FI925522A - Menetelmä hypoglykeemisten ja hypokolesteroleemisten oksa- ja tiatsolidiinidionien valmistamiseksi - Google Patents

Menetelmä hypoglykeemisten ja hypokolesteroleemisten oksa- ja tiatsolidiinidionien valmistamiseksi Download PDF

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Publication number
FI925522A
FI925522A FI925522A FI925522A FI925522A FI 925522 A FI925522 A FI 925522A FI 925522 A FI925522 A FI 925522A FI 925522 A FI925522 A FI 925522A FI 925522 A FI925522 A FI 925522A
Authority
FI
Finland
Prior art keywords
oxa
hypocholesterolemic
thiazolidinediones
hypoglycemic
preparation
Prior art date
Application number
FI925522A
Other languages
English (en)
Swedish (sv)
Other versions
FI94756B (fi
FI94756C (fi
FI925522A0 (fi
Inventor
Steven Wayne Goldstein
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI925522A0 publication Critical patent/FI925522A0/fi
Publication of FI925522A publication Critical patent/FI925522A/fi
Publication of FI94756B publication Critical patent/FI94756B/fi
Application granted granted Critical
Publication of FI94756C publication Critical patent/FI94756C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Paints Or Removers (AREA)
FI925522A 1990-06-05 1992-12-04 Menetelmä hypoglykeemisten ja hypokolesteroleemisten oksa- ja tiatsolidiinidionien valmistamiseksi FI94756C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53361590 1990-06-05
US07/533,615 US5037842A (en) 1990-06-05 1990-06-05 Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents
PCT/US1991/003541 WO1991019704A2 (en) 1990-06-05 1991-05-20 Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents
US9103541 1991-05-20

Publications (4)

Publication Number Publication Date
FI925522A0 FI925522A0 (fi) 1992-12-04
FI925522A true FI925522A (fi) 1992-12-04
FI94756B FI94756B (fi) 1995-07-14
FI94756C FI94756C (fi) 1995-10-25

Family

ID=24126737

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925522A FI94756C (fi) 1990-06-05 1992-12-04 Menetelmä hypoglykeemisten ja hypokolesteroleemisten oksa- ja tiatsolidiinidionien valmistamiseksi

Country Status (20)

