FI92064B - Förfarande för framställning av terapeutiskt användbara N-bensopyranyllaktamer - Google Patents

Förfarande för framställning av terapeutiskt användbara N-bensopyranyllaktamer Download PDF

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Publication number
FI92064B
FI92064B FI880468A FI880468A FI92064B FI 92064 B FI92064 B FI 92064B FI 880468 A FI880468 A FI 880468A FI 880468 A FI880468 A FI 880468A FI 92064 B FI92064 B FI 92064B
Authority
FI
Finland
Prior art keywords
dimethyl
benzo
compounds
pyran
dihydro
Prior art date
Application number
FI880468A
Other languages
English (en)
Finnish (fi)
Other versions
FI92064C (sv
FI880468A (sv
FI880468A0 (sv
Inventor
Bernward Schoelkens
Heinrich Christian Englert
Hans-Jochen Lang
Dieter Mania
Erik Klaus
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19873703229 external-priority patent/DE3703229A1/de
Priority claimed from DE19873724876 external-priority patent/DE3724876A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI880468A0 publication Critical patent/FI880468A0/sv
Publication of FI880468A publication Critical patent/FI880468A/sv
Application granted granted Critical
Publication of FI92064B publication Critical patent/FI92064B/sv
Publication of FI92064C publication Critical patent/FI92064C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (3)

1. Förfarande för framställning av terapeutiskt användbara N-bensopyranyllaktamer med formeln I • 5 o-· ΊοΓ 1
8. V 15 väri R1 är CN, SOj-C^-alkyl eller S02-fenyl, R2 är H eller Cj.j-alkoxi, R3 och R4 är lika eller olika ooh de är C^-al-kyler och X är en (CH2)B-kedja, vilken är substituerad med en C1.2-alkylgrupp, och m är 3 eller 4, varvid konfiguratio-nen vid C3 och C4 alltid är motsatt, känneteck-20 n a t därav, att (a) föreningar med formeln 11 CH ‘ “ R4 väri symbolerna R1, R2, R3 och R4 har ovan nämnda betydel-30 ser, bringas att reagera med laktamer med formeln III t \ Cl 35
35 H 24 92064 eller (b) föreningar med formeln IV 5 rä\ R2^\^O^r3 R4 10 väri symbolerna R1, R2, R3 och R4 har ovan nämnda betydel-ser, brlngas att reagera med laktamer med formeln III.
2. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att (-)-3R,4S,5'R-6-cyano-3,4-dihyd-ro-2,2-dimetyl-4-( 2 ’ -oxo-5' -metyl-1' -pyrrolidinyl)-2H-ben-15 so[b]-pyran-3-ol framställs.
3. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att (-)-(3S,4R,5'R)-6-cyano-3,4-di-hydro-2,2-dimetyl-4-(21-oxo-5f-metyl-1'-pyrrolidinyl)-2H-benso[b]-pyran-3-ol framställs. * «
FI880468A 1987-02-04 1988-02-02 Förfarande för framställning av terapeutiskt användbara N-bensopyranyllaktamer FI92064C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3703229 1987-02-04
DE19873703229 DE3703229A1 (de) 1987-02-04 1987-02-04 Alkylsubstituierte n-benzopyranyllactame, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
DE19873724876 DE3724876A1 (de) 1987-07-28 1987-07-28 Alkylsubstituierte n-benzopyranyllactame, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
DE3724876 1987-07-28

Publications (4)

Publication Number Publication Date
FI880468A0 FI880468A0 (sv) 1988-02-02
FI880468A FI880468A (sv) 1988-08-05
FI92064B true FI92064B (sv) 1994-06-15
FI92064C FI92064C (sv) 1994-09-26

Family

ID=25852153

Family Applications (1)

Application Number Title Priority Date Filing Date
FI880468A FI92064C (sv) 1987-02-04 1988-02-02 Förfarande för framställning av terapeutiskt användbara N-bensopyranyllaktamer

Country Status (14)

Country Link
EP (1) EP0277611B1 (sv)
KR (1) KR880009957A (sv)
AU (1) AU604089B2 (sv)
DE (1) DE3881714D1 (sv)
DK (1) DK167440B1 (sv)
ES (1) ES2058148T3 (sv)
FI (1) FI92064C (sv)
HU (1) HU207729B (sv)
IE (1) IE60932B1 (sv)
IL (1) IL85289A (sv)
NO (1) NO169964C (sv)
NZ (1) NZ223384A (sv)
PH (1) PH24836A (sv)
PT (1) PT86691B (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3703227A1 (de) * 1987-02-04 1988-08-18 Hoechst Ag Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
DE3824446A1 (de) * 1988-07-19 1990-01-25 Hoechst Ag, 6230 Frankfurt Verwendung substituierter 3,4-dihydro-2h-benzopyrane als heilmittel gegen obstruktive funktionsstoerungen der lunge und/oder stoerungen der ableitenden harnwege
DE3827532A1 (de) * 1988-08-13 1990-03-01 Hoechst Ag 6-aroyl-substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
FR2637896B1 (fr) * 1988-10-17 1990-11-30 Adir Nouveaux derives de l'amino chromanol, leur procede de preparation et les compositions pharmaceutiques les renfermant
DE3901720A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Substituierte benzo(b)pyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
US5104890A (en) * 1989-03-28 1992-04-14 Fujisawa Pharmaceutical Company, Ltd. Benzopyran derivatives and processes for preparation thereof
IE63935B1 (en) * 1989-06-27 1995-06-28 Chem Pharm Forsch Gmbh Novel thienopyran derivatives a process for their preparation and their use
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
AU651105B2 (en) * 1990-06-18 1994-07-14 E.R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
HUT72741A (en) * 1992-12-19 1996-05-28 Alkaloida Vegyeszeti Gyar Method for producing benzopyrane derivatives and pharmaceutical compositions containing them
GB9316111D0 (en) * 1993-08-04 1993-09-22 Pfizer Ltd Benzopyrans

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2107706A (en) * 1981-09-25 1983-05-05 Beecham Group Plc Benzopyrans
DE3364734D1 (en) * 1982-10-19 1986-08-28 Beecham Group Plc Novel chromans and chromenes
GB8308062D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
GB8308064D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
DE3726261A1 (de) * 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate
DE3703227A1 (de) * 1987-02-04 1988-08-18 Hoechst Ag Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen

Also Published As

Publication number Publication date
HU207729B (en) 1993-05-28
EP0277611B1 (de) 1993-06-16
FI92064C (sv) 1994-09-26
NO880474D0 (no) 1988-02-03
PT86691A (pt) 1988-03-01
IL85289A0 (en) 1988-07-31
NO169964B (no) 1992-05-18
EP0277611A3 (en) 1990-04-25
NO880474L (no) 1988-08-05
DK55188D0 (da) 1988-02-03
EP0277611A2 (de) 1988-08-10
DE3881714D1 (de) 1993-07-22
HUT50165A (en) 1989-12-28
FI880468A (sv) 1988-08-05
KR880009957A (ko) 1988-10-06
NO169964C (no) 1992-08-26
PT86691B (pt) 1992-04-30
PH24836A (en) 1990-10-30
AU1122788A (en) 1988-09-08
IE60932B1 (en) 1994-09-07
NZ223384A (en) 1989-11-28
ES2058148T3 (es) 1994-11-01
FI880468A0 (sv) 1988-02-02
IE880295L (en) 1988-08-04
AU604089B2 (en) 1990-12-06
DK167440B1 (da) 1993-11-01
DK55188A (da) 1988-08-05
IL85289A (en) 1994-04-12

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Owner name: HOECHST AKTIENGESELLSCHAFT