FI67876C - Foerfarande foer framstaellning av antimikrobiellt och antitumoert verkande derivat av tallysomycin a och tallysomycin b - Google Patents
Foerfarande foer framstaellning av antimikrobiellt och antitumoert verkande derivat av tallysomycin a och tallysomycin b Download PDFInfo
- Publication number
- FI67876C FI67876C FI802198A FI802198A FI67876C FI 67876 C FI67876 C FI 67876C FI 802198 A FI802198 A FI 802198A FI 802198 A FI802198 A FI 802198A FI 67876 C FI67876 C FI 67876C
- Authority
- FI
- Finland
- Prior art keywords
- tallysomycin
- och
- derivatives
- fermentation
- tallycomycin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (3)
1 N_pC-NH-(CH2)3-CH-CH2-C-R N^N ° o "H2 K '1 „ un _
2 Jk AH-CH-k rJ H^'VS50 0HY^rNY^N^ ' H,C o H0_ J TTjj a 4V 0h| H2N OH U0-^-OH V-'T'-k-OH HO A 0"^NH2 där R är -NH- (CH2) 3“^^2 -nh-(ch2)3-s®(ch3)2 -nh-(ch2)3-nh-ch2-ch2oh -nh-(ch2)3-n(ch2ch2oh)2 -nh-(ch2)4-nh2 -MH-(CH2)3-NH-CH3 eller -HH-(CH2)j-«H-CH-Q , ch3 samt derivat av tallysomycin B med formeln (Ib) 67876 36 co-nh2 nh2 q ^ 0 o ",-AJ oHY^Syk^SH-CH-kT^ HW Y H!%^ Γ^^--ο H I oh I OH I H*N 0H Uq^-OH γ-τ-^-οΗ HO X Q'^mz där R är , , -nh-(ch2)3-nh2 -nh-(ch2)3-s®(ch3)2 -NH-(CH2)2-NH2 -NH-CH2-CH-CH2-NH2 OH -NH-(CH2)2-NH-CH2-CH-CH3 OH -NH-(CH2)3-NH-CH2-CH2OH -MH-(CH2)3-N(CH3)2· -NH-(CH2)3-N(CH2CH2OH)2 -NH-(CH2)2-NH-CH2-CH2OH -NH-(CH2)d-NH2 -NH-(CH2)3-NH-CH3 -NH-(CH2)3-N^J0 eller -NH-(CH2)3-n£^ ch3 -NH-(CH2)3-NH-CH-^~^ ^3 67876 37 eller farmaceutiskt godtagbara syraadditionssalter därav genom odling av en tallysomycin-producerande stam av Streptoalloteichus hindustanus i ett vattenhaltigt nSrings-medium, kännetecknat därav, att odlingen genomförs i närvaro av en aminprekursorförening med formeln NH2-(CH2)2-NH2, nh2-(ch2)3-nh2, NH2-(CH2)4-NH2, NH2-CH2-CH-CH2-NH2, OH NH2-(CH2)2-NH-CH2-CH2OH, NH2-(CH2)2-NH-CH2-CH-CH3, OH NH2-(CH2)3-NH-CH3, nh2-(ch2)3-nh-ch2-ch2oh, nh2-(ch2)3-nh-ch^) , CH3 NH2-(CH2)3-N(CH3)2, NH2-(CH2)3-N(CH2CH20H)2, NH2-(CH2)3-Q, eller nh2-(ch2)3-n^) ch3 nh2-(ch2)3-s®(ch3)2, Cl®
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/057,528 US4246400A (en) | 1979-07-13 | 1979-07-13 | Tallysomycin compounds |
| US5752879 | 1979-07-13 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI802198A FI802198A (fi) | 1981-01-14 |
| FI67876B FI67876B (fi) | 1985-02-28 |
| FI67876C true FI67876C (fi) | 1985-06-10 |
Family
ID=22011128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI802198A FI67876C (fi) | 1979-07-13 | 1980-07-09 | Foerfarande foer framstaellning av antimikrobiellt och antitumoert verkande derivat av tallysomycin a och tallysomycin b |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4246400A (sv) |
| JP (1) | JPS5659793A (sv) |
| AU (1) | AU533469B2 (sv) |
| BE (1) | BE884291A (sv) |
| CA (1) | CA1144494A (sv) |
| CH (1) | CH646982A5 (sv) |
| CY (1) | CY1317A (sv) |
| DE (1) | DE3026425A1 (sv) |
| DK (1) | DK151633C (sv) |
| ES (1) | ES8106554A1 (sv) |
| FI (1) | FI67876C (sv) |
| FR (1) | FR2460961A1 (sv) |
| GB (1) | GB2053221B (sv) |
| GR (1) | GR82324B (sv) |
| HK (1) | HK8286A (sv) |
| IE (1) | IE50020B1 (sv) |
| IL (1) | IL60541A (sv) |
| IT (1) | IT1174296B (sv) |
| LU (1) | LU82612A1 (sv) |
| MY (1) | MY8800097A (sv) |
| NL (1) | NL8003970A (sv) |
| NO (1) | NO155701C (sv) |
| NZ (1) | NZ193921A (sv) |
| SE (1) | SE449751B (sv) |
| YU (1) | YU43218B (sv) |
