FR2632321A1 - Sequence d'adn codant pour un polypeptide, cassette d'expression comprenant une telle sequence, cellule hote comprenant la cassette d'expression et procede pour produire un tel polypeptide - Google Patents

Sequence d'adn codant pour un polypeptide, cassette d'expression comprenant une telle sequence, cellule hote comprenant la cassette d'expression et procede pour produire un tel polypeptide Download PDF

Info

Publication number
FR2632321A1
FR2632321A1 FR8903952A FR8903952A FR2632321A1 FR 2632321 A1 FR2632321 A1 FR 2632321A1 FR 8903952 A FR8903952 A FR 8903952A FR 8903952 A FR8903952 A FR 8903952A FR 2632321 A1 FR2632321 A1 FR 2632321A1
Authority
FR
France
Prior art keywords
amino acid
sequence
polypeptide
amino acids
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR8903952A
Other languages
English (en)
French (fr)
Inventor
Joseph P Brown
Daniel R Twardzik
Hans Marquardt
George J Todaro
A Gregory Bruce
Timothy M Rose
Anthony F Purchio
Shiu-Lok Hu
Wen Chang
Suo Win Liu
Thomas J Franceschini
Mohammed Shoyab
Greg Plowman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of FR2632321A1 publication Critical patent/FR2632321A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
FR8903952A 1988-03-24 1989-03-24 Sequence d'adn codant pour un polypeptide, cassette d'expression comprenant une telle sequence, cellule hote comprenant la cassette d'expression et procede pour produire un tel polypeptide Withdrawn FR2632321A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17265388A 1988-03-24 1988-03-24

Publications (1)

Publication Number Publication Date
FR2632321A1 true FR2632321A1 (fr) 1989-12-08

Family

ID=22628611

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8903952A Withdrawn FR2632321A1 (fr) 1988-03-24 1989-03-24 Sequence d'adn codant pour un polypeptide, cassette d'expression comprenant une telle sequence, cellule hote comprenant la cassette d'expression et procede pour produire un tel polypeptide

Country Status (22)

Country Link
JP (1) JPH0279981A (https=)
KR (1) KR890014743A (https=)
AU (2) AU3169589A (https=)
BE (1) BE1004202A5 (https=)
CH (1) CH681081A5 (https=)
DE (1) DE3910084A1 (https=)
DK (1) DK146789A (https=)
ES (1) ES2013408A6 (https=)
FI (1) FI891308A7 (https=)
FR (1) FR2632321A1 (https=)
GB (1) GB2219799B (https=)
GR (1) GR1000876B (https=)
HU (1) HUT50501A (https=)
IE (1) IE890950L (https=)
IL (1) IL89673A0 (https=)
IT (1) IT1234961B (https=)
LU (1) LU87489A1 (https=)
NL (1) NL8900724A (https=)
NO (1) NO891273D0 (https=)
NZ (1) NZ228427A (https=)
PT (1) PT90118B (https=)
SE (1) SE8901031L (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU626524B2 (en) * 1987-05-29 1992-08-06 Bristol-Myers Squibb Company Cloning and expression of simian transforming growth factor- beta 1
CA2037440A1 (en) * 1990-03-02 1991-09-03 Gregory D. Plowman Her3: a novel egf receptor homolog
EP0739984A1 (en) * 1995-04-26 1996-10-30 San Tumorforschungs-Gmbh Bivalent polypeptides containing at least two domains
EP0910569A4 (en) * 1996-04-10 2002-05-08 Human Genome Sciences Inc EXTRA-CELLULAR PROTEINS OR EPIDERMAL GROWTH FACTORS LIKE THE PROTEIN
US6852506B1 (en) 1996-04-10 2005-02-08 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983004030A1 (en) * 1982-05-06 1983-11-24 Applied Molecular Genetics, Inc. The manufacture and expression of genes for urogastrone and polypeptide analogs thereof
EP0131868A1 (en) * 1983-07-08 1985-01-23 Wakunaga Seiyaku Kabushiki Kaisha (21-Leucine) human urogastrone, corresponding gene, corresponding recombinant plasmid, transformed cell and process for production thereof
EP0150572A1 (en) * 1983-11-01 1985-08-07 Amgen Microbial expression of type 1 transforming growth factor, polypeptide analogs thereof and hybrid EGF/TGF polypeptides
WO1986002650A1 (en) * 1984-10-30 1986-05-09 Oncogen Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides
GB2172890A (en) * 1985-03-25 1986-10-01 Wellcome Found Epidermal growth factor production
EP0234888A2 (en) * 1986-02-24 1987-09-02 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
EP0314184A1 (en) * 1987-10-30 1989-05-03 Bristol-Myers Squibb Company Expression plasmids
WO1989003886A1 (en) * 1987-10-30 1989-05-05 Oncogen, A Limited Partnership Expression systems for preparation of polypeptides in prokaryotic cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2554459B2 (ja) * 1984-07-02 1996-11-13 アース製薬 株式会社 β−ウロガストロン遺伝子、対応プラスミド組換体及び対応形質転換体
GB2210618B (en) * 1987-10-08 1991-10-16 British Bio Technology Synthetic egf gene

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983004030A1 (en) * 1982-05-06 1983-11-24 Applied Molecular Genetics, Inc. The manufacture and expression of genes for urogastrone and polypeptide analogs thereof
EP0131868A1 (en) * 1983-07-08 1985-01-23 Wakunaga Seiyaku Kabushiki Kaisha (21-Leucine) human urogastrone, corresponding gene, corresponding recombinant plasmid, transformed cell and process for production thereof
EP0150572A1 (en) * 1983-11-01 1985-08-07 Amgen Microbial expression of type 1 transforming growth factor, polypeptide analogs thereof and hybrid EGF/TGF polypeptides
WO1986002650A1 (en) * 1984-10-30 1986-05-09 Oncogen Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides
GB2172890A (en) * 1985-03-25 1986-10-01 Wellcome Found Epidermal growth factor production
EP0234888A2 (en) * 1986-02-24 1987-09-02 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
EP0314184A1 (en) * 1987-10-30 1989-05-03 Bristol-Myers Squibb Company Expression plasmids
WO1989003886A1 (en) * 1987-10-30 1989-05-05 Oncogen, A Limited Partnership Expression systems for preparation of polypeptides in prokaryotic cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AGRICULTURAL AND BIOLOGICAL CHEMISTRY. vol. 51, no. 4, 1987, TOKYO JP pages 1099 - 1104; T. OKA ET AL.: 'Efficacies of Different Secretion Vectors for Secretion of Human Epidermal Growth Factor by Escherichia coli' *
GENE. vol. 60, 1987, AMSTERDAM NL pages 175 - 182; A. F. PURCHIO ET AL.: 'Synthesis of an active hybrid growth factor (GF) in bacteria: transforming GF-alpha/vaccinia GF fusion protein' *
NUCLEIC ACIDS RESEARCH. vol. 14, no. 15, 1986, ARLINGTON, VIRGINIA US pages 6159 - 6168; W. L. SUNG ET AL.: 'Simultaneous synthesis of human-, mouse- and chimeric epidermal growth factor genes via hybrid gene synthesis approach' *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 84, no. 13, 1987, WASHINGTON US pages 4538 - 4542; V. K. CHAUDHARY ET AL.: 'Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin' *

Also Published As

Publication number Publication date
IE890950L (en) 1989-09-24
NL8900724A (nl) 1989-10-16
GB2219799B (en) 1992-10-14
BE1004202A5 (fr) 1992-10-13
IL89673A0 (en) 1989-09-28
CH681081A5 (https=) 1993-01-15
IT8919917A0 (it) 1989-03-24
FI891308L (fi) 1989-09-25
LU87489A1 (fr) 1989-10-26
DK146789D0 (da) 1989-03-22
FI891308A0 (fi) 1989-03-20
SE8901031D0 (sv) 1989-03-22
SE8901031L (sv) 1989-09-25
NZ228427A (en) 1993-03-26
GB8906758D0 (en) 1989-05-10
HUT50501A (en) 1990-02-28
DE3910084A1 (de) 1989-11-16
AU2990492A (en) 1993-03-04
ES2013408A6 (es) 1990-05-01
PT90118A (pt) 1989-11-10
GB2219799A (en) 1989-12-20
AU3169589A (en) 1989-09-28
GR1000876B (el) 1993-03-16
NO891273D0 (no) 1989-03-22
DK146789A (da) 1989-09-25
JPH0279981A (ja) 1990-03-20
PT90118B (pt) 1994-07-29
IT1234961B (it) 1992-06-09
GR890100185A (en) 1990-01-19
FI891308A7 (fi) 1989-09-25
KR890014743A (ko) 1989-10-25

Similar Documents

Publication Publication Date Title
JP2716416B2 (ja) 上皮細胞に特異的な成長因子をコードするｄｎａ
BE1004201A5 (fr) L'amphireguline: une nouvelle glycoproteine bifonctionnelle modulatrice de la croissance.
CN101553243B (zh) 组织损伤修复中的基质细胞衍生因子1的蛋白酶抗性突变体
AU729880C (en) Recombinant vascular endothelial cell growth factor D (VEGF-D)
HK137794A (en) Expression of human proapolipoprotein a-1
WO1986006406A1 (fr) Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
JPH08503858A (ja) 生物活性ポリペプチド融合ダイマー
JPH07509611A (ja) 形態形成蛋白質溶解型複合体，及びその組成
FR2632321A1 (fr) Sequence d'adn codant pour un polypeptide, cassette d'expression comprenant une telle sequence, cellule hote comprenant la cassette d'expression et procede pour produire un tel polypeptide
JPH10262668A (ja) 血管形成誘導因子をコードするタンパク質コード配列を包含するｄｎａ配列
JP2000503850A (ja) Ｓ―層―タンパク質の組み換え発現
CA1245584A (fr) VECTEURS DE CLONAGE ET D'EXPRESSION DE L'INTERFERON- .gamma., BACTERIES TRANSFORMEES ET PROCEDE DE PREPARATION DE L'INTERFERON-.gamma.
AU633377B2 (en) Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides
JP2770926B2 (ja) 毛管内皮細胞プロテアーゼ合成、ｄｎａ合成および遊走を促進することの出来るヒト胎盤血管形成誘導因子
EP0686194B1 (fr) Facteurs de croissance de la famille de l'harp, procede d'obtention et applications
FR2562088A1 (fr) Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
CA2000570A1 (fr) Polypeptides recombinants biologiquement purs, acides nucleiques les codant, application de ces polypeptides a la vaccination contre le virus de la septicemie hemorragique virale du poisson
KR19980075710A (ko) 인간 트롬보포이에틴 (hTPO) 활성을 나타내는 단백질 및 그의 제조방법
PH25991A (en) Antibodies to novel polypeptide having growth factor activity
FR2679910A1 (fr) Ligands de kit solubles.
JPH0584084A (ja) マウス・インターロイキン−１産生プラスミド及びそれを用いたマウス・インターロイキン−１の製造法
CN101955543A (zh) 与层粘连蛋白结合的神经生长因子及其编码基因与应用
HK1136211B (en) Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
JPH08301898A (ja) 新規なポリペプチド、その製造方法、そのポリペプチドをコードするｄｎａ、そのｄｎａからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのペプチドまたは抗体を含有する薬学的組成物

Legal Events

Date Code Title Description
ST Notification of lapse