FR2926297B1 - Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. - Google Patents

Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.

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Publication number
FR2926297B1
FR2926297B1 FR0850144A FR0850144A FR2926297B1 FR 2926297 B1 FR2926297 B1 FR 2926297B1 FR 0850144 A FR0850144 A FR 0850144A FR 0850144 A FR0850144 A FR 0850144A FR 2926297 B1 FR2926297 B1 FR 2926297B1
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FR
France
Prior art keywords
splice
anomalies
treating diseases
diseases resulting
chemical molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR0850144A
Other languages
English (en)
French (fr)
Other versions
FR2926297A1 (fr
Inventor
Jamal Tazi
David Grierson
Betzer Florence Mahuteau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut Curie
Universite de Montpellier
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority to FR0850144A priority Critical patent/FR2926297B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to DK09700499.8T priority patent/DK2235000T3/da
Priority to EP09700499.8A priority patent/EP2235000B1/en
Priority to JP2010541800A priority patent/JP5784909B2/ja
Priority to ES09700499T priority patent/ES2816178T3/es
Priority to CA2946329A priority patent/CA2946329C/en
Priority to HRP20201369TT priority patent/HRP20201369T1/hr
Priority to PT97004998T priority patent/PT2235000T/pt
Priority to CA2711652A priority patent/CA2711652C/en
Priority to ES19164367T priority patent/ES2934810T3/es
Priority to CA2946336A priority patent/CA2946336C/en
Priority to CN201410299552.7A priority patent/CN104086482B/zh
Priority to EP19164367.5A priority patent/EP3536691B1/en
Priority to PL09700499T priority patent/PL2235000T3/pl
Priority to CA2946326A priority patent/CA2946326C/en
Priority to CN200980106361.1A priority patent/CN101965341B/zh
Priority to CA3072245A priority patent/CA3072245C/en
Priority to PCT/EP2009/050280 priority patent/WO2009087238A2/en
Priority to US12/811,931 priority patent/US8604063B2/en
Priority to CN201410301260.2A priority patent/CN104130242B/zh
Publication of FR2926297A1 publication Critical patent/FR2926297A1/fr
Priority to FR1350599A priority patent/FR2983199B1/fr
Priority to FR1350600A priority patent/FR2983196B1/fr
Priority to FR1350601A priority patent/FR2983200B1/fr
Application granted granted Critical
Publication of FR2926297B1 publication Critical patent/FR2926297B1/fr
Priority to US14/070,799 priority patent/US9233931B2/en
Priority to US14/958,602 priority patent/US10130595B2/en
Priority to US16/153,249 priority patent/US10654813B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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FR0850144A 2008-01-10 2008-01-10 Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. Active FR2926297B1 (fr)

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FR0850144A FR2926297B1 (fr) 2008-01-10 2008-01-10 Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
CN200980106361.1A CN101965341B (zh) 2008-01-10 2009-01-12 用于治疗由剪接异常引起的疾病的抑制剪接机理的化学分子
JP2010541800A JP5784909B2 (ja) 2008-01-10 2009-01-12 スプライシング異常からもたらされる疾患を処置する為のスライスする機構を阻害する化学分子
ES09700499T ES2816178T3 (es) 2008-01-10 2009-01-12 Moléculas químicas que inhiben el mecanismo de corte para tratar enfermedades causadas por anomalías de empalme
CA2946329A CA2946329C (en) 2008-01-10 2009-01-12 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
HRP20201369TT HRP20201369T1 (hr) 2008-01-10 2009-01-12 Kemijske molekule koje inhibiraju mehanizam prekrajanja za lječenje bolesti koje proizlaze iz anomalija prekrajanja
PT97004998T PT2235000T (pt) 2008-01-10 2009-01-12 Moléculas químicas que inibem o mecanismo de corte para o tratamento de doenças resultantes de anomalias de splicing
CA2711652A CA2711652C (en) 2008-01-10 2009-01-12 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
ES19164367T ES2934810T3 (es) 2008-01-10 2009-01-12 Moléculas químicas que inhiben el mecanismo de empalme para tratar enfermedades causadas por anomalías de empalme
