FR2761687B1 - Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques - Google Patents
Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiquesInfo
- Publication number
- FR2761687B1 FR2761687B1 FR9704289A FR9704289A FR2761687B1 FR 2761687 B1 FR2761687 B1 FR 2761687B1 FR 9704289 A FR9704289 A FR 9704289A FR 9704289 A FR9704289 A FR 9704289A FR 2761687 B1 FR2761687 B1 FR 2761687B1
- Authority
- FR
- France
- Prior art keywords
- aryl
- group
- different
- alkyl
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- XNMYNYSCEJBRPZ-UHFFFAOYSA-N 2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine Chemical class C1=CC=C2C(OCCN(C)C)=NC(CCCC)=CC2=C1 XNMYNYSCEJBRPZ-UHFFFAOYSA-N 0.000 title 1
- 230000000840 anti-viral effect Effects 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000002391 heterocyclic compounds Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- -1 -N(Q)-(CH2)m- Chemical group 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9704289A FR2761687B1 (fr) | 1997-04-08 | 1997-04-08 | Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques |
| EP98920581A EP0975597B1 (fr) | 1997-04-08 | 1998-04-07 | Derives de quinoleines en tant qu'inhibiteurs de la vih integrase |
| DK98920581T DK0975597T3 (da) | 1997-04-08 | 1998-04-07 | Chinolinderivater som inhibitorer af HIV-integrase |
| CA2286385A CA2286385C (fr) | 1997-04-08 | 1998-04-07 | Derives de quinoleines en tant qu'inhibiteurs de la vih integrase |
| US09/402,858 US6670377B1 (en) | 1997-04-08 | 1998-04-07 | Quinoline derivatives, having in particular antiviral properties, preparation and biological applications thereof |
| JP54245998A JP4697679B2 (ja) | 1997-04-08 | 1998-04-07 | Ｈｉｖインテグラーゼの阻害剤としてのキノリン誘導体 |
| DE69841119T DE69841119D1 (de) | 1997-04-08 | 1998-04-07 | Chinolinderivate mit insbesondere antiviralen eigenschaften, herstellung und biologische anwendungen davon |
| AT98920581T ATE441634T1 (de) | 1997-04-08 | 1998-04-07 | Chinolinderivate mit insbesondere antiviralen eigenschaften, herstellung und biologische anwendungen davon |
| PT98920581T PT975597E (pt) | 1997-04-08 | 1998-04-07 | Derivados de quinoleínas enquanto inibidores da vih integrase |
| ES98920581T ES2332434T3 (es) | 1997-04-08 | 1998-04-07 | Derivados de quirolina como inhibidores de la integrasa del vih. |
| PCT/FR1998/000701 WO1998045269A1 (fr) | 1997-04-08 | 1998-04-07 | Derives de quinoleines en tant qu'inhibiteurs de la vih integrase |
| CY20091101257T CY1109553T1 (el) | 1997-04-08 | 2009-12-01 | Παραγωγα κινολεϊνων ως αναστολεις της ιντεγρασης του hiv |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9704289A FR2761687B1 (fr) | 1997-04-08 | 1997-04-08 | Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2761687A1 FR2761687A1 (fr) | 1998-10-09 |
| FR2761687B1 true FR2761687B1 (fr) | 2000-09-15 |
Family
ID=9505648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9704289A Expired - Fee Related FR2761687B1 (fr) | 1997-04-08 | 1997-04-08 | Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6670377B1 (enExample) |
| EP (1) | EP0975597B1 (enExample) |
| JP (1) | JP4697679B2 (enExample) |
| AT (1) | ATE441634T1 (enExample) |
| CA (1) | CA2286385C (enExample) |
| CY (1) | CY1109553T1 (enExample) |
| DE (1) | DE69841119D1 (enExample) |
| DK (1) | DK0975597T3 (enExample) |
| ES (1) | ES2332434T3 (enExample) |
