HRP20201369T1 - Kemijske molekule koje inhibiraju mehanizam prekrajanja za lječenje bolesti koje proizlaze iz anomalija prekrajanja - Google Patents
Kemijske molekule koje inhibiraju mehanizam prekrajanja za lječenje bolesti koje proizlaze iz anomalija prekrajanja Download PDFInfo
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- HRP20201369T1 HRP20201369T1 HRP20201369TT HRP20201369T HRP20201369T1 HR P20201369 T1 HRP20201369 T1 HR P20201369T1 HR P20201369T T HRP20201369T T HR P20201369TT HR P20201369 T HRP20201369 T HR P20201369T HR P20201369 T1 HRP20201369 T1 HR P20201369T1
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- Croatia
- Prior art keywords
- benzamide
- phenylamino
- trifluoromethoxy
- methoxy
- propyl
- Prior art date
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- 201000010099 disease Diseases 0.000 title claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 7
- 150000001875 compounds Chemical class 0.000 claims 4
- 208000030507 AIDS Diseases 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- RRNFHBAWFDBTBS-UHFFFAOYSA-N 3-methyl-n-(3-methylbutyl)-4-[4-(trifluoromethoxy)anilino]benzamide Chemical compound CC1=CC(C(=O)NCCC(C)C)=CC=C1NC1=CC=C(OC(F)(F)F)C=C1 RRNFHBAWFDBTBS-UHFFFAOYSA-N 0.000 claims 1
- MJNPBAIZWHGFQN-UHFFFAOYSA-N 4-(4-methoxyanilino)-3-methyl-n-(3-methylbutyl)benzamide Chemical compound C1=CC(OC)=CC=C1NC1=CC=C(C(=O)NCCC(C)C)C=C1C MJNPBAIZWHGFQN-UHFFFAOYSA-N 0.000 claims 1
- QUEACOJWZZCAIP-UHFFFAOYSA-N 4-(5-chloro-1h-imidazol-2-yl)-n-(4-methoxyphenyl)-2-methylaniline Chemical compound C1=CC(OC)=CC=C1NC1=CC=C(C=2NC(Cl)=CN=2)C=C1C QUEACOJWZZCAIP-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- BASNBMRFRNZZRC-UHFFFAOYSA-N n-(3-imidazol-1-ylpropyl)-2-(4-methoxyanilino)benzamide Chemical compound C1=CC(OC)=CC=C1NC1=CC=CC=C1C(=O)NCCCN1C=NC=C1 BASNBMRFRNZZRC-UHFFFAOYSA-N 0.000 claims 1
- RPIINHOYBAFYGL-UHFFFAOYSA-N n-(3-imidazol-1-ylpropyl)-2-[4-(trifluoromethoxy)anilino]benzamide Chemical compound C1=CC(OC(F)(F)F)=CC=C1NC1=CC=CC=C1C(=O)NCCCN1C=NC=C1 RPIINHOYBAFYGL-UHFFFAOYSA-N 0.000 claims 1
- NLNIABZQDKVDNC-UHFFFAOYSA-N n-(3-imidazol-1-ylpropyl)-4-[4-(trifluoromethoxy)anilino]benzamide Chemical compound C1=CC(OC(F)(F)F)=CC=C1NC1=CC=C(C(=O)NCCCN2C=NC=C2)C=C1 NLNIABZQDKVDNC-UHFFFAOYSA-N 0.000 claims 1
- OGWMDNOQYLEVCB-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-2-(4-methoxyanilino)benzamide Chemical compound CCN(CC)CCNC(=O)C1=CC=CC=C1NC1=CC=C(OC)C=C1 OGWMDNOQYLEVCB-UHFFFAOYSA-N 0.000 claims 1
- QOWOCAIBBUSUOK-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-2-[4-(trifluoromethoxy)anilino]benzamide Chemical compound CCN(CC)CCNC(=O)C1=CC=CC=C1NC1=CC=C(OC(F)(F)F)C=C1 QOWOCAIBBUSUOK-UHFFFAOYSA-N 0.000 claims 1
