FI89491B - Analogifoerfarande foer framstaellning av farmakologiskt vaerdefulla 5-halogentienoisotiazol-3(2H)-on-1,1-dioxider - Google Patents
Analogifoerfarande foer framstaellning av farmakologiskt vaerdefulla 5-halogentienoisotiazol-3(2H)-on-1,1-dioxider Download PDFInfo
- Publication number
- FI89491B FI89491B FI890690A FI890690A FI89491B FI 89491 B FI89491 B FI 89491B FI 890690 A FI890690 A FI 890690A FI 890690 A FI890690 A FI 890690A FI 89491 B FI89491 B FI 89491B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- dioxide
- compounds
- compound
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (2)
1. Förfarande för framställning av farmakologiskt värdeful-la 5-halogentienoisotiazol-3(2H)-on-1,1-dioxider med for-5 me1n (I ) 0 0 10 “2— (α'2,η~·'( R’ 5 li där är väte, (-C^)-a 1 ky1 eller halogen,
15 R2 är halogen och n är ett heltal 2-6, samt deras farmaceutiskt godtagbara syraadditionssalter, kännetecknat därav, att en förening med formeln (II) 20 O 0 \\ / /^Υ*\ *2—\ » - - X 25 \ 0 där R2 och n är säsom ovan definierats och X avser halogen, omsätts i ett organiskt utspädningsmedel 30 och vid 20 - 150°C med en förening med formeln (III) /-\ N λ HN V— ^ \-R1 m 35 ^-' *=* I: 17 89491 där är ovan definierad, och den sa erhällna basen med for-meln (I) omvandlas vid behov tili ett farmaceutiskt god-tagbart syraadditionssalt. 5
2. Förfarande enligt patentkravet 1, känneteck-n a t därav, att 5-klor-2-(4-(4-(2-pyrimidiny1)-1-pipera-zinyl) butyl)tieno(2,3-d)isotiazol-3(2H)-on-l,l-dioxid f ramstä11 s. 10
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT88390A ATA39088A (de) | 1988-02-18 | 1988-02-18 | Basisch substituierte thienoisothiazol-3(2h)-on-1,1-dioxide und ihre pharmazeutisch vertraeglichen salze, verfahren zu ihrer herstellung und ihre verwendung |
| AT39088 | 1988-02-18 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI890690A0 FI890690A0 (fi) | 1989-02-14 |
| FI890690A FI890690A (fi) | 1989-08-19 |
| FI89491B true FI89491B (fi) | 1993-06-30 |
| FI89491C FI89491C (sv) | 1993-10-11 |
Family
ID=3489327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI890690A FI89491C (sv) | 1988-02-18 | 1989-02-14 | Analogiförfarande för framställning av farmakologiskt värdefulla 5-hal ogentienoisotiazol-3(2H)-on-1,1-dioxider |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4929616A (sv) |
| EP (1) | EP0328913B1 (sv) |
| JP (1) | JPH01249779A (sv) |
| KR (1) | KR890013033A (sv) |
| CN (1) | CN1024798C (sv) |
| AT (2) | ATA39088A (sv) |
| AU (1) | AU618577B2 (sv) |
| CA (1) | CA1317956C (sv) |
| CS (1) | CS274578B2 (sv) |
| DD (1) | DD279021A5 (sv) |
| DE (1) | DE58907804D1 (sv) |
| DK (1) | DK170047B1 (sv) |
| EG (1) | EG20261A (sv) |
| ES (1) | ES2054887T3 (sv) |
| FI (1) | FI89491C (sv) |
| HR (1) | HRP940825A2 (sv) |
| HU (1) | HU201084B (sv) |
| IL (1) | IL89185A (sv) |
| LT (1) | LT3947B (sv) |
| MY (1) | MY103825A (sv) |
| NO (1) | NO176050C (sv) |
| NZ (1) | NZ227939A (sv) |
| PH (1) | PH26156A (sv) |
| SI (1) | SI8910358A (sv) |
| SU (1) | SU1729293A3 (sv) |
| UA (1) | UA13481A (sv) |
| YU (1) | YU35889A (sv) |
| ZA (1) | ZA891108B (sv) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0376633B1 (en) * | 1988-12-28 | 1994-10-12 | Suntory Limited | Benzoxazepine derivatives |
| CA2567813C (en) | 2004-05-23 | 2015-11-24 | Gerard M. Housey | Theramutein modulators |
