YU203490A - Postupak za pravljenje koncentrata kompleksnog faktora viii za koagulaciju krvi von willebrand-ov kompleks iz ukupne plazme - Google Patents

Postupak za pravljenje koncentrata kompleksnog faktora viii za koagulaciju krvi von willebrand-ov kompleks iz ukupne plazme

Info

Publication number
YU203490A
YU203490A YU203490A YU203490A YU203490A YU 203490 A YU203490 A YU 203490A YU 203490 A YU203490 A YU 203490A YU 203490 A YU203490 A YU 203490A YU 203490 A YU203490 A YU 203490A
Authority
YU
Yugoslavia
Prior art keywords
complex
factor viii
von willebrand
procedure
blood coagulation
Prior art date
Application number
YU203490A
Other languages
English (en)
Other versions
YU48356B (sh
Inventor
M. Burnouf-Radosevich
T. Burnouf
Original Assignee
Null, Null
Centre Regional De Transfusion Sanguine De Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Null, Null, Centre Regional De Transfusion Sanguine De Lille filed Critical Null, Null
Priority to SI9012034A priority Critical patent/SI9012034B/sl
Priority to HRP-2034/90A priority patent/HRP920768B1/xx
Publication of YU203490A publication Critical patent/YU203490A/sh
Publication of YU48356B publication Critical patent/YU48356B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

Pronalazak se odnosi na postupak za pravljenje koncentrata kompleksa Faktor VII-von Willebrand-ov faktor koji ima visoku specifičnu aktivnost iz ukupne (ne-krioprecipitirane) plazme. Postupak obuhvata pred-prečišćavanje pomoću dvostrukog tretiranja sa barijum-hloridom i sa aluminijum-hidroksidom. Postupak tada obuhvata prečišćavanje hromatografijom na anjonoizmenjivačkoj amoli DEAE-Fractogel tipa. Postupak uključuje fazu inaktivacije virusa tretiranja sa rastvaračem-deterdžentom. Postupak takodje omogućuje regenerisanje fibrinogena, albumina, imunoglobulina, antitrombina III, fibronektina i protrombinskog kompleksa iz iste plazme. Različiti koncentrati koji su dobiveni postupkom prema pronalasku namenjeni su naročito za terapeutsko korišćenje.
YU203490A 1989-09-05 1990-09-05 Postupak za pravljenje koncentrata kompleksa faktora viii za koagulaciju krvi -von willebrand-ov kompleks iz ukupne plazme YU48356B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9012034A SI9012034B (sl) 1989-09-05 1990-09-05 Postopek za pripravo koncentrata kompleksa faktor VIII za koagulacijo krvi - von Willebrandov faktor iz skupne plazme
HRP-2034/90A HRP920768B1 (en) 1989-09-05 1992-10-01 Process for preparing a concentrate of blood coagulation factor viii-von willebrand factor complex from total plasma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8911567A FR2651437A1 (fr) 1989-09-05 1989-09-05 Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.

Publications (2)

Publication Number Publication Date
YU203490A true YU203490A (sh) 1993-05-28
YU48356B YU48356B (sh) 1998-07-10

Family

ID=9385124

Family Applications (1)

Application Number Title Priority Date Filing Date
YU203490A YU48356B (sh) 1989-09-05 1990-09-05 Postupak za pravljenje koncentrata kompleksa faktora viii za koagulaciju krvi -von willebrand-ov kompleks iz ukupne plazme

Country Status (24)

