FI963072A0 - Multivariantti IL-3-hematopoieesifuusioproteiini - Google Patents

Multivariantti IL-3-hematopoieesifuusioproteiini

Info

Publication number
FI963072A0
FI963072A0 FI963072A FI963072A FI963072A0 FI 963072 A0 FI963072 A0 FI 963072A0 FI 963072 A FI963072 A FI 963072A FI 963072 A FI963072 A FI 963072A FI 963072 A0 FI963072 A0 FI 963072A0
Authority
FI
Finland
Prior art keywords
fusion protein
amino acids
given
hematopoiesis
multivariate
Prior art date
Application number
FI963072A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963072A (fi
Inventor
Christopher S Bauer
Mark Allen Abrams
Sarah Ruth Bradford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Barbara Kure Klein
Kearn John Patrick Mc
Peter O Olins
Kumnan Paik
John Warren Thomas
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of FI963072A publication Critical patent/FI963072A/fi
Publication of FI963072A0 publication Critical patent/FI963072A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI963072A 1994-02-04 1996-08-02 Multivariantti IL-3-hematopoieesifuusioproteiini FI963072A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/192,325 US6057133A (en) 1992-11-24 1994-02-04 Multivariant human IL-3 fusion proteins and their recombinant production
PCT/US1995/001185 WO1995021254A1 (en) 1994-02-04 1995-02-02 Multivariant il-3 hematopoiesis fusion protein

Publications (2)

Publication Number Publication Date
FI963072A FI963072A (fi) 1996-08-02
FI963072A0 true FI963072A0 (fi) 1996-08-02

Family

ID=22709185

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963072A FI963072A0 (fi) 1994-02-04 1996-08-02 Multivariantti IL-3-hematopoieesifuusioproteiini

Country Status (17)

Country Link
US (3) US6057133A (ko)
EP (2) EP0742826B1 (ko)
JP (1) JPH10502801A (ko)
KR (1) KR100370264B1 (ko)
CN (1) CN1227604A (ko)
AT (1) ATE302275T1 (ko)
BR (1) BR9506733A (ko)
CA (1) CA2182484A1 (ko)
CZ (1) CZ289904B6 (ko)
DE (1) DE69534381T2 (ko)
FI (1) FI963072A0 (ko)
MX (1) MX9603205A (ko)
NO (1) NO963225L (ko)
NZ (2) NZ330060A (ko)
PL (1) PL315791A1 (ko)
RO (1) RO118016B1 (ko)
WO (1) WO1995021254A1 (ko)

