FI88618B - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 6-fluor-7-/4-(5-metyl-2-oxo-1,3-dioxolen-4-yl)-metyl-1-piperazinyl/-4-oxo-4h-/1,3/tiazeto/3,2-a/kinolin-3-karboxylsyraderivat - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 6-fluor-7-/4-(5-metyl-2-oxo-1,3-dioxolen-4-yl)-metyl-1-piperazinyl/-4-oxo-4h-/1,3/tiazeto/3,2-a/kinolin-3-karboxylsyraderivat Download PDFInfo
- Publication number
- FI88618B FI88618B FI885128A FI885128A FI88618B FI 88618 B FI88618 B FI 88618B FI 885128 A FI885128 A FI 885128A FI 885128 A FI885128 A FI 885128A FI 88618 B FI88618 B FI 88618B
- Authority
- FI
- Finland
- Prior art keywords
- methyl
- oxo
- dioxolen
- piperazinyl
- fluoro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Dental Preparations (AREA)
- Display Devices Of Pinball Game Machines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Quinoline Compounds (AREA)
Claims (7)
1. Förfarande för framställning av terapeutiskt användbara (6-fluor-7-[4-(5-mety1-2-oxo-l,3-dioxolen-4-y1)metyl-1-piperaziny1]-4-oxo-4H-(1,3]tiazeto[3,2-a]kinolin-3-karboxy1-syraderivat med den allmänna formeln (I) 0 F R 1 I i in CH > | -r-CHi-N ^ TT ^ J. v γ ί· väri Rl är väte, en rak eller förgrenad C14-alkyl, en fenyl eller en halogen-substituerad fenyl, r3 är väte eller en rak eller förgrenad C14-alkyl, och R3 är väte, halogen eller en rak eller förgrenad C14-alko-xi, samt farmakologiskt acceptable syraadditionssalter därav, kännetecknat av att man omsätter en förening med den allmänna formeln (II) 0 H R 3 CD) R ‘ 23 8 61 8 väri R1, R2 och R1 har saroina betydelse soin ovan, med en före-ning roed den allmanna formeIn (III) CHa "Γ | CH»—X I I , r--, o o —»uj li 0 (I] väri X representerar halogen, och, om sä önskas, hydrolyseras en erhällen förening med formeln (I) , väri R2 är alkyl och R1 och R1 har saroina betydelse son ovan, tili motsvarande förening med formeln (I), väri R2 är väte och R1 och R1 har samma betydelse son ovan, och/eller, om sä önskas, transesterifieras en erhällen förening med formeln (I), väri R2 är alkyl och Rl och R1 har samma betydelse som ovan, tili motsvarande förening med formeln (I) , väri R2 är en annan alkyl och R1 och R1 har samma betydelse som ovan, och/eller, om sä önskas, förestras en erhällen förening med formeln (I) , väri R2 är väte och R1 och R1 har samma betydelse som ovan, tili motsvarande förening med formeln (I), väri R2 är alkyl och R1 och R1 har samma betydelse som ovan, och/eller, om sä önskas, överförs en erhällen förening med den allmänna formeln (I) tili ett farmakologiskt acceptabelt syraadditionssalt.
2. Förfarande enligt patentkrav 1, kännetecknat av att man framställer ety1-6-fluor-l-metyl-7-[4-(5-metyl-2-oxo-1,3-dioxolen-4-yl)metyl-1-piperazinyl]-4-oxo-4H-(1,3]-tiazetof 3,2-a]kinolin-3-karboxylat. Förfarande enligt patentkrav 1, kännetecknat av att man framställer 6-fluor-l-metyl-7-[4-(5-metyl-2-oxo- 24 .-8 618 1.3- dioxolen-4-yl)metyl-l-piperazinyl]-4-oxo-4H-[1,3]-tiaze-to[3,2-a]kinolin-3-karboxylsyra.
4. Förfarande enligt patentkrav 1, kännetecknat av att man framställer 6-fluor-l-metyl-7-[4-(5-metyl-2-oxo- 1.3- dioxolen-4-yl)metyl-l-piperazinyl]-4-oxo-4H-[l/3]-tiaze-to[3,2-a]kinolin-3-karboxylsyra-väteklorid.
5. Förfarande enligt patentkrav 1, kännetecknat av att man framställer 6-fluor-l-metyl-7-[4-(5-metyl-2-oxo- 1.3- dioxolen-4-yl)metyl-l-piperazinyl]-4-oxo-4H-[1,3]-tiaze-to[3,2-a]kinolin-3-karboxylsyra-metansulfonat.
