FI92064B - Förfarande för framställning av terapeutiskt användbara N-bensopyranyllaktamer - Google Patents
Förfarande för framställning av terapeutiskt användbara N-bensopyranyllaktamer Download PDFInfo
- Publication number
- FI92064B FI92064B FI880468A FI880468A FI92064B FI 92064 B FI92064 B FI 92064B FI 880468 A FI880468 A FI 880468A FI 880468 A FI880468 A FI 880468A FI 92064 B FI92064 B FI 92064B
- Authority
- FI
- Finland
- Prior art keywords
- dimethyl
- benzo
- compounds
- pyran
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (3)
1. Förfarande för framställning av terapeutiskt användbara N-bensopyranyllaktamer med formeln I • 5 o-· ΊοΓ 1
8. V 15 väri R1 är CN, SOj-C^-alkyl eller S02-fenyl, R2 är H eller Cj.j-alkoxi, R3 och R4 är lika eller olika ooh de är C^-al-kyler och X är en (CH2)B-kedja, vilken är substituerad med en C1.2-alkylgrupp, och m är 3 eller 4, varvid konfiguratio-nen vid C3 och C4 alltid är motsatt, känneteck-20 n a t därav, att (a) föreningar med formeln 11 CH ‘ “ R4 väri symbolerna R1, R2, R3 och R4 har ovan nämnda betydel-30 ser, bringas att reagera med laktamer med formeln III t \ Cl 35
35 H 24 92064 eller (b) föreningar med formeln IV 5 rä\ R2^\^O^r3 R4 10 väri symbolerna R1, R2, R3 och R4 har ovan nämnda betydel-ser, brlngas att reagera med laktamer med formeln III.
2. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att (-)-3R,4S,5'R-6-cyano-3,4-dihyd-ro-2,2-dimetyl-4-( 2 ’ -oxo-5' -metyl-1' -pyrrolidinyl)-2H-ben-15 so[b]-pyran-3-ol framställs.
3. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att (-)-(3S,4R,5'R)-6-cyano-3,4-di-hydro-2,2-dimetyl-4-(21-oxo-5f-metyl-1'-pyrrolidinyl)-2H-benso[b]-pyran-3-ol framställs. * «
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3703229 | 1987-02-04 | ||
DE19873703229 DE3703229A1 (de) | 1987-02-04 | 1987-02-04 | Alkylsubstituierte n-benzopyranyllactame, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
DE19873724876 DE3724876A1 (de) | 1987-07-28 | 1987-07-28 | Alkylsubstituierte n-benzopyranyllactame, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
DE3724876 | 1987-07-28 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI880468A0 FI880468A0 (sv) | 1988-02-02 |
FI880468A FI880468A (sv) | 1988-08-05 |
FI92064B true FI92064B (sv) | 1994-06-15 |
FI92064C FI92064C (sv) | 1994-09-26 |
Family
ID=25852153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI880468A FI92064C (sv) | 1987-02-04 | 1988-02-02 | Förfarande för framställning av terapeutiskt användbara N-bensopyranyllaktamer |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0277611B1 (sv) |
KR (1) | KR880009957A (sv) |
AU (1) | AU604089B2 (sv) |
DE (1) | DE3881714D1 (sv) |
DK (1) | DK167440B1 (sv) |
ES (1) | ES2058148T3 (sv) |
FI (1) | FI92064C (sv) |
HU (1) | HU207729B (sv) |
IE (1) | IE60932B1 (sv) |
IL (1) | IL85289A (sv) |
NO (1) | NO169964C (sv) |
NZ (1) | NZ223384A (sv) |
PH (1) | PH24836A (sv) |
PT (1) | PT86691B (sv) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3703227A1 (de) * | 1987-02-04 | 1988-08-18 | Hoechst Ag | Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
GB8800199D0 (en) * | 1988-01-06 | 1988-02-10 | Beecham Group Plc | Pharmaceutical preparation |
DE3824446A1 (de) * | 1988-07-19 | 1990-01-25 | Hoechst Ag, 6230 Frankfurt | Verwendung substituierter 3,4-dihydro-2h-benzopyrane als heilmittel gegen obstruktive funktionsstoerungen der lunge und/oder stoerungen der ableitenden harnwege |
DE3827532A1 (de) * | 1988-08-13 | 1990-03-01 | Hoechst Ag | 6-aroyl-substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
