FI66751C - Foerfarande foer framstaellning av ett stabilt insulinpreparatmed laongtidsverkan - Google Patents

Foerfarande foer framstaellning av ett stabilt insulinpreparatmed laongtidsverkan Download PDF

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Publication number
FI66751C
FI66751C FI760058A FI760058A FI66751C FI 66751 C FI66751 C FI 66751C FI 760058 A FI760058 A FI 760058A FI 760058 A FI760058 A FI 760058A FI 66751 C FI66751 C FI 66751C
Authority
FI
Finland
Prior art keywords
insulin
reaction
solution
urea
protamine
Prior art date
Application number
FI760058A
Other languages
English (en)
Finnish (fi)
Other versions
FI760058A (el
FI66751B (fi
Inventor
Bruno Andre Hansen
Finn Hede Andresen
Original Assignee
Nordisk Insulinlab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordisk Insulinlab filed Critical Nordisk Insulinlab
Publication of FI760058A publication Critical patent/FI760058A/fi
Application granted granted Critical
Publication of FI66751B publication Critical patent/FI66751B/fi
Publication of FI66751C publication Critical patent/FI66751C/fi

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • C07K14/625Extraction from natural sources
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FI760058A 1975-01-15 1976-01-12 Foerfarande foer framstaellning av ett stabilt insulinpreparatmed laongtidsverkan FI66751C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK8375 1975-01-15
DK8375AA DK140801B (da) 1975-01-15 1975-01-15 Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.

Publications (3)

Publication Number Publication Date
FI760058A FI760058A (el) 1976-07-16
FI66751B FI66751B (fi) 1984-08-31
FI66751C true FI66751C (fi) 1984-12-10

Family

ID=8089535

Family Applications (1)

Application Number Title Priority Date Filing Date
FI760058A FI66751C (fi) 1975-01-15 1976-01-12 Foerfarande foer framstaellning av ett stabilt insulinpreparatmed laongtidsverkan

Country Status (36)

Country Link
JP (1) JPS5946939B2 (el)
AR (1) AR213088A1 (el)
AT (1) AT362492B (el)
BE (1) BE837600A (el)
BR (1) BR7600206A (el)
CA (1) CA1094549A (el)
CH (1) CH631625A5 (el)
CS (1) CS208147B2 (el)
DD (1) DD124379A5 (el)
DE (1) DE2600971C2 (el)
DK (1) DK140801B (el)
EG (1) EG11988A (el)
ES (1) ES444558A1 (el)
FI (1) FI66751C (el)
FR (1) FR2297634A1 (el)
GB (1) GB1524431A (el)
GR (1) GR58608B (el)
HU (1) HU175142B (el)
IE (1) IE42395B1 (el)
IL (1) IL48845A (el)
IN (1) IN143279B (el)
IT (1) IT1054211B (el)
KE (1) KE2919A (el)
LU (1) LU74175A1 (el)
MX (1) MX4052E (el)
MY (1) MY7900169A (el)
NL (1) NL166464C (el)
NO (1) NO146698C (el)
NZ (1) NZ179733A (el)
OA (1) OA05209A (el)
PL (1) PL99927B1 (el)
PT (1) PT64696B (el)
RO (1) RO71576A (el)
SE (1) SE437219B (el)
YU (1) YU8376A (el)
ZA (1) ZA7658B (el)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK374579A (da) * 1979-09-07 1981-03-08 Nordisk Insulinlab Fremgangsmaade til fremstilling af et injucerbart insulinpraeparat
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
US4801575A (en) * 1986-07-30 1989-01-31 The Regents Of The University Of California Chimeric peptides for neuropeptide delivery through the blood-brain barrier
AU609769B2 (en) * 1987-02-10 1991-05-09 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
EP2414560B1 (de) 2009-03-31 2013-10-23 Boehringer Ingelheim International GmbH Verfahren zur beschichtung einer oberfläche eines bauteils
JP5763053B2 (ja) 2009-05-18 2015-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アダプタ、吸入器具及びアトマイザ
JP5658268B2 (ja) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
WO2011064164A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
WO2011160932A1 (en) 2010-06-24 2011-12-29 Boehringer Ingelheim International Gmbh Nebulizer
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
JP6643231B2 (ja) 2013-08-09 2020-02-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
EP2835146B1 (en) 2013-08-09 2020-09-30 Boehringer Ingelheim International GmbH Nebulizer
LT3928818T (lt) 2014-05-07 2023-03-27 Boehringer Ingelheim International Gmbh Purkštuvas ir talpa
JP6580070B2 (ja) 2014-05-07 2019-09-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 容器、ネブライザ、及び使用
PL3139984T3 (pl) 2014-05-07 2021-11-08 Boehringer Ingelheim International Gmbh Nebulizator

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3758683A (en) * 1971-04-30 1973-09-11 R Jackson Insulin product

Also Published As

Publication number Publication date
DK8375A (el) 1976-07-16
BR7600206A (pt) 1976-08-31
SE437219B (sv) 1985-02-18
NL166464B (nl) 1981-03-16
ZA7658B (en) 1976-12-29
NZ179733A (en) 1978-04-28
AT362492B (de) 1981-05-25
EG11988A (en) 1978-06-30
MY7900169A (en) 1979-12-31
DE2600971A1 (de) 1976-07-22
BE837600A (fr) 1976-07-15
LU74175A1 (el) 1977-03-18
DE2600971C2 (de) 1985-12-12
FI760058A (el) 1976-07-16
IL48845A0 (en) 1976-03-31
PL99927B1 (pl) 1978-08-31
ATA21376A (de) 1980-10-15
CA1094549A (en) 1981-01-27
CH631625A5 (en) 1982-08-31
RO71576A (ro) 1980-12-30
FR2297634B1 (el) 1979-03-30
MX4052E (es) 1981-11-24
CS208147B2 (en) 1981-08-31
HU175142B (hu) 1980-05-28
GB1524431A (en) 1978-09-13
DK140801B (da) 1979-11-19
AU1030776A (en) 1977-07-21
JPS51125299A (en) 1976-11-01
JPS5946939B2 (ja) 1984-11-15
NL7600338A (nl) 1976-07-19
NO760118L (el) 1976-07-16
DD124379A5 (el) 1977-02-16
PT64696B (fr) 1977-08-10
ES444558A1 (es) 1977-05-16
NO146698C (no) 1982-11-24
NL166464C (nl) 1981-08-17
SE7600284L (sv) 1976-07-16
YU8376A (en) 1982-06-30
GR58608B (en) 1977-11-10
DK140801C (el) 1980-04-21
IT1054211B (it) 1981-11-10
IL48845A (en) 1981-06-29
PT64696A (fr) 1976-02-01
IE42395L (en) 1976-07-15
AR213088A1 (es) 1978-12-15
IN143279B (el) 1977-10-29
FR2297634A1 (fr) 1976-08-13
NO146698B (no) 1982-08-16
FI66751B (fi) 1984-08-31
OA05209A (fr) 1981-02-28
KE2919A (en) 1979-03-30
IE42395B1 (en) 1980-07-30

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Owner name: NORDISK INSULINLABORATORIUM