FI945556A - Tulehdustenvastaiset 3-aryyli-2-isoksatsoliinijohdannaiset - Google Patents
Tulehdustenvastaiset 3-aryyli-2-isoksatsoliinijohdannaiset Download PDFInfo
- Publication number
- FI945556A FI945556A FI945556A FI945556A FI945556A FI 945556 A FI945556 A FI 945556A FI 945556 A FI945556 A FI 945556A FI 945556 A FI945556 A FI 945556A FI 945556 A FI945556 A FI 945556A
- Authority
- FI
- Finland
- Prior art keywords
- pct
- aryl
- date
- sec
- inflammatory
- Prior art date
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15724193A | 1993-11-26 | 1993-11-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
FI945556A0 FI945556A0 (fi) | 1994-11-25 |
FI945556A true FI945556A (fi) | 1995-05-27 |
Family
ID=22562909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI945556A FI945556A (fi) | 1993-11-26 | 1994-11-25 | Tulehdustenvastaiset 3-aryyli-2-isoksatsoliinijohdannaiset |
Country Status (12)
Country | Link |
---|---|
US (1) | US5686434A (el) |
EP (1) | EP0730587B1 (el) |
JP (1) | JP2818820B2 (el) |
AT (1) | ATE187447T1 (el) |
CA (1) | CA2177375A1 (el) |
DE (1) | DE69422061T2 (el) |
DK (1) | DK0730587T3 (el) |
ES (1) | ES2139754T3 (el) |
FI (1) | FI945556A (el) |
GR (1) | GR3032506T3 (el) |
PT (1) | PT730587E (el) |
WO (1) | WO1995014680A1 (el) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0920421B1 (en) * | 1996-08-21 | 2002-11-06 | PHARMACIA & UPJOHN COMPANY | Isoxazoline derivatives useful as antimicrobials |
JP2001503443A (ja) * | 1996-11-11 | 2001-03-13 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規イミダゾ―及びオキサゾロピリジン |
DE59808163D1 (de) * | 1997-01-17 | 2003-06-05 | Basf Ag | Verfahren zur herstellung von schwefelhaltigen 2-chlor-3-(4,5-dihydroisoxazol-3-yl)-benzoesäuren |
US6022977A (en) | 1997-03-26 | 2000-02-08 | Dupont Pharmaceuticals Company | Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids |
ATE222894T1 (de) * | 1998-02-13 | 2002-09-15 | Upjohn Co | Substituierte aminophenylisoxazolinderivate verwendbar als antimikrobielle agenzien |
DE19852095A1 (de) | 1998-11-12 | 2000-05-18 | Basf Ag | Verfahren zur Herstellung von 2-Alkyl-3-(4,5-dihydroisoxazol-3-yl)-acylbenzolen |
CA2331816C (en) * | 1998-05-11 | 2010-11-16 | Basf Aktiengesellschaft | Method for producing isoxazoline-3-yl-acyl benzene |
AU763460B2 (en) * | 1998-10-09 | 2003-07-24 | Janssen Pharmaceutica N.V. | 4,5-dihydro-isoxazole derivatives and their pharmaceutical use |
CA2381802C (en) | 1999-08-21 | 2010-12-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Synergistic combination of roflumilast and salmeterol |
CA2388564C (en) * | 1999-09-17 | 2007-11-06 | Lg Chem Investment Ltd. | Caspase inhibitor |
KR100399361B1 (ko) | 1999-11-04 | 2003-09-26 | 주식회사 엘지생명과학 | 캐스파제 억제제 함유 치료제 조성물 |
DE19953024A1 (de) * | 1999-11-04 | 2001-05-10 | Merck Patent Gmbh | Isoxazolderivate als Phosphodiesterase VII-Hemmer |
EP1554572B1 (en) | 2001-07-25 | 2009-10-14 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
EA200501548A1 (ru) | 2003-04-01 | 2006-02-24 | Апплайд Резеч Системз Арс Холдинг Н.В. | Ингибиторы фосфодиэстераз при бесплодии |
KR100594544B1 (ko) | 2003-08-27 | 2006-06-30 | 주식회사 엘지생명과학 | 이소옥사졸린 구조를 갖는 캐스파제 저해제 |
BRPI0413330A (pt) * | 2003-08-29 | 2006-10-10 | Ranbaxy Lab Ltd | inibidores de fosfodiesterase do tipo iv, composição farmacêutica contendo os mesmos e processo para sua preparação |
WO2005051931A2 (en) * | 2003-11-26 | 2005-06-09 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
CA2557166C (en) * | 2004-03-26 | 2015-06-30 | Cytokine Pharmasciences, Inc. | Compounds, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor |
AU2005265131B2 (en) * | 2004-06-17 | 2012-02-23 | Infinity Discovery, Inc. | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners |
ES2370788T3 (es) * | 2005-02-07 | 2011-12-22 | Aerocrine Ab | Controlar flujo de aliento exhalado durante análisis. |
WO2006097273A1 (en) * | 2005-03-15 | 2006-09-21 | Ganial Immunotherapeutics Inc. | Compounds having immunomodulator activity |
EP3827747A1 (en) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
US7781460B2 (en) | 2005-09-05 | 2010-08-24 | Ranbaxy Laboratories Limited | Substituted indazoles as inhibitors of phosphodiesterase type-IV |
WO2007045980A1 (en) * | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type iv inhibitors |
EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
EP2068872A1 (en) * | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US20110021473A1 (en) * | 2006-09-22 | 2011-01-27 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type-iv |
US20100029728A1 (en) * | 2006-09-22 | 2010-02-04 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
EP2170930B3 (en) | 2007-06-04 | 2013-10-02 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
NZ616673A (en) | 2009-02-20 | 2014-08-29 | To Bbb Holding B V | Glutathione-based drug delivery system |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
CN101781294B (zh) * | 2010-03-10 | 2012-02-01 | 天津药物研究院 | 一类咪唑的衍生物、其制备方法和用途 |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
DK2681236T3 (en) | 2011-03-01 | 2018-04-16 | Synergy Pharmaceuticals Inc | PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS |
DK2691379T3 (en) | 2011-03-31 | 2017-02-13 | Bayer Ip Gmbh | HERBICID AND FUNGICID ACTIVE 3-PHENYLISOXAZOLINE-5-CARBOXAMIDES AND 3-PHENYLISOXAZOLIN-5-THIOAMIDES |
EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
IN2015DN01315A (el) * | 2012-09-25 | 2015-07-03 | Bayer Cropscience Ag | |
CA2885692C (en) * | 2012-09-25 | 2018-05-22 | Bayer Cropscience Ag | Herbicidal and fungicidal 5-oxy-substituted 3-phenylisoxazoline-5-carboxamides and 5-oxy-substituted 3-phenylisoxazoline-5-thioamides |
EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP3004138B1 (en) | 2013-06-05 | 2024-03-13 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
CN110799511B (zh) | 2017-06-13 | 2023-09-01 | 拜耳公司 | 除草活性的四氢和二氢呋喃甲酰胺的3-苯基异噁唑啉-5-甲酰胺 |
BR122023020315A2 (pt) | 2017-06-13 | 2023-12-12 | Bayer Aktiengesellschaft | 3-fenilisoxazolina-5-carboxamidas |
WO2019034602A1 (de) | 2017-08-17 | 2019-02-21 | Bayer Aktiengesellschaft | Herbizid wirksame 3-phenyl-5-trifluormethylisoxazolin-5-carboxamide von cyclopentylcarbonsäuren und -estern |
EP3743411B1 (de) | 2018-01-25 | 2022-12-21 | Bayer Aktiengesellschaft | Herbizid wirksame 3-phenylisoxazolin-5-carboxamide von cyclopentenylcarbonsäurederivaten |
DK3937637T3 (da) | 2019-03-12 | 2023-07-24 | Bayer Ag | Herbicidt virksomme 3-phenylisoxazolin-5-carboxamider af s-holdige cyclopentenylcarbonsyreestere |
US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4193926A (en) * | 1974-03-20 | 1980-03-18 | Schering Aktiengesellschaft | 4-(Polyalkoxy phenyl)-2-pyrrolidones |
JPS62103070A (ja) * | 1985-10-29 | 1987-05-13 | Mitsui Toatsu Chem Inc | イソオキサゾリン誘導体および植物生長調節剤 |
US4912120A (en) * | 1986-03-14 | 1990-03-27 | Syntex (U.S.A.) Inc. | 3,5-substituted 4,5-dihydroisoxazoles as transglutaminase inhibitors |
HU215433B (hu) * | 1986-04-29 | 2000-05-28 | Pfizer Inc. | Eljárás új 2-oxo-5-fenil-pirimidin-származékok előállítására |
IE59813B1 (en) * | 1986-05-09 | 1994-04-06 | Warner Lambert Co | Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them |
ZA872997B (en) * | 1986-05-09 | 1988-12-28 | Warner Lambert Co | Novel styryl pyrazoles,isoxazoles and analogs thereof having activity as 5-lipoxygenase inhibitors,pharmaceutical compositions and methods of use therefor |
