FR2482967B1 - - Google Patents

Info

Publication number
FR2482967B1
FR2482967B1 FR8110058A FR8110058A FR2482967B1 FR 2482967 B1 FR2482967 B1 FR 2482967B1 FR 8110058 A FR8110058 A FR 8110058A FR 8110058 A FR8110058 A FR 8110058A FR 2482967 B1 FR2482967 B1 FR 2482967B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8110058A
Other languages
French (fr)
Other versions
FR2482967A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Farmaceutici SpA
Original Assignee
Alfa Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici SpA filed Critical Alfa Farmaceutici SpA
Publication of FR2482967A1 publication Critical patent/FR2482967A1/fr
Application granted granted Critical
Publication of FR2482967B1 publication Critical patent/FR2482967B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR8110058A 1980-05-22 1981-05-20 Nouveaux derives de l'imidazo-rifamycine, leur procede de preparation et leur application en therapeutique Granted FR2482967A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03429/80A IT1154655B (it) 1980-05-22 1980-05-22 Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Publications (2)

Publication Number Publication Date
FR2482967A1 FR2482967A1 (fr) 1981-11-27
FR2482967B1 true FR2482967B1 (enExample) 1985-03-29

Family

ID=11107198

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8110058A Granted FR2482967A1 (fr) 1980-05-22 1981-05-20 Nouveaux derives de l'imidazo-rifamycine, leur procede de preparation et leur application en therapeutique

Country Status (25)

