FR2362633A1 - Procede de fabrication d'une preparation favorisant la coagulation du sang a partir de plasma sanguin humain - Google Patents

Procede de fabrication d'une preparation favorisant la coagulation du sang a partir de plasma sanguin humain

Info

Publication number
FR2362633A1
FR2362633A1 FR7725597A FR7725597A FR2362633A1 FR 2362633 A1 FR2362633 A1 FR 2362633A1 FR 7725597 A FR7725597 A FR 7725597A FR 7725597 A FR7725597 A FR 7725597A FR 2362633 A1 FR2362633 A1 FR 2362633A1
Authority
FR
France
Prior art keywords
treated
manufacturing
human
blood plasma
coagulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7725597A
Other languages
English (en)
Other versions
FR2362633B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oesterreichisches Institut fuer Haemoderivate
Original Assignee
Immuno AG
Immuno AG fuer Chemisch Medizinische Produkte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immuno AG, Immuno AG fuer Chemisch Medizinische Produkte filed Critical Immuno AG
Publication of FR2362633A1 publication Critical patent/FR2362633A1/fr
Application granted granted Critical
Publication of FR2362633B1 publication Critical patent/FR2362633B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente invention concerne un procédé de préparation favorisant la coagulation du sang à partir de plasma sanguin humain. Ce procédé se caractérise en ce que du plasma humain contenant des ions de citrate est traité en présence d'ions libres de calcium avec des substances tensio-actives au point de vue physiologie de coagulation, non solubles dans l'eau, anorganiques telles que du caolin. La nouvelle substance est formée puis on sépare les substances non solubles et le résidu est traité de maniere connue avec des échangeurs d'ions basiques. La substance FEIBA est adsorbée alors avec les facteurs II, VIII, IX, X que l'on traite ensuite par éluation et concentration. L'invention s'applique au traitement de l'hémophilie.
FR7725597A 1976-08-30 1977-08-22 Procede de fabrication d'une preparation favorisant la coagulation du sang a partir de plasma sanguin humain Granted FR2362633A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT640576A AT350726B (de) 1976-08-30 1976-08-30 Verfahren zur herstellung einer blut- gerinnungsfoerdernden praeperation aus menschlichem blutplasma

Publications (2)

Publication Number Publication Date
FR2362633A1 true FR2362633A1 (fr) 1978-03-24
FR2362633B1 FR2362633B1 (fr) 1981-06-12

Family

ID=3585985

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7725597A Granted FR2362633A1 (fr) 1976-08-30 1977-08-22 Procede de fabrication d'une preparation favorisant la coagulation du sang a partir de plasma sanguin humain

Country Status (17)

Country Link
US (1) US4160025A (fr)
AR (1) AR213861A1 (fr)
AT (1) AT350726B (fr)
BE (1) BE858031A (fr)
CA (1) CA1079191A (fr)
CH (1) CH635747A5 (fr)
DE (1) DE2734821C3 (fr)
DK (1) DK151932C (fr)
ES (1) ES461918A1 (fr)
FI (1) FI57421C (fr)
FR (1) FR2362633A1 (fr)
GB (1) GB1554051A (fr)
HU (1) HU180816B (fr)
LU (1) LU78024A1 (fr)
NL (1) NL170922C (fr)
NO (1) NO148142C (fr)
SE (1) SE443511B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014333A1 (fr) * 1979-01-20 1980-08-20 Biotest-Serum-Institut GmbH Procédé de préparation de fibrinogène, complexe de prothrombine contenant les facteurs de coagulation II, VII, IX et X, antithrombine III et solution contenant des sérumprotéines stables au stockage
FR2487199A1 (fr) * 1980-07-22 1982-01-29 Immuno Ag Preparation thromboplastique a base de proteines humaines et son procede d'obtention
EP0255651A2 (fr) * 1986-07-24 1988-02-10 BEHRINGWERKE Aktiengesellschaft Agent pour le traitement de l'hémophilie-A résistante au facteur VIII et son procédé de préparation
EP0765669A1 (fr) * 1995-08-28 1997-04-02 Immuno Ag Composition pharmaceutique pour le traitement des maladies de la coagulation sanguine, procédé de préparation et son application

