FR2358161A1 - Solutions injectables a base aqueuse - Google Patents

Solutions injectables a base aqueuse

Info

Publication number
FR2358161A1
FR2358161A1 FR7720957A FR7720957A FR2358161A1 FR 2358161 A1 FR2358161 A1 FR 2358161A1 FR 7720957 A FR7720957 A FR 7720957A FR 7720957 A FR7720957 A FR 7720957A FR 2358161 A1 FR2358161 A1 FR 2358161A1
Authority
FR
France
Prior art keywords
soluble
water
poorly
injectable solutions
pharmaceutical substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7720957A
Other languages
English (en)
French (fr)
Other versions
FR2358161B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Hans Steffen
Dieter Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT511176A external-priority patent/AT352881B/de
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2358161A1 publication Critical patent/FR2358161A1/fr
Application granted granted Critical
Publication of FR2358161B1 publication Critical patent/FR2358161B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR7720957A 1976-07-12 1977-07-07 Solutions injectables a base aqueuse Granted FR2358161A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT511176A AT352881B (de) 1976-07-12 1976-07-12 Verfahren zur herstellung von injektions- loesungen
CH699477A CH628811A5 (en) 1976-07-12 1977-06-07 Injection solutions

Publications (2)

Publication Number Publication Date
FR2358161A1 true FR2358161A1 (fr) 1978-02-10
FR2358161B1 FR2358161B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-07-25

Family

ID=25601846

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7720957A Granted FR2358161A1 (fr) 1976-07-12 1977-07-07 Solutions injectables a base aqueuse
FR7836690A Granted FR2423219A1 (fr) 1976-07-12 1978-12-28 Solutions injectables a base aqueuse contenant au moins un derive de vitamine k

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7836690A Granted FR2423219A1 (fr) 1976-07-12 1978-12-28 Solutions injectables a base aqueuse contenant au moins un derive de vitamine k

Country Status (18)

Country Link
US (1) US4158707A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS6051448B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU517249B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1082596A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2730570A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK149483C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (2) FR2358161A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1587076A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK26584A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE46037B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL52458A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1202370B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (2) LU77708A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY8500263A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL189072C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ184564A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH16333A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE448516B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0133258A3 (en) * 1983-07-22 1985-08-21 F. Hoffmann-La Roche & Co. Aktiengesellschaft Injectable solutions for vitamin e
EP0388817A3 (de) * 1989-03-21 1991-07-03 F. Hoffmann-La Roche Ag Verwendung von Mischmicellen und Mischmicell-Lösungen von Immunmodulatoren

