IN2012DN01864A - - Google Patents

Download PDF

Info

Publication number
IN2012DN01864A
IN2012DN01864A IN1864DEN2012A IN2012DN01864A IN 2012DN01864 A IN2012DN01864 A IN 2012DN01864A IN 1864DEN2012 A IN1864DEN2012 A IN 1864DEN2012A IN 2012DN01864 A IN2012DN01864 A IN 2012DN01864A
Authority
IN
India
Prior art keywords
generating
gas discharge
constituted
supported
compound
Prior art date
Application number
Inventor
Christophe Lebon
Pascal Suplie
Original Assignee
Debregeas Et Associes Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debregeas Et Associes Pharma filed Critical Debregeas Et Associes Pharma
Publication of IN2012DN01864A publication Critical patent/IN2012DN01864A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/63Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5026Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glanulating (AREA)
  • Manufacture Of Metal Powder And Suspensions Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a floating granule comprising a solid core, on which an active ingredient is supported and also comprising a compound which is capable of generating a gas discharge which is constituted by an alkaline agent, characterised in that it does not comprise an acid agent which is capable of generating a gas discharge.
IN1864DEN2012 2009-08-12 2010-08-11 IN2012DN01864A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0955641A FR2949061B1 (en) 2009-08-12 2009-08-12 FLOATING MICROGRANULES
PCT/FR2010/051691 WO2011018582A2 (en) 2009-08-12 2010-08-11 Floating microgranules

Publications (1)

Publication Number Publication Date
IN2012DN01864A true IN2012DN01864A (en) 2015-08-21

Family

ID=42115979

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1864DEN2012 IN2012DN01864A (en) 2009-08-12 2010-08-11

Country Status (35)

