FR2439201A1 - Procede de fabrication de l'oxymorphone - Google Patents

Procede de fabrication de l'oxymorphone

Info

Publication number
FR2439201A1
FR2439201A1 FR7925895A FR7925895A FR2439201A1 FR 2439201 A1 FR2439201 A1 FR 2439201A1 FR 7925895 A FR7925895 A FR 7925895A FR 7925895 A FR7925895 A FR 7925895A FR 2439201 A1 FR2439201 A1 FR 2439201A1
Authority
FR
France
Prior art keywords
oxymorphone
boron
agent
manufacturing process
boron compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7925895A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of FR2439201A1 publication Critical patent/FR2439201A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polarising Elements (AREA)

Abstract

PROCEDE DE FABRICATION DE L'OXYMORPHONE CONSISTANT A FAIRE REAGIR L'OXYCODONE AVEC UNE QUANTITE DEMETHYLANTE D'UN COMPOSE DU BORE QUI EST LE TRIBROMURE DE BORE, LE TRICHLORURE DE BORE OU LE PRODUIT DE LA REACTION DE L'UN DE CES DEUX HALOGENURES AVEC UN ALCOOL INFERIEUR, DANS UN MILIEU REACTIONNEL CONTENANT UN SOLVANT ORGANIQUE, DANS DES CONDITIONS DE DEMETHYLATION. LE MILIEU REACTIONNEL CONTIENT UNE QUANTITE SUFFISANTE D'UN AGENT D'ATTENUATION POUR AFFAIBLIR L'ACTIVITE DU COMPOSE DU BORE, CET AGENT D'ATTENUATION ETANT UNE BASE DE LEWIS FAIBLE QUI NE PEUT REAGIR AVEC LEDIT AGENT DEMETHYLANT, CE QUI PERMET D'OBTENIR L'OXYMORPHONE AVEC UN BON RENDEMENT ET PRATIQUEMENT SANS SOUS-PRODUITS. L'OXYMORPHONE EST UNE SUBSTANCE NARCOTIQUE TRES UTILISEE COMME ANALGESIQUE.
FR7925895A 1978-10-19 1979-10-18 Procede de fabrication de l'oxymorphone Withdrawn FR2439201A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95305678A 1978-10-19 1978-10-19

Publications (1)

Publication Number Publication Date
FR2439201A1 true FR2439201A1 (fr) 1980-05-16

Family

ID=25493512

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7925895A Withdrawn FR2439201A1 (fr) 1978-10-19 1979-10-18 Procede de fabrication de l'oxymorphone

Country Status (16)

Country Link
JP (1) JPS55501025A (fr)
AU (1) AU5189779A (fr)
BE (1) BE879494A (fr)
CA (1) CA1108132A (fr)
CS (1) CS211364B2 (fr)
DK (1) DK258280A (fr)
ES (1) ES485154A1 (fr)
FI (1) FI793235A (fr)
FR (1) FR2439201A1 (fr)
GB (1) GB2049680A (fr)
IL (1) IL58489A0 (fr)
IT (1) IT7969032A0 (fr)
NL (1) NL7920126A (fr)
NO (1) NO793297L (fr)
SE (1) SE8004454L (fr)
WO (1) WO1980000841A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
FR2636330B1 (fr) * 1988-09-13 1990-11-30 Sanofi Sa Procede de preparation de derives de morphinane
EP0496830B1 (fr) * 1989-10-16 1999-03-31 THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Synthese totale d'enantiomeres et de derives de northebaine, normorphine, neuroxymorphone par des intermediaires n-nor
CN1268338C (zh) 2001-07-06 2006-08-09 恩德制药公司 用作止痛剂的6－羟基羟吗啡酮的口服给药
US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE602007003197D1 (de) 2006-03-02 2009-12-24 Mallinckrodt Inc Verfahren zur herstellung von morphinan-6-on-produkten mit geringen konzentrationen von alpha-, beta-ungesättigten ketonverbindungen
JP5774853B2 (ja) 2008-01-25 2015-09-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 医薬投薬形
CA2723438C (fr) 2008-05-09 2016-10-11 Gruenenthal Gmbh Procede de preparation d'une formulation de poudre intermediaire et d'une forme galenique solide finale en utilisant une etape de congelation par pulverisation
MX2012000317A (es) 2009-07-22 2012-02-08 Gruenenthal Gmbh Forma de dosificacion de liberacion controlada extruida por fusion en caliente.
MX2012000369A (es) 2009-07-22 2012-02-01 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion para opioides sensibles a la oxidacion.
RU2604676C2 (ru) 2010-09-02 2016-12-10 Грюненталь Гмбх Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль
ES2487244T3 (es) 2010-09-02 2014-08-20 Grünenthal GmbH Forma de dosificación resistente a la manipulación que comprende un polímero aniónico
US20130028972A1 (en) 2011-07-29 2013-01-31 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
PT2736495T (pt) 2011-07-29 2017-11-30 Gruenenthal Gmbh Comprimido resistente à adulteração proporcionando libertação imediata de fármaco
BR112014019988A8 (pt) 2012-02-28 2017-07-11 Gruenenthal Gmbh Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico
JP6282261B2 (ja) 2012-04-18 2018-02-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 不正使用防止および過量放出防止医薬剤形
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
BR112015029616A2 (pt) 2013-05-29 2017-07-25 Gruenenthal Gmbh forma de dosagem resistente à adulteração com perfil de liberação bimodal
CA2907950A1 (fr) 2013-05-29 2014-12-04 Grunenthal Gmbh Forme pharmaceutique inviolable contenant une ou plusieurs particules
KR20160031526A (ko) 2013-07-12 2016-03-22 그뤼넨탈 게엠베하 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
CA2947786A1 (fr) 2014-05-12 2015-11-19 Grunenthal Gmbh Formulation pour capsule a liberation immediate resistant aux manipulations illicites comprenant du tapentadol
WO2015181059A1 (fr) 2014-05-26 2015-12-03 Grünenthal GmbH Microparticules protégées contre une libération massive dans l'éthanol
CN107889459A (zh) 2015-04-24 2018-04-06 格吕伦塔尔有限公司 具有立即释放和对溶剂萃取的抗性的抗篡改剂型
AU2016319203A1 (en) 2015-09-10 2018-02-22 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
ES2701855T3 (es) 2016-05-31 2019-02-26 Alcaliber Investig Desarrollo E Innovacion Slu Proceso para la obtención de 3,14-diacetiloximorfona a partir de oripavina

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2806033A (en) * 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3249616A (en) * 1966-05-03 Ix-dfflydroxy-g-oxo-n-phenethylmor- phinan (cis) and production thereof
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3249616A (en) * 1966-05-03 Ix-dfflydroxy-g-oxo-n-phenethylmor- phinan (cis) and production thereof
US2806033A (en) * 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/77 *

Also Published As

Publication number Publication date
AU5189779A (en) 1980-04-24
JPS55501025A (fr) 1980-11-27
ES485154A1 (es) 1980-06-16
WO1980000841A1 (fr) 1980-05-01
NO793297L (no) 1980-04-22
NL7920126A (nl) 1980-08-29
CS211364B2 (en) 1982-02-26
GB2049680A (en) 1980-12-31
BE879494A (fr) 1980-02-15
FI793235A (fi) 1980-04-20
CA1108132A (fr) 1981-09-01
SE8004454L (sv) 1980-06-16
DK258280A (da) 1980-06-17
IL58489A0 (en) 1980-01-31
IT7969032A0 (it) 1979-10-18

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Legal Events

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