FR2761687B1 - Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques - Google Patents

Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques

Info

Publication number
FR2761687B1
FR2761687B1 FR9704289A FR9704289A FR2761687B1 FR 2761687 B1 FR2761687 B1 FR 2761687B1 FR 9704289 A FR9704289 A FR 9704289A FR 9704289 A FR9704289 A FR 9704289A FR 2761687 B1 FR2761687 B1 FR 2761687B1
Authority
FR
France
Prior art keywords
aryl
group
different
alkyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9704289A
Other languages
English (en)
French (fr)
Other versions
FR2761687A1 (fr
Inventor
Khalid Mekouar
Angelo Jean D
Didier Desmaele
Jean Francois Mouscadet
Frederic Subra
Christian Auclair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Original Assignee
Centre National de la Recherche Scientifique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9704289A priority Critical patent/FR2761687B1/fr
Application filed by Centre National de la Recherche Scientifique filed Critical Centre National de la Recherche Scientifique
Priority to CA2286385A priority patent/CA2286385C/fr
Priority to DE69841119T priority patent/DE69841119D1/de
Priority to JP54245998A priority patent/JP4697679B2/ja
Priority to DK98920581T priority patent/DK0975597T3/da
Priority to EP98920581A priority patent/EP0975597B1/fr
Priority to PCT/FR1998/000701 priority patent/WO1998045269A1/fr
Priority to ES98920581T priority patent/ES2332434T3/es
Priority to US09/402,858 priority patent/US6670377B1/en
Priority to PT98920581T priority patent/PT975597E/pt
Priority to AT98920581T priority patent/ATE441634T1/de
Publication of FR2761687A1 publication Critical patent/FR2761687A1/fr
Application granted granted Critical
Publication of FR2761687B1 publication Critical patent/FR2761687B1/fr
Priority to CY20091101257T priority patent/CY1109553T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
FR9704289A 1997-04-08 1997-04-08 Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques Expired - Fee Related FR2761687B1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR9704289A FR2761687B1 (fr) 1997-04-08 1997-04-08 Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques
US09/402,858 US6670377B1 (en) 1997-04-08 1998-04-07 Quinoline derivatives, having in particular antiviral properties, preparation and biological applications thereof
JP54245998A JP4697679B2 (ja) 1997-04-08 1998-04-07 Ｈｉｖインテグラーゼの阻害剤としてのキノリン誘導体
DK98920581T DK0975597T3 (da) 1997-04-08 1998-04-07 Chinolinderivater som inhibitorer af HIV-integrase
EP98920581A EP0975597B1 (fr) 1997-04-08 1998-04-07 Derives de quinoleines en tant qu'inhibiteurs de la vih integrase
PCT/FR1998/000701 WO1998045269A1 (fr) 1997-04-08 1998-04-07 Derives de quinoleines en tant qu'inhibiteurs de la vih integrase
CA2286385A CA2286385C (fr) 1997-04-08 1998-04-07 Derives de quinoleines en tant qu'inhibiteurs de la vih integrase
DE69841119T DE69841119D1 (de) 1997-04-08 1998-04-07 Chinolinderivate mit insbesondere antiviralen eigenschaften, herstellung und biologische anwendungen davon
PT98920581T PT975597E (pt) 1997-04-08 1998-04-07 Derivados de quinoleínas enquanto inibidores da vih integrase
AT98920581T ATE441634T1 (de) 1997-04-08 1998-04-07 Chinolinderivate mit insbesondere antiviralen eigenschaften, herstellung und biologische anwendungen davon
ES98920581T ES2332434T3 (es) 1997-04-08 1998-04-07 Derivados de quirolina como inhibidores de la integrasa del vih.
CY20091101257T CY1109553T1 (el) 1997-04-08 2009-12-01 Παραγωγα κινολεϊνων ως αναστολεις της ιντεγρασης του hiv

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9704289A FR2761687B1 (fr) 1997-04-08 1997-04-08 Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques

Publications (2)

Publication Number Publication Date
FR2761687A1 FR2761687A1 (fr) 1998-10-09
FR2761687B1 true FR2761687B1 (fr) 2000-09-15

Family

ID=9505648

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9704289A Expired - Fee Related FR2761687B1 (fr) 1997-04-08 1997-04-08 Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques

Country Status (12)

