FI91167B - Ny transaminas, dess framställning och användning - Google Patents
Ny transaminas, dess framställning och användning Download PDFInfo
- Publication number
- FI91167B FI91167B FI892689A FI892689A FI91167B FI 91167 B FI91167 B FI 91167B FI 892689 A FI892689 A FI 892689A FI 892689 A FI892689 A FI 892689A FI 91167 B FI91167 B FI 91167B
- Authority
- FI
- Finland
- Prior art keywords
- transaminase
- carried out
- amino group
- range
- enzyme
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia
- Y10S435/849—Escherichia coli
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Claims (11)
1. Förfarande för framställning av ett transaminas, kannetecknat därav, att man odlar E. coli DH-1 5 (ATCC 33849) och isolerar transaminaset, vars molekylvikt är 25 000 - 100 000 dalton och vars isoelektriska punkt är inom pH-omrädeti 3,5 - 5,5 och vars pH-optimi är inom omrädet: 8,0 - 9,0, och 10 med en substratspecifitet för L-fosfinotricin, γ-amino-smörsyra och glutamat som donator av aminogruppen och motsvarande ketoföreningar som acceptor för aminogruppen.
2. Förfarande enligt patentkravet 1, kannetecknat därav, att odlingen utförs i en temperatur 15 pä 20 - 40 °C.
3. Förfarande enligt patentkravet 2, känne-t e c k n a t därav, att odlingen utförs i en temperatur pä 25 - 37 °C.
4. Förfarande enligt nägot av patentkraven 1-3, 20 kannetecknat därav, att odlingen utförs vid ett pH-värde pä 5 - 8,5.
5. Förfarande enligt patentkravet 4, känne-t e c k n a t därav, att odlingen utförs vid ett pH-värde pä 5,5 - 8,0.
6. Användning av transaminaset erhället enligt pa tentkravet 1 för transaminering av (3-karboxi-3-oxo-pro-py1)-mety1-fos finsyra.
7. Användning enligt patentkravet 6, känne-t e c k n a d därav, att transamineringsreaktionen utförs 30 vid 20 - 60 °C.
8. Användning enligt patentkravet 6 eller 7, kännetecknad därav, att transamineringsreaktionen utförs vid ett pH-värde pä 4 - 12.
9. Användning enligt ett eller flere av patentkra-35 ven 6-8, kännetecknad därav, att transami- naset används i immobiliserad form.
10. Användning enligt patentkravet 9, kanne-t e c k n a d därav, att man som bärarmaterial använder ett kopolymerat ur vinylacetat och divinyletylenurea.
11. Transaminas, kännetecknat därav, att det isolerats ur E. coli DH-1 (ATCC 33849) och att - dess molekylvikt är 25 000 - 100 000 dalton, - dess isoelektriska punkt är inom pH-omrädet: 3,5 - 5,5 10. dess pH-optimi är inom omrädet: 8-9 - det har en substratspecifitet för L-fosfinotri-cin, γ-aminosmörsyra och glutamat som donator av amino-gruppen och motsvarande ketoföreningar som acceptor för aminogruppen. II
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3818851 | 1988-06-03 | ||
DE3818851A DE3818851A1 (de) | 1988-06-03 | 1988-06-03 | Neue transaminase, ihre herstellung und ihre verwendung |
Publications (4)
Publication Number | Publication Date |
---|---|
FI892689A0 FI892689A0 (sv) | 1989-06-01 |
FI892689A FI892689A (sv) | 1989-12-04 |
FI91167B true FI91167B (sv) | 1994-02-15 |
FI91167C FI91167C (sv) | 1994-05-25 |
Family
ID=6355745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI892689A FI91167C (sv) | 1988-06-03 | 1989-06-01 | Ny transaminas, dess framställning och användning |
