FI940806A0 - Sykliset johdokset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi - Google Patents
Sykliset johdokset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksiInfo
- Publication number
- FI940806A0 FI940806A0 FI940806A FI940806A FI940806A0 FI 940806 A0 FI940806 A0 FI 940806A0 FI 940806 A FI940806 A FI 940806A FI 940806 A FI940806 A FI 940806A FI 940806 A0 FI940806 A0 FI 940806A0
- Authority
- FI
- Finland
- Prior art keywords
- compounds
- preparation
- drugs containing
- cyclic derivatives
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4305388A DE4305388A1 (de) | 1993-02-22 | 1993-02-22 | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE4332168A DE4332168A1 (de) | 1993-02-22 | 1993-09-22 | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI940806A0 true FI940806A0 (fi) | 1994-02-21 |
| FI940806A FI940806A (fi) | 1994-08-23 |
Family
ID=25923309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI940806A FI940806A (fi) | 1993-02-22 | 1994-02-21 | Sykliset johdokset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US5519036A (fi) |
| EP (1) | EP0612741B1 (fi) |
| JP (1) | JP3545446B2 (fi) |
| KR (1) | KR100322319B1 (fi) |
| CN (1) | CN1048490C (fi) |
| AT (1) | ATE167185T1 (fi) |
| AU (1) | AU673875B2 (fi) |
| CA (1) | CA2116068A1 (fi) |
| CZ (1) | CZ37494A3 (fi) |
| DE (2) | DE4332168A1 (fi) |
| DK (1) | DK0612741T3 (fi) |
| ES (1) | ES2118992T3 (fi) |
| FI (1) | FI940806A (fi) |
| HU (1) | HU222112B1 (fi) |
| IL (1) | IL108733A (fi) |
| MX (1) | MX9401315A (fi) |
| NO (1) | NO305081B1 (fi) |
| NZ (1) | NZ250944A (fi) |
| PH (1) | PH30602A (fi) |
| PL (1) | PL178215B1 (fi) |
| SG (1) | SG52300A1 (fi) |
| UA (1) | UA39099C2 (fi) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4332168A1 (de) * | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE19624069A1 (de) * | 1996-06-17 | 1997-12-18 | Thomae Gmbh Dr K | Benzazepinderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| DE4424974A1 (de) * | 1994-07-15 | 1996-01-18 | Thomae Gmbh Dr K | Harnstoff- und Carbaminsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE4427838A1 (de) * | 1994-08-05 | 1996-02-08 | Thomae Gmbh Dr K | Kondensierte Azepinderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE4429079A1 (de) * | 1994-08-17 | 1996-02-22 | Thomae Gmbh Dr K | Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| EE9700141A (et) * | 1994-12-23 | 1997-12-15 | Dr. Karl Thomae Gmbh | Piperasiinderivaadid, neid sisaldavad ravimid, nende kasutamine ja valmistamise meetod |
| ZA963391B (en) * | 1995-05-24 | 1997-10-29 | Du Pont Merck Pharma | Isoxazoline fibrinogen receptor antagonists. |
| US5925635A (en) * | 1996-04-17 | 1999-07-20 | Dupont Pharmaceuticals Company | N-(amidinophenyl) cyclourea analogs as factor XA inhibitors |
| IL123986A (en) | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| EP1009758B1 (en) | 1997-08-29 | 2005-06-01 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
| US6340687B1 (en) | 1997-09-03 | 2002-01-22 | American Home Products Corporation | Substituted tetrahydro-pyrimidine-2(1H)-thione HDL-C elevators useful as antiatherosclerotic agents |
| EP1065200A4 (en) * | 1998-03-19 | 2003-01-02 | Ajinomoto Kk | Aminoisoquinoline DERIVATIVES |
| EP1165531A1 (en) * | 1999-03-19 | 2002-01-02 | Du Pont Pharmaceuticals Company | N-adamant-1-yl-n'- 4-chlorobenzothiazol-2-yl] urea useful in the treatment of inflammation and as an anticancer radiosensitizing agent |
| US6492406B1 (en) * | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