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DE2914788A1 (de) * 1979-04-11 1980-10-16 Nattermann A & Cie Parenteral applizierbare, stabile arzneimittelloesungen mit entzuendungshemmender wirkung
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
US4264583A (en) * 1979-07-25 1981-04-28 The Procter & Gamble Company Gallstone dissolution compositions and method
JPS57163313A (en) * 1981-03-31 1982-10-07 Nippon Shinyaku Co Ltd Vitamin e pharmaceutical and its preparation
JPH0768117B2 (ja) * 1983-05-06 1995-07-26 ベスター・インコーポレイテツド 薬剤放出調整用小胞製剤
JPH0818989B2 (ja) * 1984-01-12 1996-02-28 株式会社ミドリ十字 脂肪乳剤中のプロスタグランジンの安定化方法
CA1264162A (en) * 1984-03-15 1990-01-02 Manfred Breuninger Glycerol ether phosphatides
US5002936A (en) * 1985-04-12 1991-03-26 Seymour Lieberman Lipophilic complexes of pharmacologically active inorganic mineral acid esters of organic compounds
US4831018A (en) * 1985-05-17 1989-05-16 Smithkline Beckman Corporation Polyene antibiotic emulsion formulation
ES2000384A6 (es) * 1985-08-02 1991-03-16 Merz & Co Gmbh & Co Metodo para la produccion de una composicion antiviral y antitumoral
US5023271A (en) * 1985-08-13 1991-06-11 California Biotechnology Inc. Pharmaceutical microemulsions
SE8505047L (sv) * 1985-10-25 1987-04-26 Nutritional Int Res Inst Fettemulsion
CA1319886C (en) 1987-02-03 1993-07-06 Alberto Ferro Mixed micelle solutions
DE3903753A1 (de) * 1989-02-06 1990-08-23 Schering Ag Verfahren zur herstellung waessriger mischmicelloesungen
US5085864A (en) * 1989-10-30 1992-02-04 Abbott Laboratories Injectable formulation for lipophilic drugs
DE3938030A1 (de) * 1989-11-13 1991-05-16 Schering Ag Verfahren zur herstellung waessriger mischmicelloesungen
CA2033725C (en) * 1990-01-24 2001-05-29 Folker Pittrof Pharmaceutical and cosmetic compositions containing a salt of cholanic acid
CA2033714A1 (en) * 1990-01-25 1991-07-26 Alberto Ferro Pharmaceutical preparations
FR2663224B1 (fr) * 1990-06-14 1995-01-20 Applicationes Farmaceuticas Sa Forme galenique parenterale.
DE4122661C2 (de) * 1990-08-06 1996-07-11 Nattermann A & Cie Pharmazeutisches Produkt zur Behandlung von Pneumocystis-carinii-Pneumonie
ZA916314B (en) * 1990-08-17 1992-05-27 Hoffmann La Roche Use of mixed micelles
CA2100655C (en) * 1991-02-08 2004-02-03 Reid W. Von Borstel Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
DE4336434A1 (de) * 1993-10-26 1995-04-27 Hoechst Ag Pharmazeutische Zubereitung für die parenterale, enterale und dermale Verabreichung von praktisch unlöslichen Arzneistoffen und Verfahren zu ihrer Herstellung
EP0682943B1 (de) * 1994-05-20 2003-08-20 GESELLSCHAFT FÜR MEDIZINISCHE FORSCHUNG UND WEITERBILDUNG e.V. GMF Lormetazepamhaltige Öl-in-Wasser-Emulsion
GB9426104D0 (en) * 1994-12-23 1995-02-22 Merck Sharp & Dohme Use of surfactants and emulsions
JP2740153B2 (ja) * 1995-03-07 1998-04-15 エフ・ホフマン−ラ ロシユ アーゲー 混合ミセル
US5759445A (en) * 1995-05-24 1998-06-02 Matsushita Electric Industrial Co., Ltd. Lipid-dispersed solution and process for producing the same
GB2326337A (en) 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
US6767904B2 (en) 1998-03-06 2004-07-27 Bringham Young University Steroid derived antibiotics
US6350738B1 (en) 1998-03-06 2002-02-26 Brigham Young University Steroid derived antibiotics
PT1389089E (pt) * 2001-03-27 2009-11-30 Phares Pharm Res Nv Processo e composição para solubilizar um composto biologicamente activo com uma baixa solubilidade em água
WO2005095950A1 (en) * 2004-03-30 2005-10-13 Pfizer Products Inc. Method and device for evaluation of pharmaceutical compositions
PL1758590T3 (pl) * 2004-05-19 2012-03-30 Los Angeles Biomedical Res Inst Harbor Ucla Medical Ct Zastosowanie detergentu do niechirurgicznego usuwania tłuszczu
US20060127468A1 (en) * 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
US7754230B2 (en) * 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
WO2008065502A1 (en) * 2006-11-29 2008-06-05 Pfizer Products Inc. Pharmaceutical compositions based on a) nanoparticles comprising enteric polymers and b) casein
US20100119612A1 (en) * 2007-04-17 2010-05-13 Bend Research, Inc Nanoparticles comprising non-crystalline drug
WO2008135855A2 (en) * 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer
US20100080852A1 (en) * 2007-05-03 2010-04-01 Ronald Arthur Beyerinck Phamaceutical composition comprising nanoparticles and casein
WO2008135828A2 (en) * 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
US8974827B2 (en) * 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
EP2178518A2 (en) * 2007-07-13 2010-04-28 Bend Research, Inc Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
US9233078B2 (en) * 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
WO2009073215A1 (en) * 2007-12-06 2009-06-11 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
CN102058528B (zh) * 2009-11-13 2012-12-12 中国科学院上海药物研究所 一种黄豆苷元胶束及其制备方法
GB2480632A (en) 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
MX363465B (es) 2011-02-18 2019-03-25 Kythera Biopharmaceuticals Inc Tratamiento de la grasa submental.
US8653058B2 (en) 2011-04-05 2014-02-18 Kythera Biopharmaceuticals, Inc. Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
CA2875208C (en) * 2012-05-31 2018-07-10 Terumo Kabushiki Kaisha Ph-sensitive carrier and preparation method thereof, and ph sensitive drug and ph sensitive drug composition each containing the carrier, and culture method using the same
US9321749B1 (en) 2012-07-25 2016-04-26 Globavir Biosciences, Inc. Heterocyclic compounds and uses thereof
CA3178035A1 (en) 2012-12-24 2014-07-03 Neurogastrx, Inc. Methods for treating gi tract disorders
WO2015200369A1 (en) 2014-06-24 2015-12-30 Neurogastrx, Inc. Prodrugs of metopimazine
CN110876719B (zh) * 2018-09-06 2022-08-09 中国人民解放军军事科学院军事医学研究院 一种维生素k1注射剂及其制备方法
US10836757B1 (en) 2020-04-02 2020-11-17 Neurogastrx, Inc. Polymorphic forms of metopimazine

