GB2049680A - Process for producing oxymorphone - Google Patents

Process for producing oxymorphone

Info

Publication number
GB2049680A
GB2049680A GB8014422A GB8014422A GB2049680A GB 2049680 A GB2049680 A GB 2049680A GB 8014422 A GB8014422 A GB 8014422A GB 8014422 A GB8014422 A GB 8014422A GB 2049680 A GB2049680 A GB 2049680A
Authority
GB
United Kingdom
Prior art keywords
oxymorphone
producing
producing oxymorphone
utilizing
lewis base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB8014422A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of GB2049680A publication Critical patent/GB2049680A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Abstract

A process for producing oxymorphone by converting oxycodone utilizing a suitable boron reagent in the presence of a weak Lewis base attenuating agent.
GB8014422A 1978-10-19 1979-10-18 Process for producing oxymorphone Withdrawn GB2049680A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95305678A 1978-10-19 1978-10-19

Publications (1)

Publication Number Publication Date
GB2049680A true GB2049680A (en) 1980-12-31

Family

ID=25493512

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8014422A Withdrawn GB2049680A (en) 1978-10-19 1979-10-18 Process for producing oxymorphone

Country Status (16)

Country Link
JP (1) JPS55501025A (en)
AU (1) AU5189779A (en)
BE (1) BE879494A (en)
CA (1) CA1108132A (en)
CS (1) CS211364B2 (en)
DK (1) DK258280A (en)
ES (1) ES485154A1 (en)
FI (1) FI793235A (en)
FR (1) FR2439201A1 (en)
GB (1) GB2049680A (en)
IL (1) IL58489A0 (en)
IT (1) IT7969032A0 (en)
NL (1) NL7920126A (en)
NO (1) NO793297L (en)
SE (1) SE8004454L (en)
WO (1) WO1980000841A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
FR2636330B1 (en) * 1988-09-13 1990-11-30 Sanofi Sa PROCESS FOR THE PREPARATION OF MORPHINANE DERIVATIVES
ATE178329T1 (en) * 1989-10-16 1999-04-15 Us Health TOTAL SYNTHESIS OF NORTHEBAIN, NORMORPHINE, NOROXYMORPHONE ENANTIOMERS AND DERIVATIVES VIA N-NOR INTERMEDIATE COMPOUNDS
US9820982B2 (en) 2001-07-06 2017-11-21 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE102005005446A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Break-resistant dosage forms with sustained release
DE10336400A1 (en) 2003-08-06 2005-03-24 Grünenthal GmbH Anti-abuse dosage form
DE10361596A1 (en) 2003-12-24 2005-09-29 Grünenthal GmbH Process for producing an anti-abuse dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102004032049A1 (en) 2004-07-01 2006-01-19 Grünenthal GmbH Anti-abuse, oral dosage form
DE102005005449A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Process for producing an anti-abuse dosage form
DE602007003197D1 (en) 2006-03-02 2009-12-24 Mallinckrodt Inc PROCESS FOR PREPARING MORPHINAN 6-ON PRODUCTS WITH LOW CONCENTRATIONS OF ALPHA, BETA-UNSATURATED KETONE COMPOUNDS
JP5774853B2 (en) 2008-01-25 2015-09-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Pharmaceutical dosage form
EP2273983B1 (en) 2008-05-09 2016-07-20 Grünenthal GmbH Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
ES2560210T3 (en) 2009-07-22 2016-02-17 Grünenthal GmbH Tamper-resistant dosage form for oxidation-sensitive opiates
JP5667183B2 (en) 2009-07-22 2015-02-12 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Controlled release dosage form with heat melt extrusion
RU2604676C2 (en) 2010-09-02 2016-12-10 Грюненталь Гмбх Destruction-resistant dosage form containing an inorganic salt
KR20130137627A (en) 2010-09-02 2013-12-17 그뤼넨탈 게엠베하 Tamper resistant dosage form comprising an anionic polymer
WO2013017234A1 (en) 2011-07-29 2013-02-07 Grünenthal GmbH Tamper-resistant tablet providing immediate drug release
AR087359A1 (en) 2011-07-29 2014-03-19 Gruenenthal Gmbh TEST ALTERATION TABLET PROVIDING IMMEDIATE RELEASE OF THE PHARMACO
MX356421B (en) 2012-02-28 2018-05-29 Gruenenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer.
ES2692944T3 (en) 2012-04-18 2018-12-05 Grünenthal GmbH Pharmaceutical dosage form resistant to handling and resistant to rapid discharge of the dose
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
EP3003283A1 (en) 2013-05-29 2016-04-13 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
AU2014273227B2 (en) 2013-05-29 2019-08-15 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
EA032465B1 (en) 2013-07-12 2019-05-31 Грюненталь Гмбх Tamper-resistant oral pharmaceutical dosage form containing ethylene-vinyl acetate polymer and process for the production thereof
WO2015078891A1 (en) 2013-11-26 2015-06-04 Farmaceutici Formenti S.P.A. Preparation of a powdery pharmaceutical composition by means of cryo-milling
CN106572980A (en) 2014-05-12 2017-04-19 格吕伦塔尔有限公司 Tamper resistant immediate release capsule formulation comprising tapentadol
EP3148512A1 (en) 2014-05-26 2017-04-05 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
KR20170139158A (en) 2015-04-24 2017-12-18 그뤼넨탈 게엠베하 Immediate release and solvent extraction inhibition modulated dosage form
CA2998259A1 (en) 2015-09-10 2017-03-16 Grunenthal Gmbh Protecting oral overdose with abuse deterrent immediate release formulations
EP3252055B1 (en) 2016-05-31 2018-09-19 Alcaliber Investigacion Desarrollo e Innovacion SLU Process for obtaining 3,14-diacetyloxymorphone from oripavine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3249616A (en) * 1966-05-03 Ix-dfflydroxy-g-oxo-n-phenethylmor- phinan (cis) and production thereof
US2806033A (en) * 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Also Published As

Publication number Publication date
CS211364B2 (en) 1982-02-26
ES485154A1 (en) 1980-06-16
FI793235A (en) 1980-04-20
JPS55501025A (en) 1980-11-27
FR2439201A1 (en) 1980-05-16
DK258280A (en) 1980-06-17
AU5189779A (en) 1980-04-24
NO793297L (en) 1980-04-22
IT7969032A0 (en) 1979-10-18
NL7920126A (en) 1980-08-29
SE8004454L (en) 1980-06-16
WO1980000841A1 (en) 1980-05-01
CA1108132A (en) 1981-09-01
BE879494A (en) 1980-02-15
IL58489A0 (en) 1980-01-31

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)