FI92148B - Förfarande för framställning av en farmaceutisk komposition av -/4-(1,1-dimetyletyl)fenyl/-4-hydroxidifenylmetyl)-1-piperidinbutanol - Google Patents
Förfarande för framställning av en farmaceutisk komposition av -/4-(1,1-dimetyletyl)fenyl/-4-hydroxidifenylmetyl)-1-piperidinbutanol Download PDFInfo
- Publication number
- FI92148B FI92148B FI884611A FI884611A FI92148B FI 92148 B FI92148 B FI 92148B FI 884611 A FI884611 A FI 884611A FI 884611 A FI884611 A FI 884611A FI 92148 B FI92148 B FI 92148B
- Authority
- FI
- Finland
- Prior art keywords
- weight
- composition
- amount
- added
- dimethylethyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Claims (9)
1. FÖrfarande för framstälining av en farmaceutisk komposition, kännetecknat därav, att man 5 blandar med varandra a) en terapeutiskt effektiv mängd a- [4-(1,1-dimetyletyl)fenyl]-4-hydroxidifenylmetyl)-1-pipe-ridinbutanol eller ett farmaceutiskt godtagbart sait därav, b) polyoxietylensorbitanfettsyraestern Polysorbate 80 i en mängd som är ca 0,1 vikt-% - ca 6 vikt-% av komposi- 10 tionen och c) kalciumkarbonat i en mängd som är ca 2 vikt-% - ca 50 vikt-% av kompositionen.
2. FÖrfarande enligt patentkrav 1, kännetecknat därav, att det ytterligare omfattar press-ning av den farmaceutiska kompositionen i enhetsdosform. 15
3. FÖrfarande enligt patentkrav 1, känne tecknat därav, att a-[4-(1,1-dimetyletyl)fenyl]-4-hydroxidifenylmetyl)-l-piperidinbutanol tillsätts i en mängd av 60 mg.
4. FÖrfarande enligt patentkrav 1, k ä n n e - 20 tecknat därav, att a-[4-(l,1-dimetyletyl)fenyl]-4- hydroxidifenylmetyl)-l-piperidinbutanol tillsätts i en mängd av 120 mg.
5. FÖrfarande enligt patentkrav 3 eller 4, kännetecknat därav, att polyoxietylensorbitanfett- 25 syraestern Polysorbate 80 tillsätts i en mängd som är ca 0,5 vikt-% - ca 4 vikt-% av kompositionen.
6. FÖrfarande enligt patentkrav 3 eller 4, kännetecknat därav, att polyoxietylensorbitanfett-syraestern Polysorbate 80 tillsätts in en mängd som är ca 3 0 1 vikt-% - ca 3 vikt-% av kompositionen.
7. FÖrfarande enligt patentkrav 3 eller 4, kännetecknat därav, att kalciumkarbonat tillsätts i en mängd som är ca 2 vikt-% - ca 25 vikt-% av kompositionen. II 9 2148
8. Förfarande enligt patentkrav 3 eller 4, k ä n -netecknat därav, att kalciumkarbonat tillsätts i en mängd son är ca 12 vikt-% - ca 15 vikt-% av komposi-tionen. 5
9. Förfarande enligt patentkrav 3, k ä n ne tecknat därav, att polyoxietylensorbitanfettsyra-estern Polysorbate 80 och kalciumkarbonat tillsätts i mängder ca 3 vikt-% respektive ca 15 vikt-% av komposi-tionen och ytterligare tillsätts mikrokristallin cellulo-10 sa, förgelatinerad majsstärkelse, natriumstärkelseglukolat och magnesiumstearat, varvid mängder av dessa är ca 35 vikt-%, ca 30,5 vikt-%, ca 5 vikt-% respektive ca 0,55 vikt-% av kompositionen. 4
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10592887A | 1987-10-07 | 1987-10-07 | |
| US10592887 | 1987-10-07 | ||
| US11716687A | 1987-11-04 | 1987-11-04 | |
| US11716687 | 1987-11-04 | ||
| US15268988A | 1988-02-05 | 1988-02-05 | |
| US15268988 | 1988-02-05 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI884611A0 FI884611A0 (sv) | 1988-10-07 |
| FI884611A FI884611A (sv) | 1989-04-08 |
| FI92148B true FI92148B (sv) | 1994-06-30 |
| FI92148C FI92148C (sv) | 1994-10-10 |
Family
ID=27380006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI884611A FI92148C (sv) | 1987-10-07 | 1988-10-07 | Förfarande för framställning av en farmaceutisk komposition av -/4-(1,1-dimetyletyl)fenyl/-4-hydroxidifenylmetyl)-1-piperidinbutanol |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0310999B1 (sv) |
| JP (1) | JP2722220B2 (sv) |
| KR (1) | KR960007753B1 (sv) |
| CN (1) | CN1019544B (sv) |
| AR (1) | AR240018A1 (sv) |
| AU (1) | AU615950B2 (sv) |
| CA (1) | CA1316458C (sv) |
| DE (1) | DE3873011T2 (sv) |
| DK (1) | DK172383B1 (sv) |
| ES (1) | ES2051809T3 (sv) |
| FI (1) | FI92148C (sv) |
| GR (1) | GR3005787T3 (sv) |
| HU (1) | HU200924B (sv) |
| IE (1) | IE60323B1 (sv) |
| IL (1) | IL87921A (sv) |
| NZ (1) | NZ226446A (sv) |
| PT (1) | PT88681B (sv) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA90341B (en) * | 1989-01-23 | 1990-10-31 | Merrell Dow Pharma | Liquid pharmaceutical composition for piperidinoalkanol derivatives |
| HU223774B1 (hu) * | 1992-05-11 | 2005-01-28 | Merrell Dow Pharmaceuticals Inc. | Terfenadinszármazékok alkalmazása antihisztamin hatású gyógyszerkészítmények előállítására |
| BE1006990A5 (nl) * | 1993-04-22 | 1995-02-07 | Univ Gent | Werkwijze en samenstelling om een aktief bestanddeel in een vaste toedieningsvorm te brengen. |
| MX9706449A (es) | 1995-02-28 | 1997-11-29 | Hoechst Marion Roussel Inc | Composicion farmaceutica para compuestos de piperidinalcanol. |
| WO1999009957A1 (en) * | 1997-08-26 | 1999-03-04 | Hoechst Marion Roussel, Inc. | Pharmaceutical composition for combination of piperidinoalkanol-decongestant |
| SE9802973D0 (sv) * | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
| JP2009060792A (ja) * | 2007-09-04 | 2009-03-26 | Fujifilm Corp | 錠剤またはカプセル剤の食品。 |
| JP5798544B2 (ja) * | 2007-09-06 | 2015-10-21 | 富士フイルム株式会社 | サラシア属植物の抽出物とフラボノイドを含有する食品 |
| JP5648265B2 (ja) * | 2008-10-20 | 2015-01-07 | ニプロ株式会社 | 錠剤の製造方法 |
| JP5710663B2 (ja) * | 2013-02-19 | 2015-04-30 | 富士フイルム株式会社 | 錠剤またはカプセル剤の食品。 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3878217A (en) * | 1972-01-28 | 1975-04-15 | Richardson Merrell Inc | Alpha-aryl-4-substituted piperidinoalkanol derivatives |
| US4254129A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| US4285957A (en) * | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof |
| JPS5788117A (en) * | 1980-11-21 | 1982-06-01 | Smithkline Corp | Gelatin capsule containing triamterene |
| JPS5877810A (ja) * | 1981-11-01 | 1983-05-11 | Taiho Yakuhin Kogyo Kk | ポリグリセロ−ル不飽和脂肪酸エステルを含む経口薬剤組成物 |
| ZA845180B (en) * | 1983-07-07 | 1986-02-26 | American Home Prod | Pharmaceutical composition containing a liquid lubricant |
| DK164642C (da) * | 1984-08-30 | 1992-12-14 | Merrell Dow Pharma | Farmaceutisk middel indeholdende terfenadin i form af en varmsmelte paafyldt paa kapsler |
| JPS6396126A (ja) * | 1986-10-13 | 1988-04-27 | Taisho Pharmaceut Co Ltd | 安定化組成物 |
-
1988
- 1988-10-03 AR AR312097A patent/AR240018A1/es active
- 1988-10-04 NZ NZ226446A patent/NZ226446A/xx unknown
- 1988-10-04 ES ES88116367T patent/ES2051809T3/es not_active Expired - Lifetime
- 1988-10-04 CA CA000579284A patent/CA1316458C/en not_active Expired - Lifetime
- 1988-10-04 DE DE8888116367T patent/DE3873011T2/de not_active Expired - Lifetime
- 1988-10-04 EP EP88116367A patent/EP0310999B1/en not_active Expired - Lifetime
- 1988-10-05 AU AU23460/88A patent/AU615950B2/en not_active Expired
- 1988-10-05 JP JP63250048A patent/JP2722220B2/ja not_active Expired - Lifetime
- 1988-10-05 IL IL87921A patent/IL87921A/xx active Protection Beyond IP Right Term
- 1988-10-06 PT PT88681A patent/PT88681B/pt not_active IP Right Cessation
- 1988-10-06 CN CN88109095A patent/CN1019544B/zh not_active Expired
- 1988-10-06 HU HU885185A patent/HU200924B/hu unknown
- 1988-10-06 DK DK559288A patent/DK172383B1/da active
- 1988-10-06 KR KR1019880013035A patent/KR960007753B1/ko not_active IP Right Cessation
- 1988-10-06 IE IE303288A patent/IE60323B1/en not_active IP Right Cessation
- 1988-10-07 FI FI884611A patent/FI92148C/sv not_active IP Right Cessation
-
1992
- 1992-09-24 GR GR920402109T patent/GR3005787T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI92148C (sv) | 1994-10-10 |
| PT88681B (pt) | 1992-12-31 |
| PT88681A (pt) | 1988-11-01 |
| CN1032739A (zh) | 1989-05-10 |
| KR890006235A (ko) | 1989-06-12 |
| IL87921A (en) | 1992-05-25 |
| HU200924B (en) | 1990-09-28 |
| NZ226446A (en) | 1990-09-26 |
| DK559288D0 (da) | 1988-10-06 |
| JPH01128924A (ja) | 1989-05-22 |
| DK172383B1 (da) | 1998-05-11 |
| FI884611A0 (sv) | 1988-10-07 |
| IE883032L (en) | 1989-04-07 |
| JP2722220B2 (ja) | 1998-03-04 |
| CA1316458C (en) | 1993-04-20 |
| AU615950B2 (en) | 1991-10-17 |
| IL87921A0 (en) | 1989-03-31 |
| EP0310999A1 (en) | 1989-04-12 |
| GR3005787T3 (sv) | 1993-06-07 |
| DE3873011T2 (de) | 1992-12-03 |
| DE3873011D1 (de) | 1992-08-27 |
| HUT48460A (en) | 1989-06-28 |
| AU2346088A (en) | 1989-08-10 |
| IE60323B1 (en) | 1994-06-29 |
| DK559288A (da) | 1989-04-08 |
| EP0310999B1 (en) | 1992-07-22 |
| KR960007753B1 (ko) | 1996-06-12 |
| AR240018A1 (es) | 1990-01-31 |
| CN1019544B (zh) | 1992-12-23 |
| FI884611A (sv) | 1989-04-08 |
| ES2051809T3 (es) | 1994-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| FG | Patent granted |
Owner name: MERRELL DOW PHARMACEUTICALS INC. |
|
| PC | Transfer of assignment of patent |
Owner name: AVENTIS INC. Free format text: AVENTIS INC. |
|
| MA | Patent expired |