IT1247489B - Acido metiltauroursodesossicolico e suoi derivati terapeuticamente attivi procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono - Google Patents

Acido metiltauroursodesossicolico e suoi derivati terapeuticamente attivi procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono

Info

Publication number
IT1247489B
IT1247489B ITMI911059A ITMI911059A IT1247489B IT 1247489 B IT1247489 B IT 1247489B IT MI911059 A ITMI911059 A IT MI911059A IT MI911059 A ITMI911059 A IT MI911059A IT 1247489 B IT1247489 B IT 1247489B
Authority
IT
Italy
Prior art keywords
acid
preparation
methyltaurouroxodesoxicolic
pharmaceutical compositions
compositions containing
Prior art date
Application number
ITMI911059A
Other languages
English (en)
Inventor
Massimo Parenti
Original Assignee
Prodotti Chimici Alimentari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prodotti Chimici Alimentari filed Critical Prodotti Chimici Alimentari
Priority to ITMI911059A priority Critical patent/IT1247489B/it
Publication of ITMI911059A0 publication Critical patent/ITMI911059A0/it
Priority to JP92507665A priority patent/JPH05508168A/ja
Priority to KR1019920703234A priority patent/KR930700528A/ko
Priority to EP92908736A priority patent/EP0551451A1/en
Priority to EP92201166A priority patent/EP0513887A1/en
Priority to PCT/EP1992/000874 priority patent/WO1992018524A1/en
Publication of ITMI911059A1 publication Critical patent/ITMI911059A1/it
Priority to US08/196,790 priority patent/US5500421A/en
Application granted granted Critical
Publication of IT1247489B publication Critical patent/IT1247489B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'acido tauroursodesossicolico ed i suoi derivati farmaceuticamente accettabili sono utili nella terapia di malattie e disfunzioni epatiche.Per la preparazione di quest'acido si procede alla coniugazione tra un'anidride mista dell'acido ursodesossicolico e metiltaurina, liberando poi l'acido mediante percolazione su due colonne rispettivamente contenenti una resina cationica forte in forma H ed una resina in forma anionica devole in forma OH.
ITMI911059A 1991-04-16 1991-04-17 Acido metiltauroursodesossicolico e suoi derivati terapeuticamente attivi procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono IT1247489B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITMI911059A IT1247489B (it) 1991-04-17 1991-04-17 Acido metiltauroursodesossicolico e suoi derivati terapeuticamente attivi procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono
JP92507665A JPH05508168A (ja) 1991-04-17 1992-04-16 Ｎ―アルキル―タウロウルソデオキシコール酸およびそれらの治療活性誘導体、それらの調製方法、ならびにそれらを含む医薬組成物
KR1019920703234A KR930700528A (ko) 1991-04-16 1992-04-16 N-알킬-타우토우르소데옥시콜린산과 그 약제학적 활성유도체 이것의 제조방법 및 이것을 함유한 약제학적 조성물
EP92908736A EP0551451A1 (en) 1991-04-17 1992-04-16 N-alkyl-tauroursodeoxycholic acids and their therapeutically active derivatives, a process for their preparation and pharmaceutical compositions containing them
EP92201166A EP0513887A1 (en) 1991-04-17 1992-04-16 N-alkyltauroursodeoxycholic acids and their therapeutically active derivatives, a process for their preparation and pharmaceutical compositions containing them
PCT/EP1992/000874 WO1992018524A1 (en) 1991-04-17 1992-04-16 N-alkyl-tauroursodeoxycholic acids and their therapeutically active derivatives, a process for their preparation and pharmaceutical compositions containing them
US08/196,790 US5500421A (en) 1991-04-17 1994-02-15 N-alkyl-taurourodeoxycholic acids and their therapeutically active derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911059A IT1247489B (it) 1991-04-17 1991-04-17 Acido metiltauroursodesossicolico e suoi derivati terapeuticamente attivi procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono

Publications (3)

Publication Number Publication Date
ITMI911059A0 ITMI911059A0 (it) 1991-04-17
ITMI911059A1 ITMI911059A1 (it) 1992-10-17
IT1247489B true IT1247489B (it) 1994-12-17

Family

ID=11359647

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI911059A IT1247489B (it) 1991-04-16 1991-04-17 Acido metiltauroursodesossicolico e suoi derivati terapeuticamente attivi procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono

Country Status (6)

Country Link
US (1) US5500421A (it)
EP (2) EP0513887A1 (it)
JP (1) JPH05508168A (it)
KR (1) KR930700528A (it)
IT (1) IT1247489B (it)
WO (1) WO1992018524A1 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU683049B2 (en) * 1993-03-31 1997-10-30 Mitsubishi-Tokyo Pharmaceuticals, Inc. Cholestasis ameliorant
IT1264131B1 (it) * 1993-04-16 1996-09-16 D R Drug Research Srl Derivato dell'acido iodesossicolico
IT1270853B (it) * 1993-05-20 1997-05-13 Sanofi Elf Procedimento per la preparazione di derivati taurocolanici
CA2167537A1 (en) * 1993-07-19 1995-02-02 Tsuneo Ozeki Hepatitis c virus proliferation inhibitor
DE4432708A1 (de) * 1994-09-14 1996-03-21 Hoechst Ag Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
IT1283182B1 (it) * 1996-03-04 1998-04-16 Prodotti Chimici Alimentari Composti coniugati di acidi biliari con tio-taurina e suoi n-alchilderivati
AU3596199A (en) * 1998-05-06 1999-11-23 Kobenhavns Universitet Treatment of celiac disease
US20100022495A1 (en) * 2005-11-01 2010-01-28 President And Fellows Of Harvard College Modulating endoplasmic reticulum stress in the treatment of tuberous sclerosis
KR101617584B1 (ko) 2015-05-13 2016-05-02 이화여자대학교 산학협력단 복막 섬유증의 예방 또는 치료용 약학적 조성물
GB201911821D0 (en) * 2019-08-16 2019-10-02 Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy And Undivid Compounds for use in the treatment of liver disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3622669A (en) * 1967-10-23 1971-11-23 Merck & Co Inc 5{62 -taurocholenic acids and 5{62 -taurocholadienic acids in compositions for reducing the concentration of cholesterol and liads in blood serum
US4104285A (en) * 1977-04-22 1978-08-01 Hoffmann-La Roche Inc. Taurine and glycine derivatives
IT1206112B (it) * 1983-04-29 1989-04-14 Lehner Ag Nuovi derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
US4892868A (en) * 1984-08-17 1990-01-09 Gipharmex, S.P.A. Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
HU206367B (en) * 1988-04-30 1992-10-28 Sandoz Ag Process for producing acid addition salts of steroid carboxylic acid-amidated taurine and glycine, as well as pharmaceutical compositions comprising such salts
IT1230796B (it) * 1989-05-30 1991-10-29 Prodotti Chimici Alimentari Procedimento per la preparazione di acido tauroursodesossicolico biidrato.

Also Published As

Publication number Publication date
ITMI911059A1 (it) 1992-10-17
EP0551451A1 (en) 1993-07-21
KR930700528A (ko) 1993-03-15
EP0513887A1 (en) 1992-11-19
ITMI911059A0 (it) 1991-04-17
JPH05508168A (ja) 1993-11-18
US5500421A (en) 1996-03-19
WO1992018524A1 (en) 1992-10-29

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940428