CA2946336A CA2946336C (en) 2008-01-10 2009-01-12 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
CN201410299552.7A CN104086482B (zh) 2008-01-10 2009-01-12 用于治疗由剪接异常引起的疾病的抑制剪接机理的化学分子
EP19164367.5A EP3536691B1 (en) 2008-01-10 2009-01-12 Chemical molecules that inhibit the splicing mechanism for treating diseases resulting from splicing anomalies
PL09700499T PL2235000T3 (pl) 2008-01-10 2009-01-12 Cząsteczki chemiczne hamujące mechanizm splicingu do leczenia chorób wynikających z nieprawidłowości splicingu
CA2946326A CA2946326C (en) 2008-01-10 2009-01-12 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
DK09700499.8T DK2235000T3 (da) 2008-01-10 2009-01-12 Kemiske molekyler, der hæmmer splejsningsmekanismen, til behandling af sygdomme, der skyldes splejsningsanomalier
CA3072245A CA3072245C (en) 2008-01-10 2009-01-12 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
EP09700499.8A EP2235000B1 (en) 2008-01-10 2009-01-12 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
US12/811,931 US8604063B2 (en) 2008-01-10 2009-01-12 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
CN201410301260.2A CN104130242B (zh) 2008-01-10 2009-01-12 用于治疗由剪接异常引起的疾病的抑制剪接机理的化学分子
PCT/EP2009/050280 WO2009087238A2 (en) 2008-01-10 2009-01-12 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
FR1350600A FR2983196B1 (fr) 2008-01-10 2013-01-24 Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
FR1350601A FR2983200B1 (fr) 2008-01-10 2013-01-24 Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
FR1350599A FR2983199B1 (fr) 2008-01-10 2013-01-24 Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
US14/070,799 US9233931B2 (en) 2008-01-10 2013-11-04 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
US14/958,602 US10130595B2 (en) 2008-01-10 2015-12-03 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
US16/153,249 US10654813B2 (en) 2008-01-10 2018-10-05 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies

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Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8367669B2 (en) 2005-06-15 2013-02-05 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation
US9133212B1 (en) 2005-06-15 2015-09-15 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation
FR2926297B1 (fr) * 2008-01-10 2013-03-08 Centre Nat Rech Scient Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
TW201103904A (en) 2009-06-11 2011-02-01 Hoffmann La Roche Janus kinase inhibitor compounds and methods
EP2266972A1 (en) * 2009-06-12 2010-12-29 Splicos New chemical molecules that inhibit the splicing mechanism for treating diseases resulting from splicing anomalies
US10253020B2 (en) 2009-06-12 2019-04-09 Abivax Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging
FI2440546T3 (fi) 2009-06-12 2023-03-30 Abivax Ennenaikaisen vanhenemisen ja erityisesti progerian hoitamiseen hyödyllisiä yhdisteitä
JP5819305B2 (ja) 2009-10-13 2015-11-24 リガンド・ファーマシューティカルズ・インコーポレイテッド 造血成長因子模倣小分子化合物およびそれらの使用
WO2012001941A1 (ja) * 2010-06-28 2012-01-05 Hagiwara Masatoshi 遺伝性疾患の予防・改善剤
EP2465502A1 (en) 2010-12-15 2012-06-20 Société Splicos Compounds useful for treating AIDS
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
EP2505198A1 (en) 2011-04-01 2012-10-03 Société Splicos Compounds for use as therapeutic agents affecting p53 expression and/or activity
FR2987627B1 (fr) 2012-03-05 2016-03-18 Splicos Utilisation de rbm39 comme biomarqueur
LT3495367T (lt) 2012-06-13 2021-02-25 Incyte Holdings Corporation Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
EP2712862A1 (en) * 2012-09-28 2014-04-02 Splicos New anti-invasive compounds
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
EP2757161A1 (en) 2013-01-17 2014-07-23 Splicos miRNA-124 as a biomarker of viral infection
ITMI20130444A1 (it) * 2013-03-22 2014-09-23 S B M Science Of Biology In Medici Ne Srl Composto di inclusione comprendente adjudin [1-(2,4-diclorobenzil) - 1h-indazolo-3-carboidrazide] e ciclodestrina, sua preparazione e utilizzo.
