FI854797A - Menetelmä terapeuttisesti käyttökelpoisten oksetanonien valmistamiseksi - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten oksetanonien valmistamiseksi Download PDFInfo
- Publication number
- FI854797A FI854797A FI854797A FI854797A FI854797A FI 854797 A FI854797 A FI 854797A FI 854797 A FI854797 A FI 854797A FI 854797 A FI854797 A FI 854797A FI 854797 A FI854797 A FI 854797A
- Authority
- FI
- Finland
- Prior art keywords
- alkyl
- opt
- ring
- oxetanones
- substd
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH610284 | 1984-12-21 | ||
| CH610284 | 1984-12-21 | ||
| CH393485 | 1985-09-12 | ||
| CH393485 | 1985-09-12 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI854797A0 FI854797A0 (fi) | 1985-12-04 |
| FI854797A true FI854797A (fi) | 1986-06-22 |
| FI91403B FI91403B (fi) | 1994-03-15 |
| FI91403C FI91403C (fi) | 1994-06-27 |
Family
ID=25694219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI854797A FI91403C (fi) | 1984-12-21 | 1985-12-04 | Menetelmä terapeuttisesti käyttökelpoisten oksetanonien valmistamiseksi |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US4931463A (fi) |
| EP (1) | EP0185359B1 (fi) |
| CN (1) | CN1012643B (fi) |
| AT (1) | ATE70061T1 (fi) |
| AU (1) | AU583569B2 (fi) |
| CA (1) | CA1270837A (fi) |
| CS (1) | CS262425B2 (fi) |
| DE (1) | DE3584829D1 (fi) |
| DK (1) | DK166724B1 (fi) |
| DO (1) | DOP1985004386A (fi) |
| FI (1) | FI91403C (fi) |
| HU (1) | HU200172B (fi) |
| IE (1) | IE58926B1 (fi) |
| IL (1) | IL77338A (fi) |
| MC (1) | MC1728A1 (fi) |
| NO (1) | NO171160C (fi) |
| NZ (1) | NZ214565A (fi) |
| PH (1) | PH26291A (fi) |
| PT (1) | PT81748B (fi) |
| ZW (1) | ZW20385A1 (fi) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1328881C (en) * | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
| US5246960A (en) * | 1984-12-21 | 1993-09-21 | Hoffmann-La Roche Inc. | Oxetanones |
| US4895973A (en) * | 1986-08-14 | 1990-01-23 | G. D. Searle & Company | Substituted glutaric acid lactones in the treatment of hyperlipidemia |
| US4816477A (en) * | 1987-05-26 | 1989-03-28 | Merck & Co., Inc. | Antihypercholesterolemic β-lactones |
| US4806564A (en) * | 1987-05-26 | 1989-02-21 | Merck & Co., Inc. | Antihypercholesterolemic beta-lactones |
| CA2035972C (en) * | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
| US5260310A (en) * | 1990-02-26 | 1993-11-09 | Hoffmann-La Roche Inc. | Oxetanone compounds and pharmaceutical compositions containing them |
| CA2098167C (en) * | 1992-06-24 | 2006-12-19 | Dorothea Isler | Foodstuffs and feedstuffs containing a lipase inhibitor |
| PT1017408E (pt) * | 1997-02-05 | 2005-07-29 | Hoffmann La Roche | Utilizacao de tetra-hidrolipstatina no tratamento de diabetes de tipo ii |
| CN100378118C (zh) | 1997-04-15 | 2008-04-02 | Csir公司 | 具有食欲抑制剂活性的药物组合物 |
| GB2355657B (en) * | 1999-10-27 | 2004-07-28 | Phytopharm Plc | Inhibitors Of Gastric Acid Secretion |
| CN1342169A (zh) * | 1999-10-29 | 2002-03-27 | 约翰·贾森·金特里·穆林斯 | 氧杂环丁烷酮衍生物 |
| EP1132389A1 (en) | 2000-03-06 | 2001-09-12 | Vernalis Research Limited | New aza-indolyl derivatives for the treatment of obesity |
| GB2363985B (en) * | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
