FI94756C - Menetelmä hypoglykeemisten ja hypokolesteroleemisten oksa- ja tiatsolidiinidionien valmistamiseksi - Google Patents

Menetelmä hypoglykeemisten ja hypokolesteroleemisten oksa- ja tiatsolidiinidionien valmistamiseksi

Info

Publication number
FI94756C
FI94756C FI925522A FI925522A FI94756C FI 94756 C FI94756 C FI 94756C FI 925522 A FI925522 A FI 925522A FI 925522 A FI925522 A FI 925522A FI 94756 C FI94756 C FI 94756C
Authority
FI
Finland
Prior art keywords
oxa
hypocholesterolemic
thiazolidinediones
hypoglycemic
preparation
Prior art date
Application number
FI925522A
Other languages
English (en)
Swedish (sv)
Other versions
FI94756B (fi
FI925522A (fi
FI925522A0 (fi
Inventor
Steven Wayne Goldstein
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI925522A publication Critical patent/FI925522A/fi
Publication of FI925522A0 publication Critical patent/FI925522A0/fi
Publication of FI94756B publication Critical patent/FI94756B/fi
Application granted granted Critical
Publication of FI94756C publication Critical patent/FI94756C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Paints Or Removers (AREA)
FI925522A 1990-06-05 1992-12-04 Menetelmä hypoglykeemisten ja hypokolesteroleemisten oksa- ja tiatsolidiinidionien valmistamiseksi FI94756C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53361590 1990-06-05
US07/533,615 US5037842A (en) 1990-06-05 1990-06-05 Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents
US9103541 1991-05-20
PCT/US1991/003541 WO1991019704A2 (en) 1990-06-05 1991-05-20 Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents

Publications (4)

Publication Number Publication Date
FI925522A FI925522A (fi) 1992-12-04
FI925522A0 FI925522A0 (fi) 1992-12-04
FI94756B FI94756B (fi) 1995-07-14
FI94756C true FI94756C (fi) 1995-10-25

Family

ID=24126737

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925522A FI94756C (fi) 1990-06-05 1992-12-04 Menetelmä hypoglykeemisten ja hypokolesteroleemisten oksa- ja tiatsolidiinidionien valmistamiseksi

Country Status (20)

