FR2331340A1 - Nouveaux derives du benzimidazole, procede pour leur obtention et compositions pharmaceutiques les contenant - Google Patents

Nouveaux derives du benzimidazole, procede pour leur obtention et compositions pharmaceutiques les contenant

Info

Publication number
FR2331340A1
FR2331340A1 FR7534910A FR7534910A FR2331340A1 FR 2331340 A1 FR2331340 A1 FR 2331340A1 FR 7534910 A FR7534910 A FR 7534910A FR 7534910 A FR7534910 A FR 7534910A FR 2331340 A1 FR2331340 A1 FR 2331340A1
Authority
FR
France
Prior art keywords
obtaining
pharmaceutical compositions
compositions containing
benzimidazole derivatives
new benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7534910A
Other languages
English (en)
French (fr)
Other versions
FR2331340B1 (enExample
Inventor
Peder Bernhard Berntsson
Stig Ake Ingemar Carlsson
Lars Erik Garberg
Ulf Kris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hassle AB
Original Assignee
Hassle AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SE7406513A priority Critical patent/SE416649B/xx
Priority to NO75752851A priority patent/NO143222C/no
Priority to FI752327A priority patent/FI63756C/fi
Priority to DK372175AA priority patent/DK140840B/da
Priority to GB43039/75A priority patent/GB1525958A/en
Priority to ZA00756600A priority patent/ZA756600B/xx
Priority to CY1125A priority patent/CY1125A/xx
Priority to IE2313/75A priority patent/IE42451B1/en
Priority to DE19752548340 priority patent/DE2548340A1/de
Priority to AT838075A priority patent/AT337697B/de
Priority to CS757458A priority patent/CS196289B2/cs
Priority to NL7513141A priority patent/NL7513141A/xx
Priority to US05/630,916 priority patent/US4045563A/en
Priority to HU75HE00000696A priority patent/HU172653B/hu
Priority to SU752189960A priority patent/SU602118A3/ru
Application filed by Hassle AB filed Critical Hassle AB
Priority to FR7534910A priority patent/FR2331340A1/fr
Priority to CA239,643A priority patent/CA1055033A/en
Priority to DD189463A priority patent/DD122534A5/xx
Priority to CH1481475A priority patent/CH623814A5/de
Priority to JP50137712A priority patent/JPS5262275A/ja
Priority to FR7616732A priority patent/FR2392021A1/fr
Priority to AT752276A priority patent/AT351524B/de
Publication of FR2331340A1 publication Critical patent/FR2331340A1/fr
Priority to DK783659A priority patent/DK365978A/da
Priority to CS786886A priority patent/CS196290B2/cs
Application granted granted Critical
Publication of FR2331340B1 publication Critical patent/FR2331340B1/fr
Priority to CH976079A priority patent/CH623582A5/de
Priority to FI811747A priority patent/FI65617C/fi
Priority to HK87/82A priority patent/HK8782A/xx
Priority to MY159/82A priority patent/MY8200159A/xx
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR7534910A 1974-05-16 1975-11-14 Nouveaux derives du benzimidazole, procede pour leur obtention et compositions pharmaceutiques les contenant Granted FR2331340A1 (fr)

Priority Applications (28)