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE575616C (de) * 1928-12-14 1933-04-29 Hans Much Dr Verfahren zur Herstellung bestaendiger, klarer, waessriger Loesungen von Lipoiden, Fetten oder Harzen
DE932083C (de) * 1954-03-31 1955-08-22 Upha Chem Pharm Praeparate G M Verfahren zur Herstellung stabiler waessriger Injektionsloesungen von 2-Methyl-5, 8-dimethoxy-furanochromon
DE1904562A1 (de) * 1968-02-02 1970-03-05 Merck & Co Inc 5ss-Glycochloansaeure oder 5ss-Taurocholansaeure enthaltende Arzneimittel
DE2302659A1 (de) * 1972-01-21 1973-07-26 American Home Prod Parenterales benzodiazepinhaltiges arzneimittel
DE2315609A1 (de) * 1973-03-29 1974-10-17 Holzhueter Hermann Verfahren zum loesen von indomethacin in wasser und eine indomethacin enthaltende pharmazeutische zubereitung zur parenteralen applikation
FR2277594A1 (fr) * 1974-07-10 1976-02-06 Pfrimmer & Co J Solution d'infusion pour nutrition par voie parenterale

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GB706607A (en) 1951-07-31 1954-03-31 Roche Products Ltd Process for the manufacture of dispersable solutions of fat soluble vitamins
DE1089510B (de) * 1959-03-23 1960-09-22 Rudolf Reiss Dr Verfahren zur Herstellung waessriger, injizierbarer Loesungen von 2-Methoxy-4-allylphenoxyessigsaeure-N, N-Diaethylamid
US3044931A (en) * 1960-01-27 1962-07-17 Geigy Chem Corp Aryloxy acetic acid amides: process for parenteral application
NL260444A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1960-12-05
GB1317184A (en) * 1969-06-20 1973-05-16 Glaxo Lab Ltd Steroid-containing pharmaceutical preparations
US3900561A (en) * 1970-12-17 1975-08-19 Glaxo Lab Ltd Pharmaceutical compositions
US3917830A (en) * 1970-12-17 1975-11-04 Glaxo Lab Ltd Steroidal anaesthetic composition for intraveneous injection
US4017616A (en) * 1972-01-21 1977-04-12 American Home Products Corporation Parenteral benzodiazepine compositions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE575616C (de) * 1928-12-14 1933-04-29 Hans Much Dr Verfahren zur Herstellung bestaendiger, klarer, waessriger Loesungen von Lipoiden, Fetten oder Harzen
DE932083C (de) * 1954-03-31 1955-08-22 Upha Chem Pharm Praeparate G M Verfahren zur Herstellung stabiler waessriger Injektionsloesungen von 2-Methyl-5, 8-dimethoxy-furanochromon
DE1904562A1 (de) * 1968-02-02 1970-03-05 Merck & Co Inc 5ss-Glycochloansaeure oder 5ss-Taurocholansaeure enthaltende Arzneimittel
DE2302659A1 (de) * 1972-01-21 1973-07-26 American Home Prod Parenterales benzodiazepinhaltiges arzneimittel
DE2315609A1 (de) * 1973-03-29 1974-10-17 Holzhueter Hermann Verfahren zum loesen von indomethacin in wasser und eine indomethacin enthaltende pharmazeutische zubereitung zur parenteralen applikation
FR2277594A1 (fr) * 1974-07-10 1976-02-06 Pfrimmer & Co J Solution d'infusion pour nutrition par voie parenterale

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0133258A3 (en) * 1983-07-22 1985-08-21 F. Hoffmann-La Roche & Co. Aktiengesellschaft Injectable solutions for vitamin e
EP0388817A3 (de) * 1989-03-21 1991-07-03 F. Hoffmann-La Roche Ag Verwendung von Mischmicellen und Mischmicell-Lösungen von Immunmodulatoren

Also Published As

Publication number Publication date
IT1202370B (it) 1989-02-09
JPS539314A (en) 1978-01-27
PH16333A (en) 1983-09-05
DK149483C (da) 1986-12-15
NZ184564A (en) 1979-12-11
IE771403L (en) 1978-01-12
CA1082596A (en) 1980-07-29
FR2358161B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-07-25
AU517249B2 (en) 1981-07-16
DK314777A (da) 1978-01-13
SE448516B (sv) 1987-03-02
HK26584A (en) 1984-03-30
US4158707A (en) 1979-06-19
SE7708059L (sv) 1978-01-13
NL189072C (nl) 1993-01-04
IL52458A0 (en) 1977-10-31
DE2730570C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-01-19
DE2730570A1 (de) 1978-01-19
JPS6051448B2 (ja) 1985-11-14
LU90037I2 (fr) 1997-06-13
NL189072B (nl) 1992-08-03
LU77708A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1978-09-14
DK149483B (da) 1986-06-30
FR2423219B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-10-24
IE46037B1 (en) 1983-02-09
FR2423219A1 (fr) 1979-11-16
NL7707641A (nl) 1978-01-16
MY8500263A (en) 1985-12-31
GB1587076A (en) 1981-03-25
IL52458A (en) 1980-10-26
AU2684677A (en) 1979-01-11

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Legal Events

Date Code Title Description
TP Transmission of property
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0118, 920430

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0118, 770707

CL Concession to grant licences