FI84057B - Foerfarande foer framstaellning av terapeutiskt aktiva fluorallylaminderivat. - Google Patents
Foerfarande foer framstaellning av terapeutiskt aktiva fluorallylaminderivat. Download PDFInfo
- Publication number
- FI84057B FI84057B FI852748A FI852748A FI84057B FI 84057 B FI84057 B FI 84057B FI 852748 A FI852748 A FI 852748A FI 852748 A FI852748 A FI 852748A FI 84057 B FI84057 B FI 84057B
- Authority
- FI
- Finland
- Prior art keywords
- mao
- fluoroallylamine
- methyl
- acid
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/42—Halogenated unsaturated alcohols acyclic
- C07C33/423—Halogenated unsaturated alcohols acyclic containing only double bonds as unsaturation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Claims (2)
1. Analogiförfarande för framställning av terapeu-tiskt aktiva fluorallylaminderivat med följande forme1 I
5 V λ "HF /j — X-CH0-C-CH--NHR-> (I) *2—\=/ 2 3 10 eller deras farmakologiskt godtagbara syraadditionssal-ter, i vllken formel R3 och R2 oberoende av varandra betecknar väte, klor eller fluor,
15 R3 betecknar väte eller C1.4-alkyl och X betecknar syre eller svavel, kännetecknat därav, att ett aminoskyddat derivat av l-fluor-2-brom-metyl-3-aminoprop-l-en omsätts med en fenol eller tiofe-nol med följande formel lii 20 Ri^y_XH .m» R2 ^ 25 väri R3 och R2 oberoende av varandra betecknar väte, klor eller fluor, under vattenfria förhällanden i närvaro av en stark bas i ett aprotiskt lösningsmedel, skyddsgruppen av amino avlägsnas och eventuellt, ifall man önskar en 30 förening väri R3 är alkyl, N-alkyleras produkten, väri R3 är väte.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att man framställer 2-(2',4'-di-klorfenoxi)metyl-3-fluorallylamin, 2-fenoximetyl-3-fluor- 35 allylamin eller 2-tiofenoximetyl-3-fluorallylamin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63055684A | 1984-07-13 | 1984-07-13 | |
| US63055684 | 1984-07-13 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI852748A0 FI852748A0 (fi) | 1985-07-11 |
| FI852748L FI852748L (fi) | 1986-01-14 |
| FI84057B true FI84057B (fi) | 1991-06-28 |
| FI84057C FI84057C (sv) | 1991-10-10 |
Family
ID=24527644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI852748A FI84057C (sv) | 1984-07-13 | 1985-07-11 | Förfarande för framställning av terapeutiskt aktiva fluorallylaminderi vat |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0168013B1 (sv) |
| JP (1) | JPS61257952A (sv) |
| KR (1) | KR900008113B1 (sv) |
| AR (1) | AR240043A1 (sv) |
| AT (1) | ATE32711T1 (sv) |
| AU (1) | AU575973B2 (sv) |
| CA (1) | CA1256453A (sv) |
| DE (1) | DE3561723D1 (sv) |
| DK (1) | DK166878C (sv) |
| ES (1) | ES545111A0 (sv) |
| FI (1) | FI84057C (sv) |
| GB (1) | GB2162518B (sv) |
| HU (1) | HU195181B (sv) |
| IE (1) | IE58305B1 (sv) |
| IL (1) | IL75739A (sv) |
| NO (1) | NO161313C (sv) |
| NZ (1) | NZ212675A (sv) |
| PH (1) | PH21647A (sv) |
| PT (1) | PT80805B (sv) |
| ZA (1) | ZA855101B (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0660132B2 (ja) * | 1985-12-05 | 1994-08-10 | メレルダウフア−マス−テイカルズ インコ−ポレ−テツド | 非芳香族フルオロアリルアミンｍａｏ阻害剤 |
| EP0283168A3 (en) * | 1987-03-16 | 1989-06-14 | American Home Products Corporation | Fluorooxirane carboxylates |
| US4822812A (en) * | 1987-05-21 | 1989-04-18 | Merrell Dow Pharmaceuticals Inc. | β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition |
| US4965288A (en) * | 1988-02-25 | 1990-10-23 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5252608A (en) * | 1988-02-25 | 1993-10-12 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5059714A (en) * | 1988-02-25 | 1991-10-22 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5120764A (en) * | 1988-11-01 | 1992-06-09 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5488188A (en) * | 1994-09-29 | 1996-01-30 | Merrell Dow Pharmaceuticals Inc. | Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof |
| US20070293548A1 (en) * | 2006-03-31 | 2007-12-20 | Wang Eric Y | Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases |
| AU2013255103B2 (en) | 2012-05-02 | 2016-09-29 | Pharmaxis Ltd. | Substituted 3-haloallylamine inhibitors of SSAO and uses thereof |