Country Status (14)
Country | Link |
---|---|
US (2) | US5130246A (sv) |
EP (1) | EP0344683B1 (sv) |
JP (1) | JP2883635B2 (sv) |
KR (1) | KR0170365B1 (sv) |
CN (2) | CN1052508C (sv) |
AT (1) | ATE104342T1 (sv) |
AU (1) | AU615304B2 (sv) |
CA (1) | CA1340515C (sv) |
DE (2) | DE3818851A1 (sv) |
DK (1) | DK270989A (sv) |
ES (1) | ES2051921T3 (sv) |
FI (1) | FI91167C (sv) |
IL (1) | IL90485A0 (sv) |
ZA (1) | ZA894179B (sv) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0248357B1 (de) * | 1986-06-04 | 1993-07-28 | Hoechst Aktiengesellschaft | Verfahren zur Herstellung von L-Phosphinothricin durch Transaminierung |
DE3842025A1 (de) * | 1988-12-14 | 1990-07-05 | Hoechst Ag | Verfahren zur herstellung von l-phosphinothricin |
DE3932015A1 (de) * | 1988-12-15 | 1991-04-04 | Hoechst Ag | Gen und genstruktur, codierend fuer eine aminotransferase, mikroorganismen, die dieses gen exprimieren, und transaminierungsverfahren unter verwendung des expressionsprodukts |
US4950606A (en) * | 1989-06-22 | 1990-08-21 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
DE4026628A1 (de) * | 1990-08-23 | 1992-02-27 | Hoechst Ag | Verfahren zur extraktiven trennung von l-phosphinothricin und l-glutaminsaeure in waessriger loesung |
DE4030578A1 (de) | 1990-09-27 | 1992-04-16 | Hoechst Ag | Verfahren zur herstellung von l-phosphinothricin durch eine gekoppelte enzymatische reaktion |
TW198064B (sv) * | 1990-12-24 | 1993-01-11 | Hoechst Ag | |
DE19919848A1 (de) | 1999-04-30 | 2000-11-02 | Aventis Cropscience Gmbh | Verfahren zur Herstellung von L-Phosphinothricin durch enzymatische Transaminierung mit Aspartat |
CN1298860C (zh) * | 2004-09-30 | 2007-02-07 | 南京大学 | γ-氨基丁酸的酶法转化制备方法 |
CN1295342C (zh) * | 2005-03-07 | 2007-01-17 | 浙江大学 | 控制pH发醇生产γ-氨基丁酸的方法 |
CN101974455B (zh) * | 2010-09-28 | 2012-05-09 | 郑州大学 | 高产γ-氨基丁酸的大肠杆菌菌株及其γ-氨基丁酸生产方法 |
CN103534350B (zh) * | 2010-09-28 | 2016-03-09 | 株式会社钟化 | 对于谷氨酸显示高活性的氨基转移酶、编码该酶的基因和它们的利用法 |
WO2016180755A1 (en) | 2015-05-11 | 2016-11-17 | Bayer Cropscience Aktiengesellschaft | Herbicide combinations comprising l-glufosinate and indaziflam |
CN116121316A (zh) | 2016-03-02 | 2023-05-16 | 巴斯夫欧洲公司 | 制造l-草胺膦的方法 |
US20210127681A1 (en) | 2017-07-27 | 2021-05-06 | Basf Se | Use of herbicidal compositions based on l-glufosinate in tolerant field crops |
CN110343676B (zh) | 2018-04-03 | 2020-06-23 | 上海弈柯莱生物医药科技有限公司 | 一种l-谷氨酸脱氢酶突变体及其应用 |
WO2020051188A1 (en) | 2018-09-05 | 2020-03-12 | Agrimetis, Llc | Methods for improving yields of l-glufosinate |
CN111019916B (zh) | 2018-11-23 | 2020-12-08 | 弈柯莱生物科技(上海)股份有限公司 | 一种d-氨基酸氧化酶突变体及其应用 |
CN111979208B (zh) | 2019-05-23 | 2023-01-10 | 弈柯莱生物科技(上海)股份有限公司 | 一种l-谷氨酸脱氢酶突变体及其应用 |
CR20220358A (es) | 2020-01-23 | 2022-08-30 | Basf Se | Aditivos novedosos para formulaciones agroquímicas |
WO2021151734A1 (en) | 2020-01-31 | 2021-08-05 | Basf Se | Herbicide combinations comprising glufosinate and flumiclorac-pentyl |
US20230054333A1 (en) | 2020-01-31 | 2023-02-23 | Basf Se | Herbicide Combinations Comprising Glufosinate and Saflufenacil |
US20230068414A1 (en) | 2020-01-31 | 2023-03-02 | Basf Se | Herbicide combinations comprising glufosinate and trifludimoxazin |