Country Link
US (1) US5037842A (fi)
EP (1) EP0537300B1 (fi)
JP (1) JPH0714924B2 (fi)
AT (1) ATE121736T1 (fi)
AU (1) AU640284B2 (fi)
CA (1) CA2084195A1 (fi)
DE (1) DE69109291T2 (fi)
DK (1) DK0537300T3 (fi)
ES (1) ES2071339T3 (fi)
FI (1) FI94756C (fi)
HU (1) HUT65676A (fi)
IE (1) IE65628B1 (fi)
IL (1) IL98300A (fi)
MY (1) MY135758A (fi)
NO (1) NO924696L (fi)
NZ (1) NZ238382A (fi)
PT (1) PT97856A (fi)
TW (1) TW200481B (fi)
WO (1) WO1991019704A2 (fi)
ZA (1) ZA914188B (fi)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
US5498621A (en) * 1992-05-01 1996-03-12 Pfizer Inc. Oxazolidinedione hypoglycemic agents
ATE185564T1 (de) * 1992-08-31 1999-10-15 Sankyo Co Oxazolidin-derivate mit antidiabetika und anti- fettleibigkeit-eigenschaften, ihre herstellung und therapeutische verwendung
US5594016A (en) * 1992-12-28 1997-01-14 Mitsubishi Chemical Corporation Naphthalene derivatives
TW268952B (fi) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
KR0173145B1 (ko) * 1993-04-07 1999-02-01 고바야시 유키오 티아졸리딘 유도체 및 이를 함유하는 약학적 조성물
US5641796A (en) * 1994-11-01 1997-06-24 Eli Lilly And Company Oral hypoglycemic agents
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889032A (en) * 1996-05-06 1999-03-30 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973850B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
AU744518B2 (en) 1996-07-01 2002-02-28 Dr. Reddy's Laboratories Limited Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6313113B1 (en) 1997-04-15 2001-11-06 Reddy-Cheminor, Inc. Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
EP0981526B1 (en) * 1997-05-02 2004-02-25 Dr. Reddy's Laboratories Ltd. Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
EP0894089B9 (en) * 1997-05-02 2003-04-02 Dr. Reddy's Laboratories Ltd. Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6011031A (en) * 1997-05-30 2000-01-04 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
WO1998052946A1 (en) * 1997-12-02 1998-11-26 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension
JP2003040877A (ja) * 2001-07-24 2003-02-13 Sumika Fine Chemicals Co Ltd ５−［６−（２−フルオロベンジルオキシ）−２−ナフチル］メチル−２，４−チアゾリジンジオンの製造方法及びその精製方法
ATE524741T1 (de) * 2002-12-19 2011-09-15 Scripps Research Inst Zusammensetzungen und verwendungen zur stabilisierung von transthyretin und zur hemmung von transthyretin-fehlfaltung
JP2007538103A (ja) * 2004-05-20 2007-12-27 ザ スクリップス リサーチ インスティテュート トランスサイレチン安定化
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
PT2132188E (pt) 2007-03-07 2012-02-13 Janssen Pharmaceutica Nv Tiazolidinedionas n-alquiladas fenoxi substituídas como moduladores de receptores-alfa de estrogénio
US7846953B2 (en) 2007-03-07 2010-12-07 Janssen Pharmaceutica, Nv Substituted phenoxy thiazolidinediones as estrogen related receptor-α modulators
JP2010520308A (ja) 2007-03-07 2010-06-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ エストロゲン関連受容体−アルファモジュレーターとしての置換フェノキシアミノチアゾロン
CA2763536C (en) * 2008-05-30 2017-05-09 Marvin J. Miller Anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria
AU2010330894A1 (en) 2009-12-18 2012-07-05 Janssen Pharmaceutica Nv Substituted aminothiazolone indazoles as estrogen related receptor-aalpha modulators
WO2013038351A1 (en) 2011-09-16 2013-03-21 Pfizer Inc. Solid forms of a transthyretin dissociation inhibitor
CN107001267A (zh) * 2014-08-08 2017-08-01 马合伙人株式会社 稠合杂环化合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5430171A (en) * 1977-08-10 1979-03-06 Taiho Pharmaceutical Co Ltd Isooxazole derivative and production
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
US4753956A (en) * 1981-01-02 1988-06-28 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4689336A (en) * 1981-01-02 1987-08-25 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine 2,4-diones
US4550172A (en) * 1984-09-21 1985-10-29 American Home Products Corporation Novel heterocyclic compounds as antiallergic agents
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
US4703052A (en) * 1985-05-21 1987-10-27 Pfizer Inc. Hypoglycemic thiazolidinediones
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
JPS62234085A (ja) * 1985-12-18 1987-10-14 Sankyo Co Ltd チアゾリジン誘導体を有効成分とする糖尿病性合併症治療剤
FI91869C (fi) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
ES2137915T3 (es) * 1987-09-04 2000-01-01 Beecham Group Plc Derivados de tiazolidindiona sustituida.
US4791125A (en) * 1987-12-02 1988-12-13 Pfizer Inc. Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents
US5061717A (en) * 1988-03-08 1991-10-29 Pfizer Inc. Thiazolidinedione hypoglycemic agents

Also Published As

Publication number Publication date
ZA914188B (en) 1993-01-27
ES2071339T3 (es) 1995-06-16
JPH0714924B2 (ja) 1995-02-22
NZ238382A (en) 1995-12-21
FI94756B (fi) 1995-07-14
AU640284B2 (en) 1993-08-19
HUT65676A (en) 1994-07-28
NO924696D0 (no) 1992-12-04
US5037842A (en) 1991-08-06
IE65628B1 (en) 1995-11-01
WO1991019704A3 (en) 1992-03-19
WO1991019704A2 (en) 1991-12-26
AU8753191A (en) 1992-01-07
FI94756C (fi) 1995-10-25
EP0537300B1 (en) 1995-04-26
HU9203837D0 (en) 1993-03-29
NO924696L (no) 1992-12-04
MY135758A (en) 2008-06-30
IL98300A0 (en) 1992-06-21
EP0537300A1 (en) 1993-04-21
DK0537300T3 (da) 1995-07-03
DE69109291D1 (de) 1995-06-01
FI925522A0 (fi) 1992-12-04
TW200481B (fi) 1993-02-21
JPH05506456A (ja) 1993-09-22
IE911885A1 (en) 1991-12-18
ATE121736T1 (de) 1995-05-15
CA2084195A1 (en) 1991-12-06
PT97856A (pt) 1992-03-31
IL98300A (en) 1996-01-31
DE69109291T2 (de) 1995-08-31

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