LT2986610T (lt) 2013-04-19 2018-04-10 Incyte Holdings Corporation Bicikliniai heterociklai, kaip fgfr inhibitoriai
MX382692B (es) 2013-07-05 2025-03-13 Abivax Compuestos bicíclicos útiles para el tratamiento de enfermedades causadas por retrovirus.
WO2015100322A1 (en) * 2013-12-24 2015-07-02 Oncotartis, Inc. Benzamide and nicotinamide compounds and methods of using same
EP2974729A1 (en) 2014-07-17 2016-01-20 Abivax Quinoline derivatives for use in the treatment of inflammatory diseases
JP2017523211A (ja) 2014-08-04 2017-08-17 ドレクセル ユニバーシティ 新規化合物およびそれを用いてil−1r媒介性の疾患または障害を処置するかまたは寛解させる方法
CN106714845A (zh) * 2014-08-11 2017-05-24 得克萨斯州大学系统董事会 通过crispr/cas9介导的基因编辑预防肌营养不良
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
SG11201706287PA (en) 2015-02-20 2017-09-28 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
CN110892069B (zh) * 2017-03-30 2024-02-09 国立大学法人京都大学 基于基因组编辑的外显子跳跃诱导方法
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
KR20200142039A (ko) * 2018-04-10 2020-12-21 스카이호크 테라퓨틱스, 인코포레이티드 암 치료용 화합물
MX2020011718A (es) 2018-05-04 2021-02-15 Incyte Corp Formas solidas de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr) y procesos para prepararlas.
ES3061844T3 (en) 2018-05-04 2026-04-07 Incyte Corp Salts of an fgfr inhibitor
EP3594205A1 (en) * 2018-07-09 2020-01-15 Abivax Phenyl-n-aryl derivatives for treating a rna virus infection
EP3594206A1 (en) 2018-07-09 2020-01-15 Abivax Phenyl-n-quinoline derivatives for treating a rna virus infection
EP3669873A1 (en) 2018-12-20 2020-06-24 Abivax Quinoline derivatives for use ine the traeatment of inflammation diseases
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
CN110172037A (zh) * 2019-07-01 2019-08-27 华北理工大学 一种含吡啶结构的苯乙烯基吡啶化合物、制备方法及其制备抗肿瘤药物的应用
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
EP3848356A1 (en) * 2020-01-07 2021-07-14 Abivax Aryl-n-aryl derivatives for treating a rna virus infection
PL3999493T3 (pl) * 2019-07-19 2024-04-22 Abivax Pochodne arylo-N-arylowe do leczenia zakażenia wirusem RNA
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
TWI891666B (zh) 2019-10-14 2025-08-01 美商英塞特公司 作為fgfr抑制劑之雙環雜環
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
WO2021113462A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Derivatives of an fgfr inhibitor
US20230076977A1 (en) * 2020-01-14 2023-03-09 The Trustees Of The University Of Pennsylvania Utrophin upregulation compounds for duchenne muscular dystrophy therapy
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
TW202304459A (zh) 2021-04-12 2023-02-01 美商英塞特公司 包含fgfr抑制劑及nectin-4靶向劑之組合療法
EP4352060A1 (en) 2021-06-09 2024-04-17 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
JP2024522189A (ja) 2021-06-09 2024-06-11 インサイト・コーポレイション Fgfr阻害剤としての三環式ヘテロ環
CA3237229A1 (en) 2021-11-15 2023-05-19 Narasimha Murthy Cheemala Bicyclic heteroaromatic compounds and their use as pest control agents
WO2023173081A2 (en) * 2022-03-11 2023-09-14 The Johns Hopkins University Targeting an eukaryotic initiation factor 2 alpha kinase to regulate translation under stress
WO2023218245A1 (en) * 2022-05-13 2023-11-16 Voronoi Inc. Heteroaryl derivative compounds, and pharmaceutical composition comprising thereof

