FR2456101A1 - Derives dihalogenes geminaux de pyrimidin-4-one condensees, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Derives dihalogenes geminaux de pyrimidin-4-one condensees, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
FR2456101A1
FR2456101A1 FR8010481A FR8010481A FR2456101A1 FR 2456101 A1 FR2456101 A1 FR 2456101A1 FR 8010481 A FR8010481 A FR 8010481A FR 8010481 A FR8010481 A FR 8010481A FR 2456101 A1 FR2456101 A1 FR 2456101A1
Authority
FR
France
Prior art keywords
group
condensed
pyrimidin
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8010481A
Other languages
English (en)
Other versions
FR2456101B1 (fr
Inventor
Istvan Hermecz
Tibor Breining
Lelle Vasvari
Agnes Horvath
Zoltan Meszaros
Istvan Bitter
Josef Kokosi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of FR2456101A1 publication Critical patent/FR2456101A1/fr
Application granted granted Critical
Publication of FR2456101B1 publication Critical patent/FR2456101B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B62/00—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

DERIVES DIHALOGENES GEMINAUX DE PYRIMIDINE-4-ONES CONDENSEES DE LA FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE: R REPRESENTE DE L'HYDROGENE OU UN GROUPE ALCOYLE INFERIEUR OU (ALCOXY INFERIEUR) CARBONYLE; R REPRESENTE DE L'HYDROGENE, UN GROUPE ALCOYLE INFERIEUR, CARBOXY, UN GROUPE ESTER OU UN DERIVE D'UN TEL GROUPE, UN GROUPE CYANO, PHENYLE OU UN HALOGENE; R REPRESENTE DE L'HYDROGENE OU UN GROUPE ALCOYLE INFERIEUR OU PHENYLE; X REPRESENTE UN HALOGENE; N EST L'UN DES NOMBRES ENTIERS 0, 1 ET 2, ET LEURS SELS ET ANTIPODES OPTIQUEMENT ACTIFS. APPLICATION COMME MEDICAMENTS.
FR8010481A 1979-05-11 1980-05-09 Derives dihalogenes geminaux de pyrimidin-4-one condensees, procede pour leur preparation et compositions pharmaceutiques les contenant Granted FR2456101A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU79CI1932A HU179443B (en) 1979-05-11 1979-05-11 Process for producing substituted geminal dihalogeno-derivatives of pyrido-square bracket-1,2-a-square closed-pyrimidines,pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines and pyrimido-square bracket-1,2,-a-square bracket closed-asepines

Publications (2)

Publication Number Publication Date
FR2456101A1 true FR2456101A1 (fr) 1980-12-05
FR2456101B1 FR2456101B1 (fr) 1985-04-05

Family

ID=10994747

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8010481A Granted FR2456101A1 (fr) 1979-05-11 1980-05-09 Derives dihalogenes geminaux de pyrimidin-4-one condensees, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (24)

Country Link
JP (1) JPS5615286A (fr)
AT (1) AT377261B (fr)
BE (1) BE883217A (fr)
CA (1) CA1141379A (fr)
CH (1) CH646971A5 (fr)
CS (1) CS241025B2 (fr)
DD (1) DD150605A5 (fr)
DE (1) DE3017564A1 (fr)
DK (1) DK204680A (fr)
ES (1) ES491896A0 (fr)
FI (1) FI68825C (fr)
FR (1) FR2456101A1 (fr)
GB (1) GB2051048B (fr)
GR (1) GR68518B (fr)
HU (1) HU179443B (fr)
IL (1) IL59967A (fr)
IT (1) IT1133085B (fr)
LU (1) LU82437A1 (fr)
NL (1) NL8002678A (fr)
NO (1) NO152607C (fr)
PL (1) PL124035B1 (fr)
PT (1) PT71213A (fr)
SE (1) SE441747B (fr)
SU (1) SU1151210A3 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178453B (en) * 1979-05-11 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 9-hydrazino-4-oxo-6,7,8,9-tetrahydro-4h-p-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives
US4395549A (en) 1981-10-02 1983-07-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones
ES8501397A1 (es) * 1982-08-05 1984-11-16 Erba Farmitalia "procedimiento para preparar derivados de quinazolina"
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7813M (fr) * 1966-11-02 1970-05-20
LU80601A1 (de) * 1977-12-29 1979-03-22 Chinoin Gyogyszer Es Vegyeszet Neue kondensierte pyrimidin-derivate und verfahren zu ihrer herstellung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7813M (fr) * 1966-11-02 1970-05-20
LU80601A1 (de) * 1977-12-29 1979-03-22 Chinoin Gyogyszer Es Vegyeszet Neue kondensierte pyrimidin-derivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
NO152607B (no) 1985-07-15
BE883217A (fr) 1980-09-01
DD150605A5 (de) 1981-09-09
IT8067719A0 (it) 1980-05-09
CS325880A2 (en) 1985-06-13
GR68518B (fr) 1982-01-11
PL224163A1 (fr) 1981-02-13
NL8002678A (nl) 1980-11-13
GB2051048B (en) 1983-01-19
ATA247580A (de) 1984-07-15
CS241025B2 (en) 1986-03-13
DK204680A (da) 1980-11-12
NO801378L (no) 1980-11-12
LU82437A1 (fr) 1980-07-31
ES8102570A1 (es) 1981-02-16
FR2456101B1 (fr) 1985-04-05
AT377261B (de) 1985-02-25
PL124035B1 (en) 1982-12-31
CH646971A5 (de) 1984-12-28
FI68825C (fi) 1985-11-11
CA1141379A (fr) 1983-02-15
SU1151210A3 (ru) 1985-04-15
FI68825B (fi) 1985-07-31
PT71213A (en) 1980-06-01
NO152607C (no) 1985-10-23
JPS5615286A (en) 1981-02-14
SE8003479L (sv) 1980-11-12
IT1133085B (it) 1986-07-09
HU179443B (en) 1982-10-28
DE3017564A1 (de) 1980-11-13
FI801512A (fi) 1980-11-12
IL59967A0 (en) 1980-07-31
SE441747B (sv) 1985-11-04
GB2051048A (en) 1981-01-14
ES491896A0 (es) 1981-02-16
IL59967A (en) 1984-05-31

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