| FR (1) | FR2761687B1 (enExample) |
| PT (1) | PT975597E (enExample) |
| WO (1) | WO1998045269A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2321348A1 (en) * | 2000-09-27 | 2002-03-27 | Blaise Magloire N'zemba | Aromatic derivatives with hiv integrase inhibitory properties |
| FR2819507B1 (fr) | 2001-01-17 | 2007-09-28 | Inst Rech Developpement Ird | Quinoleines substituees pour le traitement de co-infections a protozoaires et a retrovirus |
| WO2002070486A1 (en) | 2001-03-01 | 2002-09-12 | Shionogi & Co., Ltd. | Nitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity |
| FR2830863B1 (fr) * | 2001-10-12 | 2004-01-30 | Bioalliance Pharma | Derives de quinoleine, procede de synthese, et medicaments renfermant ces derives |
| FR2839646B1 (fr) * | 2002-05-17 | 2008-04-11 | Bioalliance Pharma | Utilisation de derives de quinoleine a effet anti-integrase et ses applications |
| AU2003257822A1 (en) | 2002-08-13 | 2004-04-30 | Shionogi And Co., Ltd. | Heterocyclic compound having hiv integrase inhibitory activity |
| RU2275361C3 (ru) * | 2002-11-20 | 2021-10-01 | Джапан Тобакко Инк. | Соединение 4-оксохинолина и его применение в качестве ингибитора вич интегразы |
| AR042095A1 (es) | 2002-11-20 | 2005-06-08 | Japan Tobacco Inc | Compuesto 4-oxoquinolina y aplicacion del mismo como inhibidor de integrasa de vih |
| KR100866296B1 (ko) * | 2004-05-20 | 2008-11-11 | 니뽄 다바코 산교 가부시키가이샤 | ４―옥소퀴놀린 화합물의 안정한 결정체 |
| WO2005113509A1 (en) | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| MY134672A (en) * | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| WO2006129134A1 (en) * | 2005-06-01 | 2006-12-07 | Bioalliance Pharma | Synergic combinations comprising a styrylquinoline compound and other hiv infection therapeutic agents |
| AU2007223260C1 (en) | 2006-03-06 | 2011-02-03 | Japan Tobacco Inc. | Method for producing 4-oxoquinoline compound |
| CN103450077B (zh) * | 2007-06-08 | 2016-07-06 | 满康德股份有限公司 | IRE-1α抑制剂 |
| RU2503679C2 (ru) * | 2007-11-15 | 2014-01-10 | Джилид Сайенсиз, Инк. | Ингибиторы репликации вируса иммунодефицита человека |
| US8377960B2 (en) * | 2007-11-15 | 2013-02-19 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| WO2009062285A1 (en) * | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| CA2705338A1 (en) * | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| EP2149557A1 (en) * | 2008-07-23 | 2010-02-03 | BioAlliance Pharma | Styrylquinolines, their process of preparation and their therapeutic uses |
| EP2147912A1 (en) | 2008-07-23 | 2010-01-27 | BioAlliance Pharma | Styrylquinolines, their process of preparation and their therapeutic uses |
| EP2147913A1 (en) | 2008-07-23 | 2010-01-27 | BioAlliance Pharma | Styrylquinolines, their process of preparation and their therapeutic uses |
| WO2012003498A1 (en) * | 2010-07-02 | 2012-01-05 | Gilead Sciences, Inc. | 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds |
| CA2860015C (en) | 2011-12-22 | 2020-07-07 | Universite Laval | Three-dimensional cavities of dendritic cell immunoreceptor (dcir), compounds binding thereto and therapeutic applications related to inhibition of human immunodeficiency virus type-1 (hiv-1) |
| ES2852054T3 (es) | 2013-03-15 | 2021-09-10 | Global Blood Therapeutics Inc | Compuestos y usos de los mismos para la modulación de hemoglobina |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| TWI752307B (zh) | 2016-05-12 | 2022-01-11 | 美商全球血液治療公司 | 新穎化合物及製造化合物之方法 |