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR400973A (fr) 1909-03-19 1909-08-13 Jean Victor Massillon Nouveau sertisseur à main pour la fabrication des cartouches
DE374291C (de) * 1914-03-24 1923-04-21 Alexei Ewgenjewitsch Tschitsch Verfahren zur Darstellung von Aminosubstitutionsprodukten der Pyridin- und Chinolinreihe
US2274620A (en) * 1940-01-02 1942-02-24 S M A Corp Substituted aryl amides of pyridine carboxylic acid
US2671805A (en) 1952-07-02 1954-03-09 Searle & Co Basically substituted o-arylamino-benzamides
DE1168435B (de) * 1961-12-09 1964-04-23 Kali Chemie Ag Verfahren zur Herstellung von 4-Oxo-3, 4-dihydrochinazolinen
NL132603C (enExample) * 1964-08-29
US3409668A (en) 1964-11-07 1968-11-05 Palazzo Giuseppe Substituted anthranilamides and process for the preparation thereof
GB1318291A (en) * 1970-04-15 1973-05-23 Shell Int Research Carboxamide derivatives and fungicidal compositions containing them
JPS5095285A (enExample) 1973-12-26 1975-07-29
DE2417216A1 (de) * 1974-04-09 1975-11-06 Basf Ag Fungizide
JPS52133939A (en) * 1976-04-30 1977-11-09 Ihara Chem Ind Co Ltd Preparation of 2-substituted benzanilides
FR2436786A1 (fr) 1978-09-21 1980-04-18 Anvar Nouveaux derives des pyrido (4,3-b) carbazoles (ellipticines), substitues en position 1 par une chaine polyaminee, leur obtention et leur application a titre de medicaments
US4510139A (en) * 1984-01-06 1985-04-09 Sterling Drug Inc. Substituted aminobenzamides and their use as agents which inhibit lipoxygenase activity
JPS62158252A (ja) * 1985-12-28 1987-07-14 Kirin Brewery Co Ltd 4−アミノピリジンベンズアミド誘導体
DE3819025A1 (de) * 1987-09-01 1989-05-24 Fuji Photo Film Co Ltd Verfahren zur herstellung von alkoxybenzolverbindungen
US4855308A (en) * 1987-12-04 1989-08-08 Warner-Lambert Company Method of treating senile cognitive decline with N'-substituted aminopyridine adrenergic agents
FR2627493B1 (fr) 1988-02-23 1991-10-31 Sanofi Sa Procede de preparation de derives d'isoquinoleine
FR2645861A1 (fr) 1989-04-17 1990-10-19 Inst Nat Sante Rech Med Utilisation de dipyrido (4,3-b) (3,4-f) indoles pour la preparation de medicaments utiles pour le traitement du sida
US5579033A (en) 1992-05-20 1996-11-26 International Business Machines Corporation Pointing device for retrofitting onto the keyboard of an existing computer system
GB9715584D0 (en) * 1997-07-23 1997-10-01 Eisai Co Ltd Compounds
US6268387B1 (en) * 1997-12-23 2001-07-31 Warner-Lambert Company Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis
US7223879B2 (en) * 1998-07-10 2007-05-29 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
ATE360634T1 (de) * 1998-07-10 2007-05-15 Massachusetts Inst Technology Ligande für metalle und verbesserte metall- katalysierte verfahren, die darauf basieren
FR2787444B1 (fr) 1998-12-22 2001-02-09 Rhodia Chimie Sa Composition et procede d'inhibition de la polymerisation radicalaire de monomeres aliphatiques a insaturation ethylenique
CA2358091A1 (en) * 1998-12-23 2000-07-06 Eli Lilly And Company Antithrombotic amides
FR2789576B1 (fr) 1999-02-16 2002-04-26 Oreal Composition de teinture d'oxydation des fibres keratiniques et procede de teinture mettant en oeuvre cette composition
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7101948B2 (en) 2001-12-21 2006-09-05 Air Products And Chemicals, Inc. Stabilizers to inhibit the polymerization of substituted cyclotetrasiloxane
