FR2223044A1 - - Google Patents

Info

Publication number
FR2223044A1
FR2223044A1 FR7411519A FR7411519A FR2223044A1 FR 2223044 A1 FR2223044 A1 FR 2223044A1 FR 7411519 A FR7411519 A FR 7411519A FR 7411519 A FR7411519 A FR 7411519A FR 2223044 A1 FR2223044 A1 FR 2223044A1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7411519A
Other languages
French (fr)
Other versions
FR2223044B1 (pt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2223044A1 publication Critical patent/FR2223044A1/fr
Application granted granted Critical
Publication of FR2223044B1 publication Critical patent/FR2223044B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
FR7411519A 1973-04-02 1974-03-29 Expired FR2223044B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34727573A 1973-04-02 1973-04-02

Publications (2)

Publication Number Publication Date
FR2223044A1 true FR2223044A1 (pt) 1974-10-25
FR2223044B1 FR2223044B1 (pt) 1978-06-30

Family

ID=23363051

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7411519A Expired FR2223044B1 (pt) 1973-04-02 1974-03-29

Country Status (28)

Country Link
JP (2) JPS5919117B2 (pt)
AR (2) AR204004A1 (pt)
AT (1) AT340605B (pt)
BE (1) BE813168A (pt)
BG (3) BG21612A3 (pt)
CA (1) CA1042428A (pt)
CH (1) CH603669A5 (pt)
CS (1) CS185223B2 (pt)
CY (1) CY1044A (pt)
DD (1) DD113538A5 (pt)
DE (1) DE2415980A1 (pt)
DK (1) DK141511B (pt)
ES (2) ES424882A1 (pt)
FR (1) FR2223044B1 (pt)
GB (1) GB1463575A (pt)
HK (1) HK20180A (pt)
HU (1) HU171572B (pt)
IE (1) IE39071B1 (pt)
IL (1) IL44415A (pt)
KE (1) KE3028A (pt)
MY (1) MY8100025A (pt)
NL (1) NL181079C (pt)
PH (1) PH13623A (pt)
RO (2) RO73524B (pt)
SE (1) SE416206B (pt)
SU (4) SU731900A3 (pt)
YU (3) YU39719B (pt)
ZA (1) ZA741674B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (pt) * 1976-09-08 1982-07-07 Lilly Co Eli
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
USRE30560E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
BRPI0606480A (pt) 2005-01-21 2008-03-11 Astex Therapeutics Ltd compostos farmacêuticos
WO2007011962A2 (en) 2005-07-18 2007-01-25 Bipar Sciences, Inc. Treatment of cancer
US8143447B2 (en) 2006-09-05 2012-03-27 Bipar Sciences, Inc. Treatment of cancer
AU2007292306A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
EP2217227B1 (en) 2007-11-12 2013-08-21 BiPar Sciences, Inc. Treatment of breast cancer with 4-iodo-3-nitrobenzamide in combination with anti-tumor agents
EP2987794B1 (en) * 2013-04-19 2018-05-30 Jinan University Vinblastine derivatives, preparation method therefor and application thereof
CN113456797B (zh) * 2021-06-18 2024-03-08 暨南大学 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine

Also Published As

Publication number Publication date
YU113980A (en) 1982-05-31
SU784783A3 (ru) 1980-11-30
IL44415A (en) 1978-08-31
SE416206B (sv) 1980-12-08
AR204004A1 (es) 1975-11-12
ES446571A1 (es) 1977-06-16
BG21235A3 (pt) 1976-03-20
JPS5919117B2 (ja) 1984-05-02
YU81774A (en) 1982-05-31
RO77533A (ro) 1982-02-01
AU6671974A (en) 1975-09-18
IE39071B1 (en) 1978-08-02
MY8100025A (en) 1981-12-31
AT340605B (de) 1977-12-27
PH13623A (en) 1980-08-07
FR2223044B1 (pt) 1978-06-30
JPS6033837B2 (ja) 1985-08-05
BE813168A (fr) 1974-10-02
HK20180A (en) 1980-04-25
GB1463575A (en) 1977-02-02
CH603669A5 (pt) 1978-08-31
YU39719B (en) 1985-04-30
HU171572B (hu) 1978-02-28
RO73524B (ro) 1984-11-30
SU731900A3 (ru) 1980-04-30
BG21612A3 (pt) 1976-07-20
SU652896A3 (ru) 1979-03-15
JPS59193895A (ja) 1984-11-02
YU39876B (en) 1985-04-30
CA1042428A (en) 1978-11-14
YU113880A (en) 1982-05-31
KE3028A (en) 1980-03-28
DE2415980C2 (pt) 1989-11-09
ES424882A1 (es) 1976-12-16
DK141511C (pt) 1980-09-29
NL7404423A (pt) 1974-10-04
YU39875B (en) 1985-04-30
CS185223B2 (en) 1978-09-15
NL181079C (nl) 1987-06-16
IL44415A0 (en) 1974-06-30
DE2415980A1 (de) 1974-10-10
NL181079B (nl) 1987-01-16
ATA267974A (de) 1977-04-15
AR203882A1 (es) 1975-10-31
RO73524A (ro) 1984-10-31
IE39071L (en) 1974-10-02
DD113538A5 (pt) 1975-06-12
SU623522A3 (ru) 1978-09-05
BG22831A3 (pt) 1977-04-20
ZA741674B (en) 1975-10-29
JPS49128000A (pt) 1974-12-07
DK141511B (da) 1980-04-08
CY1044A (en) 1980-08-01

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0014, 920211

CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0051, 920323

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0014, 740329

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0051, 740329

CL Concession to grant licences