Country Link
US (1) US8916202B2 (en)
EP (1) EP2464333B1 (en)
JP (1) JP6068142B2 (en)
KR (2) KR20120050477A (en)
CN (1) CN102548541B (en)
AR (1) AR077864A1 (en)
AU (1) AU2010283608B9 (en)
BR (1) BR112012003289B1 (en)
CA (1) CA2771053C (en)
CL (1) CL2012000376A1 (en)
CY (1) CY1118119T1 (en)
DK (1) DK2464333T3 (en)
EA (1) EA023532B1 (en)
ES (1) ES2588430T3 (en)
FR (1) FR2949061B1 (en)
HK (1) HK1172824A1 (en)
HR (1) HRP20161149T1 (en)
HU (1) HUE030027T2 (en)
IL (1) IL218072A (en)
IN (1) IN2012DN01864A (en)
LT (1) LT2464333T (en)
MA (1) MA33523B1 (en)
MX (1) MX2012001878A (en)
NZ (1) NZ598468A (en)
PE (1) PE20120805A1 (en)
PL (1) PL2464333T3 (en)
PT (1) PT2464333T (en)
SG (1) SG180305A1 (en)
SI (1) SI2464333T1 (en)
SM (1) SMT201600347B (en)
TN (1) TN2012000068A1 (en)
TW (1) TWI478731B (en)
UA (1) UA107361C2 (en)
WO (1) WO2011018582A2 (en)
ZA (1) ZA201201711B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
NZ581862A (en) 2007-05-25 2012-06-29 Tolmar Therapeutics Inc Injectable subcutaneous formulation comprising risperidone capable of forming a solid, microporous implant in a patient
FR2938431B1 (en) 2008-11-14 2013-12-20 Debregeas Et Associes Pharma NOVEL COMPOSITION BASED ON GAMMA-HYDROXYBUTYRIC ACID
FR2949062B1 (en) 2009-08-12 2011-09-02 Debregeas Et Associes Pharma NEW PHARMACEUTICAL FORMULATIONS AGAINST MEASURING MEDICINES
GB2513060B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
US9321956B2 (en) 2012-11-28 2016-04-26 Halliburton Energy Services, Inc. Methods for hindering the settling of particulates in a subterranean formation
US9790774B2 (en) 2014-01-02 2017-10-17 Halliburton Energy Services, Inc. Generating and maintaining conductivity of microfractures in tight formations by generating gas and heat
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
CA2989297A1 (en) 2015-07-24 2017-02-02 Halliburton Energy Services, Inc. Microbubbles for heat and/or gas generation in subterranean formations
CA2986545C (en) 2015-07-24 2019-09-03 Halliburton Energy Services, Inc. Microbubbles for treatment chemical delivery in subterranean formations
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (en) 2016-07-22 2017-11-30 Flamel Ireland Ltd FORMULATIONS OF GAMMA-MODIFIED RELEASE HYDROXIBUTIRATE WITH IMPROVED PHARMACOCINETICS
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11666546B2 (en) 2017-12-18 2023-06-06 Tris Pharma, Inc GHB pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
CN112004520A (en) * 2017-12-18 2020-11-27 特瑞斯制药公司 Modified release drug powder compositions comprising a gastric retentive raft forming system with triggered pulsed drug release
BR112021013766A2 (en) 2019-03-01 2021-09-21 Flamel Ireland Limited GAMMA-HYDROXYBUTYRATE COMPOSITIONS WITH IMPROVED PHARMACOKINETICS IN THE FED STATE
NL2024652B1 (en) * 2020-01-10 2021-09-07 Stabican B V Process for preparing cannabinoid-containing particles
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5276418A (en) * 1975-12-19 1977-06-27 Microbial Chem Res Found Method of preparing foamable micro-capsule preparations
US4101650A (en) * 1977-04-06 1978-07-18 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Pepstatin floating minicapsules
US4424235A (en) 1981-09-14 1984-01-03 Hoffmann-La Roche Inc. Hydrodynamically balanced controlled release compositions containing L-dopa and a decarboxylase inhibitor
JPS62195323A (en) * 1986-02-24 1987-08-28 Eisai Co Ltd Gastric resident particle
IT1217783B (en) 1988-06-03 1990-03-30 Farmaceutico Ct S R L Lab USE OF SALO DELL, BUTYRIC HYDROXIC ACID RANGE FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS SUITABLE FOR USE IN THE ALCOHOLIC THERAPY AND RELATED COMPOSITIONS
IT1248588B (en) 1991-06-28 1995-01-19 Gaetano Crepaldi PHARMACEUTICAL COMPOSITIONS FOR THERAPY OF ABSTINENCE, "CRAVING", DEPENDENCE ON AMAZING SUBSTANCES, PSYCHOACTIVE SUBSTANCES, NICOTINE AND FOOD DISORDERS.
