FI86140B - Foerfarande foer framstaellning av en farmaceutisk beredning som innehaoller ett i vatten svaorloesligt eller i vatten instabilt laekemedel. - Google Patents

Foerfarande foer framstaellning av en farmaceutisk beredning som innehaoller ett i vatten svaorloesligt eller i vatten instabilt laekemedel. Download PDF

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Publication number
FI86140B
FI86140B FI853198A FI853198A FI86140B FI 86140 B FI86140 B FI 86140B FI 853198 A FI853198 A FI 853198A FI 853198 A FI853198 A FI 853198A FI 86140 B FI86140 B FI 86140B
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FI
Finland
Prior art keywords
water
preparation
cyclodextrin
prepared
process according
Prior art date
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FI853198A
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English (en)
Finnish (fi)
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FI86140C (sv
FI853198A0 (fi
FI853198L (fi
Inventor
Ulrich Brauns
Bernhard Willi Werner Mueller
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI853198A0 publication Critical patent/FI853198A0/fi
Publication of FI853198L publication Critical patent/FI853198L/fi
Publication of FI86140B publication Critical patent/FI86140B/fi
Application granted granted Critical
Publication of FI86140C publication Critical patent/FI86140C/sv

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (13)

1. Förfarande för framställning av en farmaceutisk bered-ning genom att upplösa en β-cyklodextrineter i vatten och tillsätta ett läkemedel som är svärlösligt i vatten eller är instabil i vatten för bildande av ett inklusionkomplex och möjligen torka den erhällna lösningen av inklusionkomplexet, förutsatt att inklusionkomplexen av retinoider med β-cyklo-dextrinetrar är utslutna, dä deras etersubstituenter är me-tyl-, etyl- och 2-hydroxietylgrupper, kännetecknat av att man som β-cyklodextrineter använder ett partiellt företrat β-cyklodextrin, vars etersubstituenter är hydroxietyl-, hydroxipropyl- eller dihydroxipropylgrupper, varvid en del av etersubstituenterna kan möjligen vara metyl- eller etyl-grupper, och att β-cyklodextrinetern har en vattenlöslighet som är större än 1,8 g i 100 ml vatten.
2. Förfarande enligt patentkravet 1, kännetecknat av att man framställer en beredning som innehäller ett partiellt företrat β-cyklodextrin, väri hydroxialkylsubstituenternas molara substitueringsgrad är 0,05-10 och alkylsubstituenter-nas substitueringsgrad är 0,05-2,0.
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat av att man framställer en beredning som innehäller läkemed-let och β-cyklodextrinetern i molförhällandet 1:6-4:1.
; ; 4. Förfarande enligt nägot av patentkraven 1-3, känneteck nat av att man framställer en beredning, vilken säsom läkemedel innehäller ett icke-steroid-antireumatiskt medel, en steroid, en hjärtglykosid eller derivat av bensodiazepin, bensimidazol, piperidin, piperazin, imidazol eller triazol.
5. Förfarande enligt nägot av patentkraven 1-4, känneteck-: nat av att man framställer en beredning, vilken säsom läke- medel innehäller etomidat. • ♦ i7 861 40
6. Förfarande enligt nägot av patentkraven 1-4, känneteck-nat av att man framställer en beredning, vilken säsom läke-medel innehäller ketokonazol.
7. Förfarande enligt nägot av patentkraven 1-4, känneteck-nat av att man framställer en beredning, vilken säsom läke-medel innehäller itrakonazol.
8. Förfarande enligt nägot av patentkraven 1-4, känneteck-nat av att man framställer en beredning, vilken säsom läke-medel innehäller levokabastin.
9. Förfarande enligt nägot av patentkraven 1-4, känneteck-nat av att man framställer en beredning, vilken säsom läke-medel innehäller flunarizin.
10. Förfarande enligt nägot av patentkraven 1-4, känneteck-nat av att man framställer en beredning, vilken säsom läke-medel innehäller tubulazol.
11. Förfarande enligt nägot av patentkraven 1-10, känne-tecknat av att äterstoden som erhälls efter avlägsnande av lösningsmedlet pulveriseras och möjligen efter tillsats av ytterligare hjälpmedel, överförs i en fast doseringsform.
12. Förfarande enligt nägot av patentkraven 1-11, känne-tecknat av att man i vattnet tillsätter ytterligare fysiolo-giskt lämpliga medel.
13. Förfarande enligt patentkravet 12, kännetecknat av att man i vattnet tillsätter natriumklorid, glukos, mannitol, sorbitol, xylitol eller en fosfat- eller citratbuffert.
FI853198A 1983-12-21 1985-08-20 Förfarande för framställning av en farmaceutisk beredning som innehåll er ett i vatten svårlösligt eller i vatten instabilt läkemedel FI86140C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3346123 1983-12-21
DE19833346123 DE3346123A1 (de) 1983-12-21 1983-12-21 Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
EP8400417 1984-12-20
PCT/EP1984/000417 WO1985002767A1 (en) 1983-12-21 1984-12-20 Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation

Publications (4)

Publication Number Publication Date
FI853198A0 FI853198A0 (fi) 1985-08-20
FI853198L FI853198L (fi) 1985-08-20
FI86140B true FI86140B (fi) 1992-04-15
FI86140C FI86140C (sv) 1992-07-27

Family

ID=6217510

Family Applications (1)

Application Number Title Priority Date Filing Date
FI853198A FI86140C (sv) 1983-12-21 1985-08-20 Förfarande för framställning av en farmaceutisk beredning som innehåll er ett i vatten svårlösligt eller i vatten instabilt läkemedel

Country Status (17)

Country Link
EP (1) EP0149197B2 (sv)
JP (1) JPS61500788A (sv)
AT (1) ATE51145T1 (sv)
AU (1) AU565966B2 (sv)
CA (1) CA1222697A (sv)
CY (1) CY1689A (sv)
DE (2) DE3346123A1 (sv)
DK (1) DK175288B1 (sv)
FI (1) FI86140C (sv)
HK (1) HK131293A (sv)
HU (1) HU200943B (sv)
LU (1) LU90283I2 (sv)
NL (1) NL980009I1 (sv)
NO (1) NO2000007I1 (sv)
SG (1) SG24893G (sv)
WO (1) WO1985002767A1 (sv)
ZA (1) ZA8410042B (sv)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920214A (en) * 1986-04-16 1990-04-24 American Maize-Products Company Process for producing modified cyclodextrins
JPH0819004B2 (ja) * 1986-12-26 1996-02-28 日清製粉株式会社 徐放性医薬製剤
IT1203968B (it) * 1987-04-24 1989-02-23 Bononi Ricerca Complessi di b-ciclodestrina ad attivita' antimicotica
NZ224497A (en) * 1987-05-18 1990-04-26 Janssen Pharmaceutica Nv Pharmaceutical composition comprising flunarizine
JP2577049B2 (ja) * 1987-06-04 1997-01-29 三共株式会社 シクロスポリン製剤
NZ225045A (en) * 1987-07-01 1990-06-26 Janssen Pharmaceutica Nv Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent
ZA884592B (en) * 1987-08-31 1989-03-29 Warner Lambert Co Cyclodextrin complexes of bis-biguanido hexane compounds
US4877774A (en) * 1987-09-09 1989-10-31 The United States Of America As Represented By The Department Of Health And Human Services Administration of steroid hormones
US5256652A (en) * 1987-11-12 1993-10-26 Pharmedic Co. Topical compositions and methods for treatment of male impotence
BE1001704A3 (fr) * 1987-12-22 1990-02-13 Glaxo Group Ltd Compositions aqueuses contenant un derive de l'acide piperidinylcyclopentylheptenoique.
US5221695A (en) * 1987-12-22 1993-06-22 Glaxo Group Limited Aqueous formulation containing a piperidinylcyclopentylheptenoic acid derivative and beta-cyclodextrin
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5017566A (en) * 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
EP0326196B1 (en) * 1988-01-14 1992-03-25 Akzo N.V. Aqueous pharmaceutical preparation
US5760015A (en) * 1988-01-19 1998-06-02 The Trustees Of The University Of Pennsylvania Cyclodextrin compounds and methods of making and use thereof
DE68910113T2 (de) * 1988-01-19 1994-03-17 Childrens Hospital Corp Wachstuminhibierendes mittel und dessen verwendung.
US5658894A (en) * 1989-04-23 1997-08-19 The Trustees Of The University Of Pennsylvania Compositions for inhibiting restenosis
US5637575A (en) * 1988-01-19 1997-06-10 The Trustees Of The University Of Pennsylvania Methods of inhibiting restenosis