- GFJGXGKCRUYVJH-UHFFFAOYSA-N n-[2-(diethylamino)propyl]-2-[4-(trifluoromethoxy)anilino]benzamide Chemical compound CCN(CC)C(C)CNC(=O)C1=CC=CC=C1NC1=CC=C(OC(F)(F)F)C=C1 GFJGXGKCRUYVJH-UHFFFAOYSA-N 0.000 claims 1
- FTCSDXMVZJRNLK-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-2-(4-methoxyanilino)benzamide Chemical compound C1=CC(OC)=CC=C1NC1=CC=CC=C1C(=O)NCCN(C)C FTCSDXMVZJRNLK-UHFFFAOYSA-N 0.000 claims 1
- XOKDWZOUYOXSBJ-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-2-[4-(trifluoromethoxy)anilino]benzamide Chemical compound CN(C)CCNC(=O)C1=CC=CC=C1NC1=CC=C(OC(F)(F)F)C=C1 XOKDWZOUYOXSBJ-UHFFFAOYSA-N 0.000 claims 1
- NYNWBLCWWOFPFI-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-3-methyl-4-[4-(trifluoromethoxy)anilino]benzamide Chemical compound CC1=CC(C(=O)NCCN(C)C)=CC=C1NC1=CC=C(OC(F)(F)F)C=C1 NYNWBLCWWOFPFI-UHFFFAOYSA-N 0.000 claims 1
- PNZMAMKNMDRBAM-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-4-(4-methoxyanilino)-3-methylbenzamide Chemical compound C1=CC(OC)=CC=C1NC1=CC=C(C(=O)NCCN(C)C)C=C1C PNZMAMKNMDRBAM-UHFFFAOYSA-N 0.000 claims 1
- FARHIFIXEBMFLL-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-4-[4-(trifluoromethoxy)anilino]benzamide Chemical compound C1=CC(C(=O)NCCN(C)C)=CC=C1NC1=CC=C(OC(F)(F)F)C=C1 FARHIFIXEBMFLL-UHFFFAOYSA-N 0.000 claims 1
- CUUVIRNLGNFTPV-UHFFFAOYSA-N n-[3-(diethylamino)propyl]-3-methyl-4-[4-(trifluoromethoxy)anilino]benzamide Chemical compound CC1=CC(C(=O)NCCCN(CC)CC)=CC=C1NC1=CC=C(OC(F)(F)F)C=C1 CUUVIRNLGNFTPV-UHFFFAOYSA-N 0.000 claims 1
- BQFHBXFWSZEKJI-UHFFFAOYSA-N n-[3-(diethylamino)propyl]-4-(4-methoxyanilino)-3-methylbenzamide Chemical compound CC1=CC(C(=O)NCCCN(CC)CC)=CC=C1NC1=CC=C(OC)C=C1 BQFHBXFWSZEKJI-UHFFFAOYSA-N 0.000 claims 1
- IFVOKBIHVVLRGK-UHFFFAOYSA-N n-[3-(dimethylamino)propyl]-2-(4-methoxyanilino)benzamide Chemical compound C1=CC(OC)=CC=C1NC1=CC=CC=C1C(=O)NCCCN(C)C IFVOKBIHVVLRGK-UHFFFAOYSA-N 0.000 claims 1
- MHCZPAMQENSUGP-UHFFFAOYSA-N n-[3-(dimethylamino)propyl]-3-(4-methoxyanilino)benzamide Chemical compound C1=CC(OC)=CC=C1NC1=CC=CC(C(=O)NCCCN(C)C)=C1 MHCZPAMQENSUGP-UHFFFAOYSA-N 0.000 claims 1
- FFSAKCDOKQPAEU-UHFFFAOYSA-N n-[3-(dimethylamino)propyl]-3-[4-(trifluoromethoxy)anilino]benzamide Chemical compound CN(C)CCCNC(=O)C1=CC=CC(NC=2C=CC(OC(F)(F)F)=CC=2)=C1 FFSAKCDOKQPAEU-UHFFFAOYSA-N 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Claims (4)
1. Spoj naznačen time što je izabran iz skupine koja sadrži:
• N-(3-Dimetilamino-propil)-3-(4-trifluorometoksi-fenilamino)-benzamid;
• 4-(4-Metoksi-fenilamino)-3-metil-N-(3-metil-butil)-benzamid;