| ZA (1) | ZA804150B (sv) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4650765A (en) * | 1981-02-23 | 1987-03-17 | American Cyanamid Company | Biologically pure culture of Streptoverticillium stramineum sp. nov. |
| EP0058838A1 (en) * | 1981-02-23 | 1982-09-01 | American Cyanamid Company | Antibiotic LL BO1208 alpha and LL BO1208 beta |
| JPH02267083A (ja) * | 1989-04-07 | 1990-10-31 | Nissan Motor Co Ltd | 自動車のフロントボデー補強構造 |
| US5420228A (en) * | 1991-04-05 | 1995-05-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Fluorescent-labelled bleomycin analogues |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1038242A (en) * | 1963-03-05 | 1966-08-10 | Zaidan Hojin Biseibutsu | Bleomycin and processes for preparation thereof |
| GB1292081A (en) * | 1969-02-15 | 1972-10-11 | Zaidan Hojin Biseibutsu | Process for producing bleomycin antibiotics |
| US3846400A (en) * | 1969-02-15 | 1974-11-05 | Microbial Chem Res Found | Novel process for producing antibiotics bleomycin |
| US3814796A (en) * | 1969-10-09 | 1974-06-04 | Upjohn Co | Antibiotics zorbonomycin and zorbonomycin b and process for the preparation thereof |
| US3922262A (en) * | 1971-04-28 | 1975-11-25 | Nippon Kayaku Kk | N-Substituted derivatives of bleomycins |
| JPS5739751B2 (sv) * | 1972-03-03 | 1982-08-23 | ||
| US4051237A (en) * | 1975-08-28 | 1977-09-27 | Bristol-Myers Company | Glycopeptide antibiotics bu-2231 a and b and process for producing same |
| US4195018A (en) * | 1977-07-01 | 1980-03-25 | Nippon Kayaku Kabushiki Kaisha | 3-[(S)-1'-Phenylethylamino]propylaminobleomycin, non-toxic salt thereof, and method for producing same |
-
1979
- 1979-07-13 US US06/057,528 patent/US4246400A/en not_active Expired - Lifetime
-
1980
- 1980-05-27 CA CA000352782A patent/CA1144494A/en not_active Expired
- 1980-05-28 GR GR62069A patent/GR82324B/el unknown
- 1980-05-29 YU YU1435/80A patent/YU43218B/xx unknown
- 1980-06-04 NZ NZ193921A patent/NZ193921A/xx unknown
- 1980-06-10 AU AU59190/80A patent/AU533469B2/en not_active Ceased
- 1980-07-04 JP JP9080680A patent/JPS5659793A/ja active Granted
- 1980-07-07 IT IT49183/80A patent/IT1174296B/it active
- 1980-07-08 NO NO802048A patent/NO155701C/no unknown
- 1980-07-09 CH CH526780A patent/CH646982A5/fr not_active IP Right Cessation
- 1980-07-09 FI FI802198A patent/FI67876C/fi not_active IP Right Cessation
- 1980-07-09 NL NL8003970A patent/NL8003970A/nl not_active Application Discontinuation
- 1980-07-10 FR FR8015370A patent/FR2460961A1/fr active Granted
- 1980-07-10 IL IL60541A patent/IL60541A/xx unknown
- 1980-07-10 DK DK297980A patent/DK151633C/da not_active IP Right Cessation
- 1980-07-10 ZA ZA00804150A patent/ZA804150B/xx unknown
- 1980-07-11 DE DE19803026425 patent/DE3026425A1/de active Granted
- 1980-07-11 SE SE8005134A patent/SE449751B/sv not_active IP Right Cessation
- 1980-07-11 BE BE0/201391A patent/BE884291A/fr not_active IP Right Cessation
- 1980-07-11 CY CY1317A patent/CY1317A/xx unknown
- 1980-07-11 ES ES493350A patent/ES8106554A1/es not_active Expired
- 1980-07-11 LU LU82612A patent/LU82612A1/fr unknown
- 1980-07-11 GB GB8022703A patent/GB2053221B/en not_active Expired
- 1980-07-11 IE IE1444/80A patent/IE50020B1/en unknown
-
1986
- 1986-02-05 HK HK82/86A patent/HK8286A/xx unknown
-
1988
- 1988-12-30 MY MY97/88A patent/MY8800097A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: BRISTOL-MYERS CO |