Country Link
US (1) US5037842A (fi)
EP (1) EP0537300B1 (fi)
JP (1) JPH0714924B2 (fi)
AT (1) ATE121736T1 (fi)
AU (1) AU640284B2 (fi)
CA (1) CA2084195A1 (fi)
DE (1) DE69109291T2 (fi)
DK (1) DK0537300T3 (fi)
ES (1) ES2071339T3 (fi)
FI (1) FI94756C (fi)
HU (1) HUT65676A (fi)
IE (1) IE65628B1 (fi)
IL (1) IL98300A (fi)
MY (1) MY135758A (fi)
NO (1) NO924696L (fi)
NZ (1) NZ238382A (fi)
PT (1) PT97856A (fi)
TW (1) TW200481B (fi)
WO (1) WO1991019704A2 (fi)
ZA (1) ZA914188B (fi)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
US5498621A (en) * 1992-05-01 1996-03-12 Pfizer Inc. Oxazolidinedione hypoglycemic agents
EP0590793B1 (en) * 1992-08-31 1999-10-13 Sankyo Company Limited Oxazolidine derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses
US5594016A (en) * 1992-12-28 1997-01-14 Mitsubishi Chemical Corporation Naphthalene derivatives
TW268952B (fi) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
EP0645387A1 (en) * 1993-04-07 1995-03-29 Taiho Pharmaceutical Co., Ltd. Thiazolidine derivative and pharmaceutical composition containing the same
US5641796A (en) * 1994-11-01 1997-06-24 Eli Lilly And Company Oral hypoglycemic agents
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973848B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
CA2258949C (en) * 1996-07-01 2008-05-06 Dr. Reddy's Research Foundation Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6011036A (en) * 1997-04-15 2000-01-04 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them
EP0981526B1 (en) * 1997-05-02 2004-02-25 Dr. Reddy's Laboratories Ltd. Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
JP2001518068A (ja) * 1997-05-02 2001-10-09 ドクター・レディーズ・リサーチ・ファウンデーション 抗糖尿病、高脂血症、抗高血圧特性を有する新規なヘテロ環化合物、これらの製造方法及びこれらを含有する薬学的組成物
US6011031A (en) * 1997-05-30 2000-01-04 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
AU7595298A (en) * 1997-12-02 1998-12-11 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hy pertension
JP2003040877A (ja) * 2001-07-24 2003-02-13 Sumika Fine Chemicals Co Ltd ５−［６−（２−フルオロベンジルオキシ）−２−ナフチル］メチル−２，４−チアゾリジンジオンの製造方法及びその精製方法
PT1587821E (pt) * 2002-12-19 2008-09-23 Scripps Research Inst Composições e métodos para estabilização da transtirretina e inibição do enrolamento incorrecto da transtirretina
AU2005244999A1 (en) * 2004-05-20 2005-12-01 The Scripps Research Institute Transthyretin stabilization
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
US7846953B2 (en) 2007-03-07 2010-12-07 Janssen Pharmaceutica, Nv Substituted phenoxy thiazolidinediones as estrogen related receptor-α modulators
UA98484C2 (ru) 2007-03-07 2012-05-25 Янссен Фармацевтика Н.В. ЗАМЕЩЕННЫЕ ФЕНОКСИАМИНОТИАЗОЛОНЫ КАК МОДУЛЯТОРЫ α-РЕЦЕПТОРА ЭСТРОГЕНА
KR20090118103A (ko) 2007-03-07 2009-11-17 얀센 파마슈티카 엔.브이. 에스트로겐 관련 수용체-알파 조절제로서 치환된 페녹시 ｎ-알킬화 티아졸리딘디온
WO2009158118A2 (en) * 2008-05-30 2009-12-30 University Of Notre Dame Du Lac Anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria
WO2011075565A1 (en) 2009-12-18 2011-06-23 Janssen Pharmaceutica Nv SUBSTITUTED AMINOTHIAZOLONE INDAZOLES AS ESTROGEN RELATED RECEPTOR-Aα MODULATORS
SG2014013270A (en) 2011-09-16 2014-05-29 Pfizer Solid forms of a transthyretin dissociation inhibitor
WO2016021706A1 (ja) * 2014-08-08 2016-02-11 カズマパートナーズ株式会社 縮合複素環化合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5430171A (en) * 1977-08-10 1979-03-06 Taiho Pharmaceutical Co Ltd Isooxazole derivative and production
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
US4753956A (en) * 1981-01-02 1988-06-28 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4689336A (en) * 1981-01-02 1987-08-25 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine 2,4-diones
US4550172A (en) * 1984-09-21 1985-10-29 American Home Products Corporation Novel heterocyclic compounds as antiallergic agents
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
WO1986007056A1 (en) * 1985-05-21 1986-12-04 Pfizer Inc. Hypoglycemic thiazolidinediones
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
JPS62234085A (ja) * 1985-12-18 1987-10-14 Sankyo Co Ltd チアゾリジン誘導体を有効成分とする糖尿病性合併症治療剤
FI91869C (fi) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
DE10199003I1 (de) * 1987-09-04 2003-06-12 Beecham Group Plc Substituierte Thiazolidinionderivate
US4791125A (en) * 1987-12-02 1988-12-13 Pfizer Inc. Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents
WO1989008650A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione hypoglycemic agents

Also Published As

Publication number Publication date
DK0537300T3 (da) 1995-07-03
US5037842A (en) 1991-08-06
PT97856A (pt) 1992-03-31
JPH05506456A (ja) 1993-09-22
EP0537300A1 (en) 1993-04-21
ZA914188B (en) 1993-01-27
HU9203837D0 (en) 1993-03-29
TW200481B (fi) 1993-02-21
JPH0714924B2 (ja) 1995-02-22
IL98300A (en) 1996-01-31
ES2071339T3 (es) 1995-06-16
FI94756B (fi) 1995-07-14
ATE121736T1 (de) 1995-05-15
IE911885A1 (en) 1991-12-18
IL98300A0 (en) 1992-06-21
FI925522A (fi) 1992-12-04
IE65628B1 (en) 1995-11-01
AU640284B2 (en) 1993-08-19
MY135758A (en) 2008-06-30
FI925522A0 (fi) 1992-12-04
DE69109291D1 (de) 1995-06-01
NO924696D0 (no) 1992-12-04
NO924696L (no) 1992-12-04
WO1991019704A2 (en) 1991-12-26
HUT65676A (en) 1994-07-28
CA2084195A1 (en) 1991-12-06
AU8753191A (en) 1992-01-07
DE69109291T2 (de) 1995-08-31
NZ238382A (en) 1995-12-21
WO1991019704A3 (en) 1992-03-19
EP0537300B1 (en) 1995-04-26

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Legal Events

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