Application Number Priority Date Filing Date Title
SE7406513A SE416649B (sv) 1974-05-16 1974-05-16 Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
FI752327A FI63756C (fi) 1974-05-16 1975-08-15 Foerfarande foer framstaellning av 2-(2-pyridylmetylsulfinyl)-bensimidazolderivat med magsyrasekretionsinhiberande verkan
NO75752851A NO143222C (no) 1974-05-16 1975-08-15 Analogifremgangsmaate for fremstilling av nye substituerte pyridylsulfinyl-benzimidazoler med terapeutisk aktivitet
DK372175AA DK140840B (da) 1974-05-16 1975-08-18 Analogifremgangsmåde til fremstilling af benzimidazolderivater eller syreadditionssalte deraf.
GB43039/75A GB1525958A (en) 1974-05-16 1975-10-20 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
ZA00756600A ZA756600B (en) 1974-05-16 1975-10-20 Gastric acid secretion agents
CY1125A CY1125A (en) 1974-05-16 1975-10-20 2-(heterocaclic asbstituted alkylsulphinyl)-benzinmidazoles and their pharmaceutical compositions
IE2313/75A IE42451B1 (en) 1974-05-16 1975-10-23 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
DE19752548340 DE2548340A1 (de) 1974-05-16 1975-10-29 Benzimidazole, verfahren zu deren herstellung und sie enthaltende mittel
AT838075A AT337697B (de) 1974-05-16 1975-11-04 Verfahren zur herstellung von neuen benzimidazolderivaten und ihren salzen
CS757458A CS196289B2 (en) 1974-05-16 1975-11-05 Process for preparing new compounds
NL7513141A NL7513141A (nl) 1974-05-16 1975-11-10 Benzimidazoolderivaten en werkwijze voor het be- reiden daarvan alsmede preparaten voor het bein- vloeden van de maagzuursecretie.
US05/630,916 US4045563A (en) 1974-05-16 1975-11-11 Substituted 2-[pyridylalkylenesulfinyl]-benzimidazoles with gastric acid secretion inhibiting effects
HU75HE00000696A HU172653B (hu) 1974-05-16 1975-11-12 Sposob poluchenija zamehhennykh 2-skobka-2-piridil-metil-sul'finil-skobka zakryta-benzimidazolov
SU752189960A SU602118A3 (ru) 1974-05-16 1975-11-13 Способ получени производных бензимидазола или их солей
FR7534910A FR2331340A1 (fr) 1974-05-16 1975-11-14 Nouveaux derives du benzimidazole, procede pour leur obtention et compositions pharmaceutiques les contenant
CA239,643A CA1055033A (en) 1974-05-16 1975-11-14 2-(2-heterocyclic-methylsulphinyl)-benzimidazole compounds
DD189463A DD122534A5 (enExample) 1974-05-16 1975-11-14
CH1481475A CH623814A5 (en) 1974-05-16 1975-11-14 Process for the preparation of novel benzimidazoles
JP50137712A JPS5262275A (en) 1974-05-16 1975-11-15 Production of organic compound
FR7616732A FR2392021A1 (fr) 1974-05-16 1976-06-03 Nouveaux derives du benzimidazole et procede pour leur obtention
AT752276A AT351524B (de) 1974-05-16 1976-10-11 Verfahren zur herstellung von neuen benzimida- zolderivaten, ihren salzen und optischen isomeren
DK783659A DK365978A (da) 1974-05-16 1978-08-18 Mellemprodukt til anvendelse ved fremstilling af benzimidazolderivater
CS786886A CS196290B2 (en) 1974-05-16 1978-10-23 Process for preparing new compounds
CH976079A CH623582A5 (en) 1974-05-16 1979-10-31 Process for the preparation of benzimidazoles
FI811747A FI65617C (fi) 1974-05-16 1981-06-04 Mellanprodukt foer framstaellning av magsyrasekretionsinhiberande 2-(2-pyridylmetylsulfinyl)-benzimidazolderivat
HK87/82A HK8782A (en) 1974-05-16 1982-02-25 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
MY159/82A MY8200159A (en) 1974-05-16 1982-12-30 2-[heterocylic substituted alkylsulphinyl]-benzimidazoles and their pharmaceutical compositions