IT1266565B1 (en) 1993-07-22 1997-01-09 Ct Lab Farm Srl PHARMACEUTICAL COMPOSITIONS WITH CONTROLLED RELEASE ON THE BASIS OF ONE OR MORE PHARMACEUTICALLY ACCEPTABLE SALTS OF THE RANGE-HYDROXY-BUTYRIC ACID.
US5824339A (en) 1995-09-08 1998-10-20 Takeda Chemical Industries, Ltd Effervescent composition and its production
US6214386B1 (en) * 1995-11-22 2001-04-10 Recordati, S.A. Prompt-release oral pharmaceutical compositions for extemporaneous suspensions
US5846971A (en) 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
DE19630035A1 (en) 1996-07-25 1998-01-29 Asta Medica Ag Tramadol multiple unit formulations
US6649186B1 (en) * 1996-09-20 2003-11-18 Ethypharm Effervescent granules and methods for their preparation
FR2762213B1 (en) * 1997-04-18 1999-05-14 Synthelabo PHARMACEUTICAL COMPOSITION WITH GASTRIC RETENTION
SE9702533D0 (en) * 1997-07-01 1997-07-01 Astra Ab New oral formulation
JP3447042B2 (en) 1997-07-23 2003-09-16 フロイント産業株式会社 Method for producing single substance spherical particles
US20050244497A1 (en) * 1997-11-05 2005-11-03 Wockhardt Limited Delayed delivery system for acid-sensitive drugs
US6350470B1 (en) * 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
FR2784583B1 (en) * 1998-10-16 2002-01-25 Synthelabo PHARMACEUTICAL COMPOSITION WITH GASTRIC RESIDENCE AND CONTROLLED RELEASE
WO2000038672A2 (en) 1998-12-23 2000-07-06 Orphan Medical, Inc. Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
FR2797185B1 (en) * 1999-08-06 2001-10-26 Galenix Dev FLOATING PHARMACEUTICAL COMPOSITION COMPRISING AN ACTIVE AND A NON-ACTIVE PHASE
FR2823668B1 (en) 2001-04-20 2004-02-27 Ethypharm Lab Prod Ethiques ORODISPERSIBLE EFFERVESCENT TABLETS
KR20040060917A (en) 2001-08-06 2004-07-06 유로-셀티크 소시에떼 아노뉨 Compositions and methods to prevent abuse of opioids
US7141250B2 (en) 2001-08-06 2006-11-28 Euro-Celtique S.A. Pharmaceutical formulation containing bittering agent
US20030059397A1 (en) 2001-09-17 2003-03-27 Lyn Hughes Dosage forms
FR2829932B1 (en) 2001-09-21 2006-11-24 Ellipse Pharmaceuticals METHOD FOR MANUFACTURING ORALLY ADMINISTRATIVE PHARMACEUTICAL PRODUCT WITH REMOTE AGENTS AND PRODUCT OBTAINED
CA2409552A1 (en) * 2001-10-25 2003-04-25 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
EP1536774A1 (en) 2002-09-04 2005-06-08 Ranbaxy Laboratories Limited Taste masked dosage forms and processes for their preparation
EP2422775A3 (en) 2002-09-20 2012-04-18 Alpharma, Inc. Sequestering subunit and related compositions and methods
TWI350762B (en) 2004-02-12 2011-10-21 Euro Celtique Sa Particulates
CN1964704A (en) 2004-03-03 2007-05-16 特瓦制药工业有限公司 Stable pharmaceutical composition comprising an acid labile drug
TW200533391A (en) * 2004-03-25 2005-10-16 Sun Pharmaceutical Ind Ltd Gastric retention drug delivery system
US8193211B2 (en) 2004-09-30 2012-06-05 Supernus Pharmaceuticals, Inc. Controlled release compositions of gamma-hydroxybutyrate
WO2007002597A2 (en) 2005-06-27 2007-01-04 Biovail Laboratories International S.R.L. Modified-release formulations of a bupropion salt
ES2441766T3 (en) * 2005-08-24 2014-02-06 Endo Pharmaceuticals Inc. Sustained-release nalbuphine formulations
US20070092565A1 (en) * 2005-10-25 2007-04-26 Pharmascience Inc. Gastric retention drug delivery system
US9125833B2 (en) 2005-11-02 2015-09-08 Relmada Therapeutics, Inc. Multimodal abuse resistant and extended release opioid formulations
CA2633825A1 (en) * 2005-12-20 2007-07-05 Teva Pharmaceutical Industries Ltd. Lansoprazole orally disintegrating tablets
FR2898056B1 (en) 2006-03-01 2012-01-20 Ethypharm Sa SQUEEZE-RESISTANT TABLETS TO PREVENT UNLAWFUL MISUSE
JP2010534721A (en) * 2007-07-27 2010-11-11 ディポメド,インコーポレイティド Pulse type gastric retentive preparation
EP2240022B1 (en) 2008-01-09 2016-12-28 Charleston Laboratories, Inc. Bilayered tablets comprising oxycodone and promethazine
FR2938431B1 (en) 2008-11-14 2013-12-20 Debregeas Et Associes Pharma NOVEL COMPOSITION BASED ON GAMMA-HYDROXYBUTYRIC ACID
FR2949062B1 (en) 2009-08-12 2011-09-02 Debregeas Et Associes Pharma NEW PHARMACEUTICAL FORMULATIONS AGAINST MEASURING MEDICINES