DE3736113A1 (de) * | 1987-10-26 | 1989-05-03 | Hoechst Ag | Arzneimittel, darin enthaltene phosphorhaltige 2-isoxazoline und isoxazole, sowie herstellungsverfahren fuer diese heterocyclischen verbindungen |
US4933464A (en) * | 1988-04-25 | 1990-06-12 | W. R. Grace & Co.-Conn. | Process for forming 3-phenylisoxazolines and 3-phenylisoxazoles |
US4952700A (en) * | 1988-04-25 | 1990-08-28 | W.R. Grace & Co.-Conn. | Preparation of isoxazolines and isoxazoles |
CA2017383A1 (en) * | 1989-06-08 | 1990-12-08 | Raymond R. Martodam | Use of vanilloids for the treatment of respiratory diseases or disorders |
WO1991007177A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders |
GB9007762D0 (en) * | 1990-04-05 | 1990-06-06 | Beecham Group Plc | Novel compounds |
EP0451790A1 (de) * | 1990-04-12 | 1991-10-16 | Hoechst Aktiengesellschaft | 3,5-disubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu deren Herstellung, diese enthaltende Mittel und ihre Verwendung |
DE4026018A1 (de) * | 1990-08-17 | 1992-02-20 | Hoechst Ag | Isoxazoline oder isothiazoline enthaltende pflanzenschuetzende mittel und neue isoxazoline und isothiazoline |
AU9030691A (en) * | 1990-11-06 | 1992-05-26 | Smithkline Beecham Corporation | Imidazolidinone compounds |
PT100441A (pt) * | 1991-05-02 | 1993-09-30 | Smithkline Beecham Corp | Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso |
AU2869092A (en) * | 1991-10-11 | 1993-05-03 | Smithkline Beecham Corporation | Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production |
-
1994
- 1994-10-12 ES ES94927778T patent/ES2139754T3/es not_active Expired - Lifetime
- 1994-10-12 JP JP7514932A patent/JP2818820B2/ja not_active Expired - Fee Related
- 1994-10-12 CA CA002177375A patent/CA2177375A1/en not_active Abandoned
- 1994-10-12 DE DE69422061T patent/DE69422061T2/de not_active Expired - Fee Related
- 1994-10-12 AT AT94927778T patent/ATE187447T1/de not_active IP Right Cessation
- 1994-10-12 DK DK94927778T patent/DK0730587T3/da active
- 1994-10-12 PT PT94927778T patent/PT730587E/pt unknown
- 1994-10-12 US US08/640,945 patent/US5686434A/en not_active Expired - Fee Related
- 1994-10-12 EP EP94927778A patent/EP0730587B1/en not_active Expired - Lifetime
- 1994-10-12 WO PCT/IB1994/000313 patent/WO1995014680A1/en active IP Right Grant
- 1994-11-25 FI FI945556A patent/FI945556A/fi not_active Application Discontinuation
-
2000
- 2000-01-27 GR GR20000400200T patent/GR3032506T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69422061D1 (de) | 2000-01-13 |
CA2177375A1 (en) | 1995-06-01 |
DK0730587T3 (da) | 2000-04-10 |
EP0730587B1 (en) | 1999-12-08 |
ATE187447T1 (de) | 1999-12-15 |
DE69422061T2 (de) | 2000-03-30 |
US5686434A (en) | 1997-11-11 |
FI945556A0 (fi) | 1994-11-25 |
EP0730587A1 (en) | 1996-09-11 |
JP2818820B2 (ja) | 1998-10-30 |
ES2139754T3 (es) | 2000-02-16 |
WO1995014680A1 (en) | 1995-06-01 |
JPH09500146A (ja) | 1997-01-07 |
GR3032506T3 (en) | 2000-05-31 |
PT730587E (pt) | 2000-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI945556A (fi) | Tulehdustenvastaiset 3-aryyli-2-isoksatsoliinijohdannaiset | |
FI945557A (fi) | Isoksatsoliiniyhdisteet tulehduksenvastaisina aineina | |
FI945555A (fi) | Substituoituja oksindoleja | |
DK0672031T3 (da) | Catecholdiethere som selektive PDE IV-inhibitorer | |
ZA9810735B (en) | Novel benzenesulfonamide inhibitors of pde-iv and their therapeutic use | |
DK0980374T3 (da) | Phosphodiesterase 4-inhiberende diazepinoindoloner. | |
DK0752990T3 (da) | Benzisothiazolderivater som inhibitorer af 5-lipoxygenasebiosyntese | |
ATE186528T1 (de) | Indol-carbamate als leukotriene antagonisten | |
MX9603943A (es) | Compuestos de isoxazolina como inhibidores de 5-lipooxigenasa. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |