FI66873C - Foerfarande foer framstaellning av 3-klorcefemderivat - Google Patents

Foerfarande foer framstaellning av 3-klorcefemderivat Download PDF

Info

Publication number
FI66873C
FI66873C FI772339A FI772339A FI66873C FI 66873 C FI66873 C FI 66873C FI 772339 A FI772339 A FI 772339A FI 772339 A FI772339 A FI 772339A FI 66873 C FI66873 C FI 66873C
Authority
FI
Finland
Prior art keywords
cephem
formula
hydroxy
carboxylate
nitrobenzyl
Prior art date
Application number
FI772339A
Other languages
English (en)
Finnish (fi)
Other versions
FI66873B (fi
FI772339A (fi
Inventor
Stjepan Kukolja
Douglas Overbaugh Spry
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI772339A publication Critical patent/FI772339A/fi
Publication of FI66873B publication Critical patent/FI66873B/fi
Application granted granted Critical
Publication of FI66873C publication Critical patent/FI66873C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
FI772339A 1976-08-16 1977-08-01 Foerfarande foer framstaellning av 3-klorcefemderivat FI66873C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71494876A 1976-08-16 1976-08-16
US71494876 1976-08-16

Publications (3)

Publication Number Publication Date
FI772339A FI772339A (fi) 1978-02-17
FI66873B FI66873B (fi) 1984-08-31
FI66873C true FI66873C (fi) 1984-12-10

Family

ID=24872131

Family Applications (1)

Application Number Title Priority Date Filing Date
FI772339A FI66873C (fi) 1976-08-16 1977-08-01 Foerfarande foer framstaellning av 3-klorcefemderivat

Country Status (20)

Country Link
US (1) US4115643A (ro)
JP (1) JPS5323994A (ro)
BE (1) BE857244A (ro)
BG (1) BG28068A3 (ro)
CA (1) CA1099256A (ro)
CH (1) CH630924A5 (ro)
CS (1) CS192588B2 (ro)
DD (1) DD131858A5 (ro)
DE (1) DE2735454A1 (ro)
ES (1) ES461587A1 (ro)
FI (1) FI66873C (ro)
FR (1) FR2362145A1 (ro)
GB (1) GB1582044A (ro)
HU (1) HU179459B (ro)
IE (1) IE45158B1 (ro)
IL (1) IL52416A (ro)
NL (1) NL7709055A (ro)
PL (1) PL110242B1 (ro)
RO (1) RO71908A (ro)
SU (1) SU1018586A3 (ro)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
US4271305A (en) * 1979-02-01 1981-06-02 Eli Lilly And Company Thiazolinoazetidinones and process therefor
US4223133A (en) * 1979-02-01 1980-09-16 Eli Lilly And Company Cephalosporin reduction process
US4226986A (en) * 1979-02-01 1980-10-07 Eli Lilly And Company Process for halogenation of β-lactam compounds
US4237279A (en) * 1979-07-27 1980-12-02 Eli Lilly And Company Crystalline 3-hydroxycephalosporin solvates
US4281117A (en) * 1980-09-04 1981-07-28 Eli Lilly And Company Process for 3-chloro cephalosporin nucleus
US5159071A (en) * 1990-09-06 1992-10-27 Ranbaxy Laboratories Limited Process for the manufacture of 7-amino-3-exomethylene-3-cepham-4-carboxylic acid ester
US5350845A (en) * 1992-04-08 1994-09-27 Eli Lilly And Company Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters
IN181695B (ro) * 1992-08-10 1998-09-05 Ranbaxy Lab Ltd
US5604222A (en) * 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) * 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
KR100390551B1 (ko) * 1996-08-22 2003-11-17 주식회사 코오롱 3-할로메틸-3-세펨-4-카르복실레이트 1-옥사이드의 제조방법
CN101190921B (zh) * 2007-11-27 2010-05-19 吉林省石油化工设计研究院 一种对硝基苄基-7-苯氧基乙酰胺-3-外亚甲基头孢-4-羧酸酯-1-β-氧化物制备方法
CN102443014B (zh) * 2011-12-29 2014-07-09 上海右手医药科技开发有限公司 3-氯头孢菌素衍生物及其合成方法与在头孢克洛制备中的应用
CN103588790A (zh) * 2013-11-29 2014-02-19 中国科学院长春应用化学研究所 7-氨基-3-氯-3-头孢-4-羧酸-对硝基苄基酯的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641014A (en) * 1968-10-03 1972-02-08 Lilly Co Eli Reduction of delta**3-cephalosporin sulfoxides
AR208068A1 (es) * 1973-02-23 1976-11-30 Lilly Co Eli Un procedimiento para preparar derivados de acidos 7-acilamido-3-halo-cefem-4-carboxilico los esteres y las sales farmaceuticamente aceptables de los mismos
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins
YU36970B (en) * 1973-02-23 1984-08-31 Lilly Co Eli Process for obtaining 7-(amino)-acylamido-3-halocephalosporins
US3962227A (en) * 1973-02-23 1976-06-08 Eli Lilly And Company 3-halo cephalosporins

