FR2439201A1 - Procede de fabrication de l'oxymorphone - Google Patents
Procede de fabrication de l'oxymorphoneInfo
- Publication number
- FR2439201A1 FR2439201A1 FR7925895A FR7925895A FR2439201A1 FR 2439201 A1 FR2439201 A1 FR 2439201A1 FR 7925895 A FR7925895 A FR 7925895A FR 7925895 A FR7925895 A FR 7925895A FR 2439201 A1 FR2439201 A1 FR 2439201A1
- Authority
- FR
- France
- Prior art keywords
- oxymorphone
- boron
- agent
- manufacturing process
- boron compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Polarising Elements (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDE DE FABRICATION DE L'OXYMORPHONE CONSISTANT A FAIRE REAGIR L'OXYCODONE AVEC UNE QUANTITE DEMETHYLANTE D'UN COMPOSE DU BORE QUI EST LE TRIBROMURE DE BORE, LE TRICHLORURE DE BORE OU LE PRODUIT DE LA REACTION DE L'UN DE CES DEUX HALOGENURES AVEC UN ALCOOL INFERIEUR, DANS UN MILIEU REACTIONNEL CONTENANT UN SOLVANT ORGANIQUE, DANS DES CONDITIONS DE DEMETHYLATION. LE MILIEU REACTIONNEL CONTIENT UNE QUANTITE SUFFISANTE D'UN AGENT D'ATTENUATION POUR AFFAIBLIR L'ACTIVITE DU COMPOSE DU BORE, CET AGENT D'ATTENUATION ETANT UNE BASE DE LEWIS FAIBLE QUI NE PEUT REAGIR AVEC LEDIT AGENT DEMETHYLANT, CE QUI PERMET D'OBTENIR L'OXYMORPHONE AVEC UN BON RENDEMENT ET PRATIQUEMENT SANS SOUS-PRODUITS. L'OXYMORPHONE EST UNE SUBSTANCE NARCOTIQUE TRES UTILISEE COMME ANALGESIQUE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95305678A | 1978-10-19 | 1978-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2439201A1 true FR2439201A1 (fr) | 1980-05-16 |
Family
ID=25493512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7925895A Withdrawn FR2439201A1 (fr) | 1978-10-19 | 1979-10-18 | Procede de fabrication de l'oxymorphone |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS55501025A (fr) |
AU (1) | AU5189779A (fr) |
BE (1) | BE879494A (fr) |
CA (1) | CA1108132A (fr) |
CS (1) | CS211364B2 (fr) |
DK (1) | DK258280A (fr) |
ES (1) | ES485154A1 (fr) |
FI (1) | FI793235A (fr) |
FR (1) | FR2439201A1 (fr) |
GB (1) | GB2049680A (fr) |
IL (1) | IL58489A0 (fr) |
IT (1) | IT7969032A0 (fr) |
NL (1) | NL7920126A (fr) |
NO (1) | NO793297L (fr) |
SE (1) | SE8004454L (fr) |
WO (1) | WO1980000841A1 (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4795813A (en) * | 1981-08-17 | 1989-01-03 | The Florida Board Of Regents On Behalf Of The Florida State University | Synthesis of derivatives of codeine and other 3-O-alkylmorphines |
US5668285A (en) * | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
FR2636330B1 (fr) * | 1988-09-13 | 1990-11-30 | Sanofi Sa | Procede de preparation de derives de morphinane |
ES2129395T3 (es) * | 1989-10-16 | 1999-06-16 | Us Health | Sintesis total de enantiomeros de nortebaina, normorfina, noroximorfona y sus derivados a traves de productos intermedios n-nor. |
US8329216B2 (en) | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
EP1414458B1 (fr) | 2001-07-06 | 2007-04-11 | Endo Pharmaceuticals Inc. | Administration orale de 6-hydroxy-oxymorphone utilise en tant qu'analgesique |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
JP5695296B2 (ja) | 2006-03-02 | 2015-04-01 | マリンクロッド エルエルシー | 低レベルのアルファ,ベータ−不飽和ケトン化合物を伴うモルフィナン−6−オン生成物の製造方法 |
JP5774853B2 (ja) | 2008-01-25 | 2015-09-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 医薬投薬形 |
TWI524904B (zh) | 2008-05-09 | 2016-03-11 | 歌林達股份有限公司 | 製備醫藥用固體劑型,尤指錠劑之方法,及製備固體劑型,尤指錠劑之前驅物之方法 |
JP2012533586A (ja) | 2009-07-22 | 2012-12-27 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 酸化安定化された不正使用防止剤形 |
CA2765971C (fr) | 2009-07-22 | 2017-08-22 | Gruenenthal Gmbh | Forme galenique extrudee a chaud a liberation controlee |
NZ608865A (en) | 2010-09-02 | 2015-03-27 | Gruenenthal Chemie | Tamper resistant dosage form comprising an anionic polymer |
AU2011297901B2 (en) | 2010-09-02 | 2014-07-31 | Grunenthal Gmbh | Tamper resistant dosage form comprising inorganic salt |
PT2736497T (pt) | 2011-07-29 | 2017-11-30 | Gruenenthal Gmbh | Comprimido resistente a adulteração proporcionando libertação imediata de fármaco |
CN103841964A (zh) | 2011-07-29 | 2014-06-04 | 格吕伦塔尔有限公司 | 提供药物立即释放的抗破碎片剂 |