| CA2416900C (en) * | 2000-07-28 | 2007-07-03 | F. Hoffmann-La Roche Ag | The use of a combination of a lipase inhibitor and a pharmaceutically acceptable bile acid sequestrant for the prevention and treatment of diseases associated with high plasma cholesterol levels |
| ES2304132T3 (es) | 2000-08-09 | 2008-09-16 | F. Hoffmann-La Roche Ag | Inhibidores de lipasa para el tratamiento de la dispepsia. |
| US6900226B2 (en) | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| US6392061B1 (en) * | 2000-10-16 | 2002-05-21 | Zpro Chemical, Inc. | Process for making (2S, 3S, 5S) oxetanone derivatives |
| CN100334076C (zh) | 2000-10-16 | 2007-08-29 | 霍夫曼-拉罗奇有限公司 | 二氢吲哚衍生物及其作为5－ht2受体配体的用途 |
| GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| CA2432085C (en) | 2000-12-27 | 2009-02-24 | F. Hoffmann-La Roche Ag | Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands |
| GB0106177D0 (en) | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| ES2300478T3 (es) | 2001-05-21 | 2008-06-16 | F. Hoffmann-La Roche Ag | Derivados de quinolina como ligandos para el receptor de neuropeptido y. |
| US20030027786A1 (en) | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| US6730319B2 (en) | 2001-06-06 | 2004-05-04 | Hoffmann-La Roche Inc. | Pharmaceutical compositions having depressed melting points |
| US6787558B2 (en) | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
| GB0202015D0 (en) | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| CA2473181A1 (en) | 2002-02-04 | 2003-08-14 | F. Hoffmann-La Roche Ag | Quinoline derivatives as npy antagonists |
| ES2292992T3 (es) | 2002-02-28 | 2008-03-16 | F. Hoffmann-La Roche Ag | Derivados de tiazol como antagonistas del receptor npy. |
| WO2003088975A1 (en) * | 2002-04-17 | 2003-10-30 | The Burnham Institute | Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation |
| US7728153B2 (en) | 2002-04-17 | 2010-06-01 | The Burnham Institute For Medical Research | Method for the asymmetric synthesis of beta-lactone compounds |
| MXPA05000131A (es) | 2002-07-05 | 2005-04-11 | Hoffmann La Roche | Derivados de quinazolina. |
| EP1539722A1 (en) | 2002-08-07 | 2005-06-15 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| EP1539746B1 (en) | 2002-09-12 | 2006-11-15 | F. Hoffmann-La Roche Ag | N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes |
| US6727277B1 (en) | 2002-11-12 | 2004-04-27 | Kansas State University Research Foundation | Compounds affecting cholesterol absorption |
| MXPA05005445A (es) | 2002-11-25 | 2005-08-26 | Hoffmann La Roche | Derivados de indolilo. |
| GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
| EP1651627A2 (en) * | 2003-07-15 | 2006-05-03 | Ranbaxy Laboratories Limited | Process for preparation of oxetan-2-ones |
| CA2533463A1 (en) | 2003-08-12 | 2005-02-17 | F. Hoffmann-La Roche Ag | 2-amino-5-benzoylthiazole npy antagonists |
| KR20060037436A (ko) | 2003-08-12 | 2006-05-03 | 에프. 호프만-라 로슈 아게 | Ｎｐｙ 길항물질로서 싸이아졸 유도체 |
| US7074822B2 (en) * | 2004-02-23 | 2006-07-11 | Solvay Pharmaceuticals Gmbh | Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them |
| DE102004009076A1 (de) * | 2004-02-23 | 2005-10-27 | Solvay Pharmaceuticals Gmbh | Alkylcarbamat-substituierte β-Lactone, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US7121355B2 (en) * | 2004-09-21 | 2006-10-17 | Cnh America Llc | Bulldozer autograding system |