| US8431110B2 (en) | 2005-05-23 | 2013-04-30 | Hmi Medical Innovations, Llc. | Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators |
| CN103789389B (zh) * | 2005-11-23 | 2017-01-04 | 杰勒德·M·豪斯 | 鉴定、合成、优化和表征蛋白调节剂的化合物和方法 |
| CN101186612B (zh) * | 2006-11-15 | 2012-10-03 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用 |
| US8551560B2 (en) * | 2008-05-23 | 2013-10-08 | Intermolecular, Inc. | Methods for improving selectivity of electroless deposition processes |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL47877A (en) | 1974-08-26 | 1978-10-31 | Sparamedica Ag | Thienothiazine carboxamide derivatives,their manufacture and pharmaceutical compositions containing them |
| DE2534689B2 (de) | 1974-09-16 | 1979-03-01 | Basf Ag, 6700 Ludwigshafen | 23-Dihydro-3-oxo-thieno-isothiazol-1,1-dioxide |
| LU78009A1 (de) | 1977-08-22 | 1979-05-23 | Hoffmann La Roche | Verfahren zur herstellung von thiazinderivaten |
| AU518216B2 (en) | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
| DE2749640A1 (de) | 1977-11-05 | 1979-05-10 | Thomae Gmbh Dr K | Ein thieno eckige klammer auf 3,2-d eckige klammer zu isothiazolondioxid, verfahren zu seiner herstellung und dessen verwendung |
| AT364852B (de) * | 1977-11-05 | 1981-11-25 | Thomae Gmbh Dr K | Verfahren zur herstellung von kondensierten isothiazol-3(2h)-on-1,1-dioxiden und von deren salzen |
| DE2839266A1 (de) | 1978-09-09 | 1980-03-20 | Thomae Gmbh Dr K | Kondensierte isothiazol-3(2h)-on-1,1- dioxide, verfahren zu deren herstellung und deren verwendung |
| ATE26720T1 (de) | 1982-09-09 | 1987-05-15 | Hoffmann La Roche | Thieno(2,3-e)-1,2-thiazin-derivate. |
| DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| FI862513A (fi) * | 1985-07-04 | 1987-01-05 | Chemie Linz Ag | Nya tieno-1,2-tiazolderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska preparat. |
| US4675403A (en) * | 1985-10-16 | 1987-06-23 | American Home Products Corporation | 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity |
| US4732984A (en) * | 1985-10-17 | 1988-03-22 | American Home Products Corporation | Piperazinoisothiazolones with psychotropic activity |
-
1988
- 1988-02-18 AT AT88390A patent/ATA39088A/de not_active IP Right Cessation
-
1989
- 1989-01-26 DE DE58907804T patent/DE58907804D1/de not_active Expired - Fee Related
- 1989-01-26 AT AT89101335T patent/ATE106888T1/de active
- 1989-01-26 EP EP89101335A patent/EP0328913B1/de not_active Expired - Lifetime
- 1989-01-26 ES ES89101335T patent/ES2054887T3/es not_active Expired - Lifetime
- 1989-02-06 IL IL89185A patent/IL89185A/xx not_active IP Right Cessation
- 1989-02-06 US US07/306,744 patent/US4929616A/en not_active Expired - Fee Related
- 1989-02-07 CA CA000590351A patent/CA1317956C/en not_active Expired - Fee Related
- 1989-02-10 NZ NZ227939A patent/NZ227939A/xx unknown
- 1989-02-13 ZA ZA891108A patent/ZA891108B/xx unknown
- 1989-02-13 CS CS93189A patent/CS274578B2/cs unknown
- 1989-02-14 FI FI890690A patent/FI89491C/sv not_active IP Right Cessation
- 1989-02-14 EG EG7289A patent/EG20261A/xx active
- 1989-02-15 AU AU29945/89A patent/AU618577B2/en not_active Ceased
- 1989-02-15 PH PH38203A patent/PH26156A/en unknown
- 1989-02-16 MY MYPI89000193A patent/MY103825A/en unknown
- 1989-02-16 YU YU00358/89A patent/YU35889A/xx unknown
- 1989-02-16 SI SI8910358A patent/SI8910358A/sl unknown
