FR2824825B1 - Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2824825B1
FR2824825B1 FR0106375A FR0106375A FR2824825B1 FR 2824825 B1 FR2824825 B1 FR 2824825B1 FR 0106375 A FR0106375 A FR 0106375A FR 0106375 A FR0106375 A FR 0106375A FR 2824825 B1 FR2824825 B1 FR 2824825B1
Authority
FR
France
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
novel alpha
aminoacid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0106375A
Other languages
English (en)
French (fr)
Other versions
FR2824825A1 (fr
Inventor
Nanteuil Guillaume De
Bernard Portevin
Alain Benoist
Nigel Levens
Olivier Nosjean
Robert Bernadette Husson
Michelle Boulanger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Priority to FR0106375A priority Critical patent/FR2824825B1/fr
Priority to JP2002132484A priority patent/JP3798337B2/ja
Priority to MXPA02004642A priority patent/MXPA02004642A/es
Priority to CA002383298A priority patent/CA2383298C/fr
Priority to DE60212759T priority patent/DE60212759T2/de
Priority to NO20022285A priority patent/NO322569B1/no
Priority to AT02291192T priority patent/ATE331705T1/de
Priority to DK02291192T priority patent/DK1258476T3/da
Priority to HU0201646A priority patent/HUP0201646A3/hu
Priority to EP02291192A priority patent/EP1258476B1/fr
Priority to SI200230350T priority patent/SI1258476T1/sl
Priority to ARP020101750A priority patent/AR033735A1/es
Priority to BR0201697-4A priority patent/BR0201697A/pt
Priority to EA200200446A priority patent/EA004865B1/ru
Priority to NZ518948A priority patent/NZ518948A/en
Priority to ES02291192T priority patent/ES2266422T3/es
Priority to PT02291192T priority patent/PT1258476E/pt
Priority to AU40654/02A priority patent/AU780480B2/en
Priority to ZA200203867A priority patent/ZA200203867B/xx
Priority to KR10-2002-0026768A priority patent/KR100460782B1/ko
Priority to PL02353910A priority patent/PL353910A1/xx
Priority to CNB021199027A priority patent/CN1164573C/zh
Priority to US10/146,272 priority patent/US6706742B2/en
Publication of FR2824825A1 publication Critical patent/FR2824825A1/fr
Priority to HK03102618.5A priority patent/HK1050526B/xx
Application granted granted Critical
Publication of FR2824825B1 publication Critical patent/FR2824825B1/fr
Priority to CY20061101393T priority patent/CY1105385T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Genetics & Genomics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
FR0106375A 2001-05-15 2001-05-15 Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2824825B1 (fr)

Priority Applications (25)

