FR2848117B1 - Procede de preparation d'un extrait de centella asiatica riche en madecassoside et en terminoloside - Google Patents

Procede de preparation d'un extrait de centella asiatica riche en madecassoside et en terminoloside

Info

Publication number
FR2848117B1
FR2848117B1 FR0215613A FR0215613A FR2848117B1 FR 2848117 B1 FR2848117 B1 FR 2848117B1 FR 0215613 A FR0215613 A FR 0215613A FR 0215613 A FR0215613 A FR 0215613A FR 2848117 B1 FR2848117 B1 FR 2848117B1
Authority
FR
France
Prior art keywords
extract
terminoloside
madecassoside
passing
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0215613A
Other languages
English (en)
French (fr)
Other versions
FR2848117A1 (fr
Inventor
Alain Loiseau
Gerard Sene
Eric Theron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Consumer Care AG
Original Assignee
Roche Consumer Health AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0215613A priority Critical patent/FR2848117B1/fr
Application filed by Roche Consumer Health AG filed Critical Roche Consumer Health AG
Priority to ES03815106T priority patent/ES2329568T3/es
Priority to JP2004566117A priority patent/JP4643275B2/ja
Priority to CA2509421A priority patent/CA2509421C/fr
Priority to CNA2003801095973A priority patent/CN1774257A/zh
Priority to EP03815106A priority patent/EP1569672B1/fr
Priority to AU2003296799A priority patent/AU2003296799A1/en
Priority to PCT/FR2003/003651 priority patent/WO2004062678A1/fr
Priority to KR1020117026265A priority patent/KR20110132629A/ko
Priority to KR1020057010638A priority patent/KR101122786B1/ko
Priority to US10/537,936 priority patent/US7402669B2/en
Priority to AT03815106T priority patent/ATE439852T1/de
Priority to DE60328912T priority patent/DE60328912D1/de
Publication of FR2848117A1 publication Critical patent/FR2848117A1/fr
Application granted granted Critical
Publication of FR2848117B1 publication Critical patent/FR2848117B1/fr
Priority to US12/009,696 priority patent/US8163706B2/en
Priority to US13/425,641 priority patent/US8486900B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024Esters of saccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/16Emollients or protectives, e.g. against radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/18Antioxidants, e.g. antiradicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Birds (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0215613A 2002-12-10 2002-12-10 Procede de preparation d'un extrait de centella asiatica riche en madecassoside et en terminoloside Expired - Fee Related FR2848117B1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR0215613A FR2848117B1 (fr) 2002-12-10 2002-12-10 Procede de preparation d'un extrait de centella asiatica riche en madecassoside et en terminoloside
US10/537,936 US7402669B2 (en) 2002-12-10 2003-12-10 Method for preparing a Centella asiatica extract rich in madecassoside and in terminoloside
CA2509421A CA2509421C (fr) 2002-12-10 2003-12-10 Procede de preparation d'un extrait de centella asiatica riche en madecassoside et en terminoloside
CNA2003801095973A CN1774257A (zh) 2002-12-10 2003-12-10 制备富含羟基积雪草苷和特米诺苷的积雪草酸提取物的方法
EP03815106A EP1569672B1 (fr) 2002-12-10 2003-12-10 Utilisation d'un extrait de centella asiatica riche en madecassoside et en terminoloside
AU2003296799A AU2003296799A1 (en) 2002-12-10 2003-12-10 Method for preparing a centella asiatica extract rich in madecassoside and in terminoloside
PCT/FR2003/003651 WO2004062678A1 (fr) 2002-12-10 2003-12-10 Procede de preparation d’un extrait de centella asiatica riche en madecassoside et en terminoloside
KR1020117026265A KR20110132629A (ko) 2002-12-10 2003-12-10 마데카소시드 및 터미놀로시드가 풍부한 센텔라 아시아티카 추출물의 제조 방법
ES03815106T ES2329568T3 (es) 2002-12-10 2003-12-10 Uso de un extracto de centella asiatica en madecasosido y en terminolosido.
JP2004566117A JP4643275B2 (ja) 2002-12-10 2003-12-10 マデカソサイドおよびターミノロサイドに富むセンテラアシアチカ抽出物を調製するための方法
AT03815106T ATE439852T1 (de) 2002-12-10 2003-12-10 Verwendung eines centella asiatica extraktes , der reich an madecassoside und terminoloside ist
DE60328912T DE60328912D1 (de) 2002-12-10 2003-12-10 Verwendung eines centella asiatica extraktes , der reich an madecassoside und terminoloside ist
KR1020057010638A KR101122786B1 (ko) 2002-12-10 2003-12-10 마데카소시드 및 터미놀로시드가 풍부한 센텔라 아시아티카추출물의 제조 방법
US12/009,696 US8163706B2 (en) 2002-12-10 2008-01-22 Method for preparing a centella asiatica extract rich in madecassoside and in terminoloside
US13/425,641 US8486900B2 (en) 2002-12-10 2012-03-21 Method for preparing a Centella asiatica extract rich in madecassoside and in terminoloside