| WO2024044813A1 (en) * | 2022-08-29 | 2024-03-07 | Pharmaxis Ltd. | Novel selective inhibitors of lysyl oxidases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1027611A (en) * | 1962-01-04 | 1966-04-27 | May & Baker Ltd | Phenoxy- and phenylthio-alkylamines and acid addition salts thereof |
| US3205136A (en) * | 1962-12-24 | 1965-09-07 | Smith Kline French Lab | Antidepressant phenyloxyalkylamines |
| US3513198A (en) * | 1965-10-22 | 1970-05-19 | Hoffmann La Roche | Aryloxy- and arylthio-acetylenic amines and the salts thereof |
| CH480306A (de) * | 1966-06-03 | 1969-10-31 | Ciba Geigy | Verfahren zur Herstellung von schwefelhaltigen Aminen |
-
1985
- 1985-07-05 ZA ZA855101A patent/ZA855101B/xx unknown
- 1985-07-08 IL IL75739A patent/IL75739A/xx not_active IP Right Cessation
- 1985-07-08 DE DE8585108443T patent/DE3561723D1/de not_active Expired
- 1985-07-08 AT AT85108443T patent/ATE32711T1/de not_active IP Right Cessation
- 1985-07-08 NZ NZ212675A patent/NZ212675A/en unknown
- 1985-07-08 AU AU44660/85A patent/AU575973B2/en not_active Ceased
- 1985-07-08 EP EP85108443A patent/EP0168013B1/en not_active Expired
- 1985-07-10 GB GB08517454A patent/GB2162518B/en not_active Expired
- 1985-07-10 CA CA000486625A patent/CA1256453A/en not_active Expired
- 1985-07-10 JP JP60150325A patent/JPS61257952A/ja active Granted
- 1985-07-11 FI FI852748A patent/FI84057C/sv not_active IP Right Cessation
- 1985-07-11 ES ES545111A patent/ES545111A0/es active Granted
- 1985-07-11 AR AR300950A patent/AR240043A1/es active
- 1985-07-11 IE IE174685A patent/IE58305B1/en not_active IP Right Cessation
- 1985-07-12 PH PH32522A patent/PH21647A/en unknown
- 1985-07-12 HU HU852702A patent/HU195181B/hu not_active IP Right Cessation
- 1985-07-12 KR KR1019850004968A patent/KR900008113B1/ko not_active IP Right Cessation
- 1985-07-12 PT PT80805A patent/PT80805B/pt not_active IP Right Cessation
- 1985-07-12 DK DK320585A patent/DK166878C/da active
- 1985-07-12 NO NO852810A patent/NO161313C/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR910000251B1 (ko) | 비시클로 치환된 페닐아세토니트릴 유도체 | |
| FR2542740A1 (fr) | Derives de thiazolidine, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| FI84057B (fi) | Foerfarande foer framstaellning av terapeutiskt aktiva fluorallylaminderivat. | |
| LU82087A1 (fr) | N-benzylimidazoles inhibiteurs selectifs de thromboxannesynthetase,leur procede de production et compositions pharmaceutiques les contenant | |
| JPH0210128B2 (sv) | ||
| BG61318B2 (bg) | N-2/(4-флуорофенил)-1-метил/-2-етил-n-метил-n-пропиниламин и метод за използването му | |
| US4699928A (en) | Fluoroallylamine derivatives | |
| FI86845B (fi) | Foerfarande foer framstaellning av en terapeutiskt anvaendbar fluorallylamin. | |
| FI63751C (fi) | Analogifoerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-(3-tert-butylaminopropoxi)-2-metyl-indolderivat | |
| JP4223237B2 (ja) | ３−フェニル−３，７−ジアザビシクロ［３，３，１］ノナン−化合物、これを含有する医薬品、その使用及びその製法 | |
| CA2202169A1 (fr) | Derives metalloceniques du diarylethylene, leurs procedes de preparation et compositions pharmaceutiques contenant lesdits derives | |
| CA1190242A (en) | 2-amino-3-hydroxyphenyl-3-butenoic acid derivatives | |
| JP4009062B2 (ja) | 異常な細胞増殖を特徴とする疾患を治療または予防するために有用な、置換ジフェニルインダノン、インダン、およびインドール化合物およびそれらの類縁体 | |
| WO1994006762A1 (en) | Non-metabolizable clomiphene analogs for treatment of tamoxifen-resistant tumors | |
| FR2543952A1 (fr) | Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique | |
| FR2745572A1 (fr) | Nouveaux sulfonamides derives de benzylamines, leurs sels, ainsi que leurs procedes de fabrication, les compositions pharmaceutiques et leur utilisation comme medicaments | |
| JPS62108869A (ja) | ド−パミン−β−ヒドロキシラ−ゼ抑制物質 | |
| HU199790B (en) | Process for producing beta-/fluoromethylene/-5-hydroxy-tryptophan derivatives and pharmaceutical compositions comprising same | |
| KR840002005B1 (ko) | 피페라진 유도체의 제조방법 | |
| FR2514352A1 (sv) | ||
| JPH0770083A (ja) | イミダゾール誘導体を有効成分とする血圧降下剤 | |
| CA2362077A1 (en) | Cyclic amine derivatives and uses thereof | |
| JPH03157381A (ja) | フッ素置換アリルアミン誘導体 | |
| JPS62149649A (ja) | 非芳香族フルオロアリルアミンｍａｏ阻害剤 | |
| BE878563A (fr) | Nouvelles alpha-alkyl-o-oxybenzylamines, leur preparation et leur application comme medicaments |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: MERRELL DOW PHARMACEUTICALS INC. |