Application Number Priority Date Filing Date Title
FR0106375A FR2824825B1 (fr) 2001-05-15 2001-05-15 Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2002132484A JP3798337B2 (ja) 2001-05-15 2002-05-08 新規α−アミノ酸化合物、その調製方法及びそれを含有する医薬組成物
MXPA02004642A MXPA02004642A (es) 2001-05-15 2002-05-09 Nuevos compuestos de alfa-aminoacido, un proceso para su preparacion y las composiciones farmaceuticas que los contienen.
CA002383298A CA2383298C (fr) 2001-05-15 2002-05-10 Nouveaux derives d'.alpha.-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EA200200446A EA004865B1 (ru) 2001-05-15 2002-05-14 НОВЫЕ α-АМИНОКИСЛОТНЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ ИХ СОДЕРЖАЩИЕ
AT02291192T ATE331705T1 (de) 2001-05-15 2002-05-14 Alpha-aminosäure-derivate, verfahren zu deren herstellung sowie deren verwendung als dipeptidylpeptidase-iv inhibitoren (dpp iv)
DK02291192T DK1258476T3 (da) 2001-05-15 2002-05-14 Alfa-aminosyrederivater, fremgangsmåde til fremstilling heraf og deres anvendelse som dipeptidyl-peptidase-IV-inhibitorer (DDP IV)
HU0201646A HUP0201646A3 (en) 2001-05-15 2002-05-14 Novel alpha-amino acid derivatives, process for producing them and pharmaceutical compositions containing them
EP02291192A EP1258476B1 (fr) 2001-05-15 2002-05-14 Dérivés d'alpha-amino-acides, leur procédé de préparation ainsi que leur utilisation en tant qu'inhibiteurs de dipeptidyl-peptidase IV (DPP IV)
SI200230350T SI1258476T1 (sl) 2001-05-15 2002-05-14 Derivati alfa-aminokislin, postopek za njihovo pripravo in njihova uporaba kot inhibitorji dopeptidil-peptidaze iv (dpp iv)
ARP020101750A AR033735A1 (es) 2001-05-15 2002-05-14 Compuestos de alfa-aminoacidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
BR0201697-4A BR0201697A (pt) 2001-05-15 2002-05-14 Compostos de alfa-aminoácid0, processo para a sua preparação e composições farmacêuticas contendo os mesmos
DE60212759T DE60212759T2 (de) 2001-05-15 2002-05-14 Alpha-Aminosäure-Derivate, Verfahren zu deren Herstellung sowie deren Verwendung als Dipeptidylpeptidase-IV Inhibitoren (DPP IV)
NZ518948A NZ518948A (en) 2001-05-15 2002-05-14 New alpha-amino-acid compounds, a process for their preparation and pharmaceutical compositions containing them
ES02291192T ES2266422T3 (es) 2001-05-15 2002-05-14 Derivados de alfa-aminoacidos, su procedimiento de preparacion y su utilizacion como inhibidores de la dipeptidil-peptidasa iv (dpp iv).
PT02291192T PT1258476E (pt) 2001-05-15 2002-05-14 Derivados de alfa-amino-acidos, processo para sua preparacao assim como a sua utilizacao como inibidores de dipeptidil-peptidase iv (dpp iv).
NO20022285A NO322569B1 (no) 2001-05-15 2002-05-14 Nye <alfa>-aminosyreforbindelser, fremgangsmate ved deres fremstilling og farmasoytiske sammensetninger inneholdende dem
ZA200203867A ZA200203867B (en) 2001-05-15 2002-05-15 alpha-Amino acids compounds, a process for their preparation and pharmaceutical compositions containing them.
KR10-2002-0026768A KR100460782B1 (ko) 2001-05-15 2002-05-15 신규 α-아미노산 화합물, 이의 제조 방법 및 이를함유하는 약제학적 조성물
PL02353910A PL353910A1 (en) 2001-05-15 2002-05-15 Novel compounds 0 derivatives of alpha-amino acid, method of obtaining them and compositions containing such derivatives
CNB021199027A CN1164573C (zh) 2001-05-15 2002-05-15 新的α-氨基酸化合物、其制备方法和包含它们的药物组合物
US10/146,272 US6706742B2 (en) 2001-05-15 2002-05-15 Alpha-amino-acid compounds
AU40654/02A AU780480B2 (en) 2001-05-15 2002-05-15 Alpha-amino-acid compounds, a process for their preparation and pharmaceutical compositions containing them
HK03102618.5A HK1050526B (en) 2001-05-15 2003-04-10 New a-amino acid compounds, a process for their preparation and pharmaceutical compositions containing them
CY20061101393T CY1105385T1 (el) 2001-05-15 2006-09-27 Παραγωγα αλφα-αμινο-οξεων, μεθοδος για την παρασκευη αυτων και χρηση αυτων σαν αναστολεις διπεπτιδυλ-πεπτιδασης iv (dpp iv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0106375A FR2824825B1 (fr) 2001-05-15 2001-05-15 Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2824825A1 FR2824825A1 (fr) 2002-11-22
FR2824825B1 true FR2824825B1 (fr) 2005-05-06

Family

ID=8863284

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0106375A Expired - Fee Related FR2824825B1 (fr) 2001-05-15 2001-05-15 Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (24)

Country Link
US (1) US6706742B2 (enExample)
EP (1) EP1258476B1 (enExample)
JP (1) JP3798337B2 (enExample)
KR (1) KR100460782B1 (enExample)
CN (1) CN1164573C (enExample)
AR (1) AR033735A1 (enExample)
AT (1) ATE331705T1 (enExample)
AU (1) AU780480B2 (enExample)
BR (1) BR0201697A (enExample)
CA (1) CA2383298C (enExample)
CY (1) CY1105385T1 (enExample)
DE (1) DE60212759T2 (enExample)
DK (1) DK1258476T3 (enExample)
EA (1) EA004865B1 (enExample)
ES (1) ES2266422T3 (enExample)
FR (1) FR2824825B1 (enExample)
HU (1) HUP0201646A3 (enExample)
MX (1) MXPA02004642A (enExample)
NO (1) NO322569B1 (enExample)
NZ (1) NZ518948A (enExample)
PL (1) PL353910A1 (enExample)
PT (1) PT1258476E (enExample)
SI (1) SI1258476T1 (enExample)
ZA (1) ZA200203867B (enExample)