| WO2006035296A1 (en) * | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Process for the preparation of an orlistat derivative useful as reference standard in the determination of the purity of orlistat and process for the preparation of orlistat |
| KR100895758B1 (ko) | 2005-05-03 | 2009-04-30 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ2 리간드로서 테트라사이클릭 아자피라지노인돌린 |
| ATE430744T1 (de) | 2005-08-18 | 2009-05-15 | Hoffmann La Roche | Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren |
| US20090171104A1 (en) * | 2005-10-05 | 2009-07-02 | Killol Patel | Process for the preparation of orlistat |
| AU2006319235A1 (en) | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 5-substituted indole-2-carboxamide derivatives |
| WO2007062999A2 (en) | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 1,5-substituted indol-2-yl amide derivatives |
| DE602006021626D1 (de) | 2005-11-30 | 2011-06-09 | Hoffmann La Roche | 1,1-dioxo-thiomorpholinyl-indolyl-methanon-derivate zur verwendung als h3-modulatoren |
| CN101321761A (zh) | 2005-12-09 | 2008-12-10 | 霍夫曼-拉罗奇有限公司 | 用于治疗肥胖病的三环酰胺衍生物 |
| EP1963318B1 (en) | 2005-12-15 | 2009-11-25 | F. Hoffmann-la Roche AG | Pyrrolo[2,3-c]pyridine derivatives |
| AU2006326067A1 (en) | 2005-12-16 | 2007-06-21 | F. Hoffmann-La Roche Ag | Pyrrolo [2 , 3-b] pyridine derivatives as H3 receptor modulators |
| EP1976840A1 (en) * | 2006-01-13 | 2008-10-08 | F.Hoffmann-La Roche Ag | Cyclohexyl piperazinyl methanone derivatives and their use as histamine h3 receptor modulators |
| CN101370779B (zh) * | 2006-01-23 | 2011-07-20 | 霍夫曼-拉罗奇有限公司 | 具有h3受体活性的环己基磺酰胺衍生物 |
| US7432255B2 (en) | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| CA2652158A1 (en) * | 2006-05-30 | 2007-12-06 | Matthias Heinrich Nettekoven | Piperidinyl pyrimidine derivatives |
| US7514433B2 (en) | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| US20080146559A1 (en) | 2006-12-08 | 2008-06-19 | Li Chen | 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives |
| SG182171A1 (en) * | 2007-06-06 | 2012-07-30 | Ranbaxy Lab Ltd | Process for the preparation of orlistat |
| EP2183237A1 (en) | 2007-07-25 | 2010-05-12 | F. Hoffmann-Roche AG | Benzofuran- and benzo[b]thiophene-2-carboxylic acid amide derivatives and use thereof as histamine 3 receptor modulators |
| EP2212305A4 (en) * | 2007-10-31 | 2011-10-26 | Burnham Inst Medical Research | BETA-LACTONE COMPOUNDS |
| WO2010112569A1 (en) | 2009-03-31 | 2010-10-07 | Robert Zimmermann | Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor |
| WO2010115825A2 (en) | 2009-03-31 | 2010-10-14 | Robert Zimmermann | Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor |
| CA2798330A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| US8450350B2 (en) | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| EP4218753A3 (en) | 2017-07-12 | 2023-10-11 | Mayo Foundation for Medical Education and Research | Compounds for the reducing lipotoxic damage |
| CN112079821A (zh) * | 2020-09-14 | 2020-12-15 | 中山万汉制药有限公司 | 奥利司他与苯氨基嘧啶类化合物形成的缀合物及其制备方法与用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2478388A (en) * | 1945-09-28 | 1949-08-09 | Eastman Kodak Co | beta-lactones from unsaturated aldehydes and unsaturated ketones |