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0215613A FR2848117B1 (fr) 2002-12-10 2002-12-10 Procede de preparation d'un extrait de centella asiatica riche en madecassoside et en terminoloside

Publications (2)

Publication Number Publication Date
FR2848117A1 FR2848117A1 (fr) 2004-06-11
FR2848117B1 true FR2848117B1 (fr) 2006-08-04

Family

ID=32320170

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0215613A Expired - Fee Related FR2848117B1 (fr) 2002-12-10 2002-12-10 Procede de preparation d'un extrait de centella asiatica riche en madecassoside et en terminoloside

Country Status (12)

Country Link
US (3) US7402669B2 (https=)
EP (1) EP1569672B1 (https=)
JP (1) JP4643275B2 (https=)
KR (2) KR20110132629A (https=)
CN (1) CN1774257A (https=)
AT (1) ATE439852T1 (https=)
AU (1) AU2003296799A1 (https=)
CA (1) CA2509421C (https=)
DE (1) DE60328912D1 (https=)
ES (1) ES2329568T3 (https=)
FR (1) FR2848117B1 (https=)
WO (1) WO2004062678A1 (https=)

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WO2006012015A2 (en) * 2004-06-29 2006-02-02 Oregon Health And Science University Methods and compositions for nerve regeneration
FR2888114B1 (fr) * 2005-07-07 2009-10-30 Oreal Utilisation cosmetique du madecassoside et/ou du terminoloside comme agent empechant ou reduisant l'adhesion des microorganismes sur la surface de la peau et/ou des muqueuses
KR20080065641A (ko) * 2005-11-09 2008-07-14 바이엘 컨수머 케어 악티엔게젤샤프트 센텔라 아시아티카로부터의 화합물의 용도
ATE495749T1 (de) * 2007-02-12 2011-02-15 Indus Biotech Private Ltd Zusammensetzung für selektive hemmung der serotoninwiederaufnahme und verfahren dafür
BRPI0700767B8 (pt) * 2007-02-15 2021-05-25 Ache Laboratorios Farmaceuticos Sa composição farmacêutica, produto farmaceutico, processo para obtenção de compostos farmaceuticos e uso de tais compostos para o tratamento do vitiligo
FR2914857B1 (fr) * 2007-04-12 2011-01-21 Dermathologiques D Uriage Lab Compositions anti-inflammatoires et leur utilisation en cosmetique et/ou en dermatologie
WO2008142619A1 (en) * 2007-05-17 2008-11-27 Izun Pharmaceuticals Corporation Use of herbal compositions in the protection and enhancement of extracellular matrix components
EP2231139B1 (en) * 2008-01-11 2015-02-25 Shanghai Institute of Pharmaceutical Industry Therapeutic formulations based on asiatic acid and selected salts thereof
FR2929117B1 (fr) 2008-03-28 2010-05-07 Oreal Utilisation de l'association du 2,4-diaminopyrimidine 3-n-oxyde et du madecassosside et/ou du terminoloside pour induire et/ou stimuler la croissance de ces fibres keratiniques humaines et/ou freiner leur chute
FR2929118B1 (fr) 2008-03-28 2010-05-07 Oreal Utilisation de l'association de madecassoside et/ou de terminoloside et d'une arginine pour induire et/ou stimuler la croissance de ces fibres keratiniques humaines et/ou freiner leur chute
US8591961B2 (en) 2008-09-04 2013-11-26 Allergan, Inc. Aesthetic treatment of scars and aging skin
US8071139B2 (en) * 2008-09-04 2011-12-06 Alan David Widgerow Treatment of damaged skin
FR2932986B1 (fr) * 2008-06-26 2010-12-10 Michele Evrard Composition regeneratrice de la peau
CN101323637B (zh) * 2008-07-29 2010-12-22 卢照凯 一种积雪草甙及其制备方法
CN101407536B (zh) * 2008-11-27 2011-05-18 浙江大学 一种溶剂结晶法制备高纯度积雪草苷的工艺
FR2943253B1 (fr) 2009-03-20 2011-04-22 Oreal Composition contenant l'association de madecassoside, d'une arginine et de polysorbate
DE102009026718A1 (de) 2009-06-04 2010-04-15 Henkel Ag & Co. Kgaa Hautbehandlung zur Porenverfeinerung II
JP2011057634A (ja) * 2009-09-11 2011-03-24 Rohto Pharmaceutical Co Ltd 美白用組成物