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
SE7406513A SE416649B (sv) 1974-05-16 1974-05-16 Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
FI752327A FI63756C (fi) 1974-05-16 1975-08-15 Foerfarande foer framstaellning av 2-(2-pyridylmetylsulfinyl)-bensimidazolderivat med magsyrasekretionsinhiberande verkan
NO75752851A NO143222C (no) 1974-05-16 1975-08-15 Analogifremgangsmaate for fremstilling av nye substituerte pyridylsulfinyl-benzimidazoler med terapeutisk aktivitet
DK372175AA DK140840B (da) 1974-05-16 1975-08-18 Analogifremgangsmåde til fremstilling af benzimidazolderivater eller syreadditionssalte deraf.
ZA00756600A ZA756600B (en) 1974-05-16 1975-10-20 Gastric acid secretion agents
GB43039/75A GB1525958A (en) 1974-05-16 1975-10-20 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
IE2313/75A IE42451B1 (en) 1974-05-16 1975-10-23 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
DE19752548340 DE2548340A1 (de) 1974-05-16 1975-10-29 Benzimidazole, verfahren zu deren herstellung und sie enthaltende mittel
AT838075A AT337697B (de) 1974-05-16 1975-11-04 Verfahren zur herstellung von neuen benzimidazolderivaten und ihren salzen
CS757458A CS196289B2 (en) 1974-05-16 1975-11-05 Process for preparing new compounds
NL7513141A NL7513141A (nl) 1974-05-16 1975-11-10 Benzimidazoolderivaten en werkwijze voor het be- reiden daarvan alsmede preparaten voor het bein- vloeden van de maagzuursecretie.
US05/630,916 US4045563A (en) 1974-05-16 1975-11-11 Substituted 2-[pyridylalkylenesulfinyl]-benzimidazoles with gastric acid secretion inhibiting effects
HU75HE00000696A HU172653B (hu) 1974-05-16 1975-11-12 Sposob poluchenija zamehhennykh 2-skobka-2-piridil-metil-sul'finil-skobka zakryta-benzimidazolov
SU752189960A SU602118A3 (ru) 1974-05-16 1975-11-13 Способ получени производных бензимидазола или их солей
CA239,643A CA1055033A (en) 1974-05-16 1975-11-14 2-(2-heterocyclic-methylsulphinyl)-benzimidazole compounds
FR7534910A FR2331340A1 (fr) 1974-05-16 1975-11-14 Nouveaux derives du benzimidazole, procede pour leur obtention et compositions pharmaceutiques les contenant
CH1481475A CH623814A5 (en) 1974-05-16 1975-11-14 Process for the preparation of novel benzimidazoles
DD189463A DD122534A5 (enExample) 1974-05-16 1975-11-14
JP50137712A JPS5262275A (en) 1974-05-16 1975-11-15 Production of organic compound
FR7616732A FR2392021A1 (fr) 1974-05-16 1976-06-03 Nouveaux derives du benzimidazole et procede pour leur obtention
AT752276A AT351524B (de) 1974-05-16 1976-10-11 Verfahren zur herstellung von neuen benzimida- zolderivaten, ihren salzen und optischen isomeren
DK783659A DK365978A (da) 1974-05-16 1978-08-18 Mellemprodukt til anvendelse ved fremstilling af benzimidazolderivater
CS786886A CS196290B2 (en) 1974-05-16 1978-10-23 Process for preparing new compounds
HU8782 1982-02-25
MY159/82A MY8200159A (en) 1974-05-16 1982-12-30 2-[heterocylic substituted alkylsulphinyl]-benzimidazoles and their pharmaceutical compositions

Publications (2)

Publication Number Publication Date
FR2331340A1 true FR2331340A1 (fr) 1977-06-10
FR2331340B1 FR2331340B1 (enExample) 1979-01-19

Family

ID=40486266

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7534910A Granted FR2331340A1 (fr) 1974-05-16 1975-11-14 Nouveaux derives du benzimidazole, procede pour leur obtention et compositions pharmaceutiques les contenant
FR7616732A Granted FR2392021A1 (fr) 1974-05-16 1976-06-03 Nouveaux derives du benzimidazole et procede pour leur obtention

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7616732A Granted FR2392021A1 (fr) 1974-05-16 1976-06-03 Nouveaux derives du benzimidazole et procede pour leur obtention

Country Status (22)