Also Published As

Publication number Publication date
FI66873B (fi) 1984-08-31
ES461587A1 (es) 1978-06-01
CS192588B2 (en) 1979-08-31
BE857244A (fr) 1978-01-30
RO71908A (ro) 1981-11-24
BG28068A3 (en) 1980-02-25
FR2362145B1 (ro) 1980-02-15
NL7709055A (nl) 1978-02-20
HU179459B (en) 1982-10-28
FI772339A (fi) 1978-02-17
CH630924A5 (de) 1982-07-15
CA1099256A (en) 1981-04-14
IE45158B1 (en) 1982-06-30
DE2735454A1 (de) 1978-02-23
JPS5323994A (en) 1978-03-06
DE2735454C2 (ro) 1992-12-10
DD131858A5 (de) 1978-07-26
US4115643A (en) 1978-09-19
FR2362145A1 (fr) 1978-03-17
IL52416A0 (en) 1977-08-31
JPS6120556B2 (ro) 1986-05-22
IL52416A (en) 1980-02-29
SU1018586A3 (ru) 1983-05-15
GB1582044A (en) 1980-12-31
IE45158L (en) 1978-02-16
PL200289A1 (pl) 1978-05-08
PL110242B1 (en) 1980-07-31

Similar Documents

Publication Publication Date Title
FI66873C (fi) Foerfarande foer framstaellning av 3-klorcefemderivat
CA1041523A (en) Preparation of 1-oxapenicillins and novel intermediates therefor
FI63035B (fi) Foerfarande foer framstaellning av 7-alfa-aminoacyl-3-klorcefalosporinderivat
US4031084A (en) Process for cephalosporin antibiotic intermediates
US3632578A (en) Cleavage of acylamidocephalosporins and acylamidopenicillins
US3975385A (en) 7-Trichloroacetamido-3-desacetoxy-cephalosporanic acid esters
US4103085A (en) 7-(Syn-α-alkoxy-iminofurylacetamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids
IL44263A (en) 7-amino-or 7-acylamido-3-halo-3-cephem 4-carboxylic acids
US3941779A (en) Method for producing 2-(substituted thio)-3-cephem derivatives
US4208515A (en) 3-Halo cephalosporins
FI66186B (fi) Foerfarande foer framstaellning av penicillansyra- och cefalosporansyraderivat
US4187221A (en) Process for preparing azetidinones
US4334063A (en) Cephalosporin vinyl halides
JPS6133838B2 (ro)
HU197017B (en) Process for producing cefem carboxylic acid derivatives from the appropriate esters
US3991051A (en) [(Oxyalkyl)thioacetyl]cephalosporin derivatives
JPS606960B2 (ja) ３―メチレンセフアムスルホキシドの製法
US4005074A (en) Process for cleaving an imido side chain from penicillins and cephalosporins
US4299954A (en) Cephalosporin vinyl halides
US3994888A (en) Cephalosporin cleavage process
US4237280A (en) Intermediate for cephalosporin type compound
KR840000118B1 (ko) 옥사졸리노 아제티디논의 제조방법
JPS5823395B2 (ja) スルフイニルアゼチジノン化合物
KR800000059B1 (ko) 3,4-디카복시세팔로스포린 유도체의 제조방법
HU187912B (en) Process for producing new intermediates of pename-3-carboxylic acid and cepheme-4-carboxylic-acid derivatives

Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: ELI LILLY AND CO