FR2637896B1 (fr) * | 1988-10-17 | 1990-11-30 | Adir | Nouveaux derives de l'amino chromanol, leur procede de preparation et les compositions pharmaceutiques les renfermant |
DE3901720A1 (de) * | 1989-01-21 | 1990-07-26 | Hoechst Ag | Substituierte benzo(b)pyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
US5104890A (en) * | 1989-03-28 | 1992-04-14 | Fujisawa Pharmaceutical Company, Ltd. | Benzopyran derivatives and processes for preparation thereof |
IE63935B1 (en) * | 1989-06-27 | 1995-06-28 | Chem Pharm Forsch Gmbh | Novel thienopyran derivatives a process for their preparation and their use |
GB8924373D0 (en) * | 1989-10-30 | 1989-12-20 | Beecham Group Plc | Novel compounds |
AU651105B2 (en) * | 1990-06-18 | 1994-07-14 | E.R. Squibb & Sons, Inc. | Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents |
HUT72741A (en) * | 1992-12-19 | 1996-05-28 | Alkaloida Vegyeszeti Gyar | Method for producing benzopyrane derivatives and pharmaceutical compositions containing them |
GB9316111D0 (en) * | 1993-08-04 | 1993-09-22 | Pfizer Ltd | Benzopyrans |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2107706A (en) * | 1981-09-25 | 1983-05-05 | Beecham Group Plc | Benzopyrans |
DE3364734D1 (en) * | 1982-10-19 | 1986-08-28 | Beecham Group Plc | Novel chromans and chromenes |
GB8308062D0 (en) * | 1983-03-24 | 1983-05-05 | Beecham Group Plc | Active compounds |
GB8308064D0 (en) * | 1983-03-24 | 1983-05-05 | Beecham Group Plc | Active compounds |
GB8419516D0 (en) * | 1984-07-31 | 1984-09-05 | Beecham Group Plc | Treatment |
DE3726261A1 (de) * | 1986-12-23 | 1988-07-07 | Merck Patent Gmbh | Chromanderivate |
DE3703227A1 (de) * | 1987-02-04 | 1988-08-18 | Hoechst Ag | Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
-
1988
- 1988-01-30 EP EP88101344A patent/EP0277611B1/de not_active Expired - Lifetime
- 1988-01-30 ES ES88101344T patent/ES2058148T3/es not_active Expired - Lifetime
- 1988-01-30 DE DE8888101344T patent/DE3881714D1/de not_active Expired - Fee Related
- 1988-02-02 NZ NZ223384A patent/NZ223384A/xx unknown
- 1988-02-02 HU HU88450A patent/HU207729B/hu not_active IP Right Cessation
- 1988-02-02 FI FI880468A patent/FI92064C/sv not_active IP Right Cessation
- 1988-02-02 IL IL8528988A patent/IL85289A/en not_active IP Right Cessation
- 1988-02-02 PH PH36449A patent/PH24836A/en unknown
- 1988-02-03 PT PT86691A patent/PT86691B/pt not_active IP Right Cessation
- 1988-02-03 NO NO880474A patent/NO169964C/no unknown
- 1988-02-03 IE IE29588A patent/IE60932B1/en not_active IP Right Cessation
- 1988-02-03 AU AU11227/88A patent/AU604089B2/en not_active Ceased
- 1988-02-03 DK DK055188A patent/DK167440B1/da not_active IP Right Cessation
- 1988-02-03 KR KR1019880000967A patent/KR880009957A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HU207729B (en) | 1993-05-28 |
EP0277611B1 (de) | 1993-06-16 |
FI92064C (sv) | 1994-09-26 |
NO880474D0 (no) | 1988-02-03 |
PT86691A (pt) | 1988-03-01 |
IL85289A0 (en) | 1988-07-31 |
NO169964B (no) | 1992-05-18 |
EP0277611A3 (en) | 1990-04-25 |
NO880474L (no) | 1988-08-05 |
DK55188D0 (da) | 1988-02-03 |
EP0277611A2 (de) | 1988-08-10 |
DE3881714D1 (de) | 1993-07-22 |
HUT50165A (en) | 1989-12-28 |
FI880468A (sv) | 1988-08-05 |
KR880009957A (ko) | 1988-10-06 |
NO169964C (no) | 1992-08-26 |
PT86691B (pt) | 1992-04-30 |
PH24836A (en) | 1990-10-30 |
AU1122788A (en) | 1988-09-08 |
IE60932B1 (en) | 1994-09-07 |
NZ223384A (en) | 1989-11-28 |
ES2058148T3 (es) | 1994-11-01 |
FI880468A0 (sv) | 1988-02-02 |
IE880295L (en) | 1988-08-04 |
AU604089B2 (en) | 1990-12-06 |
DK167440B1 (da) | 1993-11-01 |
DK55188A (da) | 1988-08-05 |
IL85289A (en) | 1994-04-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: HOECHST AKTIENGESELLSCHAFT |