| AU2019344897B2 (en) | 2018-09-18 | 2024-01-18 | Nikang Therapeutics, Inc. | Tri-substituted heteroaryl derivatives AS SRC homology-2 phosphatase inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59152891A (ja) | 1983-02-18 | 1984-08-31 | Yamada Kagaku Kogyo Kk | 発色性記録材料 |
| EP0206751A3 (en) * | 1985-06-18 | 1988-05-25 | Merck Frosst Canada Inc. | 2-substituted quinolines, their preparation and use |
| EP0219307A3 (en) | 1985-10-16 | 1987-10-14 | Merck Frosst Canada Inc. | 2-substituted quinolines |
| JPS61189988A (ja) | 1986-08-11 | 1986-08-23 | Yamada Kagaku Kogyo Kk | 発色性記録材料 |
| JPH01199979A (ja) * | 1987-04-07 | 1989-08-11 | Kanebo Ltd | 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤 |
| IL88433A0 (en) | 1987-11-25 | 1989-06-30 | Merck Frosst Canada Inc | Diarylstyrylquinoline diacids and pharmaceutical compositions containing them |
| US5438141A (en) | 1993-05-21 | 1995-08-01 | Merck Frosst Canada, Inc. | Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists |
| EP0643045B1 (de) | 1993-09-10 | 2000-03-08 | Novartis AG | Chinolin-Verbindungen als Leukotriene Antagonisten |
| GB9414590D0 (en) | 1994-07-20 | 1994-09-07 | Leo Pharm Prod Ltd | Chemical compounds |
| ES2103180B1 (es) | 1994-08-01 | 1998-04-01 | Menarini Lab | Fenilacetamidas con accion antagonista de los leucotrienos. |
| EP0725063A1 (de) | 1995-02-01 | 1996-08-07 | Ciba-Geigy Ag | Chinolin-Derivate |
| AU4172197A (en) * | 1996-09-10 | 1998-04-02 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
-
1997
- 1997-04-08 FR FR9704289A patent/FR2761687B1/fr not_active Expired - Fee Related
-
1998
- 1998-04-07 PT PT98920581T patent/PT975597E/pt unknown
- 1998-04-07 WO PCT/FR1998/000701 patent/WO1998045269A1/fr not_active Ceased
- 1998-04-07 EP EP98920581A patent/EP0975597B1/fr not_active Expired - Lifetime
- 1998-04-07 US US09/402,858 patent/US6670377B1/en not_active Expired - Fee Related
- 1998-04-07 ES ES98920581T patent/ES2332434T3/es not_active Expired - Lifetime
- 1998-04-07 AT AT98920581T patent/ATE441634T1/de active
- 1998-04-07 CA CA2286385A patent/CA2286385C/fr not_active Expired - Fee Related
- 1998-04-07 DK DK98920581T patent/DK0975597T3/da active
- 1998-04-07 JP JP54245998A patent/JP4697679B2/ja not_active Expired - Fee Related
- 1998-04-07 DE DE69841119T patent/DE69841119D1/de not_active Expired - Lifetime
-
2009
- 2009-12-01 CY CY20091101257T patent/CY1109553T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6670377B1 (en) | 2003-12-30 |
| ES2332434T3 (es) | 2010-02-04 |
| PT975597E (pt) | 2010-01-04 |
| WO1998045269A1 (fr) | 1998-10-15 |
| CA2286385A1 (fr) | 1998-10-15 |
| CY1109553T1 (el) | 2014-08-13 |
| EP0975597B1 (fr) | 2009-09-02 |
| JP2001518890A (ja) | 2001-10-16 |
| DE69841119D1 (de) | 2009-10-15 |
| EP0975597A1 (fr) | 2000-02-02 |
| DK0975597T3 (da) | 2009-11-02 |
| CA2286385C (fr) | 2011-02-01 |
| ATE441634T1 (de) | 2009-09-15 |
| FR2761687A1 (fr) | 1998-10-09 |
| JP4697679B2 (ja) | 2011-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TQ | Partial transmission of property | ||
| TQ | Partial transmission of property | ||
| RM | Correction of a material error | ||
| ST | Notification of lapse |
Effective date: 20111230 |