Country Link
US (1) US4045563A (enExample)
JP (1) JPS5262275A (enExample)
AT (2) AT337697B (enExample)
CA (1) CA1055033A (enExample)
CH (2) CH623814A5 (enExample)
CS (2) CS196289B2 (enExample)
CY (1) CY1125A (enExample)
DD (1) DD122534A5 (enExample)
DE (1) DE2548340A1 (enExample)
DK (2) DK140840B (enExample)
FI (2) FI63756C (enExample)
FR (2) FR2331340A1 (enExample)
GB (1) GB1525958A (enExample)
HK (1) HK8782A (enExample)
HU (1) HU172653B (enExample)
IE (1) IE42451B1 (enExample)
MY (1) MY8200159A (enExample)
NL (1) NL7513141A (enExample)
NO (1) NO143222C (enExample)
SE (1) SE416649B (enExample)
SU (1) SU602118A3 (enExample)
ZA (1) ZA756600B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2403340A1 (fr) * 1977-09-19 1979-04-13 Hoffmann La Roche Derives imidazoliques utiles comme medicaments
FR2488890A1 (fr) * 1980-08-21 1982-02-26 Hoffmann La Roche Derives tricycliques de l'imidazole, leur preparation et leurs utilisations therapeutiques
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
AT406119B (de) * 1978-04-14 2000-02-25 Haessle Ab Verfahren zur herstellung von granulaten bzw. tabletten oder kapseln zur oralen verabreichung
AT375365B (de) * 1978-04-14 1984-07-25 Haessle Ab Verfahren zur herstellung von neuen 2-pyridylalkyl-sulfinyl-benzimidazolen, von deren hydraten, stereoisomeren und salzen
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
ZA825106B (en) * 1981-08-13 1983-04-27 Haessle Ab Novel pharmaceutical compositions
KR840002371A (ko) * 1981-11-05 1984-06-25 귄터 미카엘, 헤르페르트 수키 치환된 벤즈 이미다졸의 제조방법
DE3216843C2 (de) * 1982-05-05 1986-10-23 Ludwig Heumann & Co GmbH, 8500 Nürnberg 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
IL71664A (en) * 1983-05-03 1987-11-30 Byk Gulden Lomberg Chem Fab Fluoroalkoxy compounds,process for their preparation and pharmaceutical compositions containing the same
HU191757B (en) * 1983-05-03 1987-04-28 Byk Gulden Lomberg Chem Fab Process for producing new tricyclic ethers
CA1259070A (en) * 1983-07-01 1989-09-05 Upjohn Company (The) Substituted 2-¬monoannelated(3,4-,4,5-, and 5,6-)- pyridylalkylenesulfinyl|-benzimidazoles
US5077407A (en) * 1983-07-01 1991-12-31 The Upjohn Company Substituted 2-[monoannelated (3,4-,4,5-, and 5,6-) pyridylalkylenesulfinyl]benzimidazoles
DE3333314A1 (de) * 1983-09-15 1985-03-28 Hoechst Ag, 6230 Frankfurt Substituierte pyrido(1,2-c)imidazo(1,2-a)benzimidazole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
DE3585252D1 (de) * 1984-07-06 1992-03-05 Fisons Plc Benzimidazole, und verfahren zu deren herstellung, deren formulierung und verwendung als magensaeuresekretionshemmende verbindungen.
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
US4619997A (en) * 1984-09-06 1986-10-28 The Upjohn Company Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
KR890000387B1 (ko) * 1984-09-24 1989-03-16 디 엎존 캄파니 2-(피리딜알켄술 피닐)벤즈 이미드아졸류의 n-치환 유도체의 제조방법
DE3579436D1 (de) * 1984-12-18 1990-10-04 Otsuka Pharma Co Ltd Tetrahydrochinolin- derivate, verfahren zu deren herstellung und diese enthaltende antimagengeschwuerzusammensetzungen.
GB8526154D0 (en) * 1985-02-06 1985-11-27 Kotobuki Seiyaku Co Ltd 2-substituted cyclo-heptoimidazoles
DK8600939A (enExample) * 1985-03-05 1986-09-06
FI861772L (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning.
US5869513A (en) * 1985-05-24 1999-02-09 G. D. Searle & Co. 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines
AU5768886A (en) 1985-05-24 1986-11-27 G.D. Searle & Co. 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
DK337086A (da) * 1985-08-12 1987-02-13 Hoffmann La Roche Benzimidazolderivater
AR243167A1 (es) 1985-08-24 1993-07-30 Hoechst Ag Procedimiento para la preparacion de toluidinas sustituidas.
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
US5433959A (en) 1986-02-13 1995-07-18 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
US6749864B2 (en) * 1986-02-13 2004-06-15 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
SE8600658D0 (sv) * 1986-02-14 1986-02-14 Haessle Ab Novel composition of matter
ES2032394T3 (es) * 1986-02-20 1993-02-16 Hoechst Aktiengesellschaft Procedimiento para preparar derivados de tienoimidazol sustituidos.
WO1987005296A1 (en) * 1986-03-07 1987-09-11 Pfizer Inc. 2-[(2-pyridyl)methylsulfinyl]thienoimidazoles and related compounds as antiulcer agents
KR870008853A (ko) * 1986-03-28 1987-10-21 오쯔까 아끼히꼬 하이드로퀴놀린 화합물의 제조방법
US4687775A (en) * 1986-07-17 1987-08-18 G. D. Searle & Co. 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles
US4772619A (en) * 1986-07-17 1988-09-20 G. D. Searle & Co. [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines
US4721718A (en) * 1986-08-18 1988-01-26 G. D. Searle & Co. 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers
SE8604998D0 (sv) 1986-11-21 1986-11-21 Haessle Ab Novel pharmacological compounds
NZ222495A (en) 1986-11-21 1991-04-26 Haessle Ab Benzimidazole derivatives and pharmaceutical compositions
DE3639926A1 (de) * 1986-11-22 1988-06-01 Hoechst Ag Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
US5330982A (en) * 1986-12-17 1994-07-19 Glaxo Group Limited Pharmaceutical composition containing a 5-HT receptor antagonist and an H+ K+ Atpase inhibitor and a method of treating gastrointestingal disorders therewith
GB8630080D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
DE3723327A1 (de) * 1987-07-15 1989-02-02 Hoechst Ag Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer, magenschutzmittel sowie als medikament gegen intestinale entzuendungen
AU2621888A (en) * 1987-10-30 1989-05-23 Aktiebolaget Hassle Omeprazole for treatment of diseases related to bone loss
AU617217B2 (en) * 1988-09-20 1991-11-21 Hisamitsu Pharmaceutical Co., Inc. Novel dibenz(b,e)oxepin derivatives
IE64199B1 (en) * 1988-12-22 1995-07-12 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
SE8804628D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New compounds
SE8804629D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
US5149702A (en) * 1989-11-29 1992-09-22 Toa Eiyo Ltd. Cycloheptenopyridine derivatives, process for preparation thereof and antiulcer agents containing the same
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
JP2524420B2 (ja) * 1990-05-16 1996-08-14 明治製菓株式会社 ピペリジン誘導体及びそれらを有効成分とする抗潰瘍剤
SE9002206D0 (sv) 1990-06-20 1990-06-20 Haessle Ab New compounds
US5364875A (en) * 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
HUT71885A (en) * 1992-07-08 1996-02-28 Monsanto Co Process for preparing a composition containing benzimidazoles for treatment stomach ulcer in swine
AU674015B2 (en) * 1992-07-28 1996-12-05 Astra Aktiebolag Injection and injection kit containing omeprazole and its analogs
TW280770B (enExample) 1993-10-15 1996-07-11 Takeda Pharm Industry Co Ltd
AU2395095A (en) * 1994-04-29 1995-11-29 G.D. Searle & Co. Method of using (h+/k+) atpase inhibitors as antiviral agents
US5998456A (en) 1995-07-17 1999-12-07 Fuji Photo Film Co., Ltd. Benzimidazole compounds containing 1,2,4-triazole ring, and compositions and methods of use containing the same
US5824339A (en) * 1995-09-08 1998-10-20 Takeda Chemical Industries, Ltd Effervescent composition and its production
DE69628444T2 (de) * 1995-09-21 2004-05-06 Pharma Pass Ii Llc, Irvine Säurelabile omeprazol enthaltende pharmazeutische zusammensetzung und verfahren zu dessen herstellung
CN1169807C (zh) * 1997-07-11 2004-10-06 卫材株式会社 制备吡啶衍生物的方法
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
GB9805558D0 (en) * 1998-03-17 1998-05-13 Knoll Ag Chemical process`
KR100554924B1 (ko) 1998-05-18 2006-03-03 다케다 야쿠힌 고교 가부시키가이샤 구강내 붕괴 정제
DE69905171T2 (de) 1998-08-10 2003-11-20 Dept Of Veterans Affairs Washi Prodrugs für proton-pump-inhibitoren
US6093734A (en) * 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
US6733778B1 (en) * 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
BR0017140A (pt) 2000-02-24 2004-05-25 Kopran Res Lab Ltd Derivados de benzimidazol anti-úlcera estáveis ácidos para administração oral
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
WO2002026210A2 (en) * 2000-09-29 2002-04-04 Geneva Pharmaceuticals Inc. Proton pump inhibitor formulation
EP1437352A4 (en) * 2001-09-25 2004-12-08 Takeda Chemical Industries Ltd BENZIMIDAZOLE COMPOUND, METHOD FOR THE PRODUCTION AND USE THEREOF
DK1459737T3 (da) 2001-10-17 2013-01-02 Takeda Pharmaceutical Granulat indeholdende syreustabilt kemisk middel i stor mængde
RU2215739C1 (ru) * 2002-04-03 2003-11-10 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" Способ получения 5-метокси-2-(4-метокси-3,5-диметил-2-пиридилметилтио)бензимидазола
US20030228363A1 (en) * 2002-06-07 2003-12-11 Patel Mahendra R. Stabilized pharmaceutical compositons containing benzimidazole compounds
PL373085A1 (en) * 2002-06-14 2005-08-08 Takeda Pharmaceutical Company Limited Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. peptic ulcers
BR0312802A (pt) * 2002-07-19 2005-04-19 Michael E Garst Pró-drogas de inibidores de bombas de próton
