TWI350762B (en) 2004-02-12 2011-10-21 Euro Celtique Sa Particulates
MXPA06009991A (es) 2004-03-03 2007-04-10 Teva Pharma Una composicion farmaceutica estable que comprende un farmaco labil acido.
TW200533391A (en) * 2004-03-25 2005-10-16 Sun Pharmaceutical Ind Ltd Gastric retention drug delivery system
US8193211B2 (en) 2004-09-30 2012-06-05 Supernus Pharmaceuticals, Inc. Controlled release compositions of gamma-hydroxybutyrate
EP1896002A4 (en) 2005-06-27 2009-11-25 Biovail Lab Int Srl BUPROPIONAL SALT FORMULATIONS WITH MODIFIED RELEASE
PT1931315E (pt) * 2005-08-24 2014-01-03 Endo Pharmaceuticals Inc Formulações de libertação sustentada de nalbufina
US20070092565A1 (en) * 2005-10-25 2007-04-26 Pharmascience Inc. Gastric retention drug delivery system
US9125833B2 (en) 2005-11-02 2015-09-08 Relmada Therapeutics, Inc. Multimodal abuse resistant and extended release opioid formulations
WO2007075980A2 (en) * 2005-12-20 2007-07-05 Teva Pharmaceutical Industries Ltd. Lansoprazole orally disintegrating tablets
ZA200807571B (en) 2006-03-01 2009-08-26 Ethypharm Sa Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion
EP2192892A2 (en) * 2007-07-27 2010-06-09 Depomed, Inc. Pulsatile gastric retentive dosage forms
EP2240022B1 (en) 2008-01-09 2016-12-28 Charleston Laboratories, Inc. Bilayered tablets comprising oxycodone and promethazine
FR2938431B1 (fr) 2008-11-14 2013-12-20 Debregeas Et Associes Pharma Nouvelle composition a base d'acide gamma-hydroxybutyrique
FR2949062B1 (fr) 2009-08-12 2011-09-02 Debregeas Et Associes Pharma Nouvelles formulations pharmaceutiques contre le mesusage des medicaments

Also Published As

Publication number Publication date
PE20120805A1 (es) 2012-07-25
HRP20161149T1 (hr) 2016-11-18
EP2464333A2 (fr) 2012-06-20
ZA201201711B (en) 2012-11-28
EA023532B1 (ru) 2016-06-30
CL2012000376A1 (es) 2013-01-04
IL218072A0 (en) 2012-04-30
BR112012003289A2 (pt) 2020-08-11
CN102548541A (zh) 2012-07-04
TWI478731B (zh) 2015-04-01
JP6068142B2 (ja) 2017-01-25
PL2464333T3 (pl) 2016-12-30
TN2012000068A1 (fr) 2013-09-19
CA2771053C (fr) 2017-05-02
DK2464333T3 (en) 2016-10-03
PT2464333T (pt) 2016-10-03
CA2771053A1 (fr) 2011-02-17
FR2949061A1 (fr) 2011-02-18
EP2464333B1 (fr) 2016-06-29
HUE030027T2 (en) 2017-04-28
KR20120050477A (ko) 2012-05-18
HK1172824A1 (en) 2013-05-03
NZ598468A (en) 2015-05-29
SMT201600347B (it) 2016-11-10
AU2010283608B2 (en) 2015-07-30
UA107361C2 (en) 2014-12-25
LT2464333T (lt) 2016-09-12
IN2012DN01864A (enExample) 2015-08-21
SI2464333T1 (sl) 2016-10-28
JP2013501762A (ja) 2013-01-17
AR077864A1 (es) 2011-09-28
EA201200269A1 (ru) 2012-11-30
SG180305A1 (en) 2012-06-28
CN102548541B (zh) 2015-03-11
ES2588430T3 (es) 2016-11-02
CY1118119T1 (el) 2017-06-28
TW201127419A (en) 2011-08-16
WO2011018582A2 (fr) 2011-02-17
AU2010283608B9 (en) 2015-08-27
US20120207843A1 (en) 2012-08-16
IL218072A (en) 2016-08-31
BR112012003289B1 (pt) 2021-07-13
AU2010283608A1 (en) 2012-03-29
WO2011018582A3 (fr) 2011-05-19
KR20170119743A (ko) 2017-10-27
MA33523B1 (fr) 2012-08-01
MX2012001878A (es) 2012-06-01
US8916202B2 (en) 2014-12-23

Similar Documents

Publication Publication Date Title
FIC20220037I1 (fi) Tebentafuspi
FIC20210039I1 (fi) Duvelisibi
FR2949061B1 (fr) Microgranules flottants
DK2435742T3 (da) Bøjebegrænser
DE112009005323A5 (de) Hebelarmprüfmaschine
BRPI1008070A2 (pt) tricianoboratos
EP2508411A4 (en) STRUCTURE
EP2454221A4 (en) cineole
EP2380788A4 (en) SAFETY BELT RETRACTOR
ES1070429Y (es) Traspaleta mejorada
EP2390537A4 (en) SEALED STRUCTURE
FI20090100A0 (fi) Biotinidaasimääritys
IS8844A (is) Endurbætt flotvarpa
FI20095735A0 (fi) Puhdistinrakenne
FR2968020B1 (fr) Brise-lames flottant
FI8691U1 (fi) Aukirullain
FR2969575B1 (fr) Structure flottante
FI20090013A0 (fi) Vene
BRPI0924006A2 (pt) estrutura
ES1071420Y (es) Prelapida
FI20095409A0 (fi) Soluviljelysupplementti
ES1072446Y (es) Embudo flotante
TH104720B (th) ทุ่นลอยน้ำ
FI9124U1 (fi) Maustesirotin
FI8552U1 (fi) Matonpesulaitteisto

Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 8

ST Notification of lapse

Effective date: 20180430