FR2651437A1 - Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. - Google Patents

Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. Download PDF

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Publication number
FR2651437A1
FR2651437A1 FR8911567A FR8911567A FR2651437A1 FR 2651437 A1 FR2651437 A1 FR 2651437A1 FR 8911567 A FR8911567 A FR 8911567A FR 8911567 A FR8911567 A FR 8911567A FR 2651437 A1 FR2651437 A1 FR 2651437A1
Authority
FR
France
Prior art keywords
chromatography
buffer
factor viii
von willebrand
plasma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8911567A
Other languages
English (en)
French (fr)
Other versions
FR2651437B1 (enExample
Inventor
Burnouf Miryana-Nee-Ratosevich
Burnouf Thierry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LILLE TRANSFUSION SANGUINE
Original Assignee
LILLE TRANSFUSION SANGUINE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LILLE TRANSFUSION SANGUINE filed Critical LILLE TRANSFUSION SANGUINE
Priority to FR8911567A priority Critical patent/FR2651437A1/fr
Priority to AT90402395T priority patent/ATE91896T1/de
Priority to EP90402395A priority patent/EP0416983B1/fr
Priority to ES90402395T priority patent/ES2057475T3/es
Priority to DE90402395T priority patent/DE69002427T2/de
Priority to DK90402395.9T priority patent/DK0416983T3/da
Priority to SU904831275A priority patent/RU2025129C1/ru
Priority to UA4831275A priority patent/UA26847C2/uk
Priority to FI904381A priority patent/FI95654C/fi
Priority to CS904312A priority patent/CZ277939B6/cs
Priority to SK4312-90A priority patent/SK279367B6/sk
Priority to PL90286746A priority patent/PL164754B1/pl
Priority to HU905797A priority patent/HU206378B/hu
Priority to US07/577,368 priority patent/US5679776A/en
Priority to SI9012034A priority patent/SI9012034B/sl
Priority to YU203490A priority patent/YU48356B/sh
Priority to NO903865A priority patent/NO178716C/no
Priority to DD90343869A priority patent/DD298110A5/de
Priority to CA002024667A priority patent/CA2024667C/en
Priority to AU62218/90A priority patent/AU627618B2/en
Priority to BR909004626A priority patent/BR9004626A/pt
Publication of FR2651437A1 publication Critical patent/FR2651437A1/fr
Priority to HRP-2034/90A priority patent/HRP920768B1/xx
Priority to LVP-92-496A priority patent/LV10053B/lv
Priority to LTIP263A priority patent/LT3418B/lt
Application granted granted Critical
Publication of FR2651437B1 publication Critical patent/FR2651437B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
FR8911567A 1989-09-05 1989-09-05 Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. Granted FR2651437A1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FR8911567A FR2651437A1 (fr) 1989-09-05 1989-09-05 Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.
AT90402395T ATE91896T1 (de) 1989-09-05 1990-08-30 Verfahren zur herstellung eines konzentrats des faktor viii-von willebrand-faktor-komplexes der blutgerinnung aus vollplasma.
EP90402395A EP0416983B1 (fr) 1989-09-05 1990-08-30 Procédé de préparation de concentré du complexe Facteur VIII-facteur von Willebrand de la coagulation sanguine à partir de plasma total
ES90402395T ES2057475T3 (es) 1989-09-05 1990-08-30 Procedimiento para la preparacion de concentrado de complejo factor viii-factor de willebrand de la coagulacion sanguinea a partir de plasma total.
DE90402395T DE69002427T2 (de) 1989-09-05 1990-08-30 Verfahren zur Herstellung eines Konzentrats des Faktor VIII-von Willebrand-Faktor-Komplexes der Blutgerinnung aus Vollplasma.
DK90402395.9T DK0416983T3 (da) 1989-09-05 1990-08-30 Fremgangsmåde til fremstilling af et koncentrat af komplekset Faktor VIII-von Willebrand-faktor med høj specifik aktivitet ud fra total blodplasma
UA4831275A UA26847C2 (uk) 1989-09-05 1990-09-04 Спосіб одержаhhя коhцеhтрату фактора vііі і фактора фоh-віллебраhда
SU904831275A RU2025129C1 (ru) 1989-09-05 1990-09-04 Способ получения концентрата фактора viii и фактора фон виллебранда
HU905797A HU206378B (en) 1989-09-05 1990-09-05 Process for producing complex concentrate consisting of blood coagulation factor viii and von willebrand factor from full plasma, as well as pharmaceutical compositions comprising such concentrate
CS904312A CZ277939B6 (en) 1989-09-05 1990-09-05 Process for preparing stable concentrate of a complex factor viii-von willebrand factor exhibiting high specific activity
SK4312-90A SK279367B6 (sk) 1989-09-05 1990-09-05 Spôsob prípravy stabilného koncentrátu komplexu fa
PL90286746A PL164754B1 (pl) 1989-09-05 1990-09-05 Sposób wytwarzania koncentratu kompleksu czynnika krzepniecia krwi VIII z czynnikiemWlllebranda PL PL PL PL PL
FI904381A FI95654C (fi) 1989-09-05 1990-09-05 Menetelmä veren hyytymistekijän VIII ja von Willebrand-tekijän kompleksin konsentraatin valmistamiseksi kokoplasmasta
US07/577,368 US5679776A (en) 1989-09-05 1990-09-05 Process for preparing a concentrate of blood coagulation factor VIII-von willebrand factor complex from total plasma
SI9012034A SI9012034B (sl) 1989-09-05 1990-09-05 Postopek za pripravo koncentrata kompleksa faktor VIII za koagulacijo krvi - von Willebrandov faktor iz skupne plazme
YU203490A YU48356B (sh) 1989-09-05 1990-09-05 Postupak za pravljenje koncentrata kompleksa faktora viii za koagulaciju krvi -von willebrand-ov kompleks iz ukupne plazme
NO903865A NO178716C (no) 1989-09-05 1990-09-05 Fremgangsmåte for fremstilling av et stabilt konsentrat av Faktor VIII-von Willebrand faktor kompleks
DD90343869A DD298110A5 (de) 1989-09-05 1990-09-05 Verfahren zur herstellung eines konzentrats des blutgerinnungsfaktor-viii-von-willebrand-faktor-komplexes aus gesamten plasma
CA002024667A CA2024667C (en) 1989-09-05 1990-09-05 Process for preparing a concentrate of blood coagulation factor viii-von willebrand factor complex from total plasma
AU62218/90A AU627618B2 (en) 1989-09-05 1990-09-06 Process for preparing a concentrate of blood coagulation factor v111-von willebrand factor complex from total plasma
BR909004626A BR9004626A (pt) 1989-09-05 1990-09-17 Processo para preparar um concentrado estavel de complexo de fator viii-fator de von willebrand,concentrado de complexo de fator viii-fator de von willebrand e concentrados de proteina derivados de plasma
HRP-2034/90A HRP920768B1 (en) 1989-09-05 1992-10-01 Process for preparing a concentrate of blood coagulation factor viii-von willebrand factor complex from total plasma
LVP-92-496A LV10053B (en) 1989-09-05 1992-12-24 Process for preparing a concentrate of blood coagulation factor viii-von willebrand factor complex from total plasma
LTIP263A LT3418B (en) 1989-09-05 1992-12-29 Process for the preparing a concentrate of blood coagulation factor vii-von willebrand factor complex from total plasma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8911567A FR2651437A1 (fr) 1989-09-05 1989-09-05 Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.

