FI881063A - Förfarande för framställning av terapeutiskt användbara etoxietyl-bensimidazol- eller imidazopyridinföreningar - Google Patents

Förfarande för framställning av terapeutiskt användbara etoxietyl-bensimidazol- eller imidazopyridinföreningar Download PDF

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Publication number
FI881063A
FI881063A FI881063A FI881063A FI881063A FI 881063 A FI881063 A FI 881063A FI 881063 A FI881063 A FI 881063A FI 881063 A FI881063 A FI 881063A FI 881063 A FI881063 A FI 881063A
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FI
Finland
Prior art keywords
compounds
alk
formula
ethoxyethylbenzimidazole
preparation
Prior art date
Application number
FI881063A
Other languages
English (en)
Finnish (fi)
Other versions
FI881063A0 (sv
FI93728B (sv
FI93728C (sv
Inventor
Frans Eduard Janssens
Gaston Stanislas Marcell Diels
Joseph Leo Ghislanus Torremans
Francois Maria Sommen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI881063A0 publication Critical patent/FI881063A0/sv
Publication of FI881063A publication Critical patent/FI881063A/sv
Publication of FI93728B publication Critical patent/FI93728B/sv
Application granted granted Critical
Publication of FI93728C publication Critical patent/FI93728C/sv

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
FI881063A 1987-03-09 1988-03-08 Förfarande för framställning av terapeutiskt användbara etoxietyl-bensimidazol- eller imidazopyridinföreningar FI93728C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2373987A 1987-03-09 1987-03-09
US2373987 1987-03-09

Publications (4)

Publication Number Publication Date
FI881063A0 FI881063A0 (sv) 1988-03-08
FI881063A true FI881063A (sv) 1988-09-10
FI93728B FI93728B (sv) 1995-02-15
FI93728C FI93728C (sv) 1995-05-26

Family

ID=21816923

Family Applications (1)

Application Number Title Priority Date Filing Date
FI881063A FI93728C (sv) 1987-03-09 1988-03-08 Förfarande för framställning av terapeutiskt användbara etoxietyl-bensimidazol- eller imidazopyridinföreningar

Country Status (20)

Country Link
EP (1) EP0282133B1 (sv)
JP (1) JPS63301879A (sv)
KR (1) KR960009430B1 (sv)
CN (1) CN1026588C (sv)
AT (1) ATE92065T1 (sv)
AU (1) AU593720B2 (sv)
CA (1) CA1266048A (sv)
DE (1) DE3882556T2 (sv)
DK (1) DK171181B1 (sv)
ES (1) ES2059489T3 (sv)
FI (1) FI93728C (sv)
HU (1) HU204270B (sv)
IE (1) IE61595B1 (sv)
IL (1) IL85661A (sv)
NO (1) NO170485C (sv)
NZ (1) NZ223654A (sv)
PH (1) PH26652A (sv)
PT (1) PT86917B (sv)
SU (1) SU1637663A3 (sv)
ZA (1) ZA881660B (sv)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
ES2013411A6 (es) * 1989-03-28 1990-05-01 Espanola Prod Quimicos Procedimientos de preparacion de nuevos derivados de la 1-difenilmetilpiperidina.
IT1229231B (it) * 1989-05-08 1991-07-26 Dompe Farmaceutici Spa Aminoimidazopiridine farmacologicamente attive
DE3915025A1 (de) * 1989-05-08 1990-11-15 Dompe Farmaceutici Spa 2-substituierte 3-(2'aethoxy)-aethyl)-imidazo(4,5-b)pyridinderivate und diese enthaltende arzneimittel
IT1229230B (it) * 1989-05-08 1991-07-26 Dompe Farmaceutici Spa Piperidinilimidazopiridine farmacologicamente attive.
GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
FR2668150B1 (fr) * 1990-10-17 1994-11-18 Theramex Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.
WO1993014083A1 (en) * 1992-01-09 1993-07-22 Janssen Pharmaceutica N.V. Pharmaceutically active substituted benzimidazole derivatives
CA2189964A1 (en) * 1994-05-18 1995-11-23 Haruhiko Kikuchi Novel diaminomethylidene derivative
DE4425145A1 (de) * 1994-07-15 1996-01-18 Basf Ag Verwendung von Thiazol- und Thiadiazolverbindungen
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
TW429256B (en) * 1995-12-27 2001-04-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
FR2771093B1 (fr) 1997-11-19 2000-01-21 Synthelabo Derives d'imidazole, leur preparation et leur application en therapeutique
ATE258928T1 (de) 1999-06-28 2004-02-15 Janssen Pharmaceutica Nv Respiratorisches syncytialvirus replikation inhibitoren
KR100453916B1 (ko) * 2002-03-11 2004-10-20 주식회사 코오롱 1,2,5,6-테트라히드로피리디닐벤즈이미다졸 유도체 및 그제조방법
ATE325125T1 (de) 2002-09-06 2006-06-15 Janssen Pharmaceutica Nv Thienopyrrolyl und furanopyrrolyl verbindungen und deren verwendung als histamin h4 rezeptor liganden
US8193359B2 (en) * 2004-12-24 2012-06-05 Prosidion Limited G-protein coupled receptor agonists
ATE478075T1 (de) 2005-03-08 2010-09-15 Janssen Pharmaceutica Nv Diazaspiro-ä4,4ü-nonanderivate als neurokinin- (nk1)-antagonisten
RU2540074C2 (ru) * 2007-06-21 2015-01-27 Кара Терапеутикс, Инк Производные имидазопиразина или имидазодиазепина, активные в отношении рецептора св2
CZ307500B6 (cs) * 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1140119A (en) * 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
EP0144101B1 (en) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
ES2052544T3 (es) * 1986-02-03 1994-07-16 Janssen Pharmaceutica Nv Composiciones anti-histaminicas que contienen n-heterociclil-4-piperidinaminas.

Also Published As

Publication number Publication date
DE3882556T2 (de) 1993-11-18
CN88101286A (zh) 1988-09-28
AU1270288A (en) 1988-09-08
DK124488A (da) 1988-09-10
NO881027L (no) 1988-09-12
DK124488D0 (da) 1988-03-08
KR960009430B1 (en) 1996-07-19
HU204270B (en) 1991-12-30
ATE92065T1 (de) 1993-08-15
SU1637663A3 (ru) 1991-03-23
FI881063A0 (sv) 1988-03-08
AU593720B2 (en) 1990-02-15
IL85661A (en) 1992-07-15
DE3882556D1 (de) 1993-09-02
CN1026588C (zh) 1994-11-16
EP0282133B1 (en) 1993-07-28
IE61595B1 (en) 1994-11-16
PT86917A (pt) 1988-04-01
NO881027D0 (no) 1988-03-08
NO170485C (no) 1992-10-21
DK171181B1 (da) 1996-07-15
CA1266048A (en) 1990-02-20
FI93728B (sv) 1995-02-15
NO170485B (no) 1992-07-13
IL85661A0 (en) 1988-08-31
EP0282133A2 (en) 1988-09-14
FI93728C (sv) 1995-05-26
HUT46679A (en) 1988-11-28
ES2059489T3 (es) 1994-11-16
KR880011143A (ko) 1988-10-26
JPS63301879A (ja) 1988-12-08
IE880668L (en) 1988-09-09
PH26652A (en) 1992-09-04
EP0282133A3 (en) 1989-06-07
NZ223654A (en) 1990-03-27
PT86917B (pt) 1992-05-29
ZA881660B (en) 1989-11-29

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Owner name: JANSSEN PHARMACEUTICA N.V.