| NZ551453A (en) | 2001-04-18 | 2008-02-29 | Euro Celtique Sa | Nociceptin analogs for the treatment of pain |
| US7291603B2 (en) | 2002-07-24 | 2007-11-06 | Ptc Therapeutics, Inc. | Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations |
| US7135484B2 (en) | 2002-08-14 | 2006-11-14 | Abbott Laboratories | Azabicyclic compounds are central nervous system active agents |
| JP4629576B2 (ja) * | 2002-08-14 | 2011-02-09 | アボット・ラボラトリーズ | 中枢神経系活性剤であるアザビシクロ化合物 |
| US7696193B2 (en) | 2002-12-20 | 2010-04-13 | Glaxo Group Limited | Benzazepine derivatives for the treatment of neurological disorders |
| GB0405628D0 (en) * | 2004-03-12 | 2004-04-21 | Glaxo Group Ltd | Novel compounds |
| EP1621535A1 (en) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
| EP1799684B1 (en) * | 2004-10-04 | 2014-12-03 | Millennium Pharmaceuticals, Inc. | Lactam compounds useful as protein kinase inhibitors |
| WO2006117657A1 (en) * | 2005-05-03 | 2006-11-09 | Ranbaxy Laboratories Limited | Triazolone derivatives as anti-inflammatory agents |
| EP1910297B1 (en) | 2005-07-11 | 2016-05-25 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| PE20080942A1 (es) | 2006-06-20 | 2008-09-03 | Wyeth Corp | Compuestos 1-n-amino-2-imidazolidinonas como inhibidores del canal de potasion kv1.5 |
| JP2009543812A (ja) * | 2006-07-20 | 2009-12-10 | キャスケイド・セラピューティクス・インコーポレイテッド | ５−ＨＴ２Ｃリガンドとしてのテトラヒドロ−５Ｈ−ピリド［２，３−ｄ］アゼピン |
| WO2008036540A2 (en) | 2006-09-20 | 2008-03-27 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| JP5562865B2 (ja) | 2007-12-17 | 2014-07-30 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｔｒｐｖ１のイミダゾロ−、オキサゾロ−、及びチアゾロピリミジン・モジュレーター |
| WO2009079765A1 (en) * | 2007-12-21 | 2009-07-02 | Cascade Therapeutics Inc. | Compounds with activity at the 5-ht2c receptor |
| US8455514B2 (en) * | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| AR074487A1 (es) | 2008-12-05 | 2011-01-19 | Millennium Pharm Inc | Tiolactamas inhibidoras de proteinquinasas plk, composiciones farmaceuticas que las contienen y usos de las mismas para el tratamiento de trastornos proliferativos e inflamatorios, en particular cancer. |
| JP2012525386A (ja) | 2009-05-01 | 2012-10-22 | アエリエ・ファーマシューティカルズ・インコーポレーテッド | 疾患の治療のための二重機構阻害剤 |
| UA105794C2 (uk) * | 2009-06-26 | 2014-06-25 | Новартіс Аг | 1,3-ДИЗАМІЩЕНІ ПОХІДНІ ІМІДАЗОЛІДИН-2-ОНУ ЯК ІНГІБІТОРИ Cyp17 |
| ES2656218T3 (es) | 2011-04-28 | 2018-02-26 | Novartis Ag | Inhibidores de 17 alfa-hidroxilasa/C17,20-liasa |
| US20140275160A1 (en) | 2013-03-15 | 2014-09-18 | Aerie Pharmaceuticals, Inc. | Combination therapy |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| KR102579582B1 (ko) | 2015-11-17 | 2023-09-15 | 에어리 파마슈티컬즈, 인코포레이티드 | 키나아제 억제제 및 이의 중간체의 제조 방법 |
| CA3035566A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| KR20190135027A (ko) | 2017-03-31 | 2019-12-05 | 에어리 파마슈티컬즈, 인코포레이티드 | 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물 |
| US11427563B2 (en) | 2018-09-14 | 2022-08-30 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CA3216456A1 (en) * | 2021-05-05 | 2022-11-10 | Diamond Therapeutics Inc. | 5-ht2a and/or 5-ht2c receptor agonists |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9106571D0 (en) * | 1991-03-27 | 1991-05-15 | Erba Carlo Spa | Derivatives of substituted imidazol-2-one and process for their preparation |