Publications (2)

Publication Number Publication Date
FR2651437A1 true FR2651437A1 (fr) 1991-03-08
FR2651437B1 FR2651437B1 (enExample) 1994-08-19

Family

ID=9385124

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8911567A Granted FR2651437A1 (fr) 1989-09-05 1989-09-05 Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.

Country Status (24)

Country Link
US (1) US5679776A (enExample)
EP (1) EP0416983B1 (enExample)
AT (1) ATE91896T1 (enExample)
AU (1) AU627618B2 (enExample)
BR (1) BR9004626A (enExample)
CA (1) CA2024667C (enExample)
CZ (1) CZ277939B6 (enExample)
DD (1) DD298110A5 (enExample)
DE (1) DE69002427T2 (enExample)
DK (1) DK0416983T3 (enExample)
ES (1) ES2057475T3 (enExample)
FI (1) FI95654C (enExample)
FR (1) FR2651437A1 (enExample)
HR (1) HRP920768B1 (enExample)
HU (1) HU206378B (enExample)
LT (1) LT3418B (enExample)
LV (1) LV10053B (enExample)
NO (1) NO178716C (enExample)
PL (1) PL164754B1 (enExample)
RU (1) RU2025129C1 (enExample)
SI (1) SI9012034B (enExample)
SK (1) SK279367B6 (enExample)
UA (1) UA26847C2 (enExample)
YU (1) YU48356B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3904354A1 (de) * 1989-02-14 1990-08-16 Behringwerke Ag Pasteurisiertes, gereinigtes von willebrand-faktor-konzentrat und verfahren zu seiner herstellung
ES2042138T3 (es) * 1989-05-24 1993-12-01 Miles Inc. Filtracion en gel del factor viii tratado termicamente.
AT403991B (de) * 1990-04-04 1998-07-27 Atomic Austria Gmbh Alpinschi
AT403992B (de) * 1991-02-22 1998-07-27 Head Sport Ag Ski
DE4204694C3 (de) * 1992-02-01 1995-10-12 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie
IT1256622B (it) * 1992-12-04 1995-12-12 Sclavo Spa Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale.
DE4430205A1 (de) * 1994-08-26 1996-02-29 Behringwerke Ag Zusammensetzungen, die als Gegenmittel für Blut-Antikoagulanzien geeignet sind und deren Verwendung
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
AT403765B (de) 1996-04-12 1998-05-25 Immuno Ag Verfahren zur herstellung einer präparation enthaltend einen hochgereinigten komplex
AT406373B (de) * 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
EP1029546A1 (en) * 1997-11-05 2000-08-23 Yoshitomi Pharmaceutical Industries, Ltd. Heparin cofactor ii preparations and process for producing the same
DE69811628T2 (de) 1998-02-11 2003-12-18 Zlb Bioplasma Ag, Bern Verfahren zur Entfernung von Erregern übertragbarer spongiformer Encephalophatien aus Proteinlösungen
PT2193809E (pt) 1999-02-22 2015-08-24 Baxter Int Formulações de fator viii livres de albumina
DE19937218A1 (de) * 1999-08-06 2001-02-08 Aventis Behring Gmbh Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Affinitätschromatographie
ES2229931B1 (es) * 2003-10-03 2006-01-16 Grifols, S.A. Composicion liquida bilogicamente estable de fviii, de fvw o del complejo fviii/fvw humanos.
RU2253475C1 (ru) * 2004-02-02 2005-06-10 Общество с ограниченной ответственностью "Гемоцентр" Способ получения препарата фактора viii
FR2874216B1 (fr) * 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
BRPI0921429B1 (pt) 2008-11-07 2022-07-12 Takeda Pharmaceutical Company Limited Formulação farmacêutica liofilizada estável, e, método para preparar um fator liofilizado estável
US20150080309A1 (en) 2012-04-24 2015-03-19 Nova Nordisk A/S Compounds Suitable for Treatment of Haemophilia
ES2693380T3 (es) 2013-11-08 2018-12-11 Csl Limited Nuevo método para concentrar el factor de von Willebrand o complejos de este
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma
CN104231073B (zh) * 2014-09-25 2017-01-25 广东双林生物制药有限公司 一种人凝血因子viii的制备方法
CN105315365A (zh) * 2015-11-17 2016-02-10 上海洲跃生物科技有限公司 一种人抗凝血酶iii的制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2184898A1 (enExample) * 1972-05-17 1973-12-28 Baxter Laboratories Inc
EP0053046A1 (en) * 1980-11-26 1982-06-02 Gail Ann Rock Stabilisation of factor VIII activity in blood plasma
US4386068A (en) * 1980-02-26 1983-05-31 Cutter Laboratories, Inc. Antihemophilic factor concentrate and method for preparation
US4435318A (en) * 1981-05-22 1984-03-06 Ionics, Incorporated Electrodialysis preparation of purified AHF concentrate
EP0104356A1 (en) * 1982-08-05 1984-04-04 The University Of Rochester Highly purified human antihemophilic factor and method for the preparation thereof
EP0176926A2 (en) * 1984-10-04 1986-04-09 Miles Inc. Process for producing a high purity antihemophilic factor concentrate
EP0359593A1 (fr) * 1988-06-07 1990-03-21 Centre Regional De Transfusion Sanguine De Lille Séparation chromatographique des protéines du plasma, notamment du facteur VIII, du facteur von Willebrand, de la fibronectine et du fibrinogène

