FR21C1012I2 - Promedicament derive de carbamoylpyridone polycyclique substituee - Google Patents
Promedicament derive de carbamoylpyridone polycyclique substitueeInfo
- Publication number
- FR21C1012I2 FR21C1012I2 FR21C1012C FR21C1012C FR21C1012I2 FR 21C1012 I2 FR21C1012 I2 FR 21C1012I2 FR 21C1012 C FR21C1012 C FR 21C1012C FR 21C1012 C FR21C1012 C FR 21C1012C FR 21C1012 I2 FR21C1012 I2 FR 21C1012I2
- Authority
- FR
- France
- Prior art keywords
- substituted polycyclic
- polycyclic carbamoylpyridone
- derived prodrug
- prodrug
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- OHEKQGOBJIKKIF-AWEZNQCLSA-N (12as)-n-[(4-fluorophenyl)methyl]-7-hydroxy-6,8-dioxo-3,4,12,12a-tetrahydro-2h-pyrido[5,6]pyrazino[2,6-b][1,3]oxazine-9-carboxamide Chemical compound C([C@@H]1OCCCN1C(=O)C1=C(C2=O)O)N1C=C2C(=O)NCC1=CC=C(F)C=C1 OHEKQGOBJIKKIF-AWEZNQCLSA-N 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010213012 | 2010-09-24 | ||
| PCT/JP2011/071446 WO2012039414A1 (ja) | 2010-09-24 | 2011-09-21 | 置換された多環性カルバモイルピリドン誘導体のプロドラッグ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR21C1012I1 FR21C1012I1 (fr) | 2021-05-07 |
| FR21C1012I2 true FR21C1012I2 (fr) | 2023-02-17 |
Family
ID=45873898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR21C1012C Active FR21C1012I2 (fr) | 2010-09-24 | 2021-03-15 | Promedicament derive de carbamoylpyridone polycyclique substituee |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US8987441B2 (pt) |
| EP (1) | EP2620436B1 (pt) |
| JP (2) | JP5553393B2 (pt) |
| KR (1) | KR101773226B1 (pt) |
| CN (1) | CN103228653B (pt) |
| AU (1) | AU2011307087B2 (pt) |
| BR (1) | BR112013006722B1 (pt) |
| CA (1) | CA2812363C (pt) |
| DK (1) | DK2620436T3 (pt) |
| ES (1) | ES2683153T3 (pt) |
| FR (1) | FR21C1012I2 (pt) |
| HR (1) | HRP20181250T1 (pt) |
| HU (2) | HUE039859T2 (pt) |
| LT (2) | LT2620436T (pt) |
| MX (1) | MX2013003139A (pt) |
| NO (1) | NO2021011I1 (pt) |
| PL (1) | PL2620436T3 (pt) |
| PT (1) | PT2620436T (pt) |
| RS (1) | RS57490B1 (pt) |
| RU (1) | RU2608519C2 (pt) |
| SI (1) | SI2620436T1 (pt) |
| TR (1) | TR201810736T4 (pt) |
| TW (1) | TWI518085B (pt) |
| WO (1) | WO2012039414A1 (pt) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI520959B (zh) * | 2009-06-15 | 2016-02-11 | 鹽野義製藥股份有限公司 | 經取代的多環胺甲醯吡啶酮衍生物及其用途 |
| US9200009B2 (en) * | 2011-10-12 | 2015-12-01 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative having integrase inhibitory activity |
| CN111303152B (zh) | 2012-12-21 | 2023-04-11 | 吉利德科学公司 | 多环-氨基甲酰基吡啶酮化合物及其药物用途 |
| US9045486B2 (en) * | 2013-01-08 | 2015-06-02 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| NO2865735T3 (pt) | 2013-07-12 | 2018-07-21 | ||
| DK3019503T3 (da) | 2013-07-12 | 2017-11-20 | Gilead Sciences Inc | Polycykliske-carbamoylpyridon-forbindelser og anvendelse deraf til behandling af hiv-infektioner |
| CA2923075C (en) | 2013-09-12 | 2022-07-26 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| CA2922943A1 (en) | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Pyridazinone compounds and uses thereof |
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| NO2717902T3 (pt) | 2014-06-20 | 2018-06-23 | ||
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| CA2953867A1 (en) * | 2014-07-07 | 2016-01-14 | F. Hoffmann-La Roche Ag | Pyridopyrazine compounds and their use in the treatment, amelioration or prevention of influenza |
| JPWO2016027879A1 (ja) * | 2014-08-22 | 2017-06-01 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有する多環性ピリドン誘導体 |
| TWI695003B (zh) * | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| JP6858712B2 (ja) | 2015-01-30 | 2021-04-14 | リーバー インスティテュート フォー ブレイン ディベロップメントＬｉｅｂｅｒ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｒａｉｎ Ｄｅｖｅｌｏｐｍｅｎｔ | Ｃｏｍｔ阻害方法及び組成物 |
| US10730888B2 (en) * | 2015-02-06 | 2020-08-04 | Mylan Laboratories Limited | Process for the preparation of dolutegravir |
| CA2979216A1 (en) * | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| EP3466490B1 (en) | 2015-04-02 | 2020-10-21 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| CN112876473A (zh) * | 2015-04-28 | 2021-06-01 | 盐野义制药株式会社 | 经取代的多环性吡啶酮衍生物及其前药 |
| MX2021006404A (es) * | 2015-04-28 | 2022-08-02 | Shionogi & Co | Derivados de piridona policiclica sustituida y profarmaco de los mismos. |
| CN105030819B (zh) * | 2015-07-06 | 2019-04-05 | 中国科学技术大学 | 一种3-羟基-4-吡啶酮类高分子铁螯合剂的用途 |
| US9988390B2 (en) | 2015-10-30 | 2018-06-05 | F. Hoffmann-La Roche Ag | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| EP3380471B8 (en) * | 2015-11-25 | 2022-01-19 | Lieber Institute Inc. DBA Lieber Institute For Brain Development | Tetrahydro-8h-pyrido[1,2-a]pyrazine-8-ones as comt inhibitors for the treatment of neurodegenerative disorders |
| PE20181516A1 (es) * | 2015-12-15 | 2018-09-21 | Shionogi & Co | Medicamento para tratar la gripe caracterizado por combinar un inhibidor de endonucleasa dependiente de cap y un farmaco antigripal |
| WO2017109088A1 (en) | 2015-12-23 | 2017-06-29 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| JP6806413B2 (ja) * | 2016-02-03 | 2021-01-06 | 塩野義製薬株式会社 | 多環性ピリドン誘導体およびそのプロドラッグ |
| ES2881776T3 (es) | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
| WO2017158151A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| WO2017158147A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| US11261198B2 (en) * | 2016-06-20 | 2022-03-01 | Shionogi & Co., Ltd. | Process for preparing substituted polycyclic pyridone derivative and crystal thereof |
| KR20190014086A (ko) * | 2016-08-10 | 2019-02-11 | 시오노기세야쿠 가부시키가이샤 | 치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물 |
| JOP20170169A1 (ar) * | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| EP3649130B1 (en) * | 2017-07-06 | 2024-05-22 | Promega Corporation | Serum stable pro-coelenterazine analogues |
| EP3686201A4 (en) * | 2017-09-18 | 2021-04-28 | Sunshine Lake Pharma Co., Ltd. | INHIBITOR OF INFLUENZA VIRUS REPLICATION AND ITS USE |
| CA3078442A1 (en) * | 2017-10-06 | 2019-04-11 | Shionogi & Co., Ltd. | Stereoselective process for preparing substituted polycyclic pyridone derivatives |
| KR102477187B1 (ko) | 2018-01-17 | 2022-12-12 | 장시 카이시 파마슈티컬 테크놀로지 컴퍼니 리미티드 | 피리돈 유도체, 이의 입체 이성질체 및 항인플루엔자 바이러스 약물로서의 응용 |
| CN111303147A (zh) * | 2018-12-12 | 2020-06-19 | 银杏树药业(苏州)有限公司 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
| CN110041327B (zh) * | 2018-01-17 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
| CN109503625A (zh) * | 2018-01-19 | 2019-03-22 | 赵蕾 | 一种多环吡啶酮化合物及其药物组合和用途 |
| US10596171B2 (en) | 2018-01-22 | 2020-03-24 | Taigen Biotechnology Co., Ltd. | Cap-dependent endonuclease inhibitors |
| CN111801333A (zh) | 2018-02-28 | 2020-10-20 | 诺华股份有限公司 | 作为正粘病毒复制抑制剂用于治疗流感的10-(二(苯基)甲基)-4-羟基-8,9,9a,10-四氢-7H-吡咯并[1’,2’:4,5]吡嗪并[1,2-b]哒嗪-3,5-二酮衍生物及相关化合物 |
| CN108440564B (zh) * | 2018-04-11 | 2019-08-06 | 安帝康（无锡）生物科技有限公司 | 被取代的多环氨基甲酰基吡啶酮衍生物及其前药 |
| JP7307412B2 (ja) * | 2018-06-27 | 2023-07-12 | 国立大学法人北海道大学 | 多環性カルバモイルピリドン誘導体を含有するアレナウイルス増殖阻害剤 |
| WO2020015669A1 (zh) * | 2018-07-17 | 2020-01-23 | 南京明德新药研发有限公司 | 抗流感病毒三并环衍生物 |
| CN110317211B (zh) * | 2018-07-27 | 2022-05-13 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的多环性吡啶酮化合物及其前药 |
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| CN116375735A (zh) | 2018-10-22 | 2023-07-04 | 内布拉斯加大学董事会 | 抗病毒前药及其纳米制剂 |
| CN109134428A (zh) * | 2018-10-25 | 2019-01-04 | 南京科技职业学院 | 一种巴洛沙韦中间体的制备方法 |
| WO2020112716A1 (en) * | 2018-11-26 | 2020-06-04 | Cocrystal Pharma, Inc. | Inhibitors of influenza virus replication |
| CN113614085B (zh) * | 2019-03-05 | 2022-12-23 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
| KR20210137140A (ko) | 2019-03-12 | 2021-11-17 | 시오노기 앤드 컴파니, 리미티드 | 인플루엔자 및 합병증 위험 인자를 갖는 대상체에서 치환된 폴리사이클릭 피리돈 유도체 및 그의 전구약물을 사용한 인플루엔자 치료 |
| EP3714889A1 (en) | 2019-03-29 | 2020-09-30 | F. Hoffmann-La Roche AG | Baloxavir for the prevention of transmission of influenza virus |
| WO2020205832A1 (en) * | 2019-04-01 | 2020-10-08 | Nikang Therapeutics, Inc. | Fused polycyclic pyridone compounds as influenza virus replication inhibitors |
| RU2720305C1 (ru) * | 2019-05-07 | 2020-04-28 | Андрей Александрович Иващенко | Замещенный 3,4,12,12а-тетрагидро-1Н-[1,4]оксазино[3,4-c]пиридо[2,1-f] [1,2,4]триазин-6,8-дион, фармацевтическая композиция, способы их получения и применения |
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| CN112174955B (zh) * | 2019-07-05 | 2023-01-13 | 广州南鑫药业有限公司 | 一种2-取代-5-六氢哒嗪酮-4-羧酸胺衍生物及其用途 |
| CN112174956B (zh) * | 2019-07-05 | 2023-01-13 | 广州南鑫药业有限公司 | 一种2-取代-5-六氢哒嗪酮-4-羧酸酯衍生物及其用途 |
| BR112022003673A2 (pt) * | 2019-08-27 | 2022-05-24 | Atriva Therapeutics Gmbh | Combinações de inibidores de mek com inibidores de endonuclease dependente de cap |
| CN112521386B (zh) * | 2019-09-19 | 2023-05-26 | 周雨恬 | 具有抗病毒作用的多环吡啶酮化合物及其药物组合和用途 |
| CN112574170A (zh) * | 2019-09-29 | 2021-03-30 | 江西东邦药业有限公司 | 一种二苯并七元环衍生物及其制备方法和应用 |
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| CN111233891B (zh) * | 2020-03-04 | 2021-05-04 | 江苏柯菲平医药股份有限公司 | 一种稠环吡啶酮衍生物及其制备方法和用途 |
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