AU626538B2 (en) * 1988-01-19 1992-08-06 Moses Judah Folkman Growth inhibiting agent and the use thereof
US5019562A (en) * 1988-01-19 1991-05-28 The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation Growth inhibiting agent and the use thereof
DE3809808A1 (de) * 1988-03-23 1989-10-05 Hexal Pharma Gmbh & Co Kg Feste, insbesondere festorale und rektale, etofenamat enthaltende arzneimittel
US5236944A (en) * 1988-03-28 1993-08-17 Janssen Pharmaceutica N.V. Compounds, compositions and anti-neoplastic methods
DE3815902A1 (de) * 1988-05-10 1989-11-23 Schwarz Pharma Gmbh Einschlussverbindungen des 1-(4-(2-(5-chloro-2-methoxybenzamido)ethyl) -phenylsulfonyl)-3-cyclohexylharnstoffs mit (alpha)-,ss-,(gamma)-cyclodextrinen, jeweils diese enthaltendes pharmazeutisches praeparat und verfahren zu deren herstellung
GB8813682D0 (en) * 1988-06-09 1988-07-13 Reckitt & Colmann Prod Ltd Pharmaceutical compositions
NL8801670A (nl) 1988-07-01 1990-02-01 Walter Adrianus Josephus Johan Farmaceutisch preparaat.
US5229370A (en) * 1988-08-15 1993-07-20 Ammeraal Robert N Water soluble branched beta cyclodextrin steroid complex
EP0381747A4 (en) * 1988-08-15 1991-09-11 American Maize-Products Company Water soluble branched beta cyclodextrin steroid complex
MY106598A (en) * 1988-08-31 1995-06-30 Australian Commercial Res & Development Ltd Compositions and methods for drug delivery and chromatography.
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
JP2929108B2 (ja) * 1988-10-28 1999-08-03 株式会社資生堂 化粧料および粉末化粧料
AU616571B2 (en) * 1988-10-28 1991-10-31 Shiseido Company Ltd. Cosmetic composition containing inclusion product with hydroxyalkylated cyclodextrin
IT1227626B (it) * 1988-11-28 1991-04-23 Vectorpharma Int Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione
US5441944A (en) * 1989-04-23 1995-08-15 The Trustees Of The University Of Pennsylvania Substituted cyclodextrin sulfates and their uses as growth modulating agents
GB8910069D0 (en) * 1989-05-03 1989-06-21 Janssen Pharmaceutica Nv Method of topically treating acne vulgaris
JPH0737390B2 (ja) * 1989-08-29 1995-04-26 久光製薬株式会社 軟膏組成物
EP0491812A4 (en) * 1989-09-14 1992-11-04 Australian Commercial Research & Development Limited Drug delivery compositions
US5053240A (en) * 1989-10-24 1991-10-01 Kalamazoo Holdings, Inc. Norbixin adducts with water-soluble or water-dispersible proteins or branched-chain or cyclic polysaccharides
GB9001987D0 (en) * 1990-01-29 1990-03-28 Janssen Pharmaceutica Nv Improved cyclodextrin based erythropietin formulation
EP0518930A4 (en) * 1990-03-02 1993-09-15 Australian Commercial Research & Development Limited Cyclodextrin compositions and methods for pharmaceutical and industrial applications
FR2660309B1 (fr) * 1990-03-27 1992-07-17 Roussel Uclaf Nouveaux complexes de l'acide tiaprofenique ou de ses esters insolubles ou partiellement solubles avec les cyclodextrines ou leurs derives.