| JPS608117B2 (ja) * | 1977-02-08 | 1985-02-28 | 財団法人微生物化学研究会 | 新生理活性物質エステラスチンおよびその製造法 |
| GB2023604B (en) * | 1978-05-25 | 1982-07-28 | Microbial Chem Res Found | Physiologically active derivatives of esterastin and production thereof |
| JPS5587720A (en) * | 1978-12-27 | 1980-07-02 | Meiji Seika Kaisha Ltd | Anti-inflammatory agent |
| JPS56128774A (en) * | 1980-03-14 | 1981-10-08 | Microbial Chem Res Found | New physiologically active substance ebelactone and its preparation |
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
-
1985
- 1985-11-12 CA CA000495058A patent/CA1270837A/en not_active Expired - Lifetime
- 1985-11-15 ZW ZW203/85A patent/ZW20385A1/xx unknown
- 1985-12-04 FI FI854797A patent/FI91403C/fi not_active IP Right Cessation
- 1985-12-09 CS CS859016A patent/CS262425B2/cs not_active IP Right Cessation
- 1985-12-16 AU AU51259/85A patent/AU583569B2/en not_active Expired
- 1985-12-16 IL IL77338A patent/IL77338A/xx not_active IP Right Cessation
- 1985-12-16 NZ NZ214565A patent/NZ214565A/xx unknown
- 1985-12-17 AT AT85116096T patent/ATE70061T1/de not_active IP Right Cessation
- 1985-12-17 EP EP85116096A patent/EP0185359B1/de not_active Expired - Lifetime
- 1985-12-17 DE DE8585116096T patent/DE3584829D1/de not_active Expired - Lifetime
- 1985-12-18 PH PH33205A patent/PH26291A/en unknown
- 1985-12-18 MC MC851814A patent/MC1728A1/xx unknown
- 1985-12-18 HU HU854832A patent/HU200172B/hu unknown
- 1985-12-19 CN CN85108888A patent/CN1012643B/zh not_active Expired
- 1985-12-20 DK DK600385A patent/DK166724B1/da not_active IP Right Cessation
- 1985-12-20 IE IE327785A patent/IE58926B1/en not_active IP Right Cessation
- 1985-12-20 PT PT81748A patent/PT81748B/pt unknown
- 1985-12-20 NO NO855213A patent/NO171160C/no not_active IP Right Cessation
- 1985-12-30 DO DO1985004386A patent/DOP1985004386A/es unknown
-
1987
- 1987-12-17 US US07/134,322 patent/US4931463A/en not_active Expired - Lifetime
-
1990
- 1990-03-19 US US07/495,809 patent/US5175186A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US4931463A (en) | 1990-06-05 |
| CS262425B2 (en) | 1989-03-14 |
| EP0185359A3 (en) | 1987-08-26 |
| CN1012643B (zh) | 1991-05-22 |
| EP0185359A2 (de) | 1986-06-25 |
| IL77338A (en) | 1991-04-15 |
| NZ214565A (en) | 1989-06-28 |
| US5175186A (en) | 1992-12-29 |
| PT81748B (pt) | 1988-07-29 |
| PH26291A (en) | 1992-04-10 |
| DK600385D0 (da) | 1985-12-20 |
| PT81748A (en) | 1986-01-02 |
| AU583569B2 (en) | 1989-05-04 |
| DK166724B1 (da) | 1993-07-05 |
| HUT39440A (en) | 1986-09-29 |
| DE3584829D1 (de) | 1992-01-16 |
| EP0185359B1 (de) | 1991-12-04 |
| NO171160B (no) | 1992-10-26 |
| CA1270837A (en) | 1990-06-26 |
| DOP1985004386A (es) | 1991-04-20 |
| IE853277L (en) | 1986-06-21 |
| AU5125985A (en) | 1986-06-26 |
| MC1728A1 (fr) | 1986-12-15 |
| FI91403B (fi) | 1994-03-15 |
| NO855213L (no) | 1986-06-23 |
| DK600385A (da) | 1986-06-22 |
| FI854797A0 (fi) | 1985-12-04 |
| ZW20385A1 (en) | 1986-03-05 |
| FI91403C (fi) | 1994-06-27 |
| NO171160C (no) | 1993-02-03 |
| HU200172B (en) | 1990-04-28 |
| ATE70061T1 (de) | 1991-12-15 |
| IE58926B1 (en) | 1993-12-01 |
| CN85108888A (zh) | 1986-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| FG | Patent granted |
Owner name: F. HOFFMANN-LA ROCHE AG |
|
| MA | Patent expired |