FR21C1012I2 - SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVED PRODRUG - Google Patents
SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVED PRODRUGInfo
- Publication number
- FR21C1012I2 FR21C1012I2 FR21C1012C FR21C1012C FR21C1012I2 FR 21C1012 I2 FR21C1012 I2 FR 21C1012I2 FR 21C1012 C FR21C1012 C FR 21C1012C FR 21C1012 C FR21C1012 C FR 21C1012C FR 21C1012 I2 FR21C1012 I2 FR 21C1012I2
- Authority
- FR
- France
- Prior art keywords
- substituted polycyclic
- polycyclic carbamoylpyridone
- derived prodrug
- prodrug
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- OHEKQGOBJIKKIF-AWEZNQCLSA-N (12as)-n-[(4-fluorophenyl)methyl]-7-hydroxy-6,8-dioxo-3,4,12,12a-tetrahydro-2h-pyrido[5,6]pyrazino[2,6-b][1,3]oxazine-9-carboxamide Chemical compound C([C@@H]1OCCCN1C(=O)C1=C(C2=O)O)N1C=C2C(=O)NCC1=CC=C(F)C=C1 OHEKQGOBJIKKIF-AWEZNQCLSA-N 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010213012 | 2010-09-24 | ||
PCT/JP2011/071446 WO2012039414A1 (en) | 2010-09-24 | 2011-09-21 | Substituted polycyclic carbamoyl pyridone derivative prodrug |
Publications (2)
Publication Number | Publication Date |
---|---|
FR21C1012I1 FR21C1012I1 (en) | 2021-05-07 |
FR21C1012I2 true FR21C1012I2 (en) | 2023-02-17 |
Family
ID=45873898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR21C1012C Active FR21C1012I2 (en) | 2010-09-24 | 2021-03-15 | SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVED PRODRUG |
Country Status (24)
Country | Link |
---|---|
US (6) | US8987441B2 (en) |
EP (1) | EP2620436B1 (en) |
JP (2) | JP5553393B2 (en) |
KR (1) | KR101773226B1 (en) |
CN (1) | CN103228653B (en) |
AU (1) | AU2011307087B2 (en) |
BR (1) | BR112013006722B1 (en) |
CA (1) | CA2812363C (en) |
DK (1) | DK2620436T3 (en) |
ES (1) | ES2683153T3 (en) |
FR (1) | FR21C1012I2 (en) |
HR (1) | HRP20181250T1 (en) |
HU (2) | HUE039859T2 (en) |
LT (2) | LT2620436T (en) |
MX (1) | MX2013003139A (en) |
NO (1) | NO2021011I1 (en) |
PL (1) | PL2620436T3 (en) |
PT (1) | PT2620436T (en) |
RS (1) | RS57490B1 (en) |
RU (1) | RU2608519C2 (en) |
SI (1) | SI2620436T1 (en) |
TR (1) | TR201810736T4 (en) |
TW (1) | TWI518085B (en) |
WO (1) | WO2012039414A1 (en) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT2444400T (en) * | 2009-06-15 | 2018-06-11 | Shionogi & Co., Ltd. | Substituted polycyclic carbamoylpyridone derivative |
WO2013054862A1 (en) * | 2011-10-12 | 2013-04-18 | 塩野義製薬株式会社 | Polycyclic pyridone derivative having integrase-inhibiting activity |
MD4841B1 (en) | 2012-12-21 | 2023-01-31 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
CN104918942A (en) | 2013-01-08 | 2015-09-16 | 萨维拉制药有限公司 | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
NO2865735T3 (en) | 2013-07-12 | 2018-07-21 | ||
EP3252058B1 (en) | 2013-07-12 | 2021-01-20 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their use for the treatment of hiv infections |
CA2923075C (en) | 2013-09-12 | 2022-07-26 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
SI3030549T1 (en) | 2013-09-12 | 2019-08-30 | Janssen Biopharma, Inc. | Pyridazinone compounds and uses thereof |
TWI744723B (en) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | Synthesis of polycyclic-carbamoylpyridone compounds |
NO2717902T3 (en) | 2014-06-20 | 2018-06-23 | ||
TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
CA2953867A1 (en) * | 2014-07-07 | 2016-01-14 | F. Hoffmann-La Roche Ag | Pyridopyrazine compounds and their use in the treatment, amelioration or prevention of influenza |
WO2016027879A1 (en) * | 2014-08-22 | 2016-02-25 | 塩野義製薬株式会社 | Polycyclic pyridone derivative having integrase-inhibiting activity |
TWI738321B (en) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
EP3250209B1 (en) | 2015-01-30 | 2023-09-13 | Lieber Institute For Brain Development | Comt inhibiting methods and compositions |
CA2975884A1 (en) * | 2015-02-06 | 2016-08-11 | Mylan Laboratories Limited | Processes for the preparation of dolutegravir |
CA2979216A1 (en) * | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
SG11201707905WA (en) | 2015-04-02 | 2017-10-30 | Gilead Sciences Inc | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
RS64012B1 (en) * | 2015-04-28 | 2023-03-31 | Shionogi & Co | Substituted polycyclic pyridone derivatives and prodrug thereof |
MX2017013809A (en) | 2015-04-28 | 2018-03-15 | Shionogi & Co | Substituted polycyclic pyridone derivative and prodrug thereof. |
CN105030819B (en) * | 2015-07-06 | 2019-04-05 | 中国科学技术大学 | A kind of purposes of 3- hydroxyl -4- pyridinone macromolecule iron chelating agent |
US9988390B2 (en) | 2015-10-30 | 2018-06-05 | F. Hoffmann-La Roche Ag | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
EP3380471B8 (en) | 2015-11-25 | 2022-01-19 | Lieber Institute Inc. DBA Lieber Institute For Brain Development | Tetrahydro-8h-pyrido[1,2-a]pyrazine-8-ones as comt inhibitors for the treatment of neurodegenerative disorders |
JP6323860B2 (en) * | 2015-12-15 | 2018-05-16 | 塩野義製薬株式会社 | A medicine for treating influenza characterized by combining a cap-dependent endonuclease inhibitor and an anti-influenza drug |
WO2017109088A1 (en) | 2015-12-23 | 2017-06-29 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
JP6806413B2 (en) * | 2016-02-03 | 2021-01-06 | 塩野義製薬株式会社 | Polycyclic pyridone derivatives and their prodrugs |
CN108699059B (en) * | 2016-03-08 | 2021-06-18 | 诺华股份有限公司 | Tricyclic compounds useful for treating orthomyxovirus infections |
WO2017158151A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2017158147A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2017221869A1 (en) * | 2016-06-20 | 2017-12-28 | 塩野義製薬株式会社 | Method for producing substituted polycyclic pyridone derivative and crystal of same |
KR20190014086A (en) * | 2016-08-10 | 2019-02-11 | 시오노기세야쿠 가부시키가이샤 | Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof |
JOP20170169A1 (en) | 2016-08-29 | 2019-01-30 | Novartis Ag | Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections |
JP7204728B2 (en) * | 2017-07-06 | 2023-01-16 | プロメガ コーポレイション | Serum stable procoelenterazine analogues |
TWI785116B (en) * | 2017-09-18 | 2022-12-01 | 大陸商廣東東陽光藥業有限公司 | Inhibitors of influenza virus replication and uses thereof |
EP3693373A4 (en) | 2017-10-06 | 2021-11-03 | Shionogi & Co., Ltd. | Method for stereoselectively producing substituted polycyclic pyridone derivative |
CN110041327B (en) * | 2018-01-17 | 2022-01-21 | 江西彩石医药科技有限公司 | Pyridone derivative, composition thereof and application of pyridone derivative as anti-influenza virus medicament |
WO2019141179A1 (en) * | 2018-01-17 | 2019-07-25 | 银杏树药业(苏州)有限公司 | Pyridone derivative, composition thereof and application thereof as anti-influenza drug |
CN111303147B (en) * | 2018-12-12 | 2024-07-02 | 江西彩石医药科技有限公司 | Pyridone derivatives, compositions thereof and use as anti-influenza virus medicaments |
CN109503625A (en) * | 2018-01-19 | 2019-03-22 | 赵蕾 | A kind of polycyclic pyridines ketone compound and its pharmaceutical composition and purposes |
US10596171B2 (en) * | 2018-01-22 | 2020-03-24 | Taigen Biotechnology Co., Ltd. | Cap-dependent endonuclease inhibitors |
UA126253C2 (en) | 2018-02-28 | 2022-09-07 | Новартіс Аг | 10-(di(phenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7h-pyrrolo[1 ',2':4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza |
CN108440564B (en) * | 2018-04-11 | 2019-08-06 | 安帝康(无锡)生物科技有限公司 | Substituted polycyclic carbamoylpyridone derivative and its prodrug |
WO2020004443A1 (en) | 2018-06-27 | 2020-01-02 | 国立大学法人北海道大学 | Arenavirus growth inhibitor comprising polycyclic carbamoyl pyridone derivative |