Country Link
US (1) US6670377B1 (enExample)
EP (1) EP0975597B1 (enExample)
JP (1) JP4697679B2 (enExample)
AT (1) ATE441634T1 (enExample)
CA (1) CA2286385C (enExample)
CY (1) CY1109553T1 (enExample)
DE (1) DE69841119D1 (enExample)
DK (1) DK0975597T3 (enExample)
ES (1) ES2332434T3 (enExample)
FR (1) FR2761687B1 (enExample)
PT (1) PT975597E (enExample)
WO (1) WO1998045269A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2321348A1 (en) 2000-09-27 2002-03-27 Blaise Magloire N'zemba Aromatic derivatives with hiv integrase inhibitory properties
FR2819507B1 (fr) * 2001-01-17 2007-09-28 Inst Rech Developpement Ird Quinoleines substituees pour le traitement de co-infections a protozoaires et a retrovirus
CN1659143A (zh) 2001-03-01 2005-08-24 盐野义制药株式会社 具有hiv整合酶抑制活性的含氮杂芳基化合物
FR2830863B1 (fr) * 2001-10-12 2004-01-30 Bioalliance Pharma Derives de quinoleine, procede de synthese, et medicaments renfermant ces derives
FR2839646B1 (fr) * 2002-05-17 2008-04-11 Bioalliance Pharma Utilisation de derives de quinoleine a effet anti-integrase et ses applications
ATE404537T1 (de) 2002-08-13 2008-08-15 Shionogi & Co Heterocyclische verbindungen mit hiv-integrase- hemmender wirkung
US7176220B2 (en) * 2002-11-20 2007-02-13 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as pharmaceutical agent
RU2275361C3 (ru) * 2002-11-20 2021-10-01 Джапан Тобакко Инк. Соединение 4-оксохинолина и его применение в качестве ингибитора вич интегразы
MY134672A (en) * 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
KR100866296B1 (ko) * 2004-05-20 2008-11-11 니뽄 다바코 산교 가부시키가이샤 ４―옥소퀴놀린 화합물의 안정한 결정체
US7531554B2 (en) 2004-05-20 2009-05-12 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as HIV integrase inhibitor
JP2008542352A (ja) * 2005-06-01 2008-11-27 ビオアリアンス ファルマ キノリン化合物及び他のｈｉｖ感染治療薬を含む相乗作用のコンビネーション
JP4669040B2 (ja) 2006-03-06 2011-04-13 日本たばこ産業株式会社 ４−オキソキノリン化合物の製造方法
ES2569660T3 (es) 2007-06-08 2016-05-12 Mannkind Corporation Inhibidores de la IRE-1alfa
KR20100108337A (ko) * 2007-11-15 2010-10-06 베링거 인겔하임 인터내셔날 게엠베하 사람 면역결핍 바이러스 복제의 억제제
SI2220076T1 (sl) * 2007-11-15 2012-05-31 Gilead Sciences Inc Inhibitorji replikacije virusa humane imunske pomankljivosti
JP5269087B2 (ja) * 2007-11-16 2013-08-21 ギリアード サイエンシス インコーポレーテッド ヒト免疫不全ウイルス複製のインヒビター
US8354429B2 (en) * 2007-11-16 2013-01-15 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
EP2147912A1 (en) 2008-07-23 2010-01-27 BioAlliance Pharma Styrylquinolines, their process of preparation and their therapeutic uses
EP2149557A1 (en) 2008-07-23 2010-02-03 BioAlliance Pharma Styrylquinolines, their process of preparation and their therapeutic uses
EP2147913A1 (en) * 2008-07-23 2010-01-27 BioAlliance Pharma Styrylquinolines, their process of preparation and their therapeutic uses
EP2588455B1 (en) * 2010-07-02 2018-04-04 Gilead Sciences, Inc. 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
CA2860015C (en) 2011-12-22 2020-07-07 Universite Laval Three-dimensional cavities of dendritic cell immunoreceptor (dcir), compounds binding thereto and therapeutic applications related to inhibition of human immunodeficiency virus type-1 (hiv-1)
JP6426694B2 (ja) 2013-03-15 2018-11-21 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
TWI663160B (zh) 2016-05-12 2019-06-21 全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
JP7337174B2 (ja) 2018-09-18 2023-09-01 ニカング セラピューティクス， インコーポレイテッド Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての三置換ヘテロアリール誘導体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59152891A (ja) * 1983-02-18 1984-08-31 Yamada Kagaku Kogyo Kk 発色性記録材料
ES8801209A1 (es) * 1985-06-18 1988-01-01 Merck Frosst Canada Inc Un procedimiento para la preparacion de quinolinas 2-sustituidas.
EP0219307A3 (en) * 1985-10-16 1987-10-14 Merck Frosst Canada Inc. 2-substituted quinolines
JPS61189988A (ja) * 1986-08-11 1986-08-23 Yamada Kagaku Kogyo Kk 発色性記録材料
JPH01199979A (ja) 1987-04-07 1989-08-11 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
EP0318093A3 (en) * 1987-11-25 1990-12-05 Merck Frosst Canada Inc. Diarylquinoline diacids and their use as medicaments
US5438141A (en) * 1993-05-21 1995-08-01 Merck Frosst Canada, Inc. Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists
EP0643045B1 (de) * 1993-09-10 2000-03-08 Novartis AG Chinolin-Verbindungen als Leukotriene Antagonisten
GB9414590D0 (en) * 1994-07-20 1994-09-07 Leo Pharm Prod Ltd Chemical compounds
ES2103180B1 (es) * 1994-08-01 1998-04-01 Menarini Lab Fenilacetamidas con accion antagonista de los leucotrienos.
EP0725063A1 (de) * 1995-02-01 1996-08-07 Ciba-Geigy Ag Chinolin-Derivate
AU4172197A (en) * 1996-09-10 1998-04-02 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents

