FI93309B - Förfarande för framställning av ett stabilt zink-protamin- -interferonkomplex - Google Patents
Förfarande för framställning av ett stabilt zink-protamin- -interferonkomplex Download PDFInfo
- Publication number
- FI93309B FI93309B FI893929A FI893929A FI93309B FI 93309 B FI93309 B FI 93309B FI 893929 A FI893929 A FI 893929A FI 893929 A FI893929 A FI 893929A FI 93309 B FI93309 B FI 93309B
- Authority
- FI
- Finland
- Prior art keywords
- interferon
- protamine
- zinc
- glycine
- complex
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1824387 | 1987-02-24 | ||
US07/018,243 US4853218A (en) | 1987-02-24 | 1987-02-24 | Zinc-protamine-alpha interferon complex |
PCT/US1988/000410 WO1988006456A1 (en) | 1987-02-24 | 1988-02-23 | Stable interferon complexes |
US8800410 | 1988-02-23 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI893929A0 FI893929A0 (sv) | 1989-08-22 |
FI893929A FI893929A (sv) | 1989-08-22 |
FI93309B true FI93309B (sv) | 1994-12-15 |
FI93309C FI93309C (sv) | 1995-03-27 |
Family
ID=21786960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI893929A FI93309C (sv) | 1987-02-24 | 1989-08-22 | Förfarande för framställning av ett stabilt zink-protamin- -interferonkomplex |
Country Status (23)
Country | Link |
---|---|
US (1) | US4853218A (sv) |
EP (2) | EP0375678A1 (sv) |
JP (1) | JPH0611712B2 (sv) |
KR (1) | KR940001372B1 (sv) |
AT (1) | ATE76580T1 (sv) |
AU (1) | AU608584B2 (sv) |
CA (1) | CA1316105C (sv) |
DE (1) | DE3871407D1 (sv) |
DK (1) | DK167048B1 (sv) |
ES (1) | ES2032009T3 (sv) |
FI (1) | FI93309C (sv) |
GR (1) | GR3005358T3 (sv) |
HU (1) | HU201881B (sv) |
IE (1) | IE61340B1 (sv) |
IL (1) | IL85523A (sv) |
MX (1) | MX9203328A (sv) |
MY (1) | MY103212A (sv) |
NO (1) | NO173279C (sv) |
NZ (1) | NZ223598A (sv) |
OA (1) | OA09737A (sv) |
PT (1) | PT86810B (sv) |
WO (1) | WO1988006456A1 (sv) |
ZA (1) | ZA881258B (sv) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5028422A (en) * | 1986-05-27 | 1991-07-02 | Schering Corporation | Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon |
PH26198A (en) * | 1986-05-27 | 1992-03-18 | Schering Corp | Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon |
EP0307097B1 (en) * | 1987-09-08 | 1993-06-09 | Takeda Chemical Industries, Ltd. | Water-insolubilized cytokines |
MX9203319A (es) * | 1990-06-04 | 1992-07-31 | Schering Corp | Metodo para la preparacion de cristales de alfa-2 interferona. |
US5912015A (en) | 1992-03-12 | 1999-06-15 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
US6514533B1 (en) | 1992-06-11 | 2003-02-04 | Alkermas Controlled Therapeutics, Inc. | Device for the sustained release of aggregation-stabilized, biologically active agent |
US5711968A (en) * | 1994-07-25 | 1998-01-27 | Alkermes Controlled Therapeutics, Inc. | Composition and method for the controlled release of metal cation-stabilized interferon |
DK0674506T3 (da) * | 1992-12-02 | 2001-01-08 | Alkermes Inc | Væksthormonholdige mikrosfærer med styret frigivelse |
US5441734A (en) * | 1993-02-25 | 1995-08-15 | Schering Corporation | Metal-interferon-alpha crystals |
US6087324A (en) * | 1993-06-24 | 2000-07-11 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
