FR2381047A1 - Procede de production de l'acide 5-methyltetrahydrofolique- d,1 et de ses sels - Google Patents

Procede de production de l'acide 5-methyltetrahydrofolique- d,1 et de ses sels

Info

Publication number
FR2381047A1
FR2381047A1 FR7804847A FR7804847A FR2381047A1 FR 2381047 A1 FR2381047 A1 FR 2381047A1 FR 7804847 A FR7804847 A FR 7804847A FR 7804847 A FR7804847 A FR 7804847A FR 2381047 A1 FR2381047 A1 FR 2381047A1
Authority
FR
France
Prior art keywords
salts
production
methyltetrahydrofolic acid
acid
methyltetrahydrofolic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7804847A
Other languages
English (en)
French (fr)
Other versions
FR2381047B1 (fi
Inventor
Federico Gennari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIORESEARCH Sas
Original Assignee
BIORESEARCH Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIORESEARCH Sas filed Critical BIORESEARCH Sas
Publication of FR2381047A1 publication Critical patent/FR2381047A1/fr
Application granted granted Critical
Publication of FR2381047B1 publication Critical patent/FR2381047B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
FR7804847A 1977-02-22 1978-02-21 Procede de production de l'acide 5-methyltetrahydrofolique- d,1 et de ses sels Granted FR2381047A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7290/77A GB1572137A (en) 1977-02-22 1977-02-22 Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts

Publications (2)

Publication Number Publication Date
FR2381047A1 true FR2381047A1 (fr) 1978-09-15
FR2381047B1 FR2381047B1 (fi) 1981-07-24

Family

ID=9830275

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7804847A Granted FR2381047A1 (fr) 1977-02-22 1978-02-21 Procede de production de l'acide 5-methyltetrahydrofolique- d,1 et de ses sels
FR7820936A Granted FR2385397A1 (fr) 1977-02-22 1978-07-13 Compositions stables d'un sel alcalin ou alcalino-terreux d'acide 5-methyltetrahydrofolique a usage therapeutique

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7820936A Granted FR2385397A1 (fr) 1977-02-22 1978-07-13 Compositions stables d'un sel alcalin ou alcalino-terreux d'acide 5-methyltetrahydrofolique a usage therapeutique

Country Status (32)

Country Link
JP (1) JPS5831353B2 (fi)
AR (1) AR215162A1 (fi)
AT (1) AT380020B (fi)
AU (1) AU520715B2 (fi)
BE (1) BE863808A (fi)
CA (1) CA1093554A (fi)
CH (1) CH635344A5 (fi)
CZ (1) CZ279815B6 (fi)
DD (1) DD134099A5 (fi)
DE (1) DE2807393A1 (fi)
DK (1) DK144944C (fi)
EG (1) EG13399A (fi)
ES (1) ES467153A1 (fi)
FI (1) FI67082C (fi)
FR (2) FR2381047A1 (fi)
GB (1) GB1572137A (fi)
GR (1) GR71704B (fi)
HU (1) HU179422B (fi)
IE (1) IE46402B1 (fi)
IL (1) IL54052A (fi)
IN (1) IN149574B (fi)
LU (1) LU79067A1 (fi)
MX (1) MX5288E (fi)
NL (1) NL190285C (fi)
NO (1) NO147793C (fi)
NZ (1) NZ186465A (fi)
PL (1) PL118654B1 (fi)
PT (1) PT67656B (fi)
SE (1) SE437028B (fi)
SU (1) SU747427A3 (fi)
YU (1) YU40505B (fi)
ZA (1) ZA78837B (fi)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0401895A1 (en) * 1989-06-06 1990-12-12 Pharmachemie B.V. Aqueous folinate solution stable at refrigerator temperature, as well as process for its preparation

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5838285A (ja) * 1981-08-25 1983-03-05 Kanegafuchi Chem Ind Co Ltd ５−メチル−（６ｒｓ）−５，６，７，８−テトラヒドロ−ｌ−葉酸のマグネシウム塩またはその遊離酸の製法
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
IT1229517B (it) * 1989-01-31 1991-09-03 Bioresearch Spa Impiego di acido 5-metiltetraidrofolico, di acido 5 formiltetraidrofolico, e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato adatte ad essere impiegate nella terapia dei disordini depressivi e composizioni farmaceutiche relative.
IT1229203B (it) * 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
CH680731A5 (fi) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
CH683261A5 (it) * 1991-10-10 1994-02-15 Applied Pharma Res Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
CH682665A5 (de) * 1991-10-29 1993-10-29 Sapec Fine Chemicals Verfahren zur Reinigung von rohen Erdalkalimetallsalzen von N(5)-Methyl-5,6,7,8-tetrahydrofolsäure.
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN103214487A (zh) * 2013-04-12 2013-07-24 张家港威胜生物医药有限公司 一种重要医药化工原料(6s)-5-甲基四氢叶酸盐的合成
WO2015193778A1 (en) 2014-06-16 2015-12-23 Mylan Laboratories Ltd. Crystalline form of levomefolate calcium
US20210324176A1 (en) 2018-08-28 2021-10-21 Pmc Organometallix, Inc. Low free 2-mercaptoethanol ester and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL80276C (fi) *
GB1293541A (en) * 1969-03-18 1972-10-18 John Alexander Blair Folic acid derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856959A (en) * 1972-07-24 1974-12-24 Department Of Health Education Inhibition of leukemia utilizing 5-methyltetrahydrohomofolate
US4148999A (en) * 1977-08-22 1979-04-10 The Government Of The United States Of America Preparation and purification of citrovorum factor
CH649550A5 (en) * 1984-02-09 1985-05-31 Eprova Ag Process for the preparation of alkaline earth metal salts of 5-methyltetrahydrofolic acid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL80276C (fi) *
GB1293541A (en) * 1969-03-18 1972-10-18 John Alexander Blair Folic acid derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NV1294/73 *
NV2247/70 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0401895A1 (en) * 1989-06-06 1990-12-12 Pharmachemie B.V. Aqueous folinate solution stable at refrigerator temperature, as well as process for its preparation
US5177076A (en) * 1989-06-06 1993-01-05 Pharmachemie Bv Aqueous folinate solution stable at refrigerator temperature, as well as process for its preparation

Also Published As

Publication number Publication date
IE46402B1 (en) 1983-06-01
HU179422B (en) 1982-10-28
BE863808A (fr) 1978-05-29
NO147793B (no) 1983-03-07
NO780594L (no) 1978-08-23
FR2385397A1 (fr) 1978-10-27
GR71704B (fi) 1983-06-21
NZ186465A (en) 1980-10-08
NL190285B (nl) 1993-08-02
PL118654B1 (en) 1981-10-31
DD134099A5 (de) 1979-02-07
SU747427A3 (ru) 1980-07-23
FI780565A (fi) 1978-08-23
NL190285C (nl) 1994-01-03
YU40505B (en) 1986-02-28
IL54052A (en) 1981-07-31
FR2385397B1 (fi) 1981-07-17
DE2807393C2 (fi) 1990-06-13
CZ112978A3 (en) 1995-02-15
FI67082B (fi) 1984-09-28
CA1093554A (en) 1981-01-13
SE437028B (sv) 1985-02-04
SE7801973L (sv) 1978-08-23
CZ279815B6 (cs) 1995-07-12
IN149574B (fi) 1982-01-30
ZA78837B (en) 1979-09-26
JPS53124297A (en) 1978-10-30
DK76578A (da) 1978-08-23
AU520715B2 (en) 1982-02-25
ATA90378A (de) 1985-08-15
DK144944B (da) 1982-07-12
CH635344A5 (en) 1983-03-31
IE780285L (en) 1978-08-22
AR215162A1 (es) 1979-09-14
DK144944C (da) 1982-11-29
MX5288E (es) 1983-06-06
EG13399A (en) 1981-12-31
LU79067A1 (fr) 1978-06-27
ES467153A1 (es) 1978-11-16
YU37978A (en) 1983-01-21
FI67082C (fi) 1985-01-10
FR2381047B1 (fi) 1981-07-24
AT380020B (de) 1986-03-25
JPS5831353B2 (ja) 1983-07-05
PT67656B (en) 1979-07-19
IL54052A0 (en) 1978-04-30
DE2807393A1 (de) 1978-09-07
NL7801775A (nl) 1978-08-24
AU3343078A (en) 1979-08-30
PT67656A (en) 1978-03-01
NO147793C (no) 1983-06-15
GB1572137A (en) 1980-07-23
PL204747A1 (pl) 1979-03-12

Similar Documents

Publication Publication Date Title
FR2381047A1 (fr) Procede de production de l'acide 5-methyltetrahydrofolique- d,1 et de ses sels
NO802769L (no) Fremgangsmaate for fremstilling av fruktose fra glykose
SE7712960L (sv) Forfarande for framstellning av etylenglykol
ES411801A1 (es) Procedimiento para estabilizar peroxido de hidrogeno.
GB1073136A (en) Production of purine derivatives
AU7674881A (en) Hydroxycyanomethylphosphonic acid
ES285616A1 (es) Un procedimiento para la fabricación de derivados uridínicos
JPS528997A (en) Novel cation exchange membrane and process for producing thereof
GB1497157A (en) Process of preparing 7-mono-o-(beta-hydroxyethyl)-rutosid
GB1514807A (en) Process for preparing sulphur dioxide
ES457450A1 (es) Procedimiento para fabricar una solucion acuosa, estable y neutra, conteniendo teofilina pura.
GB782715A (en) Process for the preparation of lead azide
GB1271126A (en) A process for the production of carbonates of barium and strontium from their sulphates
ES382561A1 (es) Procedimiento para la produccion de benzotiazil - sulfena- midas sustancialmente puras.
GB887012A (en) Process for the preparation of 18ª--glycyrrhetinic acid
GB1461785A (en) Alkali metal dithionite manufacture
GB1266093A (fi)
GB1291678A (en) L-dopa and derivatives
JPS51128496A (en) Process for preparing chondroitin sulfuric acid
GB787172A (en) Process for the production of sodium sulphide
ES427812A1 (es) Procedimiento de cristalizacion de la nitroguanidina en forma microcristalina.
JPS53119292A (en) Production of gas purification catalyst
ES457818A3 (es) Un procedimiento de produccion de urokinasa.
ES398251A1 (es) Procedimiento para preparar bromuro de hidrogeno.
GB1057666A (en) Riboflavin and related compounds