EP1534278A4 (en) * 2002-08-01 2006-09-06 Nitromed Inc NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
ES2534713T3 (es) 2002-10-16 2015-04-27 Takeda Pharmaceutical Company Limited Preparaciones sólidas estables
US8802139B2 (en) 2003-06-26 2014-08-12 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
AU2004268383A1 (en) * 2003-09-03 2005-03-10 Agi Therapeutics Limited Proton pump inhibitor formulations, and methods of preparing and using such formulations
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
US20060241037A1 (en) * 2003-10-03 2006-10-26 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump ihhibitor prodrugs
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
EP1716136A1 (en) 2004-02-11 2006-11-02 Ulkar Kimya Sanayii Ve Ticaret A.S. Pyridine benzimidazole sulfoxides of high purity
WO2005082337A2 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Compositions comprising prodrugs of proton pump inhibitors
WO2005082338A2 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Prodrugs for the intravenous administration of proton pump inhibitors
MXPA06011820A (es) * 2004-04-16 2006-12-15 Santarus Inc Combinacion de inhibidor de bomba de proton, agente regulador del ph y agente procinetico.
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
KR101376360B1 (ko) 2004-09-13 2014-03-20 다케다 야쿠힌 고교 가부시키가이샤 산화 화합물 제조 방법 및 제조 장치
JP5124267B2 (ja) 2005-02-25 2013-01-23 武田薬品工業株式会社 顆粒の製造方法
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
CA2634232C (en) 2005-12-28 2013-08-20 Takeda Pharmaceutical Company Limited Method of producing solid preparation disintegrating in the oral cavity
US20070199890A1 (en) * 2006-02-27 2007-08-30 Agion Technologies, Inc. Antimicrobial activated carbon and use thereof
JP5457830B2 (ja) 2006-04-03 2014-04-02 オディディ，イサ オルガノゾル被膜を含む制御放出送達デバイス
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
US7786309B2 (en) * 2006-06-09 2010-08-31 Apotex Pharmachem Inc. Process for the preparation of esomeprazole and salts thereof
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
CA2665226C (en) 2006-10-05 2014-05-13 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
AU2007317561A1 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
EP2124884B1 (en) 2006-12-22 2019-07-10 Ironwood Pharmaceuticals, Inc. Compositions comprising bile acid sequestrants for treating esophageal disorders
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
EP2749285B1 (en) 2011-08-26 2016-11-02 National University Corporation Nagoya University Osteogenesis promoter and use thereof
CA2859284A1 (en) 2011-12-16 2013-06-20 Atopix Therapeutics Limited Combination of a crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
EP2945614B1 (en) 2013-01-15 2021-11-24 Ironwood Pharmaceuticals, Inc. Gastro-retentive sustained-release oral dosage form of a bile acid sequestrant
WO2016126625A1 (en) 2015-02-03 2016-08-11 Ironwood Pharmaceuticals, Inc. Methods of treating upper gastrointestinal disorders in ppi refractory gerd
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
WO2017145146A1 (en) 2016-02-25 2017-08-31 Dexcel Pharma Technologies Ltd. Compositions comprising proton pump inhibitors
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
NZ779170A (en) * 2016-09-14 2025-08-29 Univ Nat Taiwan Novel substituted benzimidazole derivatives as d-amino acid oxidase (daao) inhibitors
WO2024075017A1 (en) 2022-10-04 2024-04-11 Zabirnyk Arsenii Inhibition of aortic valve calcification

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234058A (enExample) * 1968-10-21 1971-06-03
DE1903755B2 (de) * 1969-01-25 1971-04-22 Th Goldschmidt AG, 4300 Essen Verfahren zur herstellung von zinnhaltigen keramischen farbkoerpern
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2403340A1 (fr) * 1977-09-19 1979-04-13 Hoffmann La Roche Derives imidazoliques utiles comme medicaments
FR2488890A1 (fr) * 1980-08-21 1982-02-26 Hoffmann La Roche Derives tricycliques de l'imidazole, leur preparation et leurs utilisations therapeutiques
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects

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SE416649B (sv) 1981-01-26
GB1525958A (en) 1978-09-27
DD122534A5 (enExample) 1976-10-12
FI65617B (fi) 1984-02-29
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HK8782A (en) 1982-03-05
FR2392021A1 (fr) 1978-12-22
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DE2548340A1 (de) 1977-05-05
FR2392021B1 (enExample) 1979-08-17
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