FI803220L - 1,2,4-oxadiatsinderivat foerfarande foer deras framstaellning och farmaceutiska blandningar innehaollande dem - Google Patents

1,2,4-oxadiatsinderivat foerfarande foer deras framstaellning och farmaceutiska blandningar innehaollande dem

Info

Publication number
FI803220L
FI803220L FI803220A FI803220A FI803220L FI 803220 L FI803220 L FI 803220L FI 803220 A FI803220 A FI 803220A FI 803220 A FI803220 A FI 803220A FI 803220 L FI803220 L FI 803220L
Authority
FI
Finland
Prior art keywords
oxadiacinderivat
blandningar
foerfarande foer
deras framstaellning
framstaellning och
Prior art date
Application number
FI803220A
Other languages
English (en)
Other versions
FI71932B (fi
FI71932C (fi
Inventor
Kalman Takacs
Ajzert Ilona Kiss
Antal Simay
Peter Literati Nagy
Papp Maria Hetyey
Puskas Marian Ecsery
Jozsef Szegi
Sandor Viragh
Nagy Sandor Juhasz
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of FI803220L publication Critical patent/FI803220L/fi
Publication of FI71932B publication Critical patent/FI71932B/fi
Application granted granted Critical
Publication of FI71932C publication Critical patent/FI71932C/fi

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/475Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D273/00Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04Six-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI803220A 1979-10-11 1980-10-10 Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 1,2,4-oxadiazinderivat. FI71932C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU79CI1973A HU179951B (en) 1979-10-11 1979-10-11 Process for preparing 1,2,4-oxadiazolin-5-one derivatives and pharmaceutical compositions containing thereof
HUCI001973 1979-10-11

Publications (3)

Publication Number Publication Date
FI803220L true FI803220L (fi) 1981-04-12
FI71932B FI71932B (fi) 1986-11-28
FI71932C FI71932C (fi) 1987-03-09

Family

ID=10994764

Family Applications (2)

Application Number Title Priority Date Filing Date
FI803220A FI71932C (fi) 1979-10-11 1980-10-10 Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 1,2,4-oxadiazinderivat.
FI803219A FI71318C (fi) 1979-10-11 1980-10-10 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,2,4-oxadiazolin-5-onderivat

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI803219A FI71318C (fi) 1979-10-11 1980-10-10 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,2,4-oxadiazolin-5-onderivat

Country Status (23)

Country Link
US (1) US4365064A (fi)
JP (1) JPS5661375A (fi)
AT (1) AT375369B (fi)
BE (1) BE885633A (fi)
CA (1) CA1154019A (fi)
CH (1) CH649547A5 (fi)
CS (1) CS241032B2 (fi)
DD (1) DD153550A5 (fi)
DE (1) DE3037432A1 (fi)
DK (1) DK149854C (fi)
ES (1) ES8106725A1 (fi)
FI (2) FI71932C (fi)
FR (1) FR2467203A1 (fi)
GB (1) GB2059967B (fi)
HU (1) HU179951B (fi)
IL (1) IL61175A (fi)
IT (1) IT1129305B (fi)
NL (1) NL8005586A (fi)
NO (1) NO154795C (fi)
PL (3) PL131451B1 (fi)
SE (1) SE452158B (fi)
SU (1) SU1087519A1 (fi)
YU (1) YU41738B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU180708B (en) * 1979-10-11 1983-04-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 1,2,4-oxadiazine derivatives
WO2001070674A1 (en) * 2000-03-20 2001-09-27 N-Gene Research Laboratories Inc. Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same
CA2894157A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
EP2935241A1 (en) * 2012-12-21 2015-10-28 Epizyme, Inc. Prmt5 inhibitors and uses thereof
EP2935240A1 (en) 2012-12-21 2015-10-28 Epizyme, Inc. Prmt5 inhibitors and uses thereof
PT2935222T (pt) 2012-12-21 2018-12-10 Epizyme Inc Inibidores de prmt5 e seus usos
US8940726B2 (en) 2012-12-21 2015-01-27 Epizyme, Inc. PRMT5 inhibitors and uses thereof
CA2953572A1 (en) 2014-08-04 2016-02-11 Epizyme, Inc. Prmt5 inhibitors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1529700A (fr) * 1967-04-11 1968-06-21 Dausse Sa Lab Tertioaminoalcoyl oxadiazolinones et leur procédé de préparation
FR1575552A (fi) * 1967-12-07 1969-07-25
US4038279A (en) * 1972-12-23 1977-07-26 Boehringer Ingelheim Gmbh N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof
US3994891A (en) * 1974-12-20 1976-11-30 Armour Pharmaceutical Company Tetrahydroisoquinoline compounds
US4187220A (en) * 1977-08-30 1980-02-05 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
HU180708B (en) * 1979-10-11 1983-04-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 1,2,4-oxadiazine derivatives

Also Published As

Publication number Publication date
FI71318C (fi) 1986-12-19
GB2059967B (en) 1983-06-02
FI71932B (fi) 1986-11-28
FR2467203A1 (fr) 1981-04-17
IL61175A0 (en) 1980-11-30
CH649547A5 (de) 1985-05-31
IT8068555A0 (it) 1980-10-09
CS673780A2 (en) 1985-06-13
FI803219L (fi) 1981-04-12
AT375369B (de) 1984-07-25
DK149854B (da) 1986-10-13
YU41738B (en) 1987-12-31
BE885633A (fr) 1981-02-02
HU179951B (en) 1983-01-28
GB2059967A (en) 1981-04-29
DD153550A5 (de) 1982-01-13
NL8005586A (nl) 1981-04-14
DK149854C (da) 1987-04-21
SE8007025L (sv) 1981-04-12
NO803044L (no) 1981-04-13
JPS5661375A (en) 1981-05-26
ES495819A0 (es) 1981-09-16
PL232293A1 (fi) 1982-04-26
PL232292A1 (fi) 1982-04-26
DE3037432A1 (de) 1981-05-27
SU1087519A1 (ru) 1984-04-23
YU259480A (en) 1984-02-29
IT1129305B (it) 1986-06-04
SE452158B (sv) 1987-11-16
IL61175A (en) 1984-08-31
FI71318B (fi) 1986-09-09
FR2467203B1 (fi) 1985-03-22
NO154795B (no) 1986-09-15
DK429780A (da) 1981-04-12
ATA501380A (de) 1983-12-15
PL227209A1 (fi) 1981-12-11
PL131375B1 (en) 1984-11-30
PL131451B1 (en) 1984-11-30
CS241032B2 (en) 1986-03-13
CA1154019A (en) 1983-09-20
US4365064A (en) 1982-12-21
ES8106725A1 (es) 1981-09-16
FI71932C (fi) 1987-03-09
PL132131B1 (en) 1985-02-28
NO154795C (no) 1986-12-29

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Legal Events

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MM Patent lapsed
MM Patent lapsed

Owner name: CHINOIN GYOGUSZER ES VEGYESZETI TERMEKEK