GB706607A - Process for the manufacture of dispersable solutions of fat soluble vitamins - Google Patents
Process for the manufacture of dispersable solutions of fat soluble vitaminsInfo
- Publication number
- GB706607A GB706607A GB18168/52A GB1816852A GB706607A GB 706607 A GB706607 A GB 706607A GB 18168/52 A GB18168/52 A GB 18168/52A GB 1816852 A GB1816852 A GB 1816852A GB 706607 A GB706607 A GB 706607A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fat
- solutions
- soluble vitamins
- water
- ethylene oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000011782 vitamin Substances 0.000 title abstract 6
- 229940088594 vitamin Drugs 0.000 title abstract 6
- 229930003231 vitamin Natural products 0.000 title abstract 6
- 235000013343 vitamin Nutrition 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 3
- 239000003995 emulsifying agent Substances 0.000 abstract 3
- 229930195729 fatty acid Natural products 0.000 abstract 3
- 239000000194 fatty acid Substances 0.000 abstract 3
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- AJFDBNQQDYLMJN-UHFFFAOYSA-N n,n-diethylacetamide Chemical compound CCN(CC)C(C)=O AJFDBNQQDYLMJN-UHFFFAOYSA-N 0.000 abstract 2
- LHENQXAPVKABON-UHFFFAOYSA-N 1-methoxypropan-1-ol Chemical compound CCC(O)OC LHENQXAPVKABON-UHFFFAOYSA-N 0.000 abstract 1
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 abstract 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 abstract 1
- BHIZVZJETFVJMJ-UHFFFAOYSA-N 2-hydroxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)O BHIZVZJETFVJMJ-UHFFFAOYSA-N 0.000 abstract 1
- PTFIPECGHSYQNR-UHFFFAOYSA-N 3-Pentadecylphenol Chemical compound CCCCCCCCCCCCCCCC1=CC=CC(O)=C1 PTFIPECGHSYQNR-UHFFFAOYSA-N 0.000 abstract 1
- IDZSDPCTCKNVHX-UHFFFAOYSA-N CCCCCCCCCCCC(O)=O.CCNO Chemical compound CCCCCCCCCCCC(O)=O.CCNO IDZSDPCTCKNVHX-UHFFFAOYSA-N 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 abstract 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 abstract 1
- 238000007792 addition Methods 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 239000007859 condensation product Substances 0.000 abstract 1
- 238000007865 diluting Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- -1 fatty acid esters Chemical class 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940026235 propylene glycol monolaurate Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 abstract 1
- 239000001570 sorbitan monopalmitate Substances 0.000 abstract 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 150000005846 sugar alcohols Polymers 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Solutions of fat-soluble vitamins dispersable in an aqueous medium comprise one or more fat-soluble vitamins, an emulsifier which consists essentially of an acetone-insoluble phosphatide fraction obtained from soya and sufficient water-free water-miscible solvent which is miscible with said vitamin or vitamins, namely acetic acid diethylamide, to render the solutions clear. The acetic acid diethylamide may be mixed with other water-free organic solvents, e.g. propylene glycol monomethyl ether, dimethyl formamide and 1-methoxy propanol. Specified fat-soluble vitamins are A, D, E and K and their fat-soluble derivatives, e.g. fatty acid esters such as palmitate. Optional additions are other emulsifiers and a polymeric substance such as polyvinyl pyrrolidone having emulsion stabilizing properties. The added emulsifiers are (a) esters of a fatty acid containing 12 to 18 carbon atoms with a polyhydric alcohol, e.g. glycerin monostearate, sorbitan monopalmitate, ascorbyl palmitate and propylene glycol monolaurate; (b) N-alkanol substituted fatty acid amides, e.g. lauric acid-N-hydroxy ethylamide and palmitic acid-N-diethanolamide; and (c) ethylene oxide condensation products, especially polyethylene glycol ethers of m-pentadecyl phenol containing 12 to 60 ethylene oxide units per molecule and of castor oil with 40 mol of ethylene oxide. The solutions are intended for use as intermediates in the preparation of drugs, e.g. by diluting with water or normal saline solution, or for vitaminization of foods, e.g. milk.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH706607X | 1951-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB706607A true GB706607A (en) | 1954-03-31 |
Family
ID=4530426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB18168/52A Expired GB706607A (en) | 1951-07-31 | 1952-07-18 | Process for the manufacture of dispersable solutions of fat soluble vitamins |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB706607A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3384545A (en) * | 1965-03-09 | 1968-05-21 | Hoffmann La Roche | Injectable aqueous emulsions of fat soluble vitamins |
| US8318196B2 (en) | 2006-06-27 | 2012-11-27 | Akzo Nobel N.V. | Formulations comprising a vitamin and the use thereof to make fortified feed and personal care formulations |
-
1952
- 1952-07-18 GB GB18168/52A patent/GB706607A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3384545A (en) * | 1965-03-09 | 1968-05-21 | Hoffmann La Roche | Injectable aqueous emulsions of fat soluble vitamins |
| US8318196B2 (en) | 2006-06-27 | 2012-11-27 | Akzo Nobel N.V. | Formulations comprising a vitamin and the use thereof to make fortified feed and personal care formulations |
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