AU706180B2 (en) * | 1994-07-25 | 1999-06-10 | Alkermes Controlled Therapeutics, Inc. | Controlled release of metal cation-stabilized interferon |
US5904935A (en) * | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
JP3837769B2 (ja) * | 1995-06-12 | 2006-10-25 | 大塚製薬株式会社 | 抗ウイルス剤 |
EP0850051A2 (en) * | 1995-08-31 | 1998-07-01 | Alkermes Controlled Therapeutics, Inc. | Composition for sustained release of an agent |
ATE203157T1 (de) * | 1996-12-20 | 2001-08-15 | Alza Corp | Injizierbare depotgelzubereitung und herstellungsverfahren |
US6465425B1 (en) * | 2000-02-10 | 2002-10-15 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins |
US20030211974A1 (en) * | 2000-03-21 | 2003-11-13 | Brodbeck Kevin J. | Gel composition and methods |
US20070196415A1 (en) * | 2002-11-14 | 2007-08-23 | Guohua Chen | Depot compositions with multiple drug release rate controls and uses thereof |
EP1446100B1 (en) * | 2001-11-14 | 2011-05-04 | Durect Corporation | Injectable depot compositions and uses thereof |
IL162001A0 (en) * | 2001-11-14 | 2005-11-20 | Alza Corp | Catheter injectable depot compositions and uses thereof |
US20030157178A1 (en) * | 2001-11-14 | 2003-08-21 | Guohua Chen | Injectable depot composition |
AR039729A1 (es) | 2002-06-25 | 2005-03-09 | Alza Corp | Formulaciones de deposito de corta duracion |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
EP2030611A1 (en) | 2002-07-31 | 2009-03-04 | Alza Corporation | Injectable multimodal polymer depot compositions and uses thereof |
KR20050038008A (ko) * | 2002-07-31 | 2005-04-25 | 알자 코포레이션 | 주사용 저장형 조성물 및 이의 용도 |
US20120225033A1 (en) * | 2010-11-24 | 2012-09-06 | Durect Corporation | Biodegradable Drug Delivery Composition |
DE60325511D1 (de) * | 2002-11-06 | 2009-02-05 | Alza Corp | Depot-formulierungen mit verzögerter freisetzung |
BR0317888A (pt) * | 2002-12-31 | 2005-12-06 | Altus Pharmaceuticals Inc | Cristais do hormÈnio do crescimento humano e processos para preparação dos mesmos |
NZ571243A (en) * | 2002-12-31 | 2010-04-30 | Altus Pharmaceuticals Inc | Complexes of protein crystals and ionic polymers comprising human growth hormone and protamine |
US20070184084A1 (en) * | 2003-05-30 | 2007-08-09 | Guohua Chen | Implantable elastomeric caprolactone depot compositions and uses thereof |
WO2004108111A1 (en) * | 2003-05-30 | 2004-12-16 | Alza Corporation | Implantable elastomeric depot compositions, uses thereof and method of manufacturing |
US20050281879A1 (en) * | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
US20050106214A1 (en) * | 2003-11-14 | 2005-05-19 | Guohua Chen | Excipients in drug delivery vehicles |
US7812049B2 (en) * | 2004-01-22 | 2010-10-12 | Vicept Therapeutics, Inc. | Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists |
US20060142234A1 (en) * | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
JP2009521486A (ja) * | 2005-12-23 | 2009-06-04 | アルタス ファーマシューティカルズ インコーポレイテッド | ポリカチオン錯化タンパク質結晶を含む組成物およびこれを使用した治療法 |
US7753078B2 (en) | 2007-04-19 | 2010-07-13 | Husco International Inc. | Hybrid hydraulic joystick with an integral pressure sensor and an outlet port |
US7753077B2 (en) | 2007-04-19 | 2010-07-13 | Husco International Inc. | Hybrid hydraulic joystick for electrically operating valves |