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287180A (en) * 1980-01-28 1981-09-01 Baxter Travenol Laboratories, Inc. Method for treating blood clotting factor inhibitors
US4286056A (en) * 1980-01-28 1981-08-25 Baxter Travenol Laboratories, Inc. Method for making therapeutic enzyme compositions
WO1981002105A1 (fr) * 1980-01-28 1981-08-06 Baxter Travenol Lab Compositions therapeutiques et procede de fabrication et d'utilisation de celles-ci
EP0035204B2 (fr) * 1980-03-05 1991-05-22 Miles Inc. Compositions pasteurisées de protéines thérapeutiquement actives
DE3172210D1 (en) * 1980-05-27 1985-10-17 Miles Lab Blood coagulation promoting product and process of preparing same
US4364861A (en) * 1980-05-27 1982-12-21 Cutter Laboratories, Inc. Blood-coagulation-promoting products and methods of preparing them
US4361510A (en) * 1980-05-27 1982-11-30 Cutter Laboratories, Inc. Blood coagulation promoting product
US4391746A (en) * 1980-05-27 1983-07-05 Cutter Laboratories, Inc. Blood-coagulation-promoting products and methods of preparing them
US4404132A (en) * 1980-05-27 1983-09-13 Cutter Laboratories, Inc. Blood coagulation promoting product
DE3101752A1 (de) * 1981-01-21 1982-08-26 Behringwerke Ag, 3550 Marburg "verfahren zur reinigung der blutgerinnungsfaktoren ii, vii, ix und/oder x und danach hergestellte praeparationen"
US4479938A (en) * 1981-06-25 1984-10-30 Baxter Travenol Laboratories, Inc. Therapeutic composition containing factor VIIa
US4382083A (en) * 1981-06-25 1983-05-03 Baxter Travenol Laboratories, Inc. Therapeutic method for treating blood-clotting defects with factor VIIa
JPS5866054A (ja) * 1981-10-14 1983-04-20 Sekisui Chem Co Ltd 血液検査用容器
JPS58105064A (ja) * 1981-12-17 1983-06-22 Sekisui Chem Co Ltd 血液凝固促進剤
AT389815B (de) * 1984-03-09 1990-02-12 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten
CA1330302C (fr) * 1988-01-18 1994-06-21 Miroslav Rybak Concentres des facteurs de coagulation ii, vii, ix et x, methode de preparation et mode d'utilisation
AT402891B (de) * 1991-06-20 1997-09-25 Immuno Ag Verfahren zur herstellung eines inaktivierten blutproduktes
AT398079B (de) * 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
AT399818B (de) * 1992-04-24 1995-07-25 Immuno Ag Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation
AU6653094A (en) * 1992-12-16 1994-07-04 Immuno Aktiengesellschaft Process for preparing a virus-safe biological composition
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
US5677162A (en) * 1995-05-01 1997-10-14 New York Blood Center, Inc. Method for activating prothrombin to thrombin
ATE296109T1 (de) * 1996-03-20 2005-06-15 Baxter Ag Pharmazeutisches präparat zur behandlung von blutgerinnungsstörungen
AT405485B (de) 1997-05-28 1999-08-25 Immuno Ag Eine das vwf-propeptid enthaltende pharmazeutische präparation
AT407484B (de) * 1997-11-12 2001-03-26 Bio Prod & Bio Eng Ag Arzneimittel zur förderung der wundheilung
DE50311422D1 (de) * 2002-07-23 2009-05-28 Bio & Bio Licensing Sa Thrombingenerierfähige und thrombinhaltige pharmazeutische wirkstoffzubereitungen und arzneimittel
RS20050051A (en) * 2002-07-23 2007-06-04 Bio-Products & Bio Engineering Ag., Pharmaceutical active ingredient preparation and medicaments that contain thrombin or have a thrombin-generating capacity
EP2305289A1 (fr) 2009-09-16 2011-04-06 Bio-Products & Bio-Engineering Aktiengesellschaft Produits médicinaux pour le traitement de troubles de la coagulation sanguine
IS2809B (is) * 2011-03-08 2012-10-15 Haskoli Islands Blóðstorkumæling
RU2648517C1 (ru) * 2017-06-23 2018-03-26 Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения Российской Федерации (ФГБУ ГНЦ Минздрава России) Способ получения лиофилизированного препарата активированного протромбинового комплекса, обладающего фактор viii-шунтирующей активностью
WO2024012853A1 (fr) 2022-07-12 2024-01-18 Biomedizinische Forschung & Bio-Produkte AG Médicament favorisant l'hémostase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2262520C3 (de) * 1972-12-20 1987-02-12 Miles Laboratories, Inc., Elkhart, Ind. Verfahren zur Herstellung eines lyophilisierten, lagerfähigen Konzentrats aus menschlichem Plasma
DE2459291C3 (de) * 1974-12-14 1981-06-04 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines antihämophiles Globulin A enthaltenden Konzentrats neben einem Prothrombin- Komplex und einer Lösung von lagerstabilen Serumproteinen
US3998946A (en) * 1975-04-23 1976-12-21 The Regents Of The University Of Minnesota Fibrinogen-free plasminogen-plasmin-free plasma and method of preparing and using same
DD121793A1 (fr) * 1975-07-17 1976-08-20
US4027013A (en) * 1976-01-22 1977-05-31 William L. Wilson Clottable fibrinogen free factor VIII and albumin product and process