6. Förfarande enligt patentkrav 1, kännetecknat av att man framställer 6,8-difluor-l-mety1-7-[4-(5-mety1-2-oxo-1,3-dioxolen-4-yl)metyl-l-piperazinyl]-4-oxo-4H-[1,3]-tiazeto[3,2-a]kinolin-3-karboxylsyra. 1 Förfarande enligt patentkrav 1, kännetecknat av att man framställer 6-fluor-8-metoxi-l-metyl-7-[4-(5-mety1-2-oxo-1,3-dioxolen-4-yl)metyl-l-piperazinyl]-4-oxo-4H- [1,3]-tiazeto[3,2-a]kinolin-3-karboxylsyra.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28155087 | 1987-11-07 | ||
| JP28155087 | 1987-11-07 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI885128A0 FI885128A0 (fi) | 1988-11-07 |
| FI885128A FI885128A (fi) | 1989-05-08 |
| FI88618B true FI88618B (fi) | 1993-02-26 |
| FI88618C FI88618C (sv) | 1993-06-10 |
Family
ID=17640743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI885128A FI88618C (sv) | 1987-11-07 | 1988-11-07 | Förfarande för framställning av nya terapeutiskt användbara 6-fluor-7- /4-(5-metyl-2-oxo-1,3-dioxolen-4-yl)-metyl-1-piperazinyl/-4-oxo-4H-/1, 3/tiazeto/3,2-a/kinolin-3-karboxylsyraderivat |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5086049A (sv) |
| EP (1) | EP0315828B1 (sv) |
| JP (1) | JPH0751579B2 (sv) |
| KR (1) | KR950011747B1 (sv) |
| CN (1) | CN1024194C (sv) |
| AT (1) | ATE74608T1 (sv) |
| CA (1) | CA1316925C (sv) |
| DE (1) | DE3869907D1 (sv) |
| DK (1) | DK172077B1 (sv) |
| ES (1) | ES2031569T3 (sv) |
| FI (1) | FI88618C (sv) |
| IL (1) | IL88303A (sv) |
| NO (1) | NO177934C (sv) |
| ZA (1) | ZA888186B (sv) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3869906D1 (de) * | 1987-11-07 | 1992-05-14 | Nippon Shinyaku Co Ltd | Chinolincarbonsaeure-derivate. |
| AU6641190A (en) * | 1989-11-17 | 1991-06-13 | Nippon Shinyaku Co. Ltd. | Quinolinecarboxylic acid derivative |
| EP0551518A4 (en) * | 1990-10-03 | 1993-09-22 | Nippon Shinyaku Company, Limited | Quinolinecarboxylic acid derivative |
| NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
| RU2270695C2 (ru) | 1999-03-17 | 2006-02-27 | Дайити Фармасьютикал Ко., Лтд. | Фармацевтическая композиция |
| CN100351258C (zh) * | 2003-04-30 | 2007-11-28 | 日本新药株式会社 | 喹啉羧酸衍生物溶剂化物的结晶 |
| WO2004096815A1 (ja) | 2003-04-30 | 2004-11-11 | Nippon Shinyaku Co. Ltd. | キノリンカルボン酸誘導体溶媒和物の結晶 |
| JPWO2005073239A1 (ja) * | 2004-01-30 | 2008-01-10 | 日本新薬株式会社 | キノリンカルボン酸誘導体の精製方法 |
| CN1321997C (zh) * | 2004-03-03 | 2007-06-20 | 刘玉辉 | 一种稳定的噻丁啶喹啉羧酸盐在制备抗感染药物中的应用 |
| CN100360539C (zh) * | 2005-09-23 | 2008-01-09 | 广州白云山制药股份有限公司广州白云山化学制药厂 | 普卢利沙星的制备方法 |
| WO2007082472A1 (en) * | 2006-01-18 | 2007-07-26 | Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical Factory | Anti-infective quinolone compound, preparation method thereof and use thereof |
| CN101003540A (zh) * | 2006-01-18 | 2007-07-25 | 广州白云山制药股份有限公司广州白云山制药总厂 | 一种抗感染化合物和用途 |
| US20100113783A1 (en) * | 2007-03-14 | 2010-05-06 | Ranbaxy Laboratories Limited | Process for the preparation of crystals of prulifloxacin |
| WO2008111016A1 (en) * | 2007-03-14 | 2008-09-18 | Ranbaxy Laboratories Limited | Process for the preparation of pure prulifloxacin |
| WO2009093268A1 (en) * | 2008-01-23 | 2009-07-30 | Ind-Swift Laboratories Limited | Process for the preparation of highly pure prulifloxacin |
| CN101565428B (zh) * | 2009-06-02 | 2011-06-29 | 重庆科瑞制药有限责任公司 | 普卢利沙星的制备方法 |
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
| CN102093393B (zh) * | 2009-12-15 | 2014-03-26 | 南京长澳医药科技有限公司 | 一种制备普卢利沙星及其中间产物的方法 |