Country Link
US (1) US5679776A (sh)
EP (1) EP0416983B1 (sh)
AT (1) ATE91896T1 (sh)
AU (1) AU627618B2 (sh)
BR (1) BR9004626A (sh)
CA (1) CA2024667C (sh)
CZ (1) CZ277939B6 (sh)
DD (1) DD298110A5 (sh)
DE (1) DE69002427T2 (sh)
DK (1) DK0416983T3 (sh)
ES (1) ES2057475T3 (sh)
FI (1) FI95654C (sh)
FR (1) FR2651437A1 (sh)
HR (1) HRP920768B1 (sh)
HU (1) HU206378B (sh)
LT (1) LT3418B (sh)
LV (1) LV10053B (sh)
NO (1) NO178716C (sh)
PL (1) PL164754B1 (sh)
RU (1) RU2025129C1 (sh)
SI (1) SI9012034B (sh)
SK (1) SK279367B6 (sh)
UA (1) UA26847C2 (sh)
YU (1) YU48356B (sh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3904354A1 (de) * 1989-02-14 1990-08-16 Behringwerke Ag Pasteurisiertes, gereinigtes von willebrand-faktor-konzentrat und verfahren zu seiner herstellung
DE69002033T2 (de) * 1989-05-24 1993-09-30 Miles Inc Gelfiltration von wärmebehandeltem Faktor VIII.
AT403991B (de) * 1990-04-04 1998-07-27 Atomic Austria Gmbh Alpinschi
AT403992B (de) * 1991-02-22 1998-07-27 Head Sport Ag Ski
DE4204694C3 (de) * 1992-02-01 1995-10-12 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie
IT1256622B (it) * 1992-12-04 1995-12-12 Sclavo Spa Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale.
DE4430205A1 (de) * 1994-08-26 1996-02-29 Behringwerke Ag Zusammensetzungen, die als Gegenmittel für Blut-Antikoagulanzien geeignet sind und deren Verwendung
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
AT403765B (de) 1996-04-12 1998-05-25 Immuno Ag Verfahren zur herstellung einer präparation enthaltend einen hochgereinigten komplex
AT406373B (de) 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
EP1029546A1 (en) * 1997-11-05 2000-08-23 Yoshitomi Pharmaceutical Industries, Ltd. Heparin cofactor ii preparations and process for producing the same
DE69811628T2 (de) * 1998-02-11 2003-12-18 Zlb Bioplasma Ag Bern Verfahren zur Entfernung von Erregern übertragbarer spongiformer Encephalophatien aus Proteinlösungen
CN101810854A (zh) 1999-02-22 2010-08-25 巴克斯特国际公司 新的无白蛋白的因子viii制剂
DE19937218A1 (de) * 1999-08-06 2001-02-08 Aventis Behring Gmbh Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Affinitätschromatographie
ES2229931B1 (es) * 2003-10-03 2006-01-16 Grifols, S.A. Composicion liquida bilogicamente estable de fviii, de fvw o del complejo fviii/fvw humanos.
FR2874216B1 (fr) 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
JP5779780B2 (ja) 2008-11-07 2015-09-16 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 第ｖｉｉｉ因子製剤
CN104411716B (zh) 2012-04-24 2018-09-07 诺和诺德股份有限公司 适用于治疗血友病的化合物
ES2693380T3 (es) * 2013-11-08 2018-12-11 Csl Limited Nuevo método para concentrar el factor de von Willebrand o complejos de este
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma
CN104231073B (zh) * 2014-09-25 2017-01-25 广东双林生物制药有限公司 一种人凝血因子viii的制备方法
CN105315365A (zh) * 2015-11-17 2016-02-10 上海洲跃生物科技有限公司 一种人抗凝血酶iii的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803115A (en) * 1972-05-17 1974-04-09 Baxter Laboratories Inc Stabilization of ahf using heparin
ES471858A1 (es) * 1977-07-25 1979-02-01 Monsanto Co Un metodo para separar el factor especifico de coagulacion de la sangre de una mezcla con otras proteinas de la sangre en un medio fluido
US4386068A (en) * 1980-02-26 1983-05-31 Cutter Laboratories, Inc. Antihemophilic factor concentrate and method for preparation
US4359463A (en) * 1980-11-26 1982-11-16 Rock Gail A Stabilization of Factor VIII activity in whole blood or blood plasma
US4435318A (en) * 1981-05-22 1984-03-06 Ionics, Incorporated Electrodialysis preparation of purified AHF concentrate
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
US4952675A (en) * 1985-02-01 1990-08-28 New York University Method for purifying antihemophilic factor
FR2632309B1 (fr) 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus

Also Published As

Publication number Publication date
UA26847C2 (uk) 1999-12-29
FI904381A0 (fi) 1990-09-05
SK431290A3 (en) 1998-10-07
DD298110A5 (de) 1992-02-06
HUT56858A (en) 1991-10-28
US5679776A (en) 1997-10-21
SI9012034B (sl) 1999-12-31
FR2651437A1 (fr) 1991-03-08
ATE91896T1 (de) 1993-08-15
NO178716B (no) 1996-02-12
BR9004626A (pt) 1992-03-24
LT3418B (en) 1995-09-25
EP0416983B1 (fr) 1993-07-28
NO903865D0 (no) 1990-09-05
FI95654B (fi) 1995-11-30
AU6221890A (en) 1992-03-12
SI9012034A (en) 1997-10-31
EP0416983A1 (fr) 1991-03-13
FR2651437B1 (sh) 1994-08-19
CZ277939B6 (en) 1993-06-16
PL286746A1 (en) 1991-05-06
CA2024667A1 (en) 1991-03-06
HU905797D0 (en) 1991-03-28
DK0416983T3 (da) 1993-10-04
RU2025129C1 (ru) 1994-12-30
DE69002427T2 (de) 1993-12-23
CZ431290A3 (en) 1993-01-13
NO178716C (no) 1996-05-22
HRP920768B1 (en) 1998-12-31
DE69002427D1 (de) 1993-09-02
LV10053A (lv) 1994-05-10
LV10053B (en) 1995-02-20
CA2024667C (en) 2001-07-31
PL164754B1 (pl) 1994-10-31
FI95654C (fi) 1996-03-11
HU206378B (en) 1992-10-28
AU627618B2 (en) 1992-08-27
ES2057475T3 (es) 1994-10-16
LTIP263A (en) 1994-10-25
HRP920768A2 (en) 1995-02-28
SK279367B6 (sk) 1998-10-07
NO903865L (no) 1991-03-06
YU48356B (sh) 1998-07-10

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