• 3-Metil-N-(3-metil-butil)-4-(4-trifluorometoksi-fenilamino)-benzamid;
• N-(2-Dimetilamino-etil)-2-(4-trifluorometoksi-fenilamino)-benzamid;
• N-(2-Dietilamino-etil)-2-(4-trifluorometoksifenilamino)-benzamid;
• N-(2-Dietilamino-propil)-2-(4-trifluorometoksi-fenilamino)-benzamid;
• N-(3-Imidazol-1-il-propil)-2-(4-metoksi-fenilamino)-benzamid;
• N-(3-Imidazol-1-il-propil)-2-(4-trifluorometoksi-fenilamino)-benzamid;
• N-(2-Dimetilamino-etil)-4-(4-trifluorometoksi-fenilamino)-benzamid;
• N-(2-Dimetilamino-etil)-4-(4-metoksi-fenilamino)-3-metil-benzamid;
• N-(3-Dietilamino-propil)-4-(4-metoksi-fenilamino)-3-metil-benzamid;
• N-(3-Dietilamino-propil)-3-metil-4-(4-trifluorometoksi-fenilamino)-benzamid;
• N-(2-Dimetilamino-etil)-3-metil-4-(4-trifluorometoksi-fenilamino)-benzamid;
• [4-(5-Kloro-1H-imidazol-2-il)-2-metil-fenil]-(4-metoksi-fenil)-amin;
• N-(2-Dimetilamino-etil)-2-(4-metoksi-fenilamino)-benzamid;
• N-(3-Imidazol-1-il-propil)-4-(4-trifluorometoksi-fenilamino)-benzamid;
• N-(2-Dietilamino-etil)-2-(4-metoksi-fenilamino)-benzamid;
• N-(3-Dimetilamino-propil)-3-(4-metoksi-fenilamino)-benzamid; i
• N-(3-Dimetilamino-propil)-2-(4-metoksi-fenilamino)-benzamid.
2. Farmaceutski pripravak, naznačen time što sadrži najmanje jedan spoj iz zahtjeva 1 i, po izboru, farmaceutski prihvatljiv nosač.
3. Upotreba najmanje jednog spoja prema patentnom zahtjevu 1 za pripravu lijeka za liječenje, kod subjekta, bolesti koja se odnosi na proces prekrajanja pred-glasničkih RNA u stanici, naznačen time što je navedena bolest, bolest virusnog porijekla, poželjno AIDS.
4. Spoj prema patentnom zahtjevu 1 za uporabu za liječenje, kod subjekta, bolesti koja se odnosi na proces prekrajanja pred-glasničkih RNA u stanici, naznačen time što je navedena bolest, bolest virusnog porijekla, poželjno AIDS.
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FR0850144A FR2926297B1 (fr) | 2008-01-10 | 2008-01-10 | Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. |
EP09700499.8A EP2235000B1 (en) | 2008-01-10 | 2009-01-12 | Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies |
PCT/EP2009/050280 WO2009087238A2 (en) | 2008-01-10 | 2009-01-12 | Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies |
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HRP20201369TT HRP20201369T1 (hr) | 2008-01-10 | 2020-08-28 | Kemijske molekule koje inhibiraju mehanizam prekrajanja za lječenje bolesti koje proizlaze iz anomalija prekrajanja |
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US (4) | US8604063B2 (hr) |
EP (2) | EP3536691B1 (hr) |
JP (1) | JP5784909B2 (hr) |
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