| DE4107857A1 (de) * | 1991-03-12 | 1992-09-17 | Thomae Gmbh Dr K | Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE4112014A1 (de) * | 1991-04-12 | 1992-10-15 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel zur behandlung von erkrankungen des zentralnervensystems und zur foerderung der cerebralen durchblutung |
| DE4127404A1 (de) * | 1991-08-19 | 1993-02-25 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE4332168A1 (de) * | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| AU675484B2 (en) * | 1993-03-24 | 1997-02-06 | Neurosearch A/S | Benzimidazole compounds, their use and preparation |
-
1993
- 1993-09-22 DE DE4332168A patent/DE4332168A1/de not_active Ceased
-
1994
- 1994-02-21 ES ES94102557T patent/ES2118992T3/es not_active Expired - Lifetime
- 1994-02-21 CA CA002116068A patent/CA2116068A1/en not_active Abandoned
- 1994-02-21 DK DK94102557T patent/DK0612741T3/da active
- 1994-02-21 JP JP02272794A patent/JP3545446B2/ja not_active Expired - Fee Related
- 1994-02-21 DE DE59406157T patent/DE59406157D1/de not_active Expired - Fee Related
- 1994-02-21 UA UA94005097A patent/UA39099C2/uk unknown
- 1994-02-21 NO NO940595A patent/NO305081B1/no not_active IP Right Cessation
- 1994-02-21 PL PL94302302A patent/PL178215B1/pl unknown
- 1994-02-21 PH PH47791A patent/PH30602A/en unknown
- 1994-02-21 AT AT94102557T patent/ATE167185T1/de not_active IP Right Cessation
- 1994-02-21 KR KR1019940003193A patent/KR100322319B1/ko not_active IP Right Cessation
- 1994-02-21 MX MX9401315A patent/MX9401315A/es unknown
- 1994-02-21 FI FI940806A patent/FI940806A/fi unknown
- 1994-02-21 CZ CZ94374A patent/CZ37494A3/cs unknown
- 1994-02-21 AU AU56324/94A patent/AU673875B2/en not_active Ceased
- 1994-02-21 HU HU9400493A patent/HU222112B1/hu not_active IP Right Cessation
- 1994-02-21 EP EP94102557A patent/EP0612741B1/de not_active Expired - Lifetime
- 1994-02-21 SG SG1996002477A patent/SG52300A1/en unknown
- 1994-02-22 CN CN94102252A patent/CN1048490C/zh not_active Expired - Fee Related
- 1994-02-22 US US08/200,125 patent/US5519036A/en not_active Expired - Lifetime
- 1994-02-22 NZ NZ250944A patent/NZ250944A/en unknown
- 1994-02-22 IL IL108733A patent/IL108733A/en not_active IP Right Cessation
-
1995
- 1995-05-02 US US08/434,136 patent/US5612335A/en not_active Expired - Lifetime
-
1996
- 1996-12-17 US US08/768,365 patent/US5827849A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR100322319B1 (ko) | 2002-06-26 |
| KR940019704A (ko) | 1994-09-14 |
| UA39099C2 (uk) | 2001-06-15 |
| NO940595L (no) | 1994-08-23 |
| MX9401315A (es) | 1994-08-31 |
| EP0612741A1 (de) | 1994-08-31 |
| SG52300A1 (en) | 1998-09-28 |
| HU9400493D0 (en) | 1994-05-30 |
| EP0612741B1 (de) | 1998-06-10 |
| CA2116068A1 (en) | 1994-08-23 |
| IL108733A (en) | 1998-01-04 |
| NO940595D0 (no) | 1994-02-21 |
| JP3545446B2 (ja) | 2004-07-21 |
| FI940806A (fi) | 1994-08-23 |
| ATE167185T1 (de) | 1998-06-15 |
| CN1048490C (zh) | 2000-01-19 |
| US5519036A (en) | 1996-05-21 |
| US5827849A (en) | 1998-10-27 |
| US5612335A (en) | 1997-03-18 |
| NO305081B1 (no) | 1999-03-29 |
| HU222112B1 (hu) | 2003-04-28 |
| HUT70768A (en) | 1995-10-30 |
| CZ37494A3 (en) | 1994-12-15 |
| PL178215B1 (pl) | 2000-03-31 |
| CN1099755A (zh) | 1995-03-08 |
| DK0612741T3 (da) | 1999-03-29 |
| JPH06256343A (ja) | 1994-09-13 |
| ES2118992T3 (es) | 1998-10-01 |
| NZ250944A (en) | 1996-02-27 |
| IL108733A0 (en) | 1994-05-30 |
| AU5632494A (en) | 1994-08-25 |
| PH30602A (en) | 1997-07-31 |
| DE4332168A1 (de) | 1995-03-23 |
| DE59406157D1 (de) | 1998-07-16 |
| AU673875B2 (en) | 1996-11-28 |
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