WO2020015669A1 (en) * | 2018-07-17 | 2020-01-23 | 南京明德新药研发有限公司 | Anti-influenza virus tricyclic derivative |
WO2020020267A1 (en) * | 2018-07-27 | 2020-01-30 | 深圳市塔吉瑞生物医药有限公司 | Substituted polycyclic pyridone compound and prodrug thereof |
AU2019359539A1 (en) * | 2018-10-10 | 2021-04-29 | Janssen Biopharma, Inc. | Macrocyclic flu endonuclease inhibitors |
MX2021004679A (en) | 2018-10-22 | 2021-07-15 | Univ Nebraska | Antiviral prodrugs and nanoformulations thereof. |
CN109134428A (en) * | 2018-10-25 | 2019-01-04 | 南京科技职业学院 | A kind of preparation method of Ba Luoshawei intermediate |
WO2020112716A1 (en) * | 2018-11-26 | 2020-06-04 | Cocrystal Pharma, Inc. | Inhibitors of influenza virus replication |
WO2020177715A1 (en) * | 2019-03-05 | 2020-09-10 | 广东东阳光药业有限公司 | Influenza virus replication inhibitor and use thereof |
CA3133189A1 (en) | 2019-03-12 | 2020-09-17 | Shionogi & Co., Ltd. | Methods of treating influenza in subjects with influenza and a complication risk factor |
EP3714889A1 (en) | 2019-03-29 | 2020-09-30 | F. Hoffmann-La Roche AG | Baloxavir for the prevention of transmission of influenza virus |
WO2020205835A1 (en) * | 2019-04-01 | 2020-10-08 | Nikang Therapeutics, Inc. | Fused polycyclic pyridone compounds as influenza virus replication inhibitors |
RU2720305C1 (en) * | 2019-05-07 | 2020-04-28 | Андрей Александрович Иващенко | Substituted 3,4,12,12a-tetrahydro-1h-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione, pharmaceutical composition, methods for production and use thereof |
CN111909174B (en) * | 2019-05-08 | 2022-01-21 | 江西彩石医药科技有限公司 | Crystal form of pyridone derivative, preparation method and application |
CN112174956B (en) * | 2019-07-05 | 2023-01-13 | 广州南鑫药业有限公司 | 2-substituted-5-hexahydropyridazinone-4-carboxylic ester derivative and application thereof |
CN112174955B (en) * | 2019-07-05 | 2023-01-13 | 广州南鑫药业有限公司 | 2-substituted-5-hexahydropyridazinone-4-carboxylic acid amine derivative and application thereof |
US20220370384A1 (en) * | 2019-08-27 | 2022-11-24 | Atriva Therapeutics Gmbh | Combinations of mek inhibitors with cap-dependent endonuclease inhibitors |
CN112521386B (en) * | 2019-09-19 | 2023-05-26 | 周雨恬 | Polycyclic pyridone compounds having antiviral action, pharmaceutical combinations and uses thereof |
CN112574170A (en) * | 2019-09-29 | 2021-03-30 | 江西东邦药业有限公司 | Dibenzo seven-membered ring derivative and preparation method and application thereof |
CN115135646B (en) * | 2019-12-23 | 2024-05-17 | 石家庄迪斯凯威医药科技有限公司 | Substituted polycyclic compounds, pharmaceutical compositions and uses thereof |
CN111233891B (en) * | 2020-03-04 | 2021-05-04 | 江苏柯菲平医药股份有限公司 | Fused ring pyridone derivative and preparation method and application thereof |
WO2021191872A1 (en) * | 2020-03-26 | 2021-09-30 | Janssen Biopharma, Inc. | Heteroaryl-substituted macrocyclic flu endonuclease inhibitors |
CN113620948B (en) * | 2020-05-06 | 2022-11-25 | 太景医药研发(北京)有限公司 | Cap-dependent endonuclease inhibitors |
RU2745985C1 (en) * | 2020-05-07 | 2021-04-05 | Андрей Александрович Иващенко | Anticoronavirus therapeutic agent - substituted 7-hydroxy-3,4,12,12a-tetrahydro-1h-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione for the prevention and treatment of covid-19 |
US20230212187A1 (en) | 2020-05-21 | 2023-07-06 | Cisen Pharmaceutical Co., Ltd | Fused ring derivatives and use thereof in pharmacy |
TWI796701B (en) * | 2020-05-28 | 2023-03-21 | 太景生物科技股份有限公司 | Stereoselective synthesis of intermediate for preparation of heterocyclic compound |
WO2021249522A1 (en) * | 2020-06-12 | 2021-12-16 | 上海翰森生物医药科技有限公司 | Pyridone-containing fused ring derivative inhibitor, preparation method therefor, and use thereof |
WO2022026285A1 (en) * | 2020-07-27 | 2022-02-03 | Merck Sharp & Dohme Corp. | Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza |
CN112062763B (en) * | 2020-09-10 | 2021-11-05 | 浙江大学 | Hydroxypyrimido [1,2-b ] [1,2,5] triazepine derivative, preparation and application |
CN112047945B (en) * | 2020-09-10 | 2021-11-12 | 浙江大学 | Spirocyclic pyridone derivatives and uses thereof |
WO2022105669A1 (en) * | 2020-11-17 | 2022-05-27 | 南京明德新药研发有限公司 | Se-se-containing macrocyclic compound |
CN112480007B (en) * | 2020-12-08 | 2022-11-18 | 宿迁市科莱博生物化学有限公司 | Synthetic method of 1,3-dimethyl-1H-pyrazole-4-carboxylic acid |
CN112724156B (en) * | 2020-12-30 | 2022-05-10 | 深圳市坤健创新药物研究院 | Polycyclic pyridone derivative, pharmaceutical composition and application thereof |
CN114907365B (en) * | 2021-02-09 | 2023-12-01 | 扬子江药业集团有限公司 | Influenza virus inhibitor and application thereof |
CN116829153A (en) * | 2021-05-10 | 2023-09-29 | 南京征祥医药有限公司 | Crystal forms and application of compound for treating influenza |
WO2023088370A1 (en) * | 2021-11-17 | 2023-05-25 | 辰欣药业股份有限公司 | Crystal form of fused-ring derivative and preparation method therefor |
CN117003771B (en) * | 2022-11-09 | 2024-02-02 | 石家庄迪斯凯威医药科技有限公司 | Anti-influenza virus derivative and application thereof |
WO2024109707A1 (en) * | 2022-11-21 | 2024-05-30 | 合肥医工医药股份有限公司 | Fused ring pyridone derivatives, preparation method therefor, and use thereof |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2280435A (en) | 1993-07-29 | 1995-02-01 | Merck & Co Inc | Anti-viral agent |
DE60336890D1 (en) * | 2002-02-19 | 2011-06-09 | Ono Pharmaceutical Co | CONDENSED PYRIDAZINE DERIVATIVE COMPOUNDS AND THE COMPOUNDS CONTAINING ACTIVE SUBSTANCES |
AU2003267098B2 (en) | 2002-09-11 | 2008-11-20 | Merck & Co., Inc. | Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors |
JP3879729B2 (en) * | 2003-06-04 | 2007-02-14 | 株式会社ノーリツ | Gas combustion equipment |
TW200510425A (en) * | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
US20070161639A1 (en) * | 2004-03-09 | 2007-07-12 | Philip Jones | Hiv integrase inhibitors |
JP2007528394A (en) | 2004-03-09 | 2007-10-11 | メルク エンド カムパニー インコーポレーテッド | HIV integrase inhibitor |
JP2006088173A (en) * | 2004-09-21 | 2006-04-06 | Sumitomo Light Metal Ind Ltd | Friction stir welding method for double skin shape |
WO2006066414A1 (en) | 2004-12-23 | 2006-06-29 | Virochem Pharma Inc. | Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase |
EP1852434B1 (en) * | 2005-02-21 | 2011-07-13 | Shionogi Co., Ltd. | Bicyclic carbamoylpyridone derivative having hiv integrase inhibiting activity |
UA96568C2 (en) * | 2005-04-28 | 2011-11-25 | Глаксосмиткляйн Ллк | Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor |
EP3372281B1 (en) | 2005-04-28 | 2021-07-07 | VIIV Healthcare Company | Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity |
JP4675828B2 (en) * | 2005-07-15 | 2011-04-27 | 株式会社リコー | Digital camera |
CN101346376A (en) * | 2005-10-27 | 2009-01-14 | 盐野义制药株式会社 | Polycyclic carbamoylpyridone derivative having inhibitory activity on HIV integrase |
US8188271B2 (en) * | 2005-10-27 | 2012-05-29 | Shionogi & Co., Ltd. | Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
WO2010011818A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
EP2320908B9 (en) * | 2008-07-25 | 2014-06-18 | VIIV Healthcare Company | Dolutegravir Prodrugs |
WO2010011819A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
WO2010011815A1 (en) | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
ES2395705T3 (en) * | 2008-07-25 | 2013-02-14 | Glaxosmithkline Llc | Chemical compounds |
CN105198804B (en) * | 2008-07-25 | 2018-03-23 | 盐野义制药株式会社 | Compound as hiv integrase inhibitor |
LT2444400T (en) * | 2009-06-15 | 2018-06-11 | Shionogi & Co., Ltd. | Substituted polycyclic carbamoylpyridone derivative |
WO2011011483A1 (en) | 2009-07-22 | 2011-01-27 | Glaxosmithkline Llc | Chemical compounds |
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