Also Published As

Publication number Publication date
ATE441634T1 (de) 2009-09-15
FR2761687A1 (fr) 1998-10-09
CY1109553T1 (el) 2014-08-13
DE69841119D1 (de) 2009-10-15
EP0975597B1 (fr) 2009-09-02
CA2286385C (fr) 2011-02-01
ES2332434T3 (es) 2010-02-04
WO1998045269A1 (fr) 1998-10-15
JP2001518890A (ja) 2001-10-16
JP4697679B2 (ja) 2011-06-08
US6670377B1 (en) 2003-12-30
PT975597E (pt) 2010-01-04
DK0975597T3 (da) 2009-11-02
CA2286385A1 (fr) 1998-10-15
EP0975597A1 (fr) 2000-02-02

Similar Documents

Publication Publication Date Title
CY1109553T1 (el) Παραγωγα κινολεϊνων ως αναστολεις της ιντεγρασης του hiv
WO2000010965A3 (en) Quaternary ammonium salts and their use as anti-hiv agents
PT87700A (pt) Process for the preparation of a new pyrazolopyridine compound
EA200100970A1 (ru) Аминопроизводные как ингибиторы протеазы
CA2134359A1 (en) New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
IE831564L (en) N-substituted imidazoles
MX9504349A (es) Derivados de aroilpiperidina.
HUP9802315A2 (hu) Trombin inhibitorok, eljárás előállításukra és alkalmazásuk gyógyszerkészítmények előállítására
DK0467248T3 (da) Pyrazolopyridinforbindelse og fremgangsmåder til fremstilling heraf
HRP20010573B1 (en) Tricyclic inhibitors of poly(adp-ribose) polymerases
HUP0200207A2 (hu) Helyettesített 2-aril-(heteroaril)-imidazo [1,2-a]pirimidin-származékok, előállításuk és az ezeket tartalmazó gyógyszerkészítmények
DK0799833T3 (da) Erythromycinderivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
DE69425162D1 (de) 4,5-diaryloxazol-derivate
DK0916646T3 (da) Fremgangsmåde til fremstillingen af en substitueret 2,5-diamino-3-hydroxyhexan
ATE170845T1 (de) Plättchenaggregationsinhibitoren
TNSN97214A1 (fr) Nouveaux inhibiteurs de farnesyle transferase, leur preparation, les compositions pharmaceutiques qui les contiennent et leur utilisation pour la preparation de medicaments
YU46547B (sh) 1,4-dihidropiridini i postupak za njihovo dobijanje
HUT52059A (en) Process for producing pharmaceutical compositions and new quinoline derivatives as a group of active components
YU76401A (sh) 1-amino triazolo(4,3-a)hinazolin-5-oni i/ili - 5-tioni koji inhibiraju fosfodiesteraze iv
JPS56115784A (en) Novel pyridinecarboxamide derivative and its preparation
NO953332D0 (no) Nye forbindelser
ID24846A (id) Turunan-turunan bifenilamidina
DE69315699D1 (de) Inhibitoren gegen die aggregation von blutplättchen
ES2059540T3 (es) Inhibidores de renina no peptidicos.
WO2001022951A3 (en) Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of multiple sclerosis

Legal Events

Date Code Title Description
TQ Partial transmission of property
TQ Partial transmission of property
RM Correction of a material error
ST Notification of lapse

Effective date: 20111230