JP4889782B2 (ja) * | 2008-12-24 | 2012-03-07 | 株式会社マルハニチロ食品 | プロタミン及び/またはその塩と酸性高分子化合物とを含む生理活性複合体及びその用途 |
ES2791683T3 (es) | 2009-01-28 | 2020-11-05 | Smartcells Inc | Sistemas a base de conjugados para la administración controlada de fármacos |
CA2931547A1 (en) | 2013-12-09 | 2015-06-18 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
KR20220140711A (ko) | 2020-01-13 | 2022-10-18 | 듀렉트 코퍼레이션 | 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1282504A (fr) * | 1954-06-03 | 1962-01-27 | Novo Terapeutisk Labor As | Procédé de production de suspensions stables d'insuline zinc-protamine |
US3912807A (en) * | 1974-04-18 | 1975-10-14 | American Home Prod | Treatment of diabetes using somatostatin and insulin |
IN150740B (sv) * | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
CY1346A (en) * | 1980-01-08 | 1987-01-16 | Biogen Nv | Dna sequences,recombinant dna molecules and processes for producing human interferon-like polypeptides |
ES8302778A1 (es) * | 1980-11-10 | 1983-02-01 | Genentech Inc | Un procedimiento para producir un polipeptido antiviral. |
EP0082481B2 (en) * | 1981-12-23 | 1990-09-12 | Schering Corporation | Stabilised alpha-interferon formulations and their preparation |
US4605555A (en) * | 1984-09-20 | 1986-08-12 | Sun Star Kabushiki Kaisha | Composition and method for treating keratosic disorder of skin and mucosa |
-
1987
- 1987-02-24 US US07/018,243 patent/US4853218A/en not_active Expired - Fee Related
-
1988
- 1988-02-19 MY MYPI88000169A patent/MY103212A/en unknown
- 1988-02-23 IE IE48088A patent/IE61340B1/en not_active IP Right Cessation
- 1988-02-23 ES ES198888301500T patent/ES2032009T3/es not_active Expired - Lifetime
- 1988-02-23 HU HU881926A patent/HU201881B/hu not_active IP Right Cessation
- 1988-02-23 ZA ZA881258A patent/ZA881258B/xx unknown
- 1988-02-23 AU AU13946/88A patent/AU608584B2/en not_active Ceased
- 1988-02-23 PT PT86810A patent/PT86810B/pt not_active IP Right Cessation
- 1988-02-23 NZ NZ223598A patent/NZ223598A/xx unknown
- 1988-02-23 IL IL85523A patent/IL85523A/xx not_active IP Right Cessation
- 1988-02-23 WO PCT/US1988/000410 patent/WO1988006456A1/en active IP Right Grant
- 1988-02-23 EP EP88902309A patent/EP0375678A1/en active Pending
- 1988-02-23 DE DE8888301500T patent/DE3871407D1/de not_active Expired - Fee Related
- 1988-02-23 EP EP88301500A patent/EP0281299B1/en not_active Expired - Lifetime
- 1988-02-23 JP JP63502283A patent/JPH0611712B2/ja not_active Expired - Lifetime
- 1988-02-23 CA CA000559620A patent/CA1316105C/en not_active Expired - Fee Related
- 1988-02-23 AT AT88301500T patent/ATE76580T1/de active
- 1988-02-23 KR KR1019880701321A patent/KR940001372B1/ko not_active IP Right Cessation
- 1988-10-14 NO NO884596A patent/NO173279C/no unknown
- 1988-10-19 DK DK582188A patent/DK167048B1/da not_active IP Right Cessation
-
1989
- 1989-08-22 FI FI893929A patent/FI93309C/sv not_active IP Right Cessation
- 1989-08-24 OA OA59633A patent/OA09737A/en unknown
-
1992
- 1992-06-25 MX MX9203328A patent/MX9203328A/es unknown
- 1992-08-06 GR GR920401691T patent/GR3005358T3/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: SCHERING CORPORATION |