WO2021151739A1 (en) | 2020-01-31 | 2021-08-05 | Basf Se | Herbicide combinations comprising glufosinate and pyraflufen-ethyl |
WO2021151737A1 (en) | 2020-01-31 | 2021-08-05 | Basf Se | Herbicide combinations comprising glufosinate and flumioxazin |
US20230075365A1 (en) | 2020-01-31 | 2023-03-09 | Basf Se | Herbicide combinations comprising glufosinate and selected ppo inhibitors |
BR112022014971A2 (pt) | 2020-01-31 | 2022-09-20 | Basf Se | Combinação herbicida, composição, métodos para produzir uma combinação herbicida, para controlar o crescimento indesejado das plantas e para tratar ou proteger culturas e uso de combinações herbicidas |
BR112022014824A2 (pt) | 2020-01-31 | 2022-12-13 | Basf Se | Combinação de herbicidas, composição, métodos de produção de combinações herbicidas, de tratamento ou proteção de plantas produtoras em fileiras e de tratamento ou proteção de plantas especializadas e uso da composição herbicida |
US20230091043A1 (en) | 2020-01-31 | 2023-03-23 | Basf Se | Herbicide Combinations Comprising Glufosinate and Carfentrazone-Ethyl |
WO2021151738A1 (en) | 2020-01-31 | 2021-08-05 | Basf Se | Herbicide combinations comprising glufosinate and epyrifenacil |
WO2021151744A1 (en) | 2020-01-31 | 2021-08-05 | Basf Se | Herbicide combinations comprising glufosinate and oxyfluorfen |
BR112022014809A2 (pt) | 2020-01-31 | 2022-09-20 | Basf Se | Combinação de herbicidas, composição, métodos para produzir uma combinação de herbicidas, para controlar o crescimento de plantas indesejadas e para tratar ou proteger culturas e uso de uma combinação de herbicidas |
US20230088774A1 (en) | 2020-01-31 | 2023-03-23 | Basf Se | Herbicide Combinations Comprising Glufosinate and Oxadiazon |
US20230080819A1 (en) | 2020-01-31 | 2023-03-16 | Basf Se | Herbicide combinations comprising glufosinate and tiafenacil |
EP4000400A1 (en) | 2020-11-17 | 2022-05-25 | Basf Se | Herbicide combination comprising glufosinate, saflufenacil and trifludimoxazin |
AU2021360993A1 (en) | 2020-10-12 | 2023-05-18 | Basf Se | Herbicide combination comprising glufosinate, saflufenacil and trifludimoxazin |
KR20230097101A (ko) | 2020-10-27 | 2023-06-30 | 바스프 에스이 | 살충제 마이크로에멀젼 조성물 |
AR124823A1 (es) | 2021-02-05 | 2023-05-10 | Basf Se | Composiciones herbicidas líquidas |
CN117120625A (zh) | 2021-04-01 | 2023-11-24 | 巴斯夫欧洲公司 | 制备l-草铵膦的方法 |
WO2022243546A1 (en) | 2021-05-21 | 2022-11-24 | Basf Se | Computer-implemented method for applying a glutamine synthetase inhibitor on an agricultural field |
CN118234377A (zh) | 2021-11-15 | 2024-06-21 | 巴斯夫欧洲公司 | 提高除草剂功效的方法 |
WO2024056517A1 (en) | 2022-09-14 | 2024-03-21 | Basf Se | Use of an alkylether sulfate for improving the efficacy of herbicides |
EP4338592A1 (en) | 2022-09-15 | 2024-03-20 | Basf Se | Use of compound for improving the efficacy of herbicides |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4525454A (en) * | 1983-09-01 | 1985-06-25 | Genetics Institute, Inc. | Production of L-4-phenyl-2-aminobutanoic acid by transamination |
US4859591A (en) * | 1984-07-05 | 1989-08-22 | W. R. Grace & Co.-Conn. | Transamination process for producing amino acids |
US4826766A (en) * | 1985-09-23 | 1989-05-02 | Genetics Institute, Inc. | Production of amino acids using coupled aminotransferases |