JP2867162B2 (ja) * 1990-03-31 1999-03-08 株式会社資生堂 ピールオフ型パック化粧料
US5124154A (en) * 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5120720A (en) * 1990-09-20 1992-06-09 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Preparation of lipophile:hydroxypropylcyclodextrin complexes by a method using co-solubilizers
LU87843A1 (fr) * 1990-11-15 1992-08-25 Cird Galderma Gel aqueux a base d'acide retinoique et d'hydroxypropyl-beta-cyclodextrine et son utilisation en medecine humaine et en cosmetique
JPH04351603A (ja) * 1991-05-29 1992-12-07 Toppan Printing Co Ltd β−シクロデキストリン誘導体
DE69231457T2 (de) * 1991-06-21 2001-05-23 Takeda Chemical Industries Ltd Zyklodextrin-Zusammensetzung enthaltend Fumagillol-Derivate
US5446030A (en) * 1991-09-19 1995-08-29 Weisz; Paul B. Prevention of hemolysis
ATE156019T1 (de) * 1991-10-16 1997-08-15 Schering Corp Lipophile zusammensetzungen von oligosaccharid- antibiotikasalzen
IL103558A0 (en) 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
US5254541A (en) * 1991-11-15 1993-10-19 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indole/cyclodextrin complex
DE4207922A1 (de) * 1992-03-13 1993-09-23 Pharmatech Gmbh Wasserloesliche einschlussverbindungen und verfahren zu deren herstellung
US5472954A (en) * 1992-07-14 1995-12-05 Cyclops H.F. Cyclodextrin complexation
US5324718A (en) * 1992-07-14 1994-06-28 Thorsteinn Loftsson Cyclodextrin/drug complexation
DE4227569C1 (de) * 1992-08-20 1994-06-09 Inst Chemo Biosensorik Verfahren zum empfindlichen enzymatischen Nachweis von anorganischem Phosphat
TW251236B (sv) * 1992-09-10 1995-07-11 Ciba Vision Ag
JP2879395B2 (ja) * 1992-10-26 1999-04-05 富士写真フイルム株式会社 ロダシアニン化合物及びシクロデキストリンを含有する抗癌性組成物
US5494901A (en) * 1993-01-05 1996-02-27 Javitt; Jonathan C. Topical compositions for the eye comprising a β-cyclodextrin derivative and a therapeutic agent
CA2157190A1 (en) * 1993-03-05 1994-09-15 Wilfried Fischer Crystalline cyclodextrin inclusion complexes of ranitidine hydrochloride and process for their preparation
CA2159717A1 (en) * 1993-03-31 1994-10-13 Elliot Barnathan Methods of affecting the growth of living tissue in mammals and compounds and compositions therefor
DK94093D0 (da) * 1993-08-17 1993-08-17 Finn Molke Borgbjerg Lokalanaestetisk praeparat
TW349870B (en) * 1993-09-30 1999-01-11 Janssen Pharmaceutica Nv An antifungal pharmaceutical composition for oral administration and a process for the preparation thereof
RU2135176C1 (ru) * 1993-12-14 1999-08-27 Эли Лилли Энд Компани Водорастворенный комплекс включения соединений бензотиофена с водорастворимым циклодекстрином, способ его получения и фармацевтическая композиция
US5646131A (en) * 1994-02-22 1997-07-08 The Arab Company For Drug Industries And Medical Applicances (Acdima) Method for solubilizing drugs using cyclodextrins and carboxylic acids
AU1716995A (en) * 1994-03-18 1995-10-09 Ciba-Geigy Ag Aqueous solution of levocabastine for ophthalmic use