JP6117249B2 (ja) | 2012-02-28 | 2017-04-19 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形 |
WO2013156453A1 (fr) | 2012-04-18 | 2013-10-24 | Grünenthal GmbH | Forme pharmaceutique inviolable et résistante à la libération massive |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
MX371432B (es) | 2013-05-29 | 2020-01-30 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido que contiene una o mas particulas. |
CA2913209A1 (fr) | 2013-05-29 | 2014-12-04 | Grunenthal Gmbh | Forme dosifiee inviolable a profil de liberation bimodale |
MX368846B (es) | 2013-07-12 | 2019-10-18 | Gruenenthal Gmbh | Forma de dosificación resistente a la alteración que contiene polímero de acetato de etilen-vinilo. |
EP3073994A1 (fr) | 2013-11-26 | 2016-10-05 | Grünenthal GmbH | Préparation de composition pharmaceutique en poudre par cryo-broyage |
EP3142646A1 (fr) | 2014-05-12 | 2017-03-22 | Grünenthal GmbH | Formulation pour capsule à libération immédiate résistant aux manipulations illicites comprenant du tapentadol |
EA201692388A1 (ru) | 2014-05-26 | 2017-05-31 | Грюненталь Гмбх | Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы |
EA035434B1 (ru) | 2015-04-24 | 2020-06-15 | Грюненталь Гмбх | Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями |
EP3346991A1 (fr) | 2015-09-10 | 2018-07-18 | Grünenthal GmbH | Protection contre un surdosage par voie orale à l'aide de formulations à libération immédiate dissuasives d'abus |
ES2701855T3 (es) | 2016-05-31 | 2019-02-26 | Alcaliber Investig Desarrollo E Innovacion Slu | Proceso para la obtención de 3,14-diacetiloximorfona a partir de oripavina |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2806033A (en) * | 1955-08-03 | 1957-09-10 | Lewenstein | Morphine derivative |
US3249616A (en) * | 1966-05-03 | Ix-dfflydroxy-g-oxo-n-phenethylmor- phinan (cis) and production thereof | ||
US3775414A (en) * | 1972-05-10 | 1973-11-27 | Bristol Myers Co | Process for the preparation of 14-hydroxymorphinan derivatives |
-
1979
- 1979-10-12 NO NO793297A patent/NO793297L/no unknown
- 1979-10-18 FR FR7925895A patent/FR2439201A1/fr not_active Withdrawn
- 1979-10-18 JP JP50190279A patent/JPS55501025A/ja active Pending
- 1979-10-18 IL IL58489A patent/IL58489A0/xx unknown
- 1979-10-18 AU AU51897/79A patent/AU5189779A/en not_active Abandoned
- 1979-10-18 IT IT7969032A patent/IT7969032A0/it unknown
- 1979-10-18 WO PCT/US1979/000862 patent/WO1980000841A1/fr unknown
- 1979-10-18 BE BE0/197710A patent/BE879494A/fr unknown
- 1979-10-18 ES ES485154A patent/ES485154A1/es not_active Expired
- 1979-10-18 CA CA337,908A patent/CA1108132A/fr not_active Expired
- 1979-10-18 GB GB8014422A patent/GB2049680A/en not_active Withdrawn
- 1979-10-18 NL NL7920126A patent/NL7920126A/nl unknown
- 1979-10-18 FI FI793235A patent/FI793235A/fi not_active Application Discontinuation
- 1979-10-19 CS CS797115A patent/CS211364B2/cs unknown
-
1980
- 1980-06-16 SE SE8004454A patent/SE8004454L/xx not_active Application Discontinuation
- 1980-06-17 DK DK258280A patent/DK258280A/da unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3249616A (en) * | 1966-05-03 | Ix-dfflydroxy-g-oxo-n-phenethylmor- phinan (cis) and production thereof | ||
US2806033A (en) * | 1955-08-03 | 1957-09-10 | Lewenstein | Morphine derivative |
US3775414A (en) * | 1972-05-10 | 1973-11-27 | Bristol Myers Co | Process for the preparation of 14-hydroxymorphinan derivatives |
Non-Patent Citations (1)
Title |
---|
EXBK/77 * |
Also Published As
Publication number | Publication date |
---|---|
AU5189779A (en) | 1980-04-24 |
FI793235A (fi) | 1980-04-20 |
WO1980000841A1 (fr) | 1980-05-01 |
GB2049680A (en) | 1980-12-31 |
IT7969032A0 (it) | 1979-10-18 |
CA1108132A (fr) | 1981-09-01 |
JPS55501025A (fr) | 1980-11-27 |
NO793297L (no) | 1980-04-22 |
CS211364B2 (en) | 1982-02-26 |
BE879494A (fr) | 1980-02-15 |
DK258280A (da) | 1980-06-17 |
SE8004454L (sv) | 1980-06-16 |
ES485154A1 (es) | 1980-06-16 |
NL7920126A (nl) | 1980-08-29 |
IL58489A0 (en) | 1980-01-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |