US8183344B2
(en)
*
|
1996-04-24 |
2012-05-22 |
University Of Michigan |
Inactivation resistant factor VIII
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
EP1615945B1
(en)
|
2003-04-09 |
2011-09-28 |
BioGeneriX AG |
Glycopegylation methods and proteins/peptides produced by the methods
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
US9005625B2
(en)
|
2003-07-25 |
2015-04-14 |
Novo Nordisk A/S |
Antibody toxin conjugates
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
DE602004026474D1
(de)
*
|
2003-12-03 |
2010-05-20 |
Univ Rochester |
Rekombinanter faktor viii mit erhöhter spezifischer aktivität
|
US8361961B2
(en)
|
2004-01-08 |
2013-01-29 |
Biogenerix Ag |
O-linked glycosylation of peptides
|
EP1771066A2
(en)
|
2004-07-13 |
2007-04-11 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1
|
WO2006050247A2
(en)
|
2004-10-29 |
2006-05-11 |
Neose Technologies, Inc. |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
JP4951527B2
(ja)
|
2005-01-10 |
2012-06-13 |
バイオジェネリックス アーゲー |
糖peg化顆粒球コロニー刺激因子
|
EP1871795A4
(en)
|
2005-04-08 |
2010-03-31 |
Biogenerix Ag |
COMPOSITIONS AND METHOD FOR PRODUCING GLYCOSYLATION MUTANTS OF A PROTEASE-RESISTANT HUMAN GROWTH HORMONE
|
CA2604299A1
(en)
*
|
2005-04-14 |
2006-10-19 |
Csl Behring Gmbh |
Modified coagulation factor viii with enhanced stability and its derivates
|
EP1891231A4
(en)
|
2005-05-25 |
2011-06-22 |
Novo Nordisk As |
GLYCOPEGYLATED FACTOR IX
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
CA2632714A1
(en)
|
2005-12-07 |
2007-06-14 |
Technische Universitaet Muenchen |
Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
|
US20080070251A1
(en)
*
|
2006-06-30 |
2008-03-20 |
Kaufman Randal J |
Method of Producing Factor VIII Proteins by Recombinant Methods
|
US20090203077A1
(en)
*
|
2006-06-30 |
2009-08-13 |
The Regents Of The University Of Michigan |
Method of producing factor viii proteins by recombinant methods
|
CN101516388B
(zh)
|
2006-07-21 |
2012-10-31 |
诺和诺德公司 |
通过o-联糖基化序列的肽的糖基化
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
EP3112471A1
(en)
|
2007-02-23 |
2017-01-04 |
Sk Chemicals Co., Ltd. |
Process for producing and purifying factor viii and its derivatives
|
PL2144923T3
(pl)
|
2007-04-03 |
2013-12-31 |
Biogenerix Ag |
Sposoby leczenia z użyciem glikopegilowanego G-CSF
|
CN101778859B
(zh)
|
2007-06-12 |
2014-03-26 |
诺和诺德公司 |
改良的用于生产核苷酸糖的方法
|
EP2711436A1
(en)
*
|
2007-11-01 |
2014-03-26 |
University Of Rochester |
Recombinant factor VIII having increased stability
|
US20100286067A1
(en)
*
|
2008-01-08 |
2010-11-11 |
Biogenerix Ag |
Glycoconjugation of polypeptides using oligosaccharyltransferases
|
US20130189239A1
(en)
|
2008-02-27 |
2013-07-25 |
Novo Nordisk A/S |
Conjugated Factor VIII Molecules
|
EP2288365A4
(en)
*
|
2008-05-16 |
2012-05-09 |
Bayer Healthcare Llc |
TARGETED COOLING FACTORS AND METHOD OF APPLICATION THEREFOR
|
ES2610356T3
(es)
|
2009-02-03 |
2017-04-27 |
Amunix Operating Inc. |
Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
|
CA2772051C
(en)
|
2009-08-24 |
2020-08-18 |
Amunix Operating Inc. |
Coagulation factor ix compositions and methods of making and using same
|
WO2011041770A1
(en)
|
2009-10-02 |
2011-04-07 |
The Children's Hospital Of Philadelphia |
Compositions and methods for enhancing coagulation factor viii function
|
SG10201907152YA
(en)
|
2009-12-06 |
2019-09-27 |
Bioverativ Therapeutics Inc |
Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof
|
EP3560962A1
(en)
|
2010-07-09 |
2019-10-30 |
Bioverativ Therapeutics Inc. |
Processable single chain molecules and polypeptides made using same
|
EP3508573A1
(en)
|
2010-07-09 |
2019-07-10 |
Bioverativ Therapeutics Inc. |
Systems for factor viii processing and methods thereof
|
WO2012061689A2
(en)
*
|
2010-11-05 |
2012-05-10 |
Ipsen Pharma S.A.S. |
A new variant of antihemophilic factor viii having increased specific activity
|
EP2717898B1
(en)
|
2011-06-10 |
2018-12-19 |
Bioverativ Therapeutics Inc. |
Pro-coagulant compounds and methods of use thereof
|
PT2729161T
(pt)
|
2011-07-08 |
2019-04-01 |
Bioverativ Therapeutics Inc |
Polipéptidos fator viii híbridos e quiméricos, e métodos de utilização dos mesmos
|
EP2737311B1
(en)
|
2011-07-25 |
2020-12-02 |
Bioverativ Therapeutics Inc. |
Assays to monitor bleeding disorders
|
KR20140083036A
(ko)
|
2011-10-18 |
2014-07-03 |
체에스엘 베링 게엠베하 |
인자 viii의 생체이용률을 향상시키기 위한 황산화 글리코사미노글리칸의 용도
|
DK2768521T3
(en)
|
2011-10-18 |
2016-10-24 |
Csl Behring Gmbh |
Combined use of a sulfated glykosamin glycan and a Hyaluronidase to improve bio-availability of factor VIII
|
HK1198541A1
(en)
*
|
2011-10-18 |
2015-05-15 |
Csl Limited |
Method for improving the stability of purified factor viii after reconstitution
|
MY201293A
(en)
|
2012-01-12 |
2024-02-15 |
Bioverativ Therapeutics Inc |
Chimeric factor viii polypeptides and uses thereof
|
RS57936B1
(sr)
|
2012-01-12 |
2019-01-31 |
Bioverativ Therapeutics Inc |
Smanjenje imunogenosti na faktor viii kod osoba na terapiji faktorom viii
|
PL3564260T3
(pl)
|
2012-02-15 |
2023-03-06 |
Bioverativ Therapeutics Inc. |
Kompozycje czynnika viii oraz sposoby ich wytwarzania i stosowania
|
EP3549953A1
(en)
|
2012-02-15 |
2019-10-09 |
Bioverativ Therapeutics Inc. |
Recombinant factor viii proteins
|
EP2863940A4
(en)
|
2012-06-08 |
2016-08-10 |
Biogen Ma Inc |
Chimeric clotting factors
|
CN104519897A
(zh)
|
2012-06-08 |
2015-04-15 |
比奥根艾迪克Ma公司 |
促凝血化合物
|
EP2870250B2
(en)
|
2012-07-06 |
2022-06-29 |
Bioverativ Therapeutics Inc. |
Cell line expressing single chain factor viii polypeptides and uses thereof
|
KR101395736B1
(ko)
*
|
2012-07-10 |
2014-05-16 |
아주대학교산학협력단 |
인간 혈액응고인자 ⅷ 도메인 특이적 항체 및 이의 제조방법
|
KR102329315B1
(ko)
|
2012-07-11 |
2021-11-19 |
바이오버라티브 테라퓨틱스 인크. |
Xten 및 폰 빌레브란트 인자 단백질과의 viii 인자 복합체 및 이의 용도
|
EP2877202A4
(en)
|
2012-07-25 |
2016-06-01 |
Biogen Ma Inc |
BLOOD FACTORY MONITOR TEST AND USES THEREOF
|
EP2908847B1
(en)
|
2012-10-18 |
2022-03-30 |
Bioverativ Therapeutics Inc. |
Methods of using a fixed dose of a clotting factor
|
WO2014070953A1
(en)
|
2012-10-30 |
2014-05-08 |
Biogen Idec Ma Inc. |
Methods of Using FVIII Polypeptide
|
LT3889173T
(lt)
|
2013-02-15 |
2023-10-10 |
Bioverativ Therapeutics Inc. |
Optimizuotas viii faktoriaus genas
|
JP6330026B2
(ja)
|
2013-03-15 |
2018-05-23 |
バイオベラティブ セラピューティクス インコーポレイテッド |
第viii因子ポリペプチド製剤
|
SG11201505926VA
(en)
|
2013-03-15 |
2015-09-29 |
Biogen Ma Inc |
Factor ix polypeptide formulations
|
EP2796145B1
(en)
|
2013-04-22 |
2017-11-01 |
CSL Ltd. |
A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
|
CA2913078A1
(en)
|
2013-06-28 |
2014-12-31 |
Biogen Ma Inc. |
Thrombin cleavable linker with xten and its uses thereof
|
EP3875106A1
(en)
|
2013-08-08 |
2021-09-08 |
Bioverativ Therapeutics Inc. |
Purification of chimeric fviii molecules
|
TWI667255B
(zh)
|
2013-08-14 |
2019-08-01 |
美商生物化學醫療公司 |
因子viii-xten融合物及其用途
|
EP3065769A4
(en)
|
2013-11-08 |
2017-05-31 |
Biogen MA Inc. |
Procoagulant fusion compound
|
ES2967617T3
(es)
|
2013-12-06 |
2024-05-03 |
Bioverativ Therapeutics Inc |
Herramientas de farmacocinética poblacional y sus usos
|
ES2927475T3
(es)
|
2014-01-10 |
2022-11-07 |
Bioverativ Therapeutics Inc |
Proteínas quiméricas de factor VIII y usos de las mismas
|
DK3097118T3
(en)
*
|
2014-01-20 |
2018-11-05 |
Octapharma Ag |
PROCEDURE FOR MANUFACTURING FACTOR VIII WITH AN IMPROVED FVIII: C / FVIII: AG RELATIONSHIP
|
AU2015214245B2
(en)
|
2014-02-04 |
2020-09-10 |
Biogen Ma Inc. |
Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications
|
EP3160478A4
(en)
|
2014-06-30 |
2018-05-16 |
Bioverativ Therapeutics Inc. |
Optimized factor ix gene
|
BR112017002090B1
(pt)
|
2014-08-04 |
2021-06-01 |
Csl Limited |
Composição aquosa de fator viii de coagulação e método de estabilizar uma molécula de fviii
|
MA40864A
(fr)
|
2014-10-31 |
2017-09-05 |
Biogen Ma Inc |
Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères
|
JP2018510212A
(ja)
|
2015-03-06 |
2018-04-12 |
ツェー・エス・エル・ベーリング・レコンビナント・ファシリティ・アクチエンゲゼルシャフト |
向上した半減期を有する改変したフォンヴィレブランド因子
|
JP6651548B2
(ja)
|
2015-05-22 |
2020-02-19 |
ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト |
改変フォン・ヴィルブランド因子を製造するための方法
|
SG10201910896UA
(en)
|
2015-05-22 |
2020-01-30 |
CSL Behring Lengnau AG |
Truncated von willebrand factor polypeptides for treating hemophilia
|
TWI741992B
(zh)
|
2015-08-03 |
2021-10-11 |
美商百歐維拉提夫治療公司 |
因子ix融合蛋白以及其製備及使用方法
|
WO2017050820A1
(en)
*
|
2015-09-22 |
2017-03-30 |
Novo Nordisk A/S |
Fviii fusion proteins
|
TWI777175B
(zh)
|
2015-11-13 |
2022-09-11 |
日商武田藥品工業股份有限公司 |
用於a型血友病基因治療之編碼表現增加之重組fviii變異體之病毒載體
|
EA202092049A1
(ru)
|
2015-11-13 |
2020-11-10 |
Баксалта Инкорпорейтед |
Вирусные векторы, кодирующие рекомбинантные варианты fviii с повышенной экспрессией для генной терапии гемофилии a
|
AU2017204955B2
(en)
|
2016-01-07 |
2021-04-01 |
CSL Behring Lengnau AG |
Mutated truncated von Willebrand Factor
|
CN116218863A
(zh)
|
2016-02-01 |
2023-06-06 |
比奥贝拉蒂治疗公司 |
优化的因子viii基因
|
US20230151078A1
(en)
|
2016-06-24 |
2023-05-18 |
Mogam Instiitute For Biomedical Research |
Recombinant single-chain fviii and chemical conjugate thereof
|
WO2017222337A1
(ko)
|
2016-06-24 |
2017-12-28 |
재단법인 목암생명과학연구소 |
Fviii 및 vwf 인자를 포함하는 키메라 단백질 및 그 용도
|
JP6351679B2
(ja)
*
|
2016-09-30 |
2018-07-04 |
エスケー ケミカルズ カンパニー リミテッド |
第viii因子とその誘導体の製造及び精製方法
|
CN110381986B
(zh)
|
2016-11-11 |
2023-08-18 |
康诺贝林伦瑙有限公司 |
用于血管外施予以治疗或预防凝血疾病的截短型冯维勒布兰德因子多肽
|
TW201828975A
(zh)
|
2016-11-11 |
2018-08-16 |
瑞士商Csl貝林重組技能公司 |
用於治療血友病之截短型類血友病因子(von Willebrand factor)多肽類
|
WO2018102743A1
(en)
|
2016-12-02 |
2018-06-07 |
Bioverativ Therapeutics Inc. |
Methods of treating hemophilic arthropathy using chimeric clotting factors
|
BR112019011198A2
(pt)
|
2016-12-02 |
2019-12-17 |
Bioverativ Therapeutics Inc |
métodos de indução de tolerância imune a fatores de coagulação
|
DK3641800T5
(da)
|
2017-06-22 |
2024-08-26 |
CSL Behring Lengnau AG |
Modulation af fviii immunogenicitet ved trunkeret vwf
|
IL322212A
(en)
|
2017-08-09 |
2025-09-01 |
Bioverativ Therapeutics Inc |
Nucleic acid molecules and their uses
|
JP7110360B2
(ja)
|
2017-10-09 |
2022-08-01 |
テルモ ビーシーティー バイオテクノロジーズ,エルエルシー |
凍結乾燥方法
|
KR20200118089A
(ko)
|
2018-02-01 |
2020-10-14 |
바이오버라티브 테라퓨틱스 인크. |
인자 viii을 발현하는 렌티바이러스 벡터의 용도
|
MX2020010369A
(es)
|
2018-04-04 |
2020-10-22 |
Sigilon Therapeutics Inc |
Particulas implantables y metodos relacionados.
