ES2123562T3 - Procedimiento para la preparacion de (s)-4-(3-(5-metil-2-fenil-4-oxazolil)-1-hidroxipropil)bromobenceno. - Google Patents

Procedimiento para la preparacion de (s)-4-(3-(5-metil-2-fenil-4-oxazolil)-1-hidroxipropil)bromobenceno.

Info

Publication number
ES2123562T3
ES2123562T3 ES92915192T ES92915192T ES2123562T3 ES 2123562 T3 ES2123562 T3 ES 2123562T3 ES 92915192 T ES92915192 T ES 92915192T ES 92915192 T ES92915192 T ES 92915192T ES 2123562 T3 ES2123562 T3 ES 2123562T3
Authority
ES
Spain
Prior art keywords
preparation
hydroxypropil
bromobenzene
oxazolyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92915192T
Other languages
English (en)
Inventor
George J Quallich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2123562T3 publication Critical patent/ES2123562T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE PRESENTA UN PROCESO PARA LA PREPARACION ESTEROSELECTIVA DE PRODUCTOS INTERMEDIOS EN LA PREPARACION DE HIPOGLICEMICOS DE TIAZOLIDINA-2,4-DIONA DE QUIRAL, DE ACCION POTENTE.
ES92915192T 1991-07-22 1992-07-01 Procedimiento para la preparacion de (s)-4-(3-(5-metil-2-fenil-4-oxazolil)-1-hidroxipropil)bromobenceno. Expired - Lifetime ES2123562T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73356491A 1991-07-22 1991-07-22

Publications (1)

Publication Number Publication Date
ES2123562T3 true ES2123562T3 (es) 1999-01-16

Family

ID=24948157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92915192T Expired - Lifetime ES2123562T3 (es) 1991-07-22 1992-07-01 Procedimiento para la preparacion de (s)-4-(3-(5-metil-2-fenil-4-oxazolil)-1-hidroxipropil)bromobenceno.

Country Status (21)

Country Link
US (1) US5512689A (es)
EP (1) EP0595868B1 (es)
JP (1) JP2671962B2 (es)
AT (1) ATE173728T1 (es)
AU (1) AU660701B2 (es)
CA (1) CA2111445C (es)
DE (1) DE69227689T2 (es)
DK (1) DK0595868T3 (es)
ES (1) ES2123562T3 (es)
FI (1) FI940306A0 (es)
HU (1) HUT70412A (es)
IE (1) IE922359A1 (es)
IL (1) IL102574A (es)
MX (1) MX9204278A (es)
MY (1) MY131277A (es)
NO (1) NO940227L (es)
NZ (1) NZ243651A (es)
PT (1) PT100710B (es)
TW (1) TW199891B (es)
WO (1) WO1993002060A1 (es)
ZA (1) ZA925469B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU660187B2 (en) * 1991-07-22 1995-06-15 Pfizer Inc. Chiral intermediates for the preparation of antidiabetics thiazoles
FR2699172B1 (fr) * 1992-12-11 1995-01-20 Adir Nouveaux dérivés de 4-méthyl-1,3-oxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
TW416958B (en) * 1993-05-14 2001-01-01 Pfizer Enantioselective oxazaborolidine catalysts
CA2383347A1 (en) * 1999-08-31 2001-03-08 Maxia Pharmaceuticals, Inc. Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes
IL157740A0 (en) 2001-03-07 2004-03-28 Incyte San Diego Inc Heterocyclic derivatives and pharmaceutical compositions containing the same
US7265139B2 (en) * 2001-03-08 2007-09-04 Incyte San Diego Inc. RXR activating molecules
CA2340824A1 (en) * 2001-03-14 2002-09-14 Ibm Canada Limited-Ibm Canada Limitee Method and system for application behavior analysis
EP1421061A4 (en) * 2001-08-17 2004-12-22 Incyte San Diego Inc OXIME DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA AND HYPERCHOLESTEROLEMIA
AU2002352706A1 (en) * 2001-11-15 2003-06-10 Maxia Pharmaceuticals, Inc. N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases
US7196108B2 (en) * 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
US7102000B2 (en) * 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
WO2004066952A2 (en) * 2003-01-29 2004-08-12 Incyte Corporation Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases
EP1643993A2 (en) * 2003-04-18 2006-04-12 Incyte San Diego Incorporated Substituted isochroman compounds for the treatment of metabolic disorders, cancer and other diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones
US5036079A (en) * 1989-12-07 1991-07-30 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
TW222626B (es) * 1991-07-22 1994-04-21 Pfizer