EP0248357B1 (de) * | 1986-06-04 | 1993-07-28 | Hoechst Aktiengesellschaft | Verfahren zur Herstellung von L-Phosphinothricin durch Transaminierung |
AU599985B2 (en) * | 1986-06-09 | 1990-08-02 | Meiji Seika Kaisha Ltd. | New process for the production of L-2-amino-4- (hydroxymethyl-phosphinyl)-butyric acid |
DE3636722A1 (de) * | 1986-10-29 | 1988-05-05 | Hoechst Ag | Klonierung und verwendung des transaminase-gens ilve |
DE3932015A1 (de) * | 1988-12-15 | 1991-04-04 | Hoechst Ag | Gen und genstruktur, codierend fuer eine aminotransferase, mikroorganismen, die dieses gen exprimieren, und transaminierungsverfahren unter verwendung des expressionsprodukts |
-
1988
- 1988-06-03 DE DE3818851A patent/DE3818851A1/de not_active Withdrawn
-
1989
- 1989-05-29 EP EP89109648A patent/EP0344683B1/de not_active Expired - Lifetime
- 1989-05-29 AT AT89109648T patent/ATE104342T1/de not_active IP Right Cessation
- 1989-05-29 DE DE58907431T patent/DE58907431D1/de not_active Expired - Fee Related
- 1989-05-29 ES ES89109648T patent/ES2051921T3/es not_active Expired - Lifetime
- 1989-06-01 IL IL90485A patent/IL90485A0/xx unknown
- 1989-06-01 US US07/359,591 patent/US5130246A/en not_active Expired - Lifetime
- 1989-06-01 FI FI892689A patent/FI91167C/sv not_active IP Right Cessation
- 1989-06-01 AU AU35953/89A patent/AU615304B2/en not_active Ceased
- 1989-06-02 ZA ZA894179A patent/ZA894179B/xx unknown
- 1989-06-02 DK DK270989A patent/DK270989A/da not_active Application Discontinuation
- 1989-06-02 CN CN89104987A patent/CN1052508C/zh not_active Expired - Fee Related
- 1989-06-02 CA CA000601591A patent/CA1340515C/en not_active Expired - Fee Related
- 1989-06-02 KR KR1019890007558A patent/KR0170365B1/ko not_active IP Right Cessation
- 1989-06-02 JP JP1139379A patent/JP2883635B2/ja not_active Expired - Fee Related
-
1992
- 1992-03-20 US US07/854,516 patent/US5162212A/en not_active Expired - Lifetime
-
1999
- 1999-08-04 CN CN99111952A patent/CN1087347C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK270989A (da) | 1989-12-04 |
ZA894179B (en) | 1990-02-28 |
JPH0284179A (ja) | 1990-03-26 |
DE58907431D1 (de) | 1994-05-19 |
CN1052508C (zh) | 2000-05-17 |
DE3818851A1 (de) | 1989-12-14 |
CN1087347C (zh) | 2002-07-10 |
EP0344683A2 (de) | 1989-12-06 |
CN1038836A (zh) | 1990-01-17 |
KR910001036A (ko) | 1991-01-30 |
FI91167C (sv) | 1994-05-25 |
EP0344683A3 (de) | 1991-06-19 |
IL90485A0 (en) | 1990-01-18 |
AU3595389A (en) | 1989-12-07 |
ES2051921T3 (es) | 1994-07-01 |
EP0344683B1 (de) | 1994-04-13 |
US5130246A (en) | 1992-07-14 |
US5162212A (en) | 1992-11-10 |
JP2883635B2 (ja) | 1999-04-19 |
FI892689A0 (sv) | 1989-06-01 |
FI892689A (sv) | 1989-12-04 |
CN1250101A (zh) | 2000-04-12 |
CA1340515C (en) | 1999-04-27 |
KR0170365B1 (ko) | 1999-02-01 |
DK270989D0 (da) | 1989-06-02 |
AU615304B2 (en) | 1991-09-26 |
ATE104342T1 (de) | 1994-04-15 |
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Legal Events
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BB | Publication of examined application | ||
MM | Patent lapsed | ||
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Owner name: HOECHST AKTIENGESELLSCHAFT |