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FR2964570A1 (fr) 2010-09-09 2012-03-16 Burgundy Procede de preparation d'un extrait de centella asiatica
WO2012050763A2 (en) 2010-09-29 2012-04-19 Access Business Group International Llc Chia seed extract and related method of manufacture
CN102603854A (zh) * 2011-01-25 2012-07-25 苏州宝泽堂医药科技有限公司 一种从积雪草中提取积雪草皂苷的方法
KR101245563B1 (ko) * 2011-03-16 2013-03-21 바이오스펙트럼 주식회사 마데카소사이드를 함유하는 피부 미백제
JP5926506B2 (ja) * 2011-06-23 2016-05-25 バイオランド・リミテッド コラーゲン産生促進剤の製造方法、mmp−1阻害剤の製造方法及び皮膚外用組成物の製造方法
DE102011083293A1 (de) 2011-09-23 2013-03-28 Henkel Ag & Co. Kgaa Wasserfreie Formulierungen mit kühlender Wirkung
CN102367263B (zh) * 2011-11-11 2013-05-29 上海师范大学 一种分离纯化积雪草三萜酸单葡萄糖苷的方法
WO2014003224A1 (en) * 2012-06-29 2014-01-03 Bio Spectrum, Inc. Compositions for whitening skin comprising madecassoside
US12440530B2 (en) 2013-03-01 2025-10-14 Envy Medical, Inc. Skin solution with solubilized bakuchiol
FR3005575B1 (fr) * 2013-05-20 2016-01-01 Oreal Composition cosmetique comprenant un agent antipelliculaire, un bisabolol et un compose de type madecassoside, et procede de traitement cosmetique
CN105168051A (zh) * 2015-09-16 2015-12-23 任海锋 肤色遮盖液
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CN107412235A (zh) * 2017-06-28 2017-12-01 上海交通大学 一种积雪草中促进pc12细胞分化的单体组合及其应用
CN107903296B (zh) * 2017-11-29 2021-01-26 桂林融通科技有限公司 羟基积雪草苷的提取方法
WO2020112590A1 (en) 2018-11-27 2020-06-04 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Solubilised centella asiatica extract
CN112773806B (zh) * 2019-11-06 2024-03-19 鲁南制药集团股份有限公司 包含淫羊藿苷元和羟基积雪草酸的药物组合物的医药用途
CN111285916B (zh) * 2020-02-14 2021-07-02 浏阳朗林生物科技有限公司 一种积雪草总苷含量高的积雪草提取物的制备方法
FR3117834B1 (fr) * 2020-12-17 2023-11-10 Oreal Composition cosmétique biphase comprenant un acide aminé et deux acides spécifiques
CN112957379B (zh) * 2021-02-20 2022-04-08 上海珈凯生物科技有限公司 一种积雪草提取物的提取方法
WO2023036404A1 (en) 2021-09-07 2023-03-16 Symrise Ag Taste balancing botanical compounds
KR102725267B1 (ko) * 2021-10-19 2024-11-01 동국제약 주식회사 병풀 정량 추출물 및 마데카소사이드를 유효성분으로 함유하는 화장료 조성물
WO2023123046A1 (en) * 2021-12-29 2023-07-06 L'oreal Composition for caring for the skin
CN115228432B (zh) * 2022-05-31 2023-04-25 西南科技大学 用于放射性核素富集的生物质衍生碳包裹纳米零价铁材料的制备及应用
CN114989239B (zh) * 2022-07-05 2023-04-18 广西昌洲天然药业有限公司 一种从积雪草中分离羟基积雪草苷方法及计算机存储介质
KR102786604B1 (ko) * 2022-12-12 2025-03-26 주식회사 코스모바이오 병풀로부터 아시아티코사이드 및 마데카소사이드의 분리 정제 방법
KR20240129658A (ko) 2023-02-20 2024-08-28 국립한국교통대학교산학협력단 병풀 착즙물을 포함하는 항염증 조성물
CN116407478A (zh) * 2023-05-11 2023-07-11 杭州以息互联网科技有限公司 一种温和的祛痘组合物及其应用
KR102883448B1 (ko) * 2023-05-16 2025-11-06 대봉엘에스 주식회사 병풀 추출물을 포함하는 화장료 조성물
CN117530893A (zh) * 2023-12-23 2024-02-09 上海琦成化妆品有限公司 一种抗炎修复组合物及其应用
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CA2509421C (fr) 2012-02-07
JP4643275B2 (ja) 2011-03-02
US20080118581A1 (en) 2008-05-22
KR101122786B1 (ko) 2012-04-12
EP1569672A1 (fr) 2005-09-07
JP2006516962A (ja) 2006-07-13
CN1774257A (zh) 2006-05-17
US8486900B2 (en) 2013-07-16
EP1569672B1 (fr) 2009-08-19
US20120178706A1 (en) 2012-07-12
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ATE439852T1 (de) 2009-09-15
CA2509421A1 (fr) 2004-07-29
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US8163706B2 (en) 2012-04-24
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US20060106206A1 (en) 2006-05-18
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US7402669B2 (en) 2008-07-22
FR2848117A1 (fr) 2004-06-11

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