| CN101768172B (zh) * | 2010-01-13 | 2012-04-18 | 海南皇隆制药股份有限公司 | 用于抗感染的普卢利沙星的光学活性化合物和制备方法 |
| CN102198135B (zh) * | 2010-03-22 | 2013-05-08 | 北京联木医药技术发展有限公司 | 一种新型稳定的普卢利沙星盐酸盐在制备抗感染药物中的应用 |
| IN2012MN02925A (sv) * | 2010-06-30 | 2015-05-22 | Cipla Ltd | |
| CN114751873A (zh) * | 2022-04-25 | 2022-07-15 | 扬州市普林斯医药科技有限公司 | 一种1-(2,3-二氯苯基)哌嗪的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57203067A (en) * | 1981-06-10 | 1982-12-13 | Kanebo Ltd | Novel quinolinecarboxylic acid derivatives, their preparations, and antibacterial agent comprising them as active ingredient |
| JPS59227887A (ja) * | 1983-06-09 | 1984-12-21 | Nippon Shinyaku Co Ltd | ナフチリジン誘導体 |
| US4659734A (en) * | 1983-08-15 | 1987-04-21 | Nippon Shinyaku Co., Ltd. | Olinecarboxylic acid derivatives |
| DE3504643A1 (de) * | 1985-02-12 | 1986-08-14 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl)-3-chinolin carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DE3542002A1 (de) * | 1985-11-28 | 1987-06-04 | Bayer Ag | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| JPS63107990A (ja) * | 1986-05-14 | 1988-05-12 | Nippon Shinyaku Co Ltd | キノリンカルボン酸誘導体 |
| EP0312794B1 (en) * | 1987-09-22 | 1993-05-19 | Nippon Shinyaku Company, Limited | Thiazetidine derivatives |
| DE3869906D1 (de) * | 1987-11-07 | 1992-05-14 | Nippon Shinyaku Co Ltd | Chinolincarbonsaeure-derivate. |
-
1988
- 1988-10-19 JP JP63263568A patent/JPH0751579B2/ja not_active Expired - Lifetime
- 1988-10-26 ES ES198888117810T patent/ES2031569T3/es not_active Expired - Lifetime
- 1988-10-26 DE DE8888117810T patent/DE3869907D1/de not_active Expired - Fee Related
- 1988-10-26 EP EP88117810A patent/EP0315828B1/en not_active Expired - Lifetime
- 1988-10-26 AT AT88117810T patent/ATE74608T1/de active
- 1988-11-01 ZA ZA888186A patent/ZA888186B/xx unknown
- 1988-11-04 DK DK616388A patent/DK172077B1/da not_active IP Right Cessation
- 1988-11-05 CN CN88107689A patent/CN1024194C/zh not_active Expired - Lifetime
- 1988-11-07 IL IL88303A patent/IL88303A/xx not_active IP Right Cessation
- 1988-11-07 CA CA000582460A patent/CA1316925C/en not_active Expired - Lifetime
- 1988-11-07 FI FI885128A patent/FI88618C/sv not_active IP Right Cessation
- 1988-11-07 KR KR88014591A patent/KR950011747B1/ko not_active IP Right Cessation
- 1988-11-07 NO NO884958A patent/NO177934C/no unknown
-
1991
- 1991-04-08 US US07/682,434 patent/US5086049A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK172077B1 (da) | 1997-10-13 |
| US5086049A (en) | 1992-02-04 |
| KR890008150A (ko) | 1989-07-10 |
| AU608911B2 (en) | 1991-04-18 |
| ATE74608T1 (de) | 1992-04-15 |
| DK616388D0 (da) | 1988-11-04 |
| ES2031569T3 (es) | 1992-12-16 |
| FI885128A (fi) | 1989-05-08 |
| CA1316925C (en) | 1993-04-27 |
| ZA888186B (en) | 1989-07-26 |
| JPH0751579B2 (ja) | 1995-06-05 |
| FI885128A0 (fi) | 1988-11-07 |
| NO177934C (no) | 1995-12-20 |
| FI88618C (sv) | 1993-06-10 |
| IL88303A (en) | 1993-05-13 |
| DK616388A (da) | 1989-05-08 |
| NO177934B (no) | 1995-09-11 |
| KR950011747B1 (en) | 1995-10-09 |
| CN1024194C (zh) | 1994-04-13 |
| DE3869907D1 (de) | 1992-05-14 |
| IL88303A0 (en) | 1989-06-30 |
| CN1033055A (zh) | 1989-05-24 |
| EP0315828A1 (en) | 1989-05-17 |
| JPH01294680A (ja) | 1989-11-28 |
| NO884958D0 (no) | 1988-11-07 |
| AU2467388A (en) | 1989-05-11 |
| EP0315828B1 (en) | 1992-04-08 |
| NO884958L (no) | 1989-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| FG | Patent granted |
Owner name: NIPPON SHINYAKU CO., LTD. |
|
| MA | Patent expired |