KR930700528A - N-알킬-타우토우르소데옥시콜린산과 그 약제학적 활성유도체 이것의 제조방법 및 이것을 함유한 약제학적 조성물 - Google Patents

N-알킬-타우토우르소데옥시콜린산과 그 약제학적 활성유도체 이것의 제조방법 및 이것을 함유한 약제학적 조성물

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Publication number
KR930700528A
KR930700528A KR1019920703234A KR920703234A KR930700528A KR 930700528 A KR930700528 A KR 930700528A KR 1019920703234 A KR1019920703234 A KR 1019920703234A KR 920703234 A KR920703234 A KR 920703234A KR 930700528 A KR930700528 A KR 930700528A
Authority
KR
South Korea
Prior art keywords
acid
alkyl
basic amino
preparation
tautosodeoxycholine
Prior art date
Application number
KR1019920703234A
Other languages
English (en)
Inventor
마씨모 파렌티
Original Assignee
원본미기재
프로도티 키미치 에 알리멘타리 쏘시에떼 퍼 아찌오니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 프로도티 키미치 에 알리멘타리 쏘시에떼 퍼 아찌오니 filed Critical 원본미기재
Publication of KR930700528A publication Critical patent/KR930700528A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

N-알킬-타우토우르소데옥시콜린산과 그 약제학적 활성 유도체 이것의 제조방법 및 이것을 함유한 약제학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 다음 구조식의 타우토우르소데옥시콜린산 공역유도체:
  3. 여기서 R은 C2-C4알킬이고 R1은 H, 알칼리금속, 알칼리토 금속 또는 염기성 아미노산의 라디칼이다.
  4. 제1항에 있어서, 염기성 아미노산은 리신, 아르기닌, 오르니틴과 히스티딘중 선택하는 것을 특징으로 하는 공역유도체.
  5. 우르소데옥시콜린산과 에틸 클로로포름산염의 혼합무수물을 알킬타우린용액과 반응시키고 그 결과 반응은 H+형태의 강 양이온수지 1차 컬럼을 통과시키고 또한 OH-형태의 약 음이온수지 2차 컬럼에 통과시키며 R1이 원하는 화합물 H와 상이할 때 염화처리하는 것을 특징으로하는 타우로우르소데옥시콜린산 N-알킬 공역유도체 제조방법.
  6. 활성성분인 타우로우르소데옥시콜린산의 N-알킬 공역유도체를 표준 부형체 및 보조제와 함께 함유하여 된 약제학적 소성물.
  7. 담석, 급성 및 만성간장염, 복강질환, 췌장기능부진, 섬유종 및 과지방단백질증의 치료에 유용한 약제학적 조성물 제조에 N-메틸-타우로우르소데옥시콜린산 혹은 알칼리금속, 알칼리토금속 또는 염기성 아미노산을 포함한 약제적 수용가능함 염을 이용하는 방법.
  8. ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019920703234A 1991-04-16 1992-04-16 N-알킬-타우토우르소데옥시콜린산과 그 약제학적 활성유도체 이것의 제조방법 및 이것을 함유한 약제학적 조성물 KR930700528A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI91A001059 1991-04-17
ITMI911059A IT1247489B (it) 1991-04-17 1991-04-17 Acido metiltauroursodesossicolico e suoi derivati terapeuticamente attivi procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono
PCT/EP1992/000874 WO1992018524A1 (en) 1991-04-17 1992-04-16 N-alkyl-tauroursodeoxycholic acids and their therapeutically active derivatives, a process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
KR930700528A true KR930700528A (ko) 1993-03-15

Family

ID=11359647

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920703234A KR930700528A (ko) 1991-04-16 1992-04-16 N-알킬-타우토우르소데옥시콜린산과 그 약제학적 활성유도체 이것의 제조방법 및 이것을 함유한 약제학적 조성물

Country Status (6)

Country Link
US (1) US5500421A (ko)
EP (2) EP0551451A1 (ko)
JP (1) JPH05508168A (ko)
KR (1) KR930700528A (ko)
IT (1) IT1247489B (ko)
WO (1) WO1992018524A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU683049B2 (en) * 1993-03-31 1997-10-30 Mitsubishi-Tokyo Pharmaceuticals, Inc. Cholestasis ameliorant
IT1264131B1 (it) * 1993-04-16 1996-09-16 D R Drug Research Srl Derivato dell'acido iodesossicolico
IT1270853B (it) * 1993-05-20 1997-05-13 Sanofi Elf Procedimento per la preparazione di derivati taurocolanici
AU688344B2 (en) * 1993-07-19 1998-03-12 Mitsubishi-Tokyo Pharmaceuticals, Inc. Hepatitis C virus proliferation inhibitor
DE4432708A1 (de) * 1994-09-14 1996-03-21 Hoechst Ag Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
IT1283182B1 (it) * 1996-03-04 1998-04-16 Prodotti Chimici Alimentari Composti coniugati di acidi biliari con tio-taurina e suoi n-alchilderivati
AU3596199A (en) * 1998-05-06 1999-11-23 Kobenhavns Universitet Treatment of celiac disease
WO2007053747A2 (en) * 2005-11-01 2007-05-10 President And Fellows Of Harvard College Modulating endoplasmic reticulum stress in the treatment of tuberous sclerosis
KR101617584B1 (ko) 2015-05-13 2016-05-02 이화여자대학교 산학협력단 복막 섬유증의 예방 또는 치료용 약학적 조성물
GB201911821D0 (en) * 2019-08-16 2019-10-02 Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy And Undivid Compounds for use in the treatment of liver disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3622669A (en) * 1967-10-23 1971-11-23 Merck & Co Inc 5{62 -taurocholenic acids and 5{62 -taurocholadienic acids in compositions for reducing the concentration of cholesterol and liads in blood serum
US4104285A (en) * 1977-04-22 1978-08-01 Hoffmann-La Roche Inc. Taurine and glycine derivatives
IT1206112B (it) * 1983-04-29 1989-04-14 Lehner Ag Nuovi derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
US4892868A (en) * 1984-08-17 1990-01-09 Gipharmex, S.P.A. Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
HU206367B (en) * 1988-04-30 1992-10-28 Sandoz Ag Process for producing acid addition salts of steroid carboxylic acid-amidated taurine and glycine, as well as pharmaceutical compositions comprising such salts
IT1230796B (it) * 1989-05-30 1991-10-29 Prodotti Chimici Alimentari Procedimento per la preparazione di acido tauroursodesossicolico biidrato.

Also Published As

Publication number Publication date
US5500421A (en) 1996-03-19
ITMI911059A0 (it) 1991-04-17
IT1247489B (it) 1994-12-17
EP0513887A1 (en) 1992-11-19
WO1992018524A1 (en) 1992-10-29
JPH05508168A (ja) 1993-11-18
EP0551451A1 (en) 1993-07-21
ITMI911059A1 (it) 1992-10-17

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