FR2836917B1 (fr) * 2002-03-11 2006-02-24 Lipha Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif
US20060040931A1 (en) * 2002-12-06 2006-02-23 Toray Industries, Inc. Benzomorpholine derivatives
AU2003296326A1 (en) * 2002-12-09 2004-06-30 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US7125997B2 (en) 2002-12-20 2006-10-24 Irm Llc Differential tumor cytotoxicity compounds and compositions
FR2859475A1 (fr) * 2003-09-04 2005-03-11 Centre Nat Rech Scient Utilisation de composes derives d'ellipticine et d'aza-ellipticine pour la preparation d'un medicament utile pour le traitement de maladies genetiques resultant de l'alteration des processus d'epissage
FR2859474B1 (fr) 2003-09-04 2006-01-13 Centre Nat Rech Scient Utilisation de composes derives d'indole pour la preparation d'un medicament utile pour le traitement de maladies genetiques resultant de l'alteration des processus d'epissage
WO2005025498A2 (en) * 2003-09-08 2005-03-24 Corus Pharma Substituted acetanilides and benzamides for the treatment of asthma and pulmonary inflammation
FR2862964B1 (fr) 2003-11-27 2006-12-29 Merck Sante Sas Derives de la diphenylamine.
FR2862965B1 (fr) * 2003-11-27 2007-09-07 Merck Sante Sas Nouveaux derives de phenoxyacetamides et leur utilisation pour la preparation de diphenylamides.
TWI380975B (zh) 2004-03-25 2013-01-01 Otsuka Pharma Co Ltd 製造胺基酚類化合物的方法
EP1845985A4 (en) 2005-02-02 2011-10-12 Nexuspharma Inc AMIN DERIVATIVE COMPOSITIONS AND METHODS FOR TREATING VIRUS DISEASES RELATED TO CANCER Aetiology
WO2006133848A1 (en) 2005-06-13 2006-12-21 Dsm Ip Assets. B.V. Additive composition comprising an amidized or imidized polymer
WO2007096647A2 (en) 2006-02-27 2007-08-30 Sterix Limited Diaryl compounds as non-steroidal inhibitors of 17-beta hydroxysteroid dehydrogenase and/or steroid sulphatase for the treatment of oestrogen-related diseases such as hormone dependent breast cancer
US20090118135A1 (en) 2007-06-08 2009-05-07 The Burnham Institute Methods and compounds for regulating apoptosis
FR2926297B1 (fr) 2008-01-10 2013-03-08 Centre Nat Rech Scient Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
EP2712862A1 (en) 2012-09-28 2014-04-02 Splicos New anti-invasive compounds

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FR2983199B1 (fr) 2015-09-25
EP2235000B1 (en) 2020-06-17
US20140155436A1 (en) 2014-06-05
US9233931B2 (en) 2016-01-12
CN104130242A (zh) 2014-11-05
FR2983200B1 (fr) 2015-09-25
WO2009087238A9 (en) 2010-02-25
CA2946329A1 (en) 2009-07-16
US20190022037A1 (en) 2019-01-24
US20160166519A1 (en) 2016-06-16
CA2946326C (en) 2019-02-19
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WO2009087238A2 (en) 2009-07-16
CN101965341B (zh) 2014-07-16
CA2946336A1 (en) 2009-07-16
PT2235000T (pt) 2020-09-03
HRP20201369T1 (hr) 2020-11-27
CN104130242B (zh) 2016-10-05
FR2926297A1 (fr) 2009-07-17
CN104086482A (zh) 2014-10-08
US20110053975A1 (en) 2011-03-03
CN104086482B (zh) 2017-10-13
EP3536691B1 (en) 2022-10-05
CA2946329C (en) 2020-09-01
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ES2934810T3 (es) 2023-02-27
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US8604063B2 (en) 2013-12-10
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