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES471858A1 (es) * 1977-07-25 1979-02-01 Monsanto Co Un metodo para separar el factor especifico de coagulacion de la sangre de una mezcla con otras proteinas de la sangre en un medio fluido
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4952675A (en) * 1985-02-01 1990-08-28 New York University Method for purifying antihemophilic factor

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2184898A1 (enExample) * 1972-05-17 1973-12-28 Baxter Laboratories Inc
US4386068A (en) * 1980-02-26 1983-05-31 Cutter Laboratories, Inc. Antihemophilic factor concentrate and method for preparation
EP0053046A1 (en) * 1980-11-26 1982-06-02 Gail Ann Rock Stabilisation of factor VIII activity in blood plasma
US4435318A (en) * 1981-05-22 1984-03-06 Ionics, Incorporated Electrodialysis preparation of purified AHF concentrate
EP0104356A1 (en) * 1982-08-05 1984-04-04 The University Of Rochester Highly purified human antihemophilic factor and method for the preparation thereof
EP0176926A2 (en) * 1984-10-04 1986-04-09 Miles Inc. Process for producing a high purity antihemophilic factor concentrate
EP0359593A1 (fr) * 1988-06-07 1990-03-21 Centre Regional De Transfusion Sanguine De Lille Séparation chromatographique des protéines du plasma, notamment du facteur VIII, du facteur von Willebrand, de la fibronectine et du fibrinogène

Also Published As

Publication number Publication date
YU203490A (sh) 1993-05-28
SI9012034B (sl) 1999-12-31
EP0416983A1 (fr) 1991-03-13
DD298110A5 (de) 1992-02-06
PL286746A1 (en) 1991-05-06
HU905797D0 (en) 1991-03-28
HRP920768A2 (en) 1995-02-28
CA2024667C (en) 2001-07-31
AU627618B2 (en) 1992-08-27
ATE91896T1 (de) 1993-08-15
SK431290A3 (en) 1998-10-07
EP0416983B1 (fr) 1993-07-28
HUT56858A (en) 1991-10-28
FI904381A0 (fi) 1990-09-05
LT3418B (en) 1995-09-25
HRP920768B1 (en) 1998-12-31
ES2057475T3 (es) 1994-10-16
NO903865D0 (no) 1990-09-05
SK279367B6 (sk) 1998-10-07
US5679776A (en) 1997-10-21
FI95654C (fi) 1996-03-11
DE69002427T2 (de) 1993-12-23
AU6221890A (en) 1992-03-12
LV10053B (en) 1995-02-20
DE69002427D1 (de) 1993-09-02
DK0416983T3 (da) 1993-10-04
LTIP263A (en) 1994-10-25
FI95654B (fi) 1995-11-30
LV10053A (lv) 1994-05-10
NO903865L (no) 1991-03-06
PL164754B1 (pl) 1994-10-31
CZ431290A3 (en) 1993-01-13
NO178716B (no) 1996-02-12
CA2024667A1 (en) 1991-03-06
FR2651437B1 (enExample) 1994-08-19
SI9012034A (en) 1997-10-31
HU206378B (en) 1992-10-28
BR9004626A (pt) 1992-03-24
NO178716C (no) 1996-05-22
UA26847C2 (uk) 1999-12-29
YU48356B (sh) 1998-07-10
CZ277939B6 (en) 1993-06-16
RU2025129C1 (ru) 1994-12-30

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