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014333A1 (fr) * 1979-01-20 1980-08-20 Biotest-Serum-Institut GmbH Procédé de préparation de fibrinogène, complexe de prothrombine contenant les facteurs de coagulation II, VII, IX et X, antithrombine III et solution contenant des sérumprotéines stables au stockage
FR2487199A1 (fr) * 1980-07-22 1982-01-29 Immuno Ag Preparation thromboplastique a base de proteines humaines et son procede d'obtention
EP0255651A2 (fr) * 1986-07-24 1988-02-10 BEHRINGWERKE Aktiengesellschaft Agent pour le traitement de l'hémophilie-A résistante au facteur VIII et son procédé de préparation
EP0255651A3 (en) * 1986-07-24 1989-10-11 Behringwerke Aktiengesellschaft Agent for treating factor viii resistant haemophilia-a and process for preparing it
EP0765669A1 (fr) * 1995-08-28 1997-04-02 Immuno Ag Composition pharmaceutique pour le traitement des maladies de la coagulation sanguine, procédé de préparation et son application
US5891843A (en) * 1995-08-28 1999-04-06 Immuno Aktiengesllschaft Pharmaceutical composition for the treatment of blood coagulation diseases, methods for the production thereof and its use
US6013620A (en) * 1995-08-28 2000-01-11 Baxter Aktiengesellschaft Pharmaceutical composition for the treatment of blood coagulation diseases, methods for the production thereof and its use

Also Published As

Publication number Publication date
SE443511B (sv) 1986-03-03
DK151932B (da) 1988-01-18
NO148142B (no) 1983-05-09
ES461918A1 (es) 1978-12-16
DE2734821A1 (de) 1978-03-02
FI772408A (fi) 1978-03-01
FI57421B (fi) 1980-04-30
DE2734821B2 (de) 1980-11-06
NL170922C (nl) 1983-01-17
HU180816B (en) 1983-04-29
GB1554051A (en) 1979-10-17
ATA640576A (de) 1978-11-15
NO772978L (no) 1978-03-01
DK151932C (da) 1988-06-20
SE7707992L (sv) 1978-03-01
FI57421C (fi) 1980-08-11
CA1079191A (fr) 1980-06-10
NL170922B (nl) 1982-08-16
DK384577A (da) 1978-03-01
BE858031A (fr) 1977-12-16
DE2734821C3 (de) 1985-03-14
NO148142C (no) 1983-08-17
FR2362633B1 (fr) 1981-06-12
AR213861A1 (es) 1979-03-30
NL7708872A (nl) 1978-03-02
CH635747A5 (de) 1983-04-29
US4160025A (en) 1979-07-03
AT350726B (de) 1979-06-11
LU78024A1 (fr) 1978-01-11

Similar Documents

Publication Publication Date Title
FR2362633A1 (fr) Procede de fabrication d'une preparation favorisant la coagulation du sang a partir de plasma sanguin humain
EP0037078B1 (fr) Procédé de traitement par la chaleur d'une solution aqueuse contenant le facteur treize de coagulation du sang humain
US4424206A (en) Process for heat treatment of aqueous solution containing cold insoluble globulin to inactivate hepatitis virus
JPS6133384B2 (fr)
EP0882455A1 (fr) Produit sanguin dans lequel les virus ont été inactivés
JP2005515191A5 (fr)
DE3043857A1 (de) Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ii und vii
EP0041173B2 (fr) Produits activant la coagulation du sang et procédé pour leur préparation
DE69737500T2 (de) Gereinigte Multimerase
EP0117064B1 (fr) Procédé pour traiter par la chaleur le facteur VIII de coagulation du sang
CA1042001A (fr) Sels d'heparine
AT407705B (de) Virusinaktivierte faktor xa-präparation
DE2715832A1 (de) Verfahren zur gewinnung von gereinigtem antihaemophilem globulin a (faktor viii)
JPS5944286B2 (ja) 牛トロンビンの精製法
Barrowcliffe et al. The effect of fatty-acid autoxidation products on blood coagulation
AT397390B (de) Verfahren zur spaltung von proteinen
US4822872A (en) Method of purifying factor VIII
DE69727736T2 (de) Verfahren zur Aktivierung von Prothrombin zu Thrombin
OA09121A (fr) Nouveau sel de strontium, son procédé de préparation et les compositions pharmaceutiques le renfermant.
Nagda et al. Effect of onion and garlic on blood coagulation and fibrinolysis in vitro
US4391746A (en) Blood-coagulation-promoting products and methods of preparing them
US4229435A (en) Preparation of blood fraction
US3318771A (en) Process for the recovery of plasminogen from animal blood serum or animal blood plasma, preferably from pig's blood
Nossel The activation and consumption of factor IX
DE68907718T2 (de) Verfahren zur pasteurisierung von wässrigen lösungen von faktor viii.