Cited By (4)

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US7803753B2 (en) 2005-01-10 2010-09-28 Arena Pharmaceuticals, Inc. Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level
US7816364B2 (en) 2006-04-11 2010-10-19 Arena Pharmaceuticals, Inc. GRP119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto
US7833730B2 (en) 2006-04-11 2010-11-16 Arena Pharmaceuticals, Inc. Methods of using GPR119 to identify compounds useful for increasing bone mass in an individual
US7838254B2 (en) 2008-04-07 2010-11-23 Arena Pharmaceuticals, Inc. Methods of using GPR119 to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY

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* Cited by examiner, † Cited by third party
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US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
DE60329316D1 (de) * 2002-11-12 2009-10-29 Merck & Co Inc Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
JP2006510630A (ja) * 2002-12-04 2006-03-30 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病を治療又は予防するためのジペプチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20040242568A1 (en) * 2003-03-25 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
EP1620091B1 (en) 2003-05-05 2010-03-31 Probiodrug AG Inhibitors of glutaminyl cyclase
JP2007511467A (ja) 2003-05-14 2007-05-10 タケダ サン ディエゴ インコーポレイテッド ジペプチジルペプチダーゼインヒビター
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
MXPA06001601A (es) * 2003-08-13 2006-08-25 Takeda Pharmaceutical Derivados de 4-pirimidona y su uso como inhibidores de dipeptidilpeptidasa.
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US20050065144A1 (en) * 2003-09-08 2005-03-24 Syrrx, Inc. Dipeptidyl peptidase inhibitors
WO2005026148A1 (en) * 2003-09-08 2005-03-24 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
WO2005028438A1 (ja) 2003-09-22 2005-03-31 Banyu Pharmaceutical Co., Ltd. 新規ピペリジン誘導体
JP2007511487A (ja) 2003-11-17 2007-05-10 ノバルティス アクチエンゲゼルシャフト ジペプチジルペプチダーゼｉｖ阻害剤の使用
WO2005058849A1 (en) * 2003-12-15 2005-06-30 Glenmark Pharmaceuticals Ltd. New dipeptidyl peptidase in inhibitors; process for their preparation and compositions containing them
JP5122144B2 (ja) * 2004-01-20 2013-01-16 ノバルティス アーゲー 直接圧縮製剤および方法
CN101618216B (zh) * 2004-01-20 2012-01-04 诺瓦提斯公司 直接压片配方和方法
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
CN102079743B (zh) * 2004-03-15 2020-08-25 武田药品工业株式会社 二肽基肽酶抑制剂
WO2005097759A1 (en) 2004-03-29 2005-10-20 Merck & Co., Inc. Diaryltriazoles as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
FR2870538B1 (fr) * 2004-05-19 2006-07-14 Servier Lab Nouveaux derives de pyrrolidines et de thiazolidines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7687638B2 (en) * 2004-06-04 2010-03-30 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
BRPI0402260B1 (pt) 2004-06-15 2015-02-18 Botica Com Farmaceutica Ltda Composição para produtos de higiene, cosméticos e perfumes.
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
EP1794120B1 (en) * 2004-07-23 2012-04-11 Nuada, LLC Peptidase inhibitors
JP2008509146A (ja) 2004-08-06 2008-03-27 メルク エンド カムパニー インコーポレーテッド １１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ−１の阻害剤としてのスルホニル化合物
AU2005293266B2 (en) 2004-10-12 2011-09-29 Glenmark Pharmaceuticals S.A. Novel dipeptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and process for their preparation
JP2008524331A (ja) * 2004-12-21 2008-07-10 武田薬品工業株式会社 ジペプチジルペプチダーゼ阻害剤
US20060223849A1 (en) * 2005-03-14 2006-10-05 Mjalli Adnan M Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors
MX2007011453A (es) * 2005-04-22 2008-02-12 Alantos Pharmaceuticals Holding Inc Inhibidores de la dipeptidil peptidasa-iv.
EP1892241B1 (en) 2005-05-30 2016-03-30 Msd K.K. Novel piperidine derivative
MY152185A (en) 2005-06-10 2014-08-29 Novartis Ag Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation
EP1916239A4 (en) 2005-08-10 2009-10-21 Banyu Pharma Co Ltd PYRIDOLVERBINDUNG
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