- 1989-02-16 DD DD89325819A patent/DD279021A5/de unknown
- 1989-02-16 KR KR1019890001758A patent/KR890013033A/ko not_active Application Discontinuation
- 1989-02-17 HU HU89810A patent/HU201084B/hu not_active IP Right Cessation
- 1989-02-17 JP JP1036407A patent/JPH01249779A/ja active Pending
- 1989-02-17 SU SU894613473A patent/SU1729293A3/ru active
- 1989-02-17 CN CN89102110A patent/CN1024798C/zh not_active Expired - Fee Related
- 1989-02-17 DK DK073289A patent/DK170047B1/da not_active IP Right Cessation
- 1989-02-17 UA UA4613473A patent/UA13481A/uk unknown
- 1989-02-17 NO NO890691A patent/NO176050C/no unknown
-
1994
- 1994-01-27 LT LTIP1813A patent/LT3947B/lt not_active IP Right Cessation
- 1994-10-26 HR HR940825A patent/HRP940825A2/xx not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CS202515B2 (en) | Method of producing novel 4-hydroxy-2h-1,2-benzothiazine-3-carboxamide-1,1-dioxides | |
| AU7451298A (en) | Novel cyclic diamine compounds and medicine containing the same | |
| CZ87793A3 (en) | Process for preparing arylpiperazinyl heterocyclic compounds | |
| PL85278B1 (sv) | ||
| IE920734A1 (en) | 4-aryl-thiazole or imidazole derivatives | |
| FI64144C (fi) | Foerfarande foer framstaellning av 2-arylamino-2-imidazolinderivat | |
| FI89491C (sv) | Analogiförfarande för framställning av farmakologiskt värdefulla 5-hal ogentienoisotiazol-3(2H)-on-1,1-dioxider | |
| NZ573352A (en) | Substituted carboxamides as group i metabotropic receptor antagonists | |
| US20040038987A1 (en) | Novel cyclic diamine compounds and medicine containing the same | |
| US5026717A (en) | 2-imino-6-polyfluoroalkoxybenzothiazole derivatives, and pharmaceutical compositions containing them | |
| FI89267B (fi) | Foerfarande foer framstaellning av terapeutiskt aktiva 4,5-dihydro-oxazoler | |
| CA2624383C (en) | Salts of modulators of ppar and methods of treating metabolic disorders | |
| CS259516B2 (en) | Method of new heterocyclic compounds production | |
| US4082757A (en) | Amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide | |
| US3853872A (en) | 2,3,4,5-substituted thiazoles | |
| Keshari et al. | Novel Mannich-bases as potential anticonvulsants: syntheses, characterization and biological evaluation | |
| EP0009142A1 (de) | Neue 4-Hydroxy-2H(1)benzothieno(2,3-e)-1,2-thiazin-3-carboxamid-1,1-dioxide sowie deren Salze, deren Verwendung und Verfahren zu ihrer Herstellung | |
| CS272769B2 (en) | Method of pyridazopyridone's new tricyclic derivatives production | |
| JPS61205275A (ja) | 新規の８‐チオテトラヒドロキノリン誘導体及びそれらの塩 | |
| Wright et al. | (2-Carboxy-1, 4-dihydro-4-oxoquinolyl) oxamic acids and (2-carboxy-1, 4-dihydro-4-oxobenzo [h] quinolyl) oxamic acids as antiallergy agents | |
| US4282225A (en) | Thiazole derivatives useful in therapy as anti-depressant agents | |
| FR2571723A1 (fr) | Derives de thieno et furo-(2,3-c) pyrroles, procedes de preparation et medicaments les contenant | |
| JPH06135925A (ja) | ヒスタミンｈ▲２▼−受容体拮抗活性をもつ置換３，４−ジアミノ−１，２，５−チアジアゾール用中間体 | |
| JPH0495071A (ja) | カルバミン酸誘導体 | |
| PL118018B1 (en) | Process for preparing novel 2,6-bis/aminoacyloamino/-benzo/1,2-d:5,4-d'/-bisthiazoles and 2-amino-6-/aminoacyloamino/-benzo/1,2-d:5,4-d'/-bisthiazoleseh:5,4-deh/-bistiazolejj i 2-amino-6-/aminoaciloamino/-benzo/1,2-deh:5,4-deh/bistiazolejj |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: CHEMISCH PHARMAZEUTISCHE |