Country Link
US (1) US4341785A (enExample)
JP (1) JPS5711987A (enExample)
AR (1) AR226212A1 (enExample)
AT (1) AT373599B (enExample)
AU (1) AU537093B2 (enExample)
BE (1) BE888895A (enExample)
CA (1) CA1142518A (enExample)
CH (1) CH648037A5 (enExample)
DE (1) DE3120460A1 (enExample)
DK (1) DK157876C (enExample)
EG (1) EG14891A (enExample)
ES (1) ES8203388A1 (enExample)
FI (1) FI69467C (enExample)
FR (1) FR2482967A1 (enExample)
GB (1) GB2079270B (enExample)
GR (1) GR75640B (enExample)
IE (1) IE51204B1 (enExample)
IT (1) IT1154655B (enExample)
LU (1) LU83376A1 (enExample)
NL (1) NL187022C (enExample)
NO (1) NO155622C (enExample)
PH (2) PH17207A (enExample)
PT (1) PT73064B (enExample)
SE (1) SE453089B (enExample)
ZA (1) ZA813430B (enExample)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199374B (it) * 1984-05-15 1988-12-30 Alfa Farmaceutici Spa Processo per la preparazione di pirido-imidazo-rifamicine
IT1264494B1 (it) * 1993-03-23 1996-09-24 Alfa Wassermann Spa Uso di rifaximin e di formulazioni che la contengono nel trattamento delle dispepsie gastriche originate da helicobacter
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US5981522A (en) * 1995-09-01 1999-11-09 Kaneka Corporation Treatment of disease caused by infection of Helicobacter
CA2230649C (en) * 1997-02-28 2007-11-06 Kaneka Corporation Medicine for a disease caused by infection of helicobacter
EP1453837A4 (en) * 2001-11-21 2007-11-07 Activbiotics Inc TARGETED THERAPEUTIC AGENTS AND USES THEREOF
US7078399B2 (en) * 2001-12-13 2006-07-18 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
WO2004041240A1 (en) * 2002-11-05 2004-05-21 Piero Chiarelli Controlled and continued delivery of rifaximin and/or other substances
US7820652B2 (en) * 2003-09-24 2010-10-26 Activbiotics Pharma, Llc Regimen for the administration of rifamycin-class antibiotics
US7906542B2 (en) * 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
ITMI20032144A1 (it) * 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US7923553B2 (en) * 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
US7902206B2 (en) * 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
US7265107B2 (en) * 2004-03-10 2007-09-04 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes
US7256187B2 (en) * 2004-03-10 2007-08-14 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime derivatives effective against drug-resistant microbes
US7202246B2 (en) * 2004-06-09 2007-04-10 Cumbre Pharmaceuticals Inc. Spiro-rifamycin derivatives targeting RNA polymerase
US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
US20060210483A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
PL1698630T3 (pl) * 2005-03-03 2014-12-31 Alfasigma Spa Nowe postacie polimorficzne rifaksyminy,sposoby ich wytwarzania i ich zastosowanie w preparatach leczniczych
ITBO20050123A1 (it) * 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
EA016059B1 (ru) 2005-08-11 2012-01-30 Тарганта Терапьютикс Инк. Фосфонированные рифамицины и их применение для профилактики и лечения костных и суставных инфекций
JP5331487B2 (ja) 2006-03-09 2013-10-30 サリックス ファーマシューティカルズ, インコーポレイテッド リファキシム抗直腸機能不全製剤
PL2054066T3 (pl) 2006-08-02 2015-12-31 Salix Pharmaceuticals Inc Sposoby leczenia popromiennego zapalenia jelit
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
CA2663776C (en) * 2006-09-22 2016-01-26 Cipla Limited Rifaximin in an amorphous form
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
US8383151B2 (en) 2007-07-06 2013-02-26 Lupin Limited Pharmaceutical compositions of rifaximin
PL2011486T5 (pl) 2007-07-06 2016-09-30 Lupin Ltd Farmaceutyczne kompozycje rifaksyminy
US7709634B2 (en) * 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
US8486956B2 (en) * 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
NZ587099A (en) 2008-02-25 2012-08-31 Salix Pharmaceuticals Ltd Forms of rifaximin and uses thereof
CN101959412A (zh) 2008-02-26 2011-01-26 萨利克斯药品有限公司 治疗肠病的方法
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
JP5752032B2 (ja) 2008-05-07 2015-07-22 サリックス ファーマシューティカルズ リミテッド 腸洗浄剤および抗生物質の投与により腸疾患を治療する方法
EP2324041A4 (en) 2008-08-13 2012-06-13 Targanta Therapeutics Corp PHOSPHONIZED RIFAMYCINS AND ITS APPLICATION FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS
CA2736285C (en) 2008-09-26 2016-08-23 Aska Pharmaceutical Co., Ltd. Agent for preventing and/or treating functional gastrointestinal disorder
CA2739436C (en) 2008-10-02 2019-08-27 Salix Pharmaceuticals, Ltd. Use of rifaximin for treating hepatic encephalopathy
US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
JP5756020B2 (ja) 2008-12-10 2015-07-29 シプラ・リミテッド リファキシミン複合体
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
RU2540513C2 (ru) 2009-06-02 2015-02-10 Саликс Фармасьютикалз, Лтд. Способы лечения печеночной энцефалопатии
CA2773982C (en) 2009-09-13 2018-12-04 Salix Pharmaceuticals, Ltd. Methods for treating irritable bowel syndrome (ibs)
KR20140015140A (ko) 2009-10-27 2014-02-06 루핀 리미티드 리팍시민의 고형 분산물
CA2781580A1 (en) 2009-11-23 2011-05-26 Cipla Limited Topical foam composition
WO2011080691A1 (en) 2009-12-28 2011-07-07 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
AU2011218129A1 (en) 2010-02-18 2012-08-23 Board Of Regents Of The University Of Texas System Methods for treating infection
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
US9211258B2 (en) 2010-03-10 2015-12-15 Lupin Limited Rifaximin ready-to-use suspension
EP2593463B1 (en) 2010-07-12 2020-05-06 Salix Pharmaceuticals, Inc. Formulations of rifaximin and uses thereof
WO2012035544A2 (en) 2010-09-13 2012-03-22 Sequent Scientific Ltd. A novel polymorphic form of rifaximin and process for its preparation
PH12013501643A1 (en) 2011-02-11 2019-10-11 Salix Pharmaceuticals Ltd Forms of rifaximin and uses thereof
EP2705042A1 (en) 2011-05-02 2014-03-12 Ranbaxy Laboratories Limited Rifaximin dimethylformamide solvate
ITMI20110890A1 (it) * 2011-05-19 2012-11-20 A M S A Anonima Materie Sint & Affini S P A Polimorfo di rifaximina e processo per la sua preparazione
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
RU2496475C2 (ru) 2011-10-26 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция и набор для лечения бактериальных инфекций
EP2773205B1 (en) 2011-11-02 2024-05-22 Salix Pharmaceuticals, Inc. Rifaximin for retreating diarrhea-predominant irritable bowel syndrome
AU2013212008A1 (en) 2012-01-25 2014-07-10 Alfa Wassermann S.P.A. Rifaximin derivative and uses thereof
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
US9849090B2 (en) 2012-12-12 2017-12-26 Sun Pharmaceutical Industries Limited Pharmaceutical compositions of rifaximin
WO2014140988A1 (en) 2013-03-15 2014-09-18 Alfa Wassermann S.P.A. Rifaximin for use in the treating of vaginal infections.
EP2971062A2 (en) 2013-03-15 2016-01-20 ALFA WASSERMANN S.p.A. Method for diagnosing vaginal infections
PL2983647T3 (pl) 2013-04-12 2021-01-25 Alfasigma S.P.A. Podawanie nlpz oraz związane z tym składniki, sposoby i układy
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
EP2927235B1 (en) 2014-03-31 2017-02-08 Euticals S.P.A. Polymorphic mixture of rifaximin and its use for the preparation of solid formulations
EP3134415A4 (en) * 2014-04-19 2017-10-25 Granules India Limited An improved process for the preparation of rifamycin derivatives
JP6693946B2 (ja) 2014-05-04 2020-05-13 サリックス ファーマスーティカルズ,インコーポレーテッド Ibs微生物叢及びその使用
SI3143027T1 (sl) 2014-05-12 2019-10-30 Alfasigma Spa Nova solvatirana kristalna oblika rifaksimina, proizvodnja, sestavki in uporaba le-teh
EP2982764A1 (en) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification of vaginal bacteria
US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
RS63751B1 (sr) 2016-09-30 2022-12-30 Salix Pharmaceuticals Inc Čvrsti disperzioni oblici rifaksimina
RU2020102511A (ru) * 2017-06-26 2021-07-27 Биофер С.П.А. Соединения пиридо-имидазо рифамицина в качестве антибактериального средства
IT201700091912A1 (it) * 2017-08-08 2019-02-08 Biofer Spa Nuove pirido-imidazo rifamicine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE273377C (enExample) *
AT273377B (de) * 1967-03-01 1969-08-11 Lepetit Spa Verfahren zur Herstellung von neuen Rifamycinen
AT344898B (de) * 1975-06-13 1978-08-10 Archifar Ind Chim Trentino Verfahren zur herstellung neuer rifamycin-verbindungen
DK345977A (da) * 1976-09-30 1978-03-31 Archifar Ind Chim Trentino G rifamycinforbindelser og fremgangsmaade til deres fremstillin
CH629212A5 (it) * 1976-10-18 1982-04-15 Erba Farmitalia Procedimento per la preparazione di composti di rifamicina.
CH633014A5 (en) * 1978-06-09 1982-11-15 Erba Farmitalia Rifamycin compounds