DE4414138A1 (de) * 1994-04-22 1995-10-26 Consortium Elektrochem Ind Acylierte gamma-Cyclodextrine
AU2531295A (en) * 1994-05-27 1995-12-21 Farmarc Nederland Bv Pharmaceutical composition
FR2726765B1 (fr) * 1994-11-14 1996-12-20 Cis Bio Int Compositions radiopharmaceutiques comprenant un complexe d'inclusion d'une cyclodextrine et d'un acide gras radiohalogene
US5576311A (en) * 1994-11-30 1996-11-19 Pharmos Corporation Cyclodextrins as suspending agents for pharmaceutical suspensions
FR2735136B1 (fr) * 1995-06-08 1997-08-14 Roquette Freres Composition pulverulente d'hydroxypropyl-betacyclodextrine et son procede de preparation.
JP2920611B2 (ja) * 1995-12-11 1999-07-19 株式会社シーエーシー 皮膚炎の治療外用剤
GB9605705D0 (en) 1996-03-19 1996-05-22 Pfizer Ltd Therapeutic agents
DE69733664T3 (de) 1996-04-19 2011-04-14 Grifols Inc. (n.d. Ges.d.Staates Delaware), Los Angeles Verfahren zur INaktivierung von Viren und Lyophilisierung von Blutproteinen
SE9601556D0 (sv) * 1996-04-24 1996-04-24 Astra Ab New pharmaceutical formulation of a thrombin inhibitor for parenteral use
ES2207748T3 (es) * 1996-08-09 2004-06-01 Alcon Manufacturing Ltd. Sistemas conservantes para composiciones farmaceuticas que contienen ciclodextrinas.
US5942501A (en) * 1996-08-16 1999-08-24 Collaborative Laboratories, Inc. Cyclodextrin derivative complex
EP0838225A3 (en) * 1996-10-25 1999-03-24 Hiji, Yasutake Aqueous local anesthetic solution
ATE241969T1 (de) * 1997-03-26 2003-06-15 Janssen Pharmaceutica Nv Tabletten mit einem kern, der mit einem pilzbekämpfungsmittel und einem polymeren beschichtet ist
GB9713149D0 (en) 1997-06-21 1997-08-27 Pfizer Ltd Pharmaceutical formulations
US6596706B1 (en) 1997-11-07 2003-07-22 Daiichi Pharmaceutical Co., Ltd. Piperazine-cyclodextrin complexes
WO1999033467A1 (en) 1997-12-31 1999-07-08 Choongwae Pharma Corporation Method and composition of an oral preparation of itraconazole
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
DE19848303A1 (de) * 1998-10-14 2000-04-20 Schering Ag Kombination aus Gestagenen und Zuckern
GB9906126D0 (en) * 1999-03-18 1999-05-12 Knoll Ag Pharmaceutical formulations
AU5975700A (en) * 1999-07-02 2001-01-22 Janssen Pharmaceutica N.V. Nasal formulation of an antifungal
SE9902988D0 (sv) * 1999-08-24 1999-08-24 Astra Ab Chemical compounds
CA2726789A1 (en) 2000-02-05 2001-11-08 Theravance, Inc. Cyclodextrin containing glycopeptide antibiotic compositions
US6468989B1 (en) 2000-07-13 2002-10-22 Dow Pharmaceutical Sciences Gel compositions containing metronidazole
PE20020300A1 (es) 2000-08-22 2002-05-10 Pharmacia Corp Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
US6962944B2 (en) 2001-07-31 2005-11-08 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
US7074824B2 (en) 2001-07-31 2006-07-11 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
US6982256B2 (en) 2001-09-07 2006-01-03 Boehringer Ingelheim Pharma Kg Tolerance of 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine in intravenous administration