Also Published As

Publication number Publication date
HUT70412A (en) 1995-10-30
CA2111445A1 (en) 1993-02-04
DE69227689T2 (de) 1999-04-22
EP0595868B1 (en) 1998-11-25
CA2111445C (en) 1997-02-18
TW199891B (es) 1993-02-11
FI940306A (fi) 1994-01-21
JP2671962B2 (ja) 1997-11-05
PT100710B (pt) 1999-07-30
AU2306292A (en) 1993-02-23
PT100710A (pt) 1993-09-30
NO940227D0 (no) 1994-01-21
IL102574A (en) 1996-07-23
HU9400188D0 (en) 1994-05-30
ATE173728T1 (de) 1998-12-15
MX9204278A (es) 1994-03-31
JPH07502017A (ja) 1995-03-02
DK0595868T3 (da) 1999-08-09
MY131277A (en) 2007-07-31
ZA925469B (en) 1994-01-21
IE922359A1 (en) 1993-01-27
US5512689A (en) 1996-04-30
DE69227689D1 (de) 1999-01-07
NZ243651A (en) 1994-01-26
AU660701B2 (en) 1995-07-06
NO940227L (no) 1994-01-21
FI940306A0 (fi) 1994-01-21
IL102574A0 (en) 1993-01-14
WO1993002060A1 (en) 1993-02-04
EP0595868A1 (en) 1994-05-11

Similar Documents

Publication Publication Date Title
ES2123562T3 (es) Procedimiento para la preparacion de (s)-4-(3-(5-metil-2-fenil-4-oxazolil)-1-hidroxipropil)bromobenceno.
NO924696D0 (no) Fremgangsmaate for fremstilling av oksazolidinon- og tiazolidinon-derivater
EP0639572A4 (en) 2- (2,6-DIFLUOROPHENYLE) -4- (2-ETHOXY-4-TERT-BUTYLPHENYLE) -2-OXAZOLINE.
DK0527887T3 (da) Farmaceutisk præparat
DE69011930T2 (de) Fungizide Oxazolidinone.
NO992226L (no) Nye forbindelser for anvendelse som neuro-protektive midler
ES8604717A1 (es) Procedimiento para la preparacion de nuevos derivados de 3-fenil-4-cianopirrol.
FI891473A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten 4-aryyli-4-piperidiinikarbinolien valmistamiseksi
DE3825170A1 (de) Substituierte 5-(4-(4,5-dihydro-2-oxazolyl)-phenoxyalkylenoxyalkyl)-isoxazole, verfahren sowie 5-(phenoxyalkylenoxyalkyl)-isoxazole als zwischenprodukte zu ihrer herstellung und ihre verwendung zur bekaempfung von krankheiten, die durch infektion mit viren hervorgerufen wurden
AR004279A1 (es) Procedimientos para preparar 3-(1-piperazinil)-1,2-benzoisotiazol
GT198400006A (es) 5-(2-alcoxifenil)-tiazolidindionas e inhibidores de la aldo sareductasa
FI900129A (fi) Menetelmä 3-(N-fenyyliasetyyliaminopiperidiini)-2,6-dionin valmistamiseksi
ITMI910457A1 (it) Processo per la preparazione di trans-(5r)-2-ossazoline -2, 4, 5, trisostituite
MX9202715A (es) Nuevos derivados de oxazol y proceso para su preparacion.
ES2073292T3 (es) Preparacion de acidos benzoicos trisustituidos y compuestos intermedios.
DK104691A (da) Cykliske imidatestere til anvendelse som udgangsmateriale ved fremstillling af 1,4-dihydropyrid-5-yl-(cyklisk imidat)estere
GR1000334B (el) Μεθοδος παρασκευης της 3-(2-(4-(4-φθοροβενζουλο)-1-πιπεριδινυλ)αιθυλο)-2,4,(1η,3η)κιναζολινοδιολης.
SE8901837D0 (sv) Substituted isoxazolidines and isoxazolines

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 595868

Country of ref document: ES