FI85978B - Foerfarande foer framstaellning av ett terapeutiskt anvaendbart salt eller ester av 3'-azido-3'deoxitymidin. - Google Patents

Foerfarande foer framstaellning av ett terapeutiskt anvaendbart salt eller ester av 3'-azido-3'deoxitymidin. Download PDF

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Publication number
FI85978B
FI85978B FI861069A FI861069A FI85978B FI 85978 B FI85978 B FI 85978B FI 861069 A FI861069 A FI 861069A FI 861069 A FI861069 A FI 861069A FI 85978 B FI85978 B FI 85978B
Authority
FI
Finland
Prior art keywords
azido
deoxythymidine
ester
group
active ingredient
Prior art date
Application number
FI861069A
Other languages
English (en)
Finnish (fi)
Other versions
FI861069A0 (fi
FI861069A (fi
FI85978C (sv
Inventor
George Andrew Freeman
Janet Rideout
David Walter Barry
Sandra Nusinoff Lehrman
Clair Martha Heider St
Phillip Allen Furman
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27516579&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI85978(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB858506869A external-priority patent/GB8506869D0/en
Priority claimed from GB858511774A external-priority patent/GB8511774D0/en
Priority claimed from US06/776,899 external-priority patent/US4724232A/en
Priority claimed from GB858523881A external-priority patent/GB8523881D0/en
Priority claimed from GB868603450A external-priority patent/GB8603450D0/en
Publication of FI861069A0 publication Critical patent/FI861069A0/fi
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI861069A publication Critical patent/FI861069A/fi
Priority to FI902941A priority Critical patent/FI902941A0/fi
Publication of FI85978B publication Critical patent/FI85978B/fi
Publication of FI85978C publication Critical patent/FI85978C/sv
Application granted granted Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Claims (2)

1. Förfarande för framställning av ett terapeu-tiskt användbart och farmaceutiskt godtagbart sait eller 5 ester av 3'-azido-3'-deoxitymidin, vilket sait eller ester inte är nägot av följande 5'-derivat: monofosfat, di-natriummonofosfat, 2-cyanetylmonofosfat, trifosfat, p-to-luensulfonat, acetat eller metansulfonat, känne-t e c k n a t därav, att (A) en förening med formeln 10 (II), 0 11 CH_ HN I 3 15 ° ^ ho an
20 M i vilken M är en halogen, hydroxi eller organosulfonyl-oxiradikal, eller ett derivat säsom en ester eller ett 25 sait av denna, bringas att reagera med litium- eller nat-riumazid för att omvandla gruppen M tili den önskade azi-dogruppen, eller (B) en förening med formeln (III), o 30 hn 0 ^ .: · 35 a / (m) N3 I; 33 85978 i vilken R är en ester-, eter- eller aralkoxigrupp, hyd-rolyseras för att omvandla nämnda grupp till den önskade hydroxigruppen; och om 3'-azido-3'-deoxitymidin erhälles, omvandlas föreningen till ett farmaceutiskt godtagbart 5 salt eller ester.
2. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att man framställer 5'-difosfat-, 5'-(3-metylbutyrat)-, 5'-oktanoat-, 5'-palmitat-, 5'-(3-klorbensoat)-, 5’-bensoat-, 5’-vätesuckinat- eller 5'-pi-10 valatestern av 3'-azido-3'-deoxitymidin.
FI861069A 1985-03-16 1986-03-14 Förfarande för framställning av ett terapeutiskt användbart salt eller ester av 3'-azido-3'-deoxitymidin FI85978C (sv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI902941A FI902941A0 (fi) 1985-03-16 1990-06-12 Foerfarande foer framstaellning av en farmaceutisk produkt.

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB858506869A GB8506869D0 (en) 1985-03-16 1985-03-16 Antiviral compound
GB858511774A GB8511774D0 (en) 1985-05-09 1985-05-09 Antiviral compounds
US77689985 1985-09-17
US06/776,899 US4724232A (en) 1985-03-16 1985-09-17 Treatment of human viral infections
GB858523881A GB8523881D0 (en) 1985-09-27 1985-09-27 Antiviral compounds
GB8506869 1986-02-12
GB868603450A GB8603450D0 (en) 1986-02-12 1986-02-12 Antiviral compounds
GB8603450 1986-02-12
GB8523881 1986-02-12
GB8511774 1986-02-12

Publications (4)

Publication Number Publication Date
FI861069A0 FI861069A0 (fi) 1986-03-14
FI861069A FI861069A (fi) 1986-09-17
FI85978B true FI85978B (fi) 1992-03-13
FI85978C FI85978C (sv) 1992-06-25