Also Published As

Publication number Publication date
DK157876B (da) 1990-02-26
FI69467C (fi) 1986-02-10
ES502906A0 (es) 1982-04-01
DK224781A (da) 1981-11-23
IT1154655B (it) 1987-01-21
CA1142518A (en) 1983-03-08
LU83376A1 (fr) 1981-09-11
BE888895A (fr) 1981-09-16
NL187022B (nl) 1990-12-03
DK157876C (da) 1990-07-30
IE811139L (en) 1981-11-22
FR2482967A1 (fr) 1981-11-27
ES8203388A1 (es) 1982-04-01
SE453089B (sv) 1988-01-11
NL8102290A (nl) 1981-12-16
IT8003429A0 (it) 1980-05-22
NO155622C (no) 1987-04-29
NL187022C (nl) 1991-05-01
NO155622B (no) 1987-01-19
JPS5711987A (en) 1982-01-21
AU7065581A (en) 1981-11-26
IE51204B1 (en) 1986-10-29
DE3120460A1 (de) 1982-03-11
PH18704A (en) 1985-09-05
ZA813430B (en) 1982-06-30
PT73064B (en) 1982-07-05
SE8103216L (sv) 1981-11-23
DE3120460C2 (enExample) 1990-12-13
EG14891A (en) 1985-12-31
PT73064A (en) 1981-06-01
US4341785A (en) 1982-07-27
GR75640B (enExample) 1984-08-02
AR226212A1 (es) 1982-06-15
PH17207A (en) 1984-06-19
JPS6123192B2 (enExample) 1986-06-04
GB2079270A (en) 1982-01-20
NO811731L (no) 1981-11-23
FI811565L (fi) 1981-11-23
ATA222781A (de) 1983-06-15
FI69467B (fi) 1985-10-31
AT373599B (de) 1984-02-10
GB2079270B (en) 1984-01-18
CH648037A5 (de) 1985-02-28
AU537093B2 (en) 1984-06-07

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