|
LT3793588T
(lt)
|
2018-05-18 |
2025-06-25 |
Bioverativ Therapeutics Inc. |
Hemofilijos a gydymo būdai
|
BR112021000695A2
(pt)
|
2018-07-16 |
2021-04-20 |
Baxalta Incorporated |
métodos para tratar hemofilia a e para monitorar a eficácia da terapia gênica de fator viii de hemofilia a.
|
JP7602454B2
(ja)
|
2018-08-09 |
2024-12-18 |
バイオベラティブ セラピューティクス インコーポレイテッド |
核酸分子及び非ウイルス遺伝子治療のためのそれらの使用
|
US20220118063A1
(en)
*
|
2018-09-19 |
2022-04-21 |
Cell Machines, Inc. |
Methods and compositions related to improved factor viii long half-life coagulation complexes
|
UY38389A
(es)
|
2018-09-27 |
2020-04-30 |
Sigilon Therapeutics Inc |
Dispositivos implantables para terapia celular y métodos relacionados
|
TWI851647B
(zh)
|
2019-01-16 |
2024-08-11 |
日商武田藥品工業股份有限公司 |
用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
|
AU2020221340A1
(en)
|
2019-02-15 |
2021-09-16 |
Bayer Healthcare Llc |
Gene editing for hemophilia A with improved Factor VIII expression
|
WO2020242552A1
(en)
|
2019-03-14 |
2020-12-03 |
Terumo Bct Biotechnologies, Llc |
Multi-part lyophilization container and method of use
|
EP3736286A1
(en)
|
2019-05-09 |
2020-11-11 |
Biotest AG |
Single chain factor viii molecule
|
BR112021015776A2
(pt)
*
|
2019-06-05 |
2021-11-09 |
Bayer Healthcare Llc |
Edição de gene para hemofilia a com expressão de fator viii melhorada
|
WO2020257462A1
(en)
|
2019-06-19 |
2020-12-24 |
Bioverativ Therapeutics Inc. |
Recombinant factor viii-fc for treating hemophilia and low bone mineral density
|
JP2022538357A
(ja)
|
2019-07-04 |
2022-09-01 |
ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト |
第VIII凝固因子のin vitroでの安定性を向上させるための切断型フォン・ヴィレブランド因子(VWF)
|
KR20220097891A
(ko)
|
2019-09-30 |
2022-07-08 |
바이오버라티브 테라퓨틱스 인크. |
렌티바이러스 벡터 제형
|
EP4058049A1
(en)
|
2019-11-11 |
2022-09-21 |
CSL Behring Lengnau AG |
Polypeptides for inducing tolerance to factor viii
|
US20230023826A1
(en)
|
2019-12-12 |
2023-01-26 |
Takeda Pharmaceutical Company Limited |
Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
|
JP7681268B2
(ja)
*
|
2020-03-30 |
2025-05-22 |
シスメックス株式会社 |
血液凝固活性の測定方法
|
KR20230074703A
(ko)
|
2020-06-24 |
2023-05-31 |
바이오버라티브 테라퓨틱스 인크. |
유리 인자 viii을 상기 단백질이 발현되도록 변형된 렌티바이러스 벡터의 제제로부터 제거하는 방법
|
CN117858895A
(zh)
|
2021-06-14 |
2024-04-09 |
武田药品工业株式会社 |
使用表达增强的编码重组fviii变体的病毒载体的血友病a基因疗法
|
JP2024532262A
(ja)
|
2021-08-23 |
2024-09-05 |
バイオベラティブ セラピューティクス インコーポレイテッド |
最適化第viii因子遺伝子
|
CN118019758A
(zh)
|
2021-09-30 |
2024-05-10 |
比奥维拉迪维治疗股份有限公司 |
编码免疫原性降低的因子viii多肽的核酸
|
WO2024081309A1
(en)
|
2022-10-11 |
2024-04-18 |
Sigilon Therapeutics, Inc. |
Engineered cells and implantable elements for treatment of disease
|
TW202517669A
(zh)
|
2023-07-05 |
2025-05-01 |
日商武田藥品工業股份有限公司 |
用於A型血友病之基因療法的編碼表現增加之重組FVlll變異體的病毒載體
|