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JPH11500308A (ja) * 1995-02-03 1999-01-12 ジー．ディー．サール アンド カンパニー 新規ｃ−ＭＰＬリガンド
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
CZ295518B6 (cs) * 1995-10-05 2005-08-17 G. D. Searle & Co. Multifunkční agonisté hematopoetických receptorů
AU703627B2 (en) * 1995-10-05 1999-03-25 G.D. Searle & Co. Interleuken-3 (IL-3) receptor agonists
WO1997023639A1 (fr) * 1995-12-22 1997-07-03 Toray Industries, Inc. Procede de production de proteines fusionnees biologiquement actives
US6967092B1 (en) 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
KR100497423B1 (ko) * 1996-10-25 2005-07-07 지.디. 썰 엘엘씨 다기능 키메라 조혈 수용체 아고니스트
DE19900743A1 (de) * 1999-01-12 2000-07-13 Aventis Pharma Gmbh Neue komplexbildende Proteine
AR025984A1 (es) * 1999-10-07 2002-12-26 Maxygen Aps Polipeptidos oligomericos de cadena simple
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
WO2001076639A2 (en) * 2000-04-06 2001-10-18 Pharmacia Corporation Chemically-modified myelopoietin conjugates
EP1322323A4 (en) 2000-09-11 2004-07-28 Therapro Technologies Inc THIONIN AS AN ANTINEOPLASTIC AND IMMUNO-STIMULATING AGENT
MXPA04000231A (es) * 2001-07-11 2004-05-04 Maxygen Holdings Ltd Conjugados del factor de estimulacion de colonias de granulocitos.
AU2002331720B2 (en) 2001-08-24 2007-10-11 Johns Hopkins University Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer
IL158569A0 (en) * 2002-06-29 2004-05-12 Aquanova Ger Solubilisate Tech Isoflavone concentrates and methods for the production thereof
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7166574B2 (en) * 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US7414028B1 (en) * 2004-02-04 2008-08-19 Biosurface Engineering Technologies, Inc. Growth factor analogs
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
US7671012B2 (en) 2004-02-10 2010-03-02 Biosurface Engineering Technologies, Inc. Formulations and methods for delivery of growth factor analogs
US20060024347A1 (en) * 2004-02-10 2006-02-02 Biosurface Engineering Technologies, Inc. Bioactive peptide coatings
US7528105B1 (en) 2004-02-10 2009-05-05 Biosurface Engineering Technologies Heterodimeric chain synthetic heparin-binding growth factor analogs
JP4895826B2 (ja) 2004-02-20 2012-03-14 バイオサーフェス エンジニアリング テクノロジーズ，インク． 骨形成蛋白−２の正のモジュレーター
EP1773981A1 (en) * 2004-07-12 2007-04-18 Sorin Group Italia S.R.L. Device and method for growing human cells
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
CA2607844C (en) 2005-06-01 2012-07-10 Maxygen Holdings Ltd. Pegylated g-csf polypeptides and methods of producing same
US20090016988A1 (en) 2005-11-21 2009-01-15 Buckley J Thomas Modified Pore-Forming Protein Toxins and Use Thereof
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
CA2692240C (en) 2006-06-22 2018-03-13 Biosurface Engineering Technologies, Inc. Composition and method for delivery of bmp-2 amplifier/co-activator for enhancement of osteogenesis
CN101139399B (zh) * 2007-08-13 2011-01-26 重庆医科大学附属第二医院 重组靶向杀伤白血病细胞的融合蛋白及其制备方法和用途
EP2498795B1 (en) 2009-10-12 2016-12-07 The United States Of America, As Represented By The Secretary, Department of Health and Human Services Granulysin in immunotherapy
NZ602255A (en) 2010-03-04 2014-04-30 Pfenex Inc Method for producing soluble recombinant interferon protein without denaturing
PL2552949T3 (pl) 2010-04-01 2017-01-31 Pfenex Inc. Sposoby wytwarzania G-CSF w komórce gospodarza Pseudomonas
KR101958612B1 (ko) 2011-09-23 2019-03-14 블루버드 바이오, 인코포레이티드. 개선된 유전자 치료 방법
AU2018347796A1 (en) 2017-10-10 2020-05-07 Medicenna Therapeutics, Inc. IL-4-fusion formulations for treatment of central nervous system (CNS) tumors
WO2020024922A1 (zh) * 2018-07-30 2020-02-06 张晋宇 蛋白质异二聚体及其用途

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US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
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US5516512A (en) * 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
ES2106017T3 (es) * 1989-08-14 1997-11-01 Gist Brocades Nv Mutantes de interleucina-3 humana.
ATE103932T1 (de) * 1989-08-22 1994-04-15 Immunex Corp Fusionsprotein bestehend aus gm-csf und il-3.
US5073627A (en) * 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
US5108910A (en) * 1989-08-22 1992-04-28 Immunex Corporation DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
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Also Published As

Publication number Publication date
CN1227604A (zh) 1999-09-01
DE69534381T2 (de) 2006-11-23
RO118016B1 (ro) 2002-12-30
KR100370264B1 (ko) 2003-05-09
MX9603205A (es) 1997-03-29
US6057133A (en) 2000-05-02
US6030812A (en) 2000-02-29
NZ330060A (en) 1999-11-29
NO963225L (no) 1996-09-25
AU697433B2 (en) 1998-10-08
EP1482044A3 (en) 2005-05-18
CA2182484A1 (en) 1995-08-10
JPH10502801A (ja) 1998-03-17
FI963072A (fi) 1996-08-02
CZ229896A3 (en) 1996-12-11
PL315791A1 (en) 1996-12-09
EP0742826A1 (en) 1996-11-20
AU1835695A (en) 1995-08-21
WO1995021254A1 (en) 1995-08-10
ATE302275T1 (de) 2005-09-15
BR9506733A (pt) 1997-09-23
US6022535A (en) 2000-02-08
NO963225D0 (no) 1996-08-01
EP1482044A2 (en) 2004-12-01
NZ281421A (en) 1998-05-27
KR970700766A (ko) 1997-02-12
EP0742826B1 (en) 2005-08-17
CZ289904B6 (cs) 2002-04-17
DE69534381D1 (de) 2005-09-22

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