Family

ID=27516579

Family Applications (1)

Application Number Title Priority Date Filing Date
FI861069A FI85978C (sv) 1985-03-16 1986-03-14 Förfarande för framställning av ett terapeutiskt användbart salt eller ester av 3'-azido-3'-deoxitymidin

Country Status (21)

Country Link
EP (2) EP0291633B1 (sv)
JP (1) JPH0780898B2 (sv)
AP (1) AP11A (sv)
AT (4) ATE44464T1 (sv)
AU (1) AU572019B2 (sv)
CA (1) CA1238277A (sv)
CS (1) CS385191A3 (sv)
CY (2) CY1508A (sv)
DE (4) DE3650130T3 (sv)
DK (1) DK164392C (sv)
FI (1) FI85978C (sv)
GR (1) GR860712B (sv)
HK (2) HK85789A (sv)
IE (1) IE56503B1 (sv)
IL (1) IL78158A (sv)
MC (1) MC1742A1 (sv)
MY (1) MY102693A (sv)
NZ (1) NZ215486A (sv)
PH (1) PH24388A (sv)
PT (1) PT82199B (sv)
SG (1) SG62889G (sv)

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US4841039A (en) * 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US5084445A (en) * 1986-05-01 1992-01-28 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine
EP0332626A1 (en) * 1986-11-21 1989-09-20 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Compositions for treating viral infections in humans
US4880782A (en) * 1986-11-21 1989-11-14 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Method of treating viral infections in humans and compositions therefor
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HU199865B (en) * 1987-03-16 1990-03-28 Wellcome Found Process for production of healing nucleosides and medical compositions containing them
EP0286825A3 (en) * 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of 3'-fluro-3' deoxythymidine for the manufacture of a medicament for the treatment of virus infections
EP0282618A1 (en) * 1987-03-18 1988-09-21 Vereniging Het Nederlands Kanker Instituut 1-Deoxynojirimycin as an anti-HIV therapeutic
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EP0292101A3 (en) * 1987-03-25 1990-01-31 The Wellcome Foundation Limited Process for the preparation of 3'-azido-3'-deoxythymidine and intermediates
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
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IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
IL86009A (en) * 1987-04-10 1991-09-16 Us Health Liposome-encapsulated phosphorylated nucleosides for treatment of retroviral diseases
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
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JPS63280026A (ja) * 1987-04-24 1988-11-17 ザ　ウエルカム　フアウンデーション　リミテッド 抗ウイルス配合組成物
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Also Published As

Publication number Publication date
AU572019B2 (en) 1988-04-28
CA1238277A (en) 1988-06-21
EP0196185B1 (en) 1989-07-12
AP11A (en) 1987-12-22
DE3650130D1 (de) 1994-12-08
DE3650130T2 (de) 1995-03-16
EP0291633A1 (en) 1988-11-23
FI861069A0 (fi) 1986-03-14
EP0196185A2 (en) 1986-10-01
NZ215486A (en) 1988-09-29
SG62889G (en) 1990-01-26
DE3650130T3 (de) 2003-07-24
EP0196185A3 (en) 1988-01-13
HK85789A (en) 1989-11-03
DE196185T1 (de) 1987-04-30
PH24388A (en) 1990-06-13
DK118086A (da) 1986-09-17
AU5475886A (en) 1986-09-18
ATA68386A (de) 1989-08-15
ATE81978T1 (de) 1992-11-15
MY102693A (en) 1992-09-30
MC1742A1 (fr) 1987-02-26
EP0291633B1 (en) 1992-11-04
CY1508A (en) 1990-08-03
DK118086D0 (da) 1986-03-14
IL78158A0 (en) 1986-07-31
JPS63290895A (ja) 1988-11-28
IE56503B1 (en) 1991-08-14
FI861069A (fi) 1986-09-17
AT390000B (de) 1990-02-26
IE860677L (en) 1986-09-16
DE3687069T2 (de) 1993-03-25
CY1889A (en) 1996-11-22
ATE44464T1 (de) 1989-07-15
ATE113603T1 (de) 1994-11-15
FI85978C (sv) 1992-06-25
DE3687069D1 (de) 1992-12-10
DE3608606A1 (de) 1986-09-18
DK164392B (da) 1992-06-22
PT82199A (en) 1986-04-01
DK164392C (da) 1992-11-09
IL78158A (en) 1988-04-29
GR860712B (en) 1986-07-16
AP8600027A0 (en) 1986-02-01
PT82199B (pt) 1990-11-07
HK164395A (en) 1995-10-27
CS385191A3 (en) 1992-05-13
JPH0780898B2 (ja) 1995-08-30

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