HRP20201369T1 - Kemijske molekule koje inhibiraju mehanizam prekrajanja za lječenje bolesti koje proizlaze iz anomalija prekrajanja - Google Patents

Kemijske molekule koje inhibiraju mehanizam prekrajanja za lječenje bolesti koje proizlaze iz anomalija prekrajanja Download PDF

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HRP20201369T1
HRP20201369T1 HRP20201369TT HRP20201369T HRP20201369T1 HR P20201369 T1 HRP20201369 T1 HR P20201369T1 HR P20201369T T HRP20201369T T HR P20201369TT HR P20201369 T HRP20201369 T HR P20201369T HR P20201369 T1 HRP20201369 T1 HR P20201369T1
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Croatia
Prior art keywords
benzamide
phenylamino
trifluoromethoxy
methoxy
propyl
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HRP20201369TT
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English (en)
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Jamal Tazi
David Grierson
Florence Mahuteau-Betzer
Pierre Roux
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Centre National De La Recherche Scientifique (C.N.R.S.)
Institut Curie
Universite De Montpellier
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Publication of HRP20201369T1 publication Critical patent/HRP20201369T1/hr

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Claims (4)

1. Spoj naznačen time što je izabran iz skupine koja sadrži: • N-(3-Dimetilamino-propil)-3-(4-trifluorometoksi-fenilamino)-benzamid; • 4-(4-Metoksi-fenilamino)-3-metil-N-(3-metil-butil)-benzamid; • 3-Metil-N-(3-metil-butil)-4-(4-trifluorometoksi-fenilamino)-benzamid; • N-(2-Dimetilamino-etil)-2-(4-trifluorometoksi-fenilamino)-benzamid; • N-(2-Dietilamino-etil)-2-(4-trifluorometoksifenilamino)-benzamid; • N-(2-Dietilamino-propil)-2-(4-trifluorometoksi-fenilamino)-benzamid; • N-(3-Imidazol-1-il-propil)-2-(4-metoksi-fenilamino)-benzamid; • N-(3-Imidazol-1-il-propil)-2-(4-trifluorometoksi-fenilamino)-benzamid; • N-(2-Dimetilamino-etil)-4-(4-trifluorometoksi-fenilamino)-benzamid; • N-(2-Dimetilamino-etil)-4-(4-metoksi-fenilamino)-3-metil-benzamid; • N-(3-Dietilamino-propil)-4-(4-metoksi-fenilamino)-3-metil-benzamid; • N-(3-Dietilamino-propil)-3-metil-4-(4-trifluorometoksi-fenilamino)-benzamid; • N-(2-Dimetilamino-etil)-3-metil-4-(4-trifluorometoksi-fenilamino)-benzamid; • [4-(5-Kloro-1H-imidazol-2-il)-2-metil-fenil]-(4-metoksi-fenil)-amin; • N-(2-Dimetilamino-etil)-2-(4-metoksi-fenilamino)-benzamid; • N-(3-Imidazol-1-il-propil)-4-(4-trifluorometoksi-fenilamino)-benzamid; • N-(2-Dietilamino-etil)-2-(4-metoksi-fenilamino)-benzamid; • N-(3-Dimetilamino-propil)-3-(4-metoksi-fenilamino)-benzamid; i • N-(3-Dimetilamino-propil)-2-(4-metoksi-fenilamino)-benzamid.
2. Farmaceutski pripravak, naznačen time što sadrži najmanje jedan spoj iz zahtjeva 1 i, po izboru, farmaceutski prihvatljiv nosač.
3. Upotreba najmanje jednog spoja prema patentnom zahtjevu 1 za pripravu lijeka za liječenje, kod subjekta, bolesti koja se odnosi na proces prekrajanja pred-glasničkih RNA u stanici, naznačen time što je navedena bolest, bolest virusnog porijekla, poželjno AIDS.
4. Spoj prema patentnom zahtjevu 1 za uporabu za liječenje, kod subjekta, bolesti koja se odnosi na proces prekrajanja pred-glasničkih RNA u stanici, naznačen time što je navedena bolest, bolest virusnog porijekla, poželjno AIDS.
HRP20201369TT 2008-01-10 2020-08-28 Kemijske molekule koje inhibiraju mehanizam prekrajanja za lječenje bolesti koje proizlaze iz anomalija prekrajanja HRP20201369T1 (hr)

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EP09700499.8A EP2235000B1 (en) 2008-01-10 2009-01-12 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
PCT/EP2009/050280 WO2009087238A2 (en) 2008-01-10 2009-01-12 Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies

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FR2926297B1 (fr) 2008-01-10 2013-03-08 Centre Nat Rech Scient Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
EP2712862A1 (en) 2012-09-28 2014-04-02 Splicos New anti-invasive compounds

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US10130595B2 (en) 2018-11-20
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CA3072245A1 (en) 2009-07-16
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CA2711652A1 (en) 2009-07-16
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