Also Published As

Publication number Publication date
AU2010283608B2 (en) 2015-07-30
CA2771053C (en) 2017-05-02
PL2464333T3 (en) 2016-12-30
JP6068142B2 (en) 2017-01-25
PT2464333T (en) 2016-10-03
MA33523B1 (en) 2012-08-01
FR2949061A1 (en) 2011-02-18
JP2013501762A (en) 2013-01-17
LT2464333T (en) 2016-09-12
CY1118119T1 (en) 2017-06-28
US20120207843A1 (en) 2012-08-16
ZA201201711B (en) 2012-11-28
PE20120805A1 (en) 2012-07-25
EA201200269A1 (en) 2012-11-30
HRP20161149T1 (en) 2016-11-18
ES2588430T3 (en) 2016-11-02
NZ598468A (en) 2015-05-29
IL218072A (en) 2016-08-31
MX2012001878A (en) 2012-06-01
AU2010283608A1 (en) 2012-03-29
IL218072A0 (en) 2012-04-30
CA2771053A1 (en) 2011-02-17
AR077864A1 (en) 2011-09-28
TN2012000068A1 (en) 2013-09-19
TW201127419A (en) 2011-08-16
KR20120050477A (en) 2012-05-18
SMT201600347B (en) 2016-11-10
FR2949061B1 (en) 2013-04-19
CL2012000376A1 (en) 2013-01-04
US8916202B2 (en) 2014-12-23
EA023532B1 (en) 2016-06-30
CN102548541B (en) 2015-03-11
TWI478731B (en) 2015-04-01
BR112012003289A2 (en) 2020-08-11
WO2011018582A3 (en) 2011-05-19
HUE030027T2 (en) 2017-04-28
AU2010283608B9 (en) 2015-08-27
EP2464333A2 (en) 2012-06-20
UA107361C2 (en) 2014-12-25
SG180305A1 (en) 2012-06-28
DK2464333T3 (en) 2016-10-03
EP2464333B1 (en) 2016-06-29
WO2011018582A2 (en) 2011-02-17
CN102548541A (en) 2012-07-04
HK1172824A1 (en) 2013-05-03
SI2464333T1 (en) 2016-10-28
BR112012003289B1 (en) 2021-07-13
KR20170119743A (en) 2017-10-27

Similar Documents

Publication Publication Date Title
IN2012DN01864A (en)
MX362613B (en) Effervescent gamma-hydroxybutyric acid granules.
IN2012DN01859A (en)
IL216468A0 (en) Compositions, methods & systems for respiratory respiratory delivery of two or more active agents
MY166613A (en) Glycerol levulinate ketals and their use
MX356282B (en) Compositions and methods comprising protease variants.
MX2012015187A (en) Method for delivering an active agent.
WO2011002808A8 (en) Hcv protease inhibitors and uses thereof
MX2013009175A (en) Compositions comprising peroxy î±-ketocarboxylic acid and methods for producing and using the same.
GEP20135960B (en) New method of synthesis of ivabradine and pharmaceutically acceptable acid-additive salts thereof
MY159251A (en) Processes for the manufacture of a pharmaceutically active agent
UA100394C2 (en) Lipoic acid pellet composition
MX2012009537A (en) Solid forms comprising a cyclopropyl amide derivative.
TR200909785A1 (en) Pharmaceutical compositions containing cefdinir as the active agent.
WO2010068920A3 (en) Diaminoquinazoline inhibitors of dihydrofolate reductase
TW200940687A (en) Antioxidant agent
WO2010111421A3 (en) Isoform nell-1 peptide
WO2011031764A3 (en) Compounds and related methods of use
EA200801449A1 (en) GAP GRANULES
EA201100764A1 (en) SOLID PHARMACEUTICAL COMPOSITION CONTAINING AT LEAST ONE STABILIZING AGENT
WO2010128755A3 (en) Composition for preventing or treating hair loss containing threonate as an active ingredient
MY160482A (en) Smoke grenade
WO2010129505A3 (en) Napthylene inhibitors of cyclooxygenase
WO2008090850A1 (en) Agent for enhancing the effect of anticancer agent
UA92872C2 (en) combined antiaggregate and antioxidant drug