WO2003033025A2 (en) 2001-10-18 2003-04-24 Decode Genetics Ehf Cyclodextrin complexes
GB0127677D0 (en) * 2001-11-19 2002-01-09 Vianex S A Inclusion complex
US6881726B2 (en) 2001-12-24 2005-04-19 Dow Pharmaceutical Sciences Aqueous compositions containing metronidazole
AR038575A1 (es) 2002-02-22 2005-01-19 Pharmacia Corp Formulacion oftalmica con nueva composicion de goma
US6951846B2 (en) * 2002-03-07 2005-10-04 The United States Of America As Represented By The Secretary Of The Army Artemisinins with improved stability and bioavailability for therapeutic drug development and application
US6818662B2 (en) 2002-05-28 2004-11-16 Taisho Pharmaceutical Co., Ltd. Pharmaceutical composition
DE10228049A1 (de) * 2002-06-24 2004-01-15 Merck Patent Gmbh Flüssige Zubereitung enthaltend Oligopeptide
MXPA05010330A (es) 2003-03-28 2006-05-31 Ivax Corp Formulaciones de cladribina para el mejor suministro oral y a traves de la mucosa.
PT1608344E (pt) 2003-03-28 2010-09-02 Ares Trading Sa Formulações orais de cladribina
UA81305C2 (en) 2003-07-02 2007-12-25 Ares Trading Sa Formulation of cladribine (variants), cladribine-cyclodextrin complex, use of cladribine-cyclodextrin complex, mixture
CN1294912C (zh) * 2004-03-01 2007-01-17 上海医药工业研究院 伊曲康唑盐酸盐组合物及其冻干粉针
DE102004011512B4 (de) 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
ITMI20041763A1 (it) * 2004-09-16 2004-12-16 Altergon Sa Nuove formulazioni iniettabili contenenti progesterone
WO2006137433A1 (ja) * 2005-06-21 2006-12-28 Wakamoto Pharmaceutical Co., Ltd. レボカバスチンを可溶化させた水性薬剤
US7744904B1 (en) 2005-09-26 2010-06-29 B.B. Scientific L.L.C. Stabilization of Clostridium botulinum neurotoxin complex
PT2054040E (pt) 2006-08-16 2011-06-30 Novartis Ag Método para produzir dispersões sólidas de compostos terapêuticos altamente cristalinos
MX2009004214A (es) * 2006-10-20 2009-05-11 Icos Corp Composiciones de inhibidores de chk1.
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
MX2009005368A (es) * 2006-11-21 2009-06-05 Novartis Ag Formulacion parenteral estable que contiene un inhibidor de rsv de una estructura de benzodiazepina.
CL2009000453A1 (es) * 2008-02-28 2010-08-13 Takeda Pharmaceuticals Co Composicion farmaceutica que comprende i) compuesto derivado triciclico nitrogenado, tal como pirido[2,3-b]indol, ii) al menos un derivado de ciclodextrina y iii) agua, util para prevenir o tratar cancer e inflamacion, entre otras; metodo para mejorar la solubilidad y estabilidad en agua de dichos compuestos.
ES2436716T3 (es) 2008-11-25 2014-01-03 Boehringer Ingelheim Vetmedica Gmbh Pimobendan para uso en el tratamiento de la cardiomiopatía hipertrófica en gatos
WO2010088924A1 (en) 2009-02-06 2010-08-12 Telormedix Sa Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
CN102499909B (zh) * 2011-12-27 2013-08-07 哈尔滨三联药业有限公司 伊曲康唑分散片及其制备方法
KR101383941B1 (ko) * 2012-03-09 2014-04-10 동아에스티 주식회사 피록시캄 또는 약제학적으로 허용되는 그의 염과 히알루론산 또는 약제학적으로 허용되는 그의 염의 안정한 액상 조성물 및 그 제조방법
ES2924478T3 (es) 2012-03-15 2022-10-07 Boehringer Ingelheim Vetmedica Gmbh Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos
JP6282644B2 (ja) * 2012-06-28 2018-02-21 ジヨンソン・アンド・ジヨンソン・コンシユーマー・インコーポレーテツドＪｏｈｎｓｏｎ ＆ Ｊｏｈｎｓｏｎ Ｃｏｎｓｕｍｅｒ Ｉｎｃ． ラセカドトリル液体組成物
EA201591710A1 (ru) * 2013-03-13 2016-03-31 Сиэтл Дженетикс, Инк. Композиции, содержащие циклодекстрин и конъюгат антитело-лекарственное средство
CN105377235A (zh) 2013-07-19 2016-03-02 勃林格殷格翰动物保健有限公司 含有防腐的醚化的环糊精衍生物的液体水性药物组合物
WO2015054429A1 (en) * 2013-10-08 2015-04-16 Innopharma, Inc Aprepitant oral liquid formulations
BR112016011111B1 (pt) 2013-12-04 2022-11-16 Boehringer Ingelheim Vetmedica Gmbh Composições farmacêuticas aprimoradas de pimobendan
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
SG11201913008TA (en) * 2017-06-30 2020-01-30 Celgene Corp Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-doxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl) -2,2-difluoroacetamide
US10716774B1 (en) 2018-01-05 2020-07-21 Yale Pharmaceuticals LLC Pharmaceutical compositions containing isotretinoin with improved dissolution profile and enhanced stability
CN112334494A (zh) * 2018-06-29 2021-02-05 罗盖特公司 新颖的羟丙基-β-环糊精及其生产方法
FR3083234B1 (fr) * 2018-06-29 2020-11-27 Roquette Freres Nouvelles hydroxypropyl-beta-cyclodextrines et leurs procedes de preparation
BR112021008139A2 (pt) 2018-10-29 2021-08-03 Cyclo Therapeutics, Inc. métodos para tratar doença de alzheimer
CN114195733B (zh) * 2022-01-07 2024-10-01 华东理工大学 一种抑制烯丙苯噻唑异构化的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459731A (en) * 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
US3453259A (en) * 1967-03-22 1969-07-01 Corn Products Co Cyclodextrin polyol ethers and their oxidation products
HU181703B (en) * 1980-05-09 1983-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing aqueus solutuins of water insoluble or hardly soluble vitamines, steroides, localanesthetics, prostanoides and non-steroid and antiphlogistic agents
US4371673A (en) * 1980-07-21 1983-02-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble forms of retinoids

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HUT40561A (en) 1987-01-28
EP0149197B1 (de) 1990-03-21
JPH0570612B2 (sv) 1993-10-05
ATE51145T1 (de) 1990-04-15
LU90283I2 (fr) 1998-11-03
AU3835285A (en) 1985-07-12
FI86140C (sv) 1992-07-27
DK175288B1 (da) 2004-08-09
EP0149197B2 (de) 1997-01-08
CA1222697A (en) 1987-06-09
DE3346123A1 (de) 1985-06-27
EP0149197A3 (en) 1985-08-14
DK359585A (da) 1985-08-07
HK131293A (en) 1993-12-03
FI853198A0 (fi) 1985-08-20
CY1689A (en) 1994-01-14
DE3481680D1 (de) 1990-04-26
NO2000007I1 (no) 2000-09-21
EP0149197A2 (de) 1985-07-24
DK359585D0 (da) 1985-08-07
FI853198L (fi) 1985-08-20
SG24893G (en) 1993-08-06
AU565966B2 (en) 1987-10-01
JPS61500788A (ja) 1986-04-24
NL980009I1 (nl) 1998-05-06
WO1985002767A1 (en) 1985-07-04
HU